Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCQ5_LEIMA

TriTrypDb:

LmjF.20.1390 , LMJLV39_200020500 , LMJSD75_200020500

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.680
CLV_C14_Caspase3-7	319	323	PF00656	0.792
CLV_NRD_NRD_1	155	157	PF00675	0.620
CLV_NRD_NRD_1	239	241	PF00675	0.619
CLV_NRD_NRD_1	250	252	PF00675	0.472
CLV_NRD_NRD_1	320	322	PF00675	0.639
CLV_NRD_NRD_1	332	334	PF00675	0.562
CLV_NRD_NRD_1	360	362	PF00675	0.700
CLV_PCSK_FUR_1	153	157	PF00082	0.620
CLV_PCSK_KEX2_1	155	157	PF00082	0.620
CLV_PCSK_KEX2_1	239	241	PF00082	0.697
CLV_PCSK_KEX2_1	245	247	PF00082	0.574
CLV_PCSK_KEX2_1	250	252	PF00082	0.507
CLV_PCSK_KEX2_1	320	322	PF00082	0.639
CLV_PCSK_KEX2_1	332	334	PF00082	0.562
CLV_PCSK_KEX2_1	360	362	PF00082	0.599
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.494
CLV_PCSK_PC7_1	246	252	PF00082	0.446
CLV_PCSK_PC7_1	356	362	PF00082	0.694
CLV_PCSK_SKI1_1	246	250	PF00082	0.494
DEG_Nend_UBRbox_1	1	4	PF02207	0.660
DEG_SIAH_1	311	319	PF03145	0.700
DOC_CYCLIN_RxL_1	356	366	PF00134	0.695
DOC_MAPK_gen_1	261	268	PF00069	0.609
DOC_MAPK_gen_1	368	377	PF00069	0.532
DOC_MAPK_MEF2A_6	368	377	PF00069	0.532
DOC_USP7_MATH_1	194	198	PF00917	0.788
DOC_USP7_MATH_1	209	213	PF00917	0.704
DOC_USP7_MATH_1	220	224	PF00917	0.662
DOC_USP7_MATH_1	69	73	PF00917	0.635
DOC_WW_Pin1_4	129	134	PF00397	0.572
DOC_WW_Pin1_4	270	275	PF00397	0.797
DOC_WW_Pin1_4	279	284	PF00397	0.694
DOC_WW_Pin1_4	384	389	PF00397	0.751
DOC_WW_Pin1_4	84	89	PF00397	0.781
LIG_14-3-3_CanoR_1	278	283	PF00244	0.614
LIG_14-3-3_CanoR_1	39	45	PF00244	0.617
LIG_14-3-3_CanoR_1	82	88	PF00244	0.661
LIG_14-3-3_CanoR_1	98	103	PF00244	0.557
LIG_APCC_ABBA_1	373	378	PF00400	0.635
LIG_APCC_ABBA_1	380	385	PF00400	0.580
LIG_BIR_III_2	322	326	PF00653	0.628
LIG_BIR_III_4	180	184	PF00653	0.696
LIG_BIR_III_4	341	345	PF00653	0.708
LIG_DLG_GKlike_1	98	105	PF00625	0.757
LIG_FHA_1	145	151	PF00498	0.714
LIG_FHA_1	247	253	PF00498	0.539
LIG_FHA_2	120	126	PF00498	0.690
LIG_FHA_2	288	294	PF00498	0.810
LIG_LIR_Gen_1	165	176	PF02991	0.606
LIG_LIR_Gen_1	29	38	PF02991	0.645
LIG_LIR_Nem_3	165	171	PF02991	0.599
LIG_LIR_Nem_3	29	34	PF02991	0.536
LIG_Pex14_1	164	168	PF04695	0.517
LIG_SH2_NCK_1	123	127	PF00017	0.669
LIG_SH2_STAP1	20	24	PF00017	0.663
LIG_SH2_STAT3	428	431	PF00017	0.674
LIG_SH2_STAT5	123	126	PF00017	0.673
LIG_SH2_STAT5	20	23	PF00017	0.674
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.717
MOD_CK1_1	101	107	PF00069	0.750
