Putative axoneme central apparatus protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paralyzed flagella protein 16

Species:

Leishmania major

UniProt:

Q4QCQ4_LEIMA

TriTrypDb:

LmjF.20.1400 , LMJLV39_200020600 , LMJSD75_200020600

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005930	axoneme	2	2
GO:0015630	microtubule cytoskeleton	6	2
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4QCQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCQ4

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0000281	mitotic cytokinesis	4	2
GO:0000910	cytokinesis	3	2
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0001578	microtubule bundle formation	4	2
GO:0003341	cilium movement	4	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022607	cellular component assembly	4	2
GO:0035082	axoneme assembly	5	2
GO:0048870	cell motility	2	2
GO:0060285	cilium-dependent cell motility	4	2
GO:0060294	cilium movement involved in cell motility	5	2
GO:0061640	cytoskeleton-dependent cytokinesis	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:1903047	mitotic cell cycle process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	184	186	PF00082	0.253
CLV_PCSK_KEX2_1	226	228	PF00082	0.301
CLV_PCSK_KEX2_1	401	403	PF00082	0.333
CLV_PCSK_KEX2_1	448	450	PF00082	0.364
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.253
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.360
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.333
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.364
CLV_PCSK_SKI1_1	255	259	PF00082	0.311
CLV_PCSK_SKI1_1	4	8	PF00082	0.505
CLV_PCSK_SKI1_1	401	405	PF00082	0.320
CLV_PCSK_SKI1_1	47	51	PF00082	0.331
DOC_CYCLIN_RxL_1	44	53	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.365
DOC_MAPK_DCC_7	166	174	PF00069	0.253
DOC_MAPK_MEF2A_6	166	174	PF00069	0.253
DOC_MAPK_RevD_3	170	185	PF00069	0.253
DOC_PP1_RVXF_1	15	21	PF00149	0.320
DOC_USP7_MATH_1	237	241	PF00917	0.325
DOC_USP7_MATH_1	390	394	PF00917	0.380
DOC_USP7_MATH_1	467	471	PF00917	0.435
DOC_USP7_MATH_1	69	73	PF00917	0.412
DOC_USP7_UBL2_3	401	405	PF12436	0.339
DOC_WW_Pin1_4	111	116	PF00397	0.360
DOC_WW_Pin1_4	195	200	PF00397	0.422
DOC_WW_Pin1_4	279	284	PF00397	0.315
DOC_WW_Pin1_4	386	391	PF00397	0.490
DOC_WW_Pin1_4	488	493	PF00397	0.360
LIG_14-3-3_CanoR_1	185	194	PF00244	0.268
LIG_14-3-3_CanoR_1	455	461	PF00244	0.324
LIG_14-3-3_CanoR_1	67	75	PF00244	0.410
LIG_Actin_WH2_2	169	186	PF00022	0.253
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_BRCT_BRCA1_1	101	105	PF00533	0.300
LIG_FHA_1	280	286	PF00498	0.310
LIG_FHA_1	324	330	PF00498	0.301
LIG_FHA_1	84	90	PF00498	0.470
LIG_FHA_2	138	144	PF00498	0.268
LIG_FHA_2	188	194	PF00498	0.268
LIG_FHA_2	21	27	PF00498	0.253
LIG_FHA_2	495	501	PF00498	0.386
LIG_FHA_2	7	13	PF00498	0.427
LIG_LIR_Apic_2	385	390	PF02991	0.354
LIG_LIR_Apic_2	488	492	PF02991	0.498
LIG_LIR_LC3C_4	245	248	PF02991	0.294
LIG_LIR_Nem_3	251	256	PF02991	0.301
LIG_LIR_Nem_3	9	13	PF02991	0.507
LIG_MYND_1	415	419	PF01753	0.318
LIG_MYND_3	414	418	PF01753	0.305
LIG_Pex14_1	147	151	PF04695	0.253
LIG_Pex14_2	253	257	PF04695	0.294
LIG_PTB_Apo_2	476	483	PF02174	0.401
LIG_SH2_CRK	437	441	PF00017	0.442
LIG_SH2_NCK_1	301	305	PF00017	0.254
