Putative RNA-binding regulatory protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein 9, putative

Species:

Leishmania major

UniProt:

Q4QCQ8_LEIMA

TriTrypDb:

LmjF.20.1370 , LMJLV39_200020300 , LMJSD75_200020300

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QCQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCQ8

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	3
GO:0010608	post-transcriptional regulation of gene expression	6	3
GO:0019222	regulation of metabolic process	3	3
GO:0050789	regulation of biological process	2	3
GO:0060255	regulation of macromolecule metabolic process	4	3
GO:0065007	biological regulation	1	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	28
GO:0003723	RNA binding	4	28
GO:0003729	mRNA binding	5	3
GO:0005488	binding	1	28
GO:0097159	organic cyclic compound binding	2	28
GO:1901363	heterocyclic compound binding	2	28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.491
CLV_C14_Caspase3-7	96	100	PF00656	0.404
CLV_NRD_NRD_1	121	123	PF00675	0.348
CLV_NRD_NRD_1	130	132	PF00675	0.361
CLV_NRD_NRD_1	15	17	PF00675	0.391
CLV_NRD_NRD_1	246	248	PF00675	0.282
CLV_NRD_NRD_1	415	417	PF00675	0.727
CLV_PCSK_KEX2_1	121	123	PF00082	0.348
CLV_PCSK_KEX2_1	130	132	PF00082	0.361
CLV_PCSK_KEX2_1	15	17	PF00082	0.391
CLV_PCSK_KEX2_1	246	248	PF00082	0.294
CLV_PCSK_KEX2_1	287	289	PF00082	0.419
CLV_PCSK_KEX2_1	313	315	PF00082	0.519
CLV_PCSK_KEX2_1	415	417	PF00082	0.528
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.423
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.590
CLV_PCSK_SKI1_1	176	180	PF00082	0.435
CLV_PCSK_SKI1_1	246	250	PF00082	0.364
CLV_PCSK_SKI1_1	294	298	PF00082	0.352
CLV_PCSK_SKI1_1	390	394	PF00082	0.474
CLV_PCSK_SKI1_1	47	51	PF00082	0.358
CLV_Separin_Metazoa	173	177	PF03568	0.435
CLV_Separin_Metazoa	387	391	PF03568	0.460
DEG_APCC_DBOX_1	120	128	PF00400	0.364
DEG_APCC_DBOX_1	175	183	PF00400	0.275
DEG_APCC_DBOX_1	246	254	PF00400	0.455
DOC_CYCLIN_RxL_1	243	252	PF00134	0.367
DOC_MAPK_gen_1	72	80	PF00069	0.429
DOC_MAPK_MEF2A_6	72	80	PF00069	0.359
DOC_USP7_MATH_1	358	362	PF00917	0.613
DOC_USP7_MATH_1	395	399	PF00917	0.468
DOC_USP7_UBL2_3	305	309	PF12436	0.396
DOC_WW_Pin1_4	40	45	PF00397	0.537
LIG_14-3-3_CanoR_1	121	125	PF00244	0.396
LIG_14-3-3_CanoR_1	204	212	PF00244	0.474
LIG_14-3-3_CanoR_1	30	37	PF00244	0.451
LIG_14-3-3_CanoR_1	390	395	PF00244	0.473
LIG_14-3-3_CanoR_1	55	65	PF00244	0.503
LIG_14-3-3_CterR_2	424	429	PF00244	0.494
LIG_Actin_WH2_1	246	263	PF00022	0.320
LIG_Actin_WH2_1	58	76	PF00022	0.337
LIG_Actin_WH2_2	59	76	PF00022	0.335
LIG_BIR_II_1	1	5	PF00653	0.407
LIG_BIR_III_2	348	352	PF00653	0.429
LIG_BIR_III_3	1	5	PF00653	0.407
LIG_CaM_IQ_9	297	313	PF13499	0.345
LIG_EH1_1	270	278	PF00400	0.379
LIG_FHA_1	214	220	PF00498	0.454
LIG_FHA_1	96	102	PF00498	0.299
LIG_FHA_2	86	92	PF00498	0.368
LIG_LIR_Gen_1	393	403	PF02991	0.732
LIG_LIR_Nem_3	188	193	PF02991	0.318
LIG_LIR_Nem_3	266	271	PF02991	0.330
LIG_LIR_Nem_3	285	289	PF02991	0.389
LIG_LIR_Nem_3	393	399	PF02991	0.728
LIG_SH2_SRC	346	349	PF00017	0.677
LIG_SH2_SRC	386	389	PF00017	0.446
LIG_SH2_STAT3	193	196	PF00017	0.289
LIG_SH2_STAT3	417	420	PF00017	0.442
LIG_SH2_STAT5	119	122	PF00017	0.420
LIG_SH2_STAT5	148	151	PF00017	0.377
