UL46

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UL46

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCQ3_LEIMA

TriTrypDb:

LmjF.20.1410 , LMJLV39_200020700 , LMJSD75_200020700

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.634
CLV_C14_Caspase3-7	852	856	PF00656	0.528
CLV_NRD_NRD_1	117	119	PF00675	0.648
CLV_NRD_NRD_1	289	291	PF00675	0.460
CLV_NRD_NRD_1	342	344	PF00675	0.460
CLV_NRD_NRD_1	809	811	PF00675	0.637
CLV_PCSK_FUR_1	113	117	PF00082	0.643
CLV_PCSK_KEX2_1	115	117	PF00082	0.655
CLV_PCSK_KEX2_1	288	290	PF00082	0.471
CLV_PCSK_KEX2_1	342	344	PF00082	0.460
CLV_PCSK_KEX2_1	79	81	PF00082	0.570
CLV_PCSK_KEX2_1	809	811	PF00082	0.640
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.646
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.570
CLV_PCSK_PC7_1	113	119	PF00082	0.714
CLV_PCSK_SKI1_1	129	133	PF00082	0.409
CLV_PCSK_SKI1_1	317	321	PF00082	0.475
CLV_PCSK_SKI1_1	348	352	PF00082	0.475
CLV_Separin_Metazoa	235	239	PF03568	0.382
CLV_Separin_Metazoa	460	464	PF03568	0.629
DEG_APCC_DBOX_1	347	355	PF00400	0.456
DEG_Nend_UBRbox_2	1	3	PF02207	0.501
DEG_SCF_FBW7_1	698	704	PF00400	0.647
DEG_SCF_TRCP1_1	706	711	PF00400	0.595
DEG_SPOP_SBC_1	513	517	PF00917	0.651
DEG_SPOP_SBC_1	679	683	PF00917	0.605
DEG_SPOP_SBC_1	685	689	PF00917	0.590
DEG_SPOP_SBC_1	835	839	PF00917	0.641
DOC_CKS1_1	698	703	PF01111	0.502
DOC_CYCLIN_RxL_1	314	325	PF00134	0.481
DOC_CYCLIN_RxL_1	844	855	PF00134	0.633
DOC_CYCLIN_RxL_1	892	902	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.369
DOC_MAPK_gen_1	809	816	PF00069	0.618
DOC_MAPK_MEF2A_6	238	247	PF00069	0.376
DOC_PP2B_LxvP_1	19	22	PF13499	0.672
DOC_PP2B_LxvP_1	666	669	PF13499	0.436
DOC_PP4_FxxP_1	103	106	PF00568	0.562
DOC_USP7_MATH_1	205	209	PF00917	0.629
DOC_USP7_MATH_1	513	517	PF00917	0.657
DOC_USP7_MATH_1	679	683	PF00917	0.520
DOC_USP7_MATH_1	701	705	PF00917	0.759
DOC_USP7_MATH_1	710	714	PF00917	0.572
DOC_USP7_MATH_1	771	775	PF00917	0.669
DOC_USP7_MATH_1	789	793	PF00917	0.601
DOC_USP7_MATH_1	808	812	PF00917	0.579
DOC_USP7_MATH_1	828	832	PF00917	0.475
DOC_USP7_MATH_1	835	839	PF00917	0.597
DOC_USP7_MATH_2	883	889	PF00917	0.548
DOC_WW_Pin1_4	178	183	PF00397	0.771
DOC_WW_Pin1_4	226	231	PF00397	0.482
DOC_WW_Pin1_4	238	243	PF00397	0.392
DOC_WW_Pin1_4	306	311	PF00397	0.517
DOC_WW_Pin1_4	39	44	PF00397	0.740