MOD_CK1_1	211	217	PF00069	0.794
MOD_CK1_1	273	279	PF00069	0.833
MOD_CK1_1	334	340	PF00069	0.842
MOD_CK1_1	386	392	PF00069	0.731
MOD_CK1_1	43	49	PF00069	0.766
MOD_CK1_1	60	66	PF00069	0.597
MOD_CK2_1	121	127	PF00069	0.680
MOD_CK2_1	156	162	PF00069	0.500
MOD_CK2_1	184	190	PF00069	0.786
MOD_CK2_1	287	293	PF00069	0.814
MOD_CK2_1	296	302	PF00069	0.752
MOD_GlcNHglycan	194	197	PF01048	0.779
MOD_GlcNHglycan	211	214	PF01048	0.756
MOD_GlcNHglycan	222	225	PF01048	0.589
MOD_GlcNHglycan	293	296	PF01048	0.832
MOD_GlcNHglycan	3	6	PF01048	0.630
MOD_GlcNHglycan	388	391	PF01048	0.728
MOD_GlcNHglycan	40	43	PF01048	0.688
MOD_GlcNHglycan	60	63	PF01048	0.536
MOD_GSK3_1	156	163	PF00069	0.433
MOD_GSK3_1	201	208	PF00069	0.752
MOD_GSK3_1	270	277	PF00069	0.670
MOD_GSK3_1	287	294	PF00069	0.578
MOD_GSK3_1	40	47	PF00069	0.748
MOD_GSK3_1	54	61	PF00069	0.679
MOD_GSK3_1	64	71	PF00069	0.637
MOD_GSK3_1	84	91	PF00069	0.754
MOD_GSK3_1	97	104	PF00069	0.616
MOD_LATS_1	244	250	PF00433	0.446
MOD_LATS_1	80	86	PF00433	0.789
MOD_N-GLC_1	287	292	PF02516	0.736
MOD_N-GLC_1	334	339	PF02516	0.733
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	351	356	PF00069	0.690
MOD_NEK2_1	38	43	PF00069	0.619
MOD_NEK2_1	83	88	PF00069	0.830
MOD_NEK2_2	201	206	PF00069	0.737
MOD_PIKK_1	144	150	PF00454	0.563
MOD_PKA_2	1	7	PF00069	0.647
MOD_PKA_2	205	211	PF00069	0.714
MOD_PKA_2	331	337	PF00069	0.777
MOD_PKA_2	351	357	PF00069	0.438
MOD_PKA_2	38	44	PF00069	0.719
MOD_PKA_2	383	389	PF00069	0.749
MOD_PKA_2	57	63	PF00069	0.772
MOD_PKA_2	76	82	PF00069	0.564
MOD_PKA_2	97	103	PF00069	0.633
MOD_Plk_1	16	22	PF00069	0.695
MOD_Plk_1	255	261	PF00069	0.673
MOD_Plk_1	344	350	PF00069	0.666
MOD_Plk_4	26	32	PF00069	0.635
MOD_ProDKin_1	129	135	PF00069	0.570
MOD_ProDKin_1	270	276	PF00069	0.806
MOD_ProDKin_1	279	285	PF00069	0.697
MOD_ProDKin_1	384	390	PF00069	0.743
MOD_ProDKin_1	84	90	PF00069	0.781
MOD_SUMO_for_1	325	328	PF00179	0.630
MOD_SUMO_rev_2	170	176	PF00179	0.644
TRG_ENDOCYTIC_2	168	171	PF00928	0.680
TRG_ER_diArg_1	153	156	PF00400	0.571
TRG_ER_diArg_1	238	240	PF00400	0.623
TRG_ER_diArg_1	250	252	PF00400	0.459
TRG_ER_diArg_1	360	362	PF00400	0.700
TRG_ER_diArg_1	420	423	PF00400	0.679
TRG_NES_CRM1_1	371	385	PF08389	0.650
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW39	Leishmania donovani	90%	97%
A4HYY2	Leishmania infantum	91%	97%
E9AIJ6	Leishmania braziliensis	62%	100%
E9AUS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	97%