SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCQ1_LEIMA

TriTrypDb:

LmjF.20.1430 , LMJLV39_200020900 , LMJSD75_200020900

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	331	337	PF00089	0.451
CLV_NRD_NRD_1	189	191	PF00675	0.403
CLV_NRD_NRD_1	249	251	PF00675	0.586
CLV_PCSK_FUR_1	246	250	PF00082	0.572
CLV_PCSK_KEX2_1	189	191	PF00082	0.403
CLV_PCSK_KEX2_1	248	250	PF00082	0.515
CLV_PCSK_SKI1_1	162	166	PF00082	0.386
CLV_PCSK_SKI1_1	178	182	PF00082	0.333
CLV_PCSK_SKI1_1	207	211	PF00082	0.309
CLV_PCSK_SKI1_1	249	253	PF00082	0.524
DEG_APCC_DBOX_1	206	214	PF00400	0.334
DEG_COP1_1	264	274	PF00400	0.455
DEG_Nend_Nbox_1	1	3	PF02207	0.522
DOC_CDC14_PxL_1	268	276	PF14671	0.351
DOC_MAPK_DCC_7	160	170	PF00069	0.478
DOC_MAPK_MEF2A_6	162	171	PF00069	0.523
DOC_PP4_MxPP_1	97	100	PF00568	0.434
DOC_USP7_MATH_1	13	17	PF00917	0.511
DOC_USP7_MATH_1	76	80	PF00917	0.486
DOC_WW_Pin1_4	135	140	PF00397	0.425
DOC_WW_Pin1_4	190	195	PF00397	0.477
DOC_WW_Pin1_4	278	283	PF00397	0.467
LIG_14-3-3_CanoR_1	249	255	PF00244	0.594
LIG_14-3-3_CanoR_1	321	331	PF00244	0.428
LIG_14-3-3_CanoR_1	8	14	PF00244	0.486
LIG_Clathr_ClatBox_1	168	172	PF01394	0.508
LIG_DLG_GKlike_1	250	258	PF00625	0.481
LIG_FHA_1	109	115	PF00498	0.459
LIG_FHA_1	153	159	PF00498	0.427
LIG_FHA_1	26	32	PF00498	0.474
LIG_FHA_1	279	285	PF00498	0.385
LIG_FHA_1	315	321	PF00498	0.493
LIG_LIR_Gen_1	121	131	PF02991	0.356
LIG_LIR_Gen_1	141	152	PF02991	0.386
LIG_LIR_Gen_1	229	238	PF02991	0.544
LIG_LIR_Gen_1	266	276	PF02991	0.520
LIG_LIR_Nem_3	121	127	PF02991	0.356
LIG_LIR_Nem_3	141	147	PF02991	0.377
LIG_LIR_Nem_3	172	176	PF02991	0.394
LIG_LIR_Nem_3	229	235	PF02991	0.496
LIG_LIR_Nem_3	266	271	PF02991	0.442
LIG_LIR_Nem_3	44	48	PF02991	0.461
LIG_MYND_1	272	276	PF01753	0.315
LIG_NRBOX	183	189	PF00104	0.477
LIG_PCNA_PIPBox_1	180	189	PF02747	0.406
LIG_PCNA_yPIPBox_3	177	190	PF02747	0.462
LIG_Pex14_1	247	251	PF04695	0.637
LIG_Pex14_2	333	337	PF04695	0.454
LIG_PTAP_UEV_1	193	198	PF05743	0.295
LIG_SH2_CRK	144	148	PF00017	0.477
LIG_SH2_CRK	232	236	PF00017	0.545
LIG_SH2_CRK	268	272	PF00017	0.397
LIG_SH2_GRB2like	143	146	PF00017	0.482
LIG_SH2_STAT5	124	127	PF00017	0.355
LIG_SH2_STAT5	232	235	PF00017	0.510
LIG_SH3_3	133	139	PF00018	0.460
LIG_SH3_3	161	167	PF00018	0.377
LIG_SH3_3	191	197	PF00018	0.433
LIG_SH3_3	279	285	PF00018	0.449
LIG_SH3_5	139	143	PF00018	0.518
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.496
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.359
LIG_SUMO_SIM_par_1	166	172	PF11976	0.516
LIG_TRAF2_1	52	55	PF00917	0.523
LIG_TRFH_1	144	148	PF08558	0.477
LIG_TRFH_1	268	272	PF08558	0.382
LIG_TYR_ITIM	201	206	PF00017	0.446
LIG_TYR_ITIM	230	235	PF00017	0.494
MOD_CDK_SPK_2	135	140	PF00069	0.451
MOD_CK1_1	138	144	PF00069	0.423
MOD_CK1_1	17	23	PF00069	0.518
MOD_CK1_1	228	234	PF00069	0.582
MOD_CK1_1	253	259	PF00069	0.650
MOD_CK1_1	81	87	PF00069	0.386
MOD_GlcNHglycan	16	19	PF01048	0.494
MOD_GlcNHglycan	194	197	PF01048	0.282
MOD_GSK3_1	13	20	PF00069	0.506
MOD_GSK3_1	226	233	PF00069	0.550
MOD_GSK3_1	250	257	PF00069	0.617
MOD_GSK3_1	67	74	PF00069	0.392
MOD_GSK3_1	76	83	PF00069	0.389
MOD_N-GLC_1	322	327	PF02516	0.365
MOD_NEK2_1	108	113	PF00069	0.502
MOD_NEK2_1	2	7	PF00069	0.559
MOD_NEK2_1	230	235	PF00069	0.508
MOD_NEK2_1	254	259	PF00069	0.570
MOD_NEK2_1	322	327	PF00069	0.365
MOD_PIKK_1	322	328	PF00454	0.398
MOD_PKA_2	7	13	PF00069	0.557
MOD_PKB_1	248	256	PF00069	0.572
MOD_Plk_1	152	158	PF00069	0.417
MOD_Plk_4	179	185	PF00069	0.356
MOD_Plk_4	2	8	PF00069	0.510
MOD_Plk_4	250	256	PF00069	0.580
MOD_Plk_4	270	276	PF00069	0.342
MOD_Plk_4	68	74	PF00069	0.355
MOD_ProDKin_1	135	141	PF00069	0.423
MOD_ProDKin_1	190	196	PF00069	0.471
MOD_ProDKin_1	278	284	PF00069	0.470
MOD_SUMO_rev_2	90	100	PF00179	0.405
TRG_DiLeu_BaEn_1	266	271	PF01217	0.462
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.521
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.313
TRG_ENDOCYTIC_2	124	127	PF00928	0.367
TRG_ENDOCYTIC_2	143	146	PF00928	0.347
TRG_ENDOCYTIC_2	203	206	PF00928	0.395
TRG_ENDOCYTIC_2	232	235	PF00928	0.478
TRG_ENDOCYTIC_2	268	271	PF00928	0.411
TRG_ER_diArg_1	188	190	PF00400	0.405
TRG_ER_diArg_1	247	250	PF00400	0.593
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5T0	Leptomonas seymouri	75%	100%
A0A0S4INP7	Bodo saltans	39%	88%
A0A1X0NW56	Trypanosomatidae	52%	98%
A0A3R7RG23	Trypanosoma rangeli	53%	99%
A0A3S7WW32	Leishmania donovani	95%	100%
A4HYY6	Leishmania infantum	97%	100%
C9ZIJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9AIK0	Leishmania braziliensis	87%	100%
E9AUT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BDU9	Trypanosoma cruzi	52%	100%