LIG_SH2_SRC	413	416	PF00017	0.454
LIG_SH2_STAP1	437	441	PF00017	0.442
LIG_SH2_STAP1	494	498	PF00017	0.375
LIG_SH2_STAT3	505	508	PF00017	0.511
LIG_SH2_STAT5	151	154	PF00017	0.293
LIG_SH2_STAT5	301	304	PF00017	0.329
LIG_SH2_STAT5	319	322	PF00017	0.379
LIG_SH2_STAT5	387	390	PF00017	0.346
LIG_SH2_STAT5	413	416	PF00017	0.454
LIG_SH2_STAT5	432	435	PF00017	0.293
LIG_SH3_3	173	179	PF00018	0.253
LIG_SH3_3	409	415	PF00018	0.339
LIG_SH3_3	420	426	PF00018	0.387
LIG_SUMO_SIM_par_1	47	53	PF11976	0.335
LIG_TRAF2_1	71	74	PF00917	0.430
LIG_WRC_WIRS_1	7	12	PF05994	0.495
MOD_CK1_1	321	327	PF00069	0.377
MOD_CK1_1	389	395	PF00069	0.485
MOD_CK1_1	53	59	PF00069	0.445
MOD_CK2_1	137	143	PF00069	0.253
MOD_CK2_1	20	26	PF00069	0.465
MOD_CK2_1	467	473	PF00069	0.430
MOD_CK2_1	494	500	PF00069	0.394
MOD_CK2_1	6	12	PF00069	0.495
MOD_CK2_1	68	74	PF00069	0.412
MOD_GlcNHglycan	101	104	PF01048	0.298
MOD_GlcNHglycan	320	323	PF01048	0.398
MOD_GlcNHglycan	366	369	PF01048	0.365
MOD_GlcNHglycan	59	62	PF01048	0.305
MOD_GlcNHglycan	80	83	PF01048	0.356
MOD_GSK3_1	137	144	PF00069	0.286
MOD_GSK3_1	302	309	PF00069	0.432
MOD_GSK3_1	386	393	PF00069	0.479
MOD_GSK3_1	467	474	PF00069	0.503
MOD_GSK3_1	53	60	PF00069	0.324
MOD_N-GLC_1	69	74	PF02516	0.401
MOD_N-GLC_2	479	481	PF02516	0.321
MOD_NEK2_1	20	25	PF00069	0.315
MOD_NEK2_1	201	206	PF00069	0.499
MOD_NEK2_1	323	328	PF00069	0.300
MOD_NEK2_1	471	476	PF00069	0.470
MOD_NEK2_1	50	55	PF00069	0.428
MOD_NEK2_1	88	93	PF00069	0.359
MOD_NEK2_2	179	184	PF00069	0.253
MOD_PIKK_1	121	127	PF00454	0.253
MOD_PIKK_1	83	89	PF00454	0.467
MOD_PKA_2	364	370	PF00069	0.326
MOD_Plk_1	179	185	PF00069	0.253
MOD_Plk_4	201	207	PF00069	0.390
MOD_Plk_4	494	500	PF00069	0.379
MOD_ProDKin_1	111	117	PF00069	0.288
MOD_ProDKin_1	195	201	PF00069	0.416
MOD_ProDKin_1	279	285	PF00069	0.310
MOD_ProDKin_1	386	392	PF00069	0.484
MOD_ProDKin_1	488	494	PF00069	0.358
MOD_SUMO_for_1	447	450	PF00179	0.351
MOD_SUMO_for_1	463	466	PF00179	0.370
MOD_SUMO_rev_2	220	225	PF00179	0.313
TRG_DiLeu_BaEn_1	242	247	PF01217	0.293
TRG_DiLeu_BaEn_1	284	289	PF01217	0.310
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.303
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.341
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.310
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.318
TRG_ENDOCYTIC_2	437	440	PF00928	0.448
TRG_ER_diArg_1	17	20	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	4	8	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE96	Leptomonas seymouri	94%	100%
A0A0S4J9K3	Bodo saltans	81%	100%
A0A1X0NXK0	Trypanosomatidae	85%	99%
A0A3Q8IEY0	Leishmania donovani	99%	100%
A0A3R7K990	Trypanosoma rangeli	85%	99%
A4HYY3	Leishmania infantum	99%	100%
B6HJ92	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	23%	92%
C9ZIJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	99%
E9AIJ7	Leishmania braziliensis	96%	78%
E9AUS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O35345	Mus musculus	21%	95%
O60684	Homo sapiens	21%	95%
O75602	Homo sapiens	63%	100%
P52293	Mus musculus	21%	96%
Q0V7M0	Bos taurus	21%	95%
Q5RBV0	Pongo abelii	21%	95%
Q5ZML1	Gallus gallus	21%	95%
Q6C5Y8	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	89%
Q9JLI7	Mus musculus	63%	100%
V5D560	Trypanosoma cruzi	86%	99%