Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCP9_LEIMA

TriTrypDb:

LmjF.20.1450 , LMJLV39_200021100 , LMJSD75_200021100

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.596
CLV_C14_Caspase3-7	78	82	PF00656	0.454
CLV_NRD_NRD_1	142	144	PF00675	0.560
CLV_NRD_NRD_1	152	154	PF00675	0.595
CLV_NRD_NRD_1	193	195	PF00675	0.548
CLV_PCSK_KEX2_1	100	102	PF00082	0.487
CLV_PCSK_KEX2_1	142	144	PF00082	0.560
CLV_PCSK_KEX2_1	152	154	PF00082	0.602
CLV_PCSK_KEX2_1	192	194	PF00082	0.475
CLV_PCSK_KEX2_1	376	378	PF00082	0.525
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.487
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.525
CLV_PCSK_SKI1_1	130	134	PF00082	0.443
CLV_PCSK_SKI1_1	142	146	PF00082	0.568
CLV_PCSK_SKI1_1	152	156	PF00082	0.501
CLV_PCSK_SKI1_1	215	219	PF00082	0.631
DEG_SPOP_SBC_1	316	320	PF00917	0.590
DOC_CKS1_1	19	24	PF01111	0.482
DOC_CYCLIN_RxL_1	364	374	PF00134	0.507
DOC_CYCLIN_RxL_1	44	55	PF00134	0.412
DOC_MAPK_gen_1	100	107	PF00069	0.444
DOC_MAPK_gen_1	58	67	PF00069	0.335
DOC_MAPK_gen_1	77	87	PF00069	0.374
DOC_MAPK_MEF2A_6	100	107	PF00069	0.350
DOC_MAPK_MEF2A_6	58	67	PF00069	0.335
DOC_MAPK_MEF2A_6	88	95	PF00069	0.399
DOC_PP1_RVXF_1	160	166	PF00149	0.346
DOC_USP7_MATH_1	201	205	PF00917	0.584
DOC_USP7_MATH_1	236	240	PF00917	0.635
DOC_USP7_MATH_1	280	284	PF00917	0.648
DOC_USP7_MATH_1	316	320	PF00917	0.583
DOC_USP7_MATH_1	328	332	PF00917	0.416
DOC_USP7_MATH_1	45	49	PF00917	0.418
DOC_USP7_MATH_1	75	79	PF00917	0.457
DOC_WW_Pin1_4	142	147	PF00397	0.535
DOC_WW_Pin1_4	18	23	PF00397	0.490
DOC_WW_Pin1_4	202	207	PF00397	0.669
DOC_WW_Pin1_4	234	239	PF00397	0.611
DOC_WW_Pin1_4	245	250	PF00397	0.622
DOC_WW_Pin1_4	257	262	PF00397	0.657
LIG_14-3-3_CanoR_1	152	161	PF00244	0.553
LIG_14-3-3_CanoR_1	180	187	PF00244	0.422
LIG_14-3-3_CanoR_1	192	198	PF00244	0.675
LIG_14-3-3_CanoR_1	215	222	PF00244	0.759
LIG_APCC_ABBAyCdc20_2	70	76	PF00400	0.489
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BIR_III_4	267	271	PF00653	0.587
LIG_BIR_III_4	30	34	PF00653	0.448
LIG_CaM_IQ_9	336	352	PF13499	0.476
LIG_FHA_1	11	17	PF00498	0.531
LIG_FHA_1	113	119	PF00498	0.361
LIG_FHA_1	181	187	PF00498	0.477
LIG_FHA_1	19	25	PF00498	0.390
LIG_FHA_1	318	324	PF00498	0.589
LIG_FHA_2	123	129	PF00498	0.330
LIG_FHA_2	316	322	PF00498	0.570
LIG_FHA_2	36	42	PF00498	0.458
LIG_FHA_2	5	11	PF00498	0.611
LIG_LIR_Apic_2	225	231	PF02991	0.625
LIG_LIR_Apic_2	283	288	PF02991	0.616
LIG_LIR_Gen_1	90	99	PF02991	0.344
LIG_LIR_Nem_3	175	181	PF02991	0.357
LIG_LIR_Nem_3	54	59	PF02991	0.440
LIG_LIR_Nem_3	90	95	PF02991	0.348
LIG_NRBOX	94	100	PF00104	0.410
LIG_PCNA_PIPBox_1	50	59	PF02747	0.436
LIG_PCNA_yPIPBox_3	47	57	PF02747	0.440
LIG_SH2_CRK	285	289	PF00017	0.613
LIG_SH2_NCK_1	265	269	PF00017	0.667
LIG_SH2_NCK_1	285	289	PF00017	0.613
LIG_SH2_PTP2	92	95	PF00017	0.329
LIG_SH2_STAP1	265	269	PF00017	0.657
LIG_SH2_STAT5	116	119	PF00017	0.408
LIG_SH2_STAT5	265	268	PF00017	0.626
LIG_SH2_STAT5	285	288	PF00017	0.701
LIG_SH2_STAT5	35	38	PF00017	0.457