DOC_WW_Pin1_4	444	449	PF00397	0.593
DOC_WW_Pin1_4	492	497	PF00397	0.708
DOC_WW_Pin1_4	643	648	PF00397	0.712
DOC_WW_Pin1_4	697	702	PF00397	0.740
DOC_WW_Pin1_4	716	721	PF00397	0.663
DOC_WW_Pin1_4	726	731	PF00397	0.552
DOC_WW_Pin1_4	785	790	PF00397	0.599
LIG_14-3-3_CanoR_1	100	106	PF00244	0.650
LIG_14-3-3_CanoR_1	116	124	PF00244	0.472
LIG_14-3-3_CanoR_1	163	169	PF00244	0.609
LIG_14-3-3_CanoR_1	359	366	PF00244	0.538
LIG_14-3-3_CanoR_1	514	519	PF00244	0.625
LIG_14-3-3_CanoR_1	52	58	PF00244	0.713
LIG_14-3-3_CanoR_1	643	647	PF00244	0.647
LIG_14-3-3_CanoR_1	809	814	PF00244	0.571
LIG_14-3-3_CanoR_1	82	90	PF00244	0.761
LIG_14-3-3_CanoR_1	827	833	PF00244	0.465
LIG_14-3-3_CanoR_1	845	850	PF00244	0.715
LIG_APCC_ABBA_1	131	136	PF00400	0.396
LIG_BIR_III_4	433	437	PF00653	0.528
LIG_BRCT_BRCA1_1	920	924	PF00533	0.561
LIG_Clathr_ClatBox_1	206	210	PF01394	0.486
LIG_deltaCOP1_diTrp_1	660	664	PF00928	0.475
LIG_FHA_1	102	108	PF00498	0.781
LIG_FHA_1	123	129	PF00498	0.468
LIG_FHA_1	14	20	PF00498	0.766
LIG_FHA_1	214	220	PF00498	0.475
LIG_FHA_1	242	248	PF00498	0.348
LIG_FHA_1	307	313	PF00498	0.476
LIG_FHA_1	381	387	PF00498	0.468
LIG_FHA_1	43	49	PF00498	0.626
LIG_FHA_1	551	557	PF00498	0.425
LIG_FHA_1	589	595	PF00498	0.567
LIG_FHA_1	625	631	PF00498	0.510
LIG_FHA_1	681	687	PF00498	0.537
LIG_FHA_1	770	776	PF00498	0.621
LIG_FHA_2	23	29	PF00498	0.634
LIG_FHA_2	817	823	PF00498	0.518
LIG_FHA_2	850	856	PF00498	0.600
LIG_FHA_2	905	911	PF00498	0.463
LIG_GBD_Chelix_1	614	622	PF00786	0.467
LIG_Integrin_RGD_1	91	93	PF01839	0.556
LIG_KLC1_Yacidic_2	818	822	PF13176	0.447
LIG_LIR_Apic_2	102	106	PF02991	0.556
LIG_LIR_Gen_1	122	132	PF02991	0.431
LIG_LIR_Gen_1	259	269	PF02991	0.412
LIG_LIR_Gen_1	357	367	PF02991	0.506
LIG_LIR_Gen_1	818	828	PF02991	0.527
LIG_LIR_Nem_3	122	127	PF02991	0.487
LIG_LIR_Nem_3	130	135	PF02991	0.453
LIG_LIR_Nem_3	232	237	PF02991	0.437
LIG_LIR_Nem_3	259	265	PF02991	0.401
LIG_LIR_Nem_3	325	329	PF02991	0.473
LIG_LIR_Nem_3	357	363	PF02991	0.496
LIG_LIR_Nem_3	739	744	PF02991	0.567
LIG_LIR_Nem_3	796	802	PF02991	0.636
LIG_LIR_Nem_3	818	823	PF02991	0.516
LIG_LIR_Nem_3	887	893	PF02991	0.553
LIG_NRBOX	350	356	PF00104	0.468
LIG_NRBOX	661	667	PF00104	0.394
LIG_NRBOX	870	876	PF00104	0.583
LIG_SH2_CRK	262	266	PF00017	0.401
LIG_SH2_CRK	279	283	PF00017	0.306