LIG_SH2_STAT5	210	213	PF00017	0.381
LIG_SH3_1	382	388	PF00018	0.461
LIG_SH3_2	385	390	PF14604	0.449
LIG_SH3_3	251	257	PF00018	0.472
LIG_SH3_3	277	283	PF00018	0.510
LIG_SH3_3	312	318	PF00018	0.451
LIG_SH3_3	382	388	PF00018	0.471
LIG_SH3_3	389	395	PF00018	0.464
LIG_SH3_3	4	10	PF00018	0.650
LIG_UBA3_1	219	226	PF00899	0.353
LIG_WW_3	387	391	PF00397	0.450
MOD_CDK_SPxxK_3	40	47	PF00069	0.336
MOD_CK1_1	117	123	PF00069	0.334
MOD_CK1_1	365	371	PF00069	0.490
MOD_CK1_1	373	379	PF00069	0.495
MOD_CK1_1	64	70	PF00069	0.500
MOD_CK2_1	123	129	PF00069	0.360
MOD_CK2_1	365	371	PF00069	0.543
MOD_CK2_1	85	91	PF00069	0.344
MOD_GlcNHglycan	134	138	PF01048	0.466
MOD_GlcNHglycan	17	20	PF01048	0.458
MOD_GlcNHglycan	360	363	PF01048	0.522
MOD_GlcNHglycan	401	404	PF01048	0.531
MOD_GlcNHglycan	411	414	PF01048	0.440
MOD_GSK3_1	199	206	PF00069	0.411
MOD_GSK3_1	325	332	PF00069	0.596
MOD_GSK3_1	358	365	PF00069	0.667
MOD_GSK3_1	366	373	PF00069	0.722
MOD_GSK3_1	395	402	PF00069	0.473
MOD_GSK3_1	91	98	PF00069	0.374
MOD_N-GLC_2	112	114	PF02516	0.385
MOD_NEK2_1	105	110	PF00069	0.368
MOD_NEK2_1	149	154	PF00069	0.357
MOD_NEK2_1	220	225	PF00069	0.330
MOD_PIKK_1	114	120	PF00454	0.370
MOD_PIKK_1	149	155	PF00454	0.336
MOD_PIKK_1	53	59	PF00454	0.402
MOD_PKA_1	15	21	PF00069	0.362
MOD_PKA_2	120	126	PF00069	0.487
MOD_PKA_2	15	21	PF00069	0.593
MOD_PKA_2	203	209	PF00069	0.484
MOD_PKA_2	29	35	PF00069	0.470
MOD_PKA_2	362	368	PF00069	0.635
MOD_Plk_1	133	139	PF00069	0.490
MOD_Plk_4	105	111	PF00069	0.351
MOD_Plk_4	123	129	PF00069	0.173
MOD_Plk_4	61	67	PF00069	0.340
MOD_ProDKin_1	40	46	PF00069	0.533
MOD_SUMO_for_1	304	307	PF00179	0.440
TRG_DiLeu_BaEn_2	386	392	PF01217	0.468
TRG_ENDOCYTIC_2	268	271	PF00928	0.303
TRG_ER_diArg_1	14	16	PF00400	0.404
TRG_ER_diArg_1	245	247	PF00400	0.363
TRG_ER_diArg_1	292	295	PF00400	0.384
TRG_ER_diArg_1	415	417	PF00400	0.470
TRG_ER_diArg_1	71	74	PF00400	0.348
TRG_NES_CRM1_1	177	188	PF08389	0.279
TRG_NES_CRM1_1	68	79	PF08389	0.341
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P473	Leptomonas seymouri	25%	77%
A0A0N1HSE0	Leptomonas seymouri	38%	90%
A0A0S4J2F9	Bodo saltans	40%	91%
A0A0S4J9I9	Bodo saltans	33%	87%
A0A1X0NJM4	Trypanosomatidae	39%	98%
A0A1X0NW83	Trypanosomatidae	57%	74%
A0A1X0P8D8	Trypanosomatidae	21%	74%
A0A3Q8IA47	Leishmania donovani	86%	73%
A0A3Q8IK20	Leishmania donovani	24%	78%
A0A3R7NFN9	Trypanosoma rangeli	54%	79%
A0A3R7NHA6	Trypanosoma rangeli	25%	75%
A0A3S5IQY1	Trypanosoma rangeli	35%	100%
A0A3S7WPA1	Leishmania donovani	34%	91%
A0A3S7WW64	Leishmania donovani	96%	79%
A4H4H3	Leishmania braziliensis	33%	89%
A4HNL0	Leishmania braziliensis	25%	78%
A4HSP8	Leishmania infantum	34%	89%
A4HYX9	Leishmania infantum	86%	73%
A4HYY0	Leishmania infantum	97%	79%
A4ICY3	Leishmania infantum	24%	78%
C9ZT94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	95%
E9AIJ1	Leishmania braziliensis	90%	92%
E9AKN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	91%
E9ASC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	78%
E9AUS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4Q274	Leishmania major	24%	78%
Q4QCQ9	Leishmania major	90%	91%
Q9LDW3	Arabidopsis thaliana	24%	77%
V5APC2	Trypanosoma cruzi	54%	80%
V5B1W9	Trypanosoma cruzi	25%	76%
V5B968	Trypanosoma cruzi	35%	92%