LIG_SH2_STAT5	56	59	PF00017	0.439
LIG_SH2_STAT5	92	95	PF00017	0.329
LIG_SH3_2	22	27	PF14604	0.416
LIG_SH3_3	19	25	PF00018	0.490
LIG_SH3_3	274	280	PF00018	0.722
LIG_SH3_3	304	310	PF00018	0.719
LIG_SH3_4	60	67	PF00018	0.427
LIG_Sin3_3	378	385	PF02671	0.458
LIG_SUMO_SIM_par_1	318	326	PF11976	0.520
LIG_SUMO_SIM_par_1	367	374	PF11976	0.502
LIG_TYR_ITIM	176	181	PF00017	0.359
LIG_UBA3_1	368	376	PF00899	0.469
MOD_CDK_SPxxK_3	202	209	PF00069	0.563
MOD_CK1_1	205	211	PF00069	0.674
MOD_CK1_1	237	243	PF00069	0.627
MOD_CK1_1	248	254	PF00069	0.442
MOD_CK1_1	283	289	PF00069	0.614
MOD_CK1_1	3	9	PF00069	0.691
MOD_CK2_1	122	128	PF00069	0.335
MOD_CK2_1	248	254	PF00069	0.696
MOD_CK2_1	257	263	PF00069	0.655
MOD_CK2_1	315	321	PF00069	0.587
MOD_CK2_1	4	10	PF00069	0.616
MOD_GlcNHglycan	2	5	PF01048	0.718
MOD_GlcNHglycan	222	225	PF01048	0.681
MOD_GlcNHglycan	234	237	PF01048	0.637
MOD_GlcNHglycan	239	242	PF01048	0.660
MOD_GlcNHglycan	250	253	PF01048	0.596
MOD_GlcNHglycan	282	285	PF01048	0.650
MOD_GlcNHglycan	304	307	PF01048	0.590
MOD_GSK3_1	10	17	PF00069	0.625
MOD_GSK3_1	201	208	PF00069	0.668
MOD_GSK3_1	232	239	PF00069	0.572
MOD_GSK3_1	317	324	PF00069	0.623
MOD_LATS_1	191	197	PF00433	0.552
MOD_N-GLC_1	213	218	PF02516	0.776
MOD_N-GLC_2	82	84	PF02516	0.358
MOD_NEK2_1	213	218	PF00069	0.713
MOD_NEK2_1	371	376	PF00069	0.485
MOD_NEK2_2	75	80	PF00069	0.403
MOD_PIKK_1	283	289	PF00454	0.641
MOD_PK_1	193	199	PF00069	0.470
MOD_PKA_1	152	158	PF00069	0.512
MOD_PKA_1	193	199	PF00069	0.692
MOD_PKA_2	152	158	PF00069	0.533
MOD_PKA_2	179	185	PF00069	0.446
MOD_PKA_2	193	199	PF00069	0.694
MOD_PKA_2	208	214	PF00069	0.675
MOD_PKA_2	357	363	PF00069	0.429
MOD_Plk_1	213	219	PF00069	0.652
MOD_Plk_1	371	377	PF00069	0.532
MOD_Plk_1	75	81	PF00069	0.374
MOD_Plk_2-3	122	128	PF00069	0.428
MOD_Plk_4	122	128	PF00069	0.369
MOD_Plk_4	288	294	PF00069	0.577
MOD_ProDKin_1	142	148	PF00069	0.543
MOD_ProDKin_1	18	24	PF00069	0.474
MOD_ProDKin_1	202	208	PF00069	0.672
MOD_ProDKin_1	234	240	PF00069	0.613
MOD_ProDKin_1	245	251	PF00069	0.623
MOD_ProDKin_1	257	263	PF00069	0.658
MOD_SUMO_for_1	59	62	PF00179	0.427
MOD_SUMO_rev_2	122	132	PF00179	0.432
TRG_DiLeu_BaEn_1	159	164	PF01217	0.437
TRG_DiLeu_BaEn_1	62	67	PF01217	0.433
TRG_DiLeu_LyEn_5	159	164	PF01217	0.437
TRG_ENDOCYTIC_2	167	170	PF00928	0.370
TRG_ENDOCYTIC_2	178	181	PF00928	0.368
TRG_ENDOCYTIC_2	56	59	PF00928	0.439
TRG_ENDOCYTIC_2	92	95	PF00928	0.329
TRG_ER_diArg_1	151	153	PF00400	0.573
TRG_ER_diArg_1	160	163	PF00400	0.323
TRG_ER_diArg_1	192	194	PF00400	0.509
TRG_NES_CRM1_1	159	172	PF08389	0.450
TRG_NES_CRM1_1	41	55	PF08389	0.391
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	330	335	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV9	Leptomonas seymouri	56%	96%
A0A1X0NWT1	Trypanosomatidae	37%	100%
A0A3S7WW52	Leishmania donovani	94%	100%
A0A422N975	Trypanosoma rangeli	38%	100%
A4HYY8	Leishmania infantum	94%	100%
E9AIK2	Leishmania braziliensis	82%	100%
E9AUT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%