LIG_SH2_CRK	360	364	PF00017	0.499
LIG_SH2_CRK	619	623	PF00017	0.499
LIG_SH2_GRB2like	785	788	PF00017	0.648
LIG_SH2_NCK_1	171	175	PF00017	0.634
LIG_SH2_NCK_1	177	181	PF00017	0.585
LIG_SH2_PTP2	820	823	PF00017	0.448
LIG_SH2_SRC	134	137	PF00017	0.376
LIG_SH2_SRC	413	416	PF00017	0.504
LIG_SH2_SRC	785	788	PF00017	0.623
LIG_SH2_SRC	820	823	PF00017	0.439
LIG_SH2_STAP1	279	283	PF00017	0.419
LIG_SH2_STAT5	134	137	PF00017	0.449
LIG_SH2_STAT5	171	174	PF00017	0.634
LIG_SH2_STAT5	177	180	PF00017	0.616
LIG_SH2_STAT5	285	288	PF00017	0.394
LIG_SH2_STAT5	360	363	PF00017	0.504
LIG_SH2_STAT5	446	449	PF00017	0.544
LIG_SH2_STAT5	62	65	PF00017	0.637
LIG_SH2_STAT5	785	788	PF00017	0.696
LIG_SH2_STAT5	820	823	PF00017	0.448
LIG_SH3_3	179	185	PF00018	0.660
LIG_SH3_3	458	464	PF00018	0.636
LIG_SH3_3	549	555	PF00018	0.414
LIG_SH3_3	591	597	PF00018	0.618
LIG_SH3_3	695	701	PF00018	0.558
LIG_SH3_3	717	723	PF00018	0.617
LIG_SH3_3	724	730	PF00018	0.607
LIG_SH3_3	890	896	PF00018	0.543
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.479
LIG_SUMO_SIM_anti_2	382	390	PF11976	0.555
LIG_SUMO_SIM_anti_2	818	826	PF11976	0.451
LIG_SUMO_SIM_par_1	349	357	PF11976	0.464
LIG_SUMO_SIM_par_1	382	390	PF11976	0.555
LIG_SUMO_SIM_par_1	872	880	PF11976	0.427
LIG_TRAF2_1	876	879	PF00917	0.579
LIG_TYR_ITIM	617	622	PF00017	0.454
LIG_WW_3	460	464	PF00397	0.629
MOD_CK1_1	123	129	PF00069	0.426
MOD_CK1_1	137	143	PF00069	0.468
MOD_CK1_1	170	176	PF00069	0.659
MOD_CK1_1	208	214	PF00069	0.385
MOD_CK1_1	241	247	PF00069	0.362
MOD_CK1_1	32	38	PF00069	0.736
MOD_CK1_1	379	385	PF00069	0.508
MOD_CK1_1	42	48	PF00069	0.623
MOD_CK1_1	482	488	PF00069	0.541
MOD_CK1_1	585	591	PF00069	0.546
MOD_CK1_1	680	686	PF00069	0.622
MOD_CK1_1	704	710	PF00069	0.738
MOD_CK1_1	713	719	PF00069	0.646
MOD_CK1_1	736	742	PF00069	0.649
MOD_CK1_1	754	760	PF00069	0.528
MOD_CK1_1	774	780	PF00069	0.626
MOD_CK1_1	839	845	PF00069	0.789
MOD_CK1_1	917	923	PF00069	0.536
MOD_CK2_1	904	910	PF00069	0.454
MOD_CMANNOS	50	53	PF00535	0.671
MOD_CMANNOS	661	664	PF00535	0.466
MOD_Cter_Amidation	113	116	PF01082	0.672
MOD_Cter_Amidation	77	80	PF01082	0.573
MOD_GlcNHglycan	109	112	PF01048	0.719
MOD_GlcNHglycan	150	153	PF01048	0.673
MOD_GlcNHglycan	178	181	PF01048	0.583
MOD_GlcNHglycan	193	198	PF01048	0.713
MOD_GlcNHglycan	210	213	PF01048	0.381
MOD_GlcNHglycan	31	34	PF01048	0.724
MOD_GlcNHglycan	333	336	PF01048	0.437
MOD_GlcNHglycan	449	452	PF01048	0.622
MOD_GlcNHglycan	481	484	PF01048	0.546
MOD_GlcNHglycan	510	513	PF01048	0.639
MOD_GlcNHglycan	520	523	PF01048	0.558
MOD_GlcNHglycan	569	573	PF01048	0.500
MOD_GlcNHglycan	584	587	PF01048	0.574
MOD_GlcNHglycan	611	614	PF01048	0.476
MOD_GlcNHglycan	683	686	PF01048	0.692
MOD_GlcNHglycan	706	709	PF01048	0.641
MOD_GlcNHglycan	710	713	PF01048	0.667
MOD_GlcNHglycan	736	739	PF01048	0.549
MOD_GlcNHglycan	789	792	PF01048	0.601
MOD_GlcNHglycan	830	833	PF01048	0.663
MOD_GlcNHglycan	838	841	PF01048	0.569
MOD_GlcNHglycan	857	860	PF01048	0.525
MOD_GSK3_1	116	123	PF00069	0.572
MOD_GSK3_1	134	141	PF00069	0.583
MOD_GSK3_1	158	165	PF00069	0.635
MOD_GSK3_1	172	179	PF00069	0.669
MOD_GSK3_1	277	284	PF00069	0.404
MOD_GSK3_1	372	379	PF00069	0.563
MOD_GSK3_1	508	515	PF00069	0.617
MOD_GSK3_1	585	592	PF00069	0.553
MOD_GSK3_1	597	604	PF00069	0.737
MOD_GSK3_1	605	612	PF00069	0.516
MOD_GSK3_1	624	631	PF00069	0.415
MOD_GSK3_1	677	684	PF00069	0.542
MOD_GSK3_1	696	703	PF00069	0.454
MOD_GSK3_1	704	711	PF00069	0.479
MOD_GSK3_1	715	722	PF00069	0.679
MOD_GSK3_1	754	761	PF00069	0.633
MOD_GSK3_1	769	776	PF00069	0.654
MOD_GSK3_1	785	792	PF00069	0.529
MOD_GSK3_1	835	842	PF00069	0.748
MOD_GSK3_1	845	852	PF00069	0.606
MOD_GSK3_1	913	920	PF00069	0.575
MOD_N-GLC_1	329	334	PF02516	0.489
MOD_N-GLC_1	379	384	PF02516	0.513
MOD_N-GLC_1	643	648	PF02516	0.647
MOD_N-GLC_1	754	759	PF02516	0.621
MOD_N-GLC_1	913	918	PF02516	0.550
MOD_NEK2_1	162	167	PF00069	0.786
MOD_NEK2_1	247	252	PF00069	0.359
MOD_NEK2_1	27	32	PF00069	0.664
MOD_NEK2_1	329	334	PF00069	0.489
MOD_NEK2_1	371	376	PF00069	0.542
MOD_NEK2_1	387	392	PF00069	0.617
MOD_NEK2_1	432	437	PF00069	0.647
MOD_NEK2_1	518	523	PF00069	0.573
MOD_NEK2_1	568	573	PF00069	0.499
MOD_NEK2_1	734	739	PF00069	0.553
MOD_NEK2_1	758	763	PF00069	0.745
MOD_NEK2_1	816	821	PF00069	0.622
MOD_NEK2_1	913	918	PF00069	0.677
MOD_PIKK_1	138	144	PF00454	0.451
MOD_PIKK_1	22	28	PF00454	0.646
MOD_PIKK_1	577	583	PF00454	0.577
MOD_PIKK_1	601	607	PF00454	0.598
MOD_PIKK_1	62	68	PF00454	0.650
MOD_PIKK_1	710	716	PF00454	0.760
MOD_PK_1	304	310	PF00069	0.554
MOD_PKA_1	116	122	PF00069	0.684
MOD_PKA_1	809	815	PF00069	0.618
MOD_PKA_2	116	122	PF00069	0.542
MOD_PKA_2	162	168	PF00069	0.601
MOD_PKA_2	358	364	PF00069	0.530
MOD_PKA_2	405	411	PF00069	0.525
MOD_PKA_2	513	519	PF00069	0.697
MOD_PKA_2	642	648	PF00069	0.612
MOD_PKA_2	808	814	PF00069	0.622
MOD_PKA_2	99	105	PF00069	0.630
MOD_Plk_1	119	125	PF00069	0.538
MOD_Plk_1	379	385	PF00069	0.508
MOD_Plk_1	589	595	PF00069	0.567
MOD_Plk_1	624	630	PF00069	0.555
MOD_Plk_1	754	760	PF00069	0.623
MOD_Plk_1	884	890	PF00069	0.546
MOD_Plk_1	913	919	PF00069	0.548
MOD_Plk_2-3	885	891	PF00069	0.742
MOD_Plk_2-3	904	910	PF00069	0.417
MOD_Plk_4	123	129	PF00069	0.426
MOD_Plk_4	277	283	PF00069	0.397
MOD_Plk_4	372	378	PF00069	0.593
MOD_Plk_4	380	386	PF00069	0.441
MOD_Plk_4	387	393	PF00069	0.448
MOD_Plk_4	494	500	PF00069	0.677
MOD_Plk_4	514	520	PF00069	0.671
MOD_Plk_4	809	815	PF00069	0.721
MOD_Plk_4	816	822	PF00069	0.591
MOD_Plk_4	885	891	PF00069	0.627
MOD_ProDKin_1	178	184	PF00069	0.769
MOD_ProDKin_1	226	232	PF00069	0.475
MOD_ProDKin_1	238	244	PF00069	0.383
MOD_ProDKin_1	306	312	PF00069	0.514
MOD_ProDKin_1	39	45	PF00069	0.741
MOD_ProDKin_1	444	450	PF00069	0.592
MOD_ProDKin_1	492	498	PF00069	0.712
MOD_ProDKin_1	643	649	PF00069	0.707
MOD_ProDKin_1	697	703	PF00069	0.741
MOD_ProDKin_1	716	722	PF00069	0.662
MOD_ProDKin_1	726	732	PF00069	0.552
MOD_ProDKin_1	785	791	PF00069	0.639
TRG_DiLeu_BaEn_1	235	240	PF01217	0.396
TRG_DiLeu_BaEn_1	908	913	PF01217	0.617
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.556
TRG_DiLeu_LyEn_5	235	240	PF01217	0.396
TRG_DiLeu_LyEn_5	908	913	PF01217	0.544
TRG_ENDOCYTIC_2	262	265	PF00928	0.377
TRG_ENDOCYTIC_2	279	282	PF00928	0.335
TRG_ENDOCYTIC_2	360	363	PF00928	0.501
TRG_ENDOCYTIC_2	619	622	PF00928	0.496
TRG_ENDOCYTIC_2	820	823	PF00928	0.517
TRG_ER_diArg_1	116	118	PF00400	0.659
TRG_ER_diArg_1	287	290	PF00400	0.592
TRG_ER_diArg_1	342	344	PF00400	0.460
TRG_ER_diArg_1	808	810	PF00400	0.670
TRG_ER_diArg_1	924	927	PF00400	0.521
TRG_NLS_MonoCore_2	114	119	PF00514	0.712
TRG_NLS_MonoExtC_3	114	120	PF00514	0.636
TRG_NLS_MonoExtN_4	113	119	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.633
TRG_PTS1	928	931	PF00515	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y6	Leptomonas seymouri	43%	88%
A0A3S7WW50	Leishmania donovani	92%	100%
A4HYY4	Leishmania infantum	91%	100%
E9AIJ8	Leishmania braziliensis	72%	100%
E9AUT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%