C2 NT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCP8_LEIMA

TriTrypDb:

LmjF.20.1460 , LMJLV39_200021200 , LMJSD75_200021200

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.534
CLV_NRD_NRD_1	167	169	PF00675	0.396
CLV_NRD_NRD_1	45	47	PF00675	0.394
CLV_PCSK_KEX2_1	167	169	PF00082	0.465
CLV_PCSK_KEX2_1	181	183	PF00082	0.404
CLV_PCSK_KEX2_1	218	220	PF00082	0.470
CLV_PCSK_KEX2_1	45	47	PF00082	0.394
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.396
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.337
CLV_PCSK_SKI1_1	181	185	PF00082	0.443
CLV_PCSK_SKI1_1	212	216	PF00082	0.485
CLV_PCSK_SKI1_1	218	222	PF00082	0.458
CLV_PCSK_SKI1_1	48	52	PF00082	0.384
DEG_MDM2_SWIB_1	175	183	PF02201	0.392
DEG_Nend_Nbox_1	1	3	PF02207	0.435
DOC_CKS1_1	326	331	PF01111	0.630
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.555
DOC_MAPK_gen_1	167	178	PF00069	0.418
DOC_MAPK_gen_1	218	226	PF00069	0.450
DOC_MAPK_gen_1	45	55	PF00069	0.380
DOC_MAPK_HePTP_8	122	134	PF00069	0.436
DOC_MAPK_HePTP_8	20	32	PF00069	0.367
DOC_MAPK_HePTP_8	63	75	PF00069	0.413
DOC_MAPK_MEF2A_6	125	134	PF00069	0.371
DOC_MAPK_MEF2A_6	171	178	PF00069	0.392
DOC_MAPK_MEF2A_6	218	226	PF00069	0.390
DOC_MAPK_MEF2A_6	23	32	PF00069	0.359
DOC_MAPK_MEF2A_6	46	55	PF00069	0.377
DOC_MAPK_MEF2A_6	66	75	PF00069	0.403
DOC_PP2B_LxvP_1	300	303	PF13499	0.562
DOC_USP7_MATH_1	260	264	PF00917	0.713
DOC_USP7_MATH_1	274	278	PF00917	0.496
DOC_WW_Pin1_4	224	229	PF00397	0.388
DOC_WW_Pin1_4	23	28	PF00397	0.369
DOC_WW_Pin1_4	254	259	PF00397	0.592
DOC_WW_Pin1_4	325	330	PF00397	0.635
DOC_WW_Pin1_4	75	80	PF00397	0.420
DOC_WW_Pin1_4	90	95	PF00397	0.392
LIG_14-3-3_CanoR_1	125	129	PF00244	0.508
LIG_14-3-3_CanoR_1	140	149	PF00244	0.343
LIG_14-3-3_CanoR_1	182	191	PF00244	0.368
LIG_14-3-3_CanoR_1	219	223	PF00244	0.449
LIG_14-3-3_CanoR_1	66	72	PF00244	0.416
LIG_APCC_ABBAyCdc20_2	171	177	PF00400	0.397
LIG_CtBP_PxDLS_1	68	72	PF00389	0.416
LIG_deltaCOP1_diTrp_1	177	184	PF00928	0.404
LIG_eIF4E_1	25	31	PF01652	0.353
LIG_FHA_1	103	109	PF00498	0.299
LIG_FHA_1	178	184	PF00498	0.376
LIG_FHA_1	219	225	PF00498	0.517
LIG_FHA_1	24	30	PF00498	0.356
LIG_FHA_2	225	231	PF00498	0.417
LIG_FHA_2	271	277	PF00498	0.745
LIG_IBAR_NPY_1	259	261	PF08397	0.650
LIG_LIR_Gen_1	190	201	PF02991	0.410
LIG_LIR_Nem_3	127	131	PF02991	0.356
LIG_LIR_Nem_3	24	28	PF02991	0.360
LIG_LIR_Nem_3	93	98	PF02991	0.396
LIG_LYPXL_S_1	304	308	PF13949	0.665
LIG_LYPXL_yS_3	305	308	PF13949	0.668
LIG_MYND_1	302	306	PF01753	0.642
LIG_NRBOX	28	34	PF00104	0.349
LIG_Pex14_2	154	158	PF04695	0.402
LIG_Pex14_2	175	179	PF04695	0.375
LIG_SH2_CRK	246	250	PF00017	0.712
LIG_SH2_CRK	25	29	PF00017	0.355
LIG_SH2_CRK	99	103	PF00017	0.385
LIG_SH2_NCK_1	261	265	PF00017	0.588
LIG_SH2_PTP2	131	134	PF00017	0.365
LIG_SH2_PTP2	56	59	PF00017	0.371
LIG_SH2_STAP1	126	130	PF00017	0.286
LIG_SH2_STAP1	261	265	PF00017	0.715
LIG_SH2_STAT5	131	134	PF00017	0.365
LIG_SH2_STAT5	25	28	PF00017	0.358
LIG_SH2_STAT5	261	264	PF00017	0.691
LIG_SH2_STAT5	266	269	PF00017	0.636
LIG_SH2_STAT5	56	59	PF00017	0.371
LIG_SH3_1	283	289	PF00018	0.650
LIG_SH3_3	101	107	PF00018	0.331
LIG_SH3_3	283	289	PF00018	0.677
LIG_SH3_3	300	306	PF00018	0.637
LIG_SH3_3	323	329	PF00018	0.645
LIG_SH3_3	62	68	PF00018	0.398
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.358
LIG_SUMO_SIM_anti_2	26	32	PF11976	0.349
LIG_SUMO_SIM_par_1	107	112	PF11976	0.346
LIG_SUMO_SIM_par_1	67	72	PF11976	0.416
LIG_TYR_ITIM	97	102	PF00017	0.391
LIG_UBA3_1	174	181	PF00899	0.376
LIG_WW_1	302	305	PF00397	0.575
MOD_CK1_1	187	193	PF00069	0.392
MOD_CK1_1	327	333	PF00069	0.666
MOD_CK1_1	74	80	PF00069	0.419
MOD_CK2_1	275	281	PF00069	0.687
MOD_Cter_Amidation	216	219	PF01082	0.513
MOD_DYRK1A_RPxSP_1	23	27	PF00069	0.373
MOD_GlcNHglycan	144	147	PF01048	0.570
MOD_GlcNHglycan	262	265	PF01048	0.718
MOD_GlcNHglycan	316	319	PF01048	0.777
MOD_GlcNHglycan	79	82	PF01048	0.445
MOD_GlcNHglycan	86	89	PF01048	0.461
MOD_GSK3_1	120	127	PF00069	0.536
MOD_GSK3_1	138	145	PF00069	0.331
MOD_GSK3_1	163	170	PF00069	0.481
MOD_GSK3_1	220	227	PF00069	0.461
MOD_GSK3_1	270	277	PF00069	0.676
MOD_GSK3_1	67	74	PF00069	0.425
MOD_N-GLC_2	269	271	PF02516	0.688
MOD_NEK2_1	102	107	PF00069	0.336
MOD_NEK2_1	124	129	PF00069	0.485
MOD_NEK2_1	184	189	PF00069	0.525
MOD_NEK2_1	231	236	PF00069	0.611
MOD_NEK2_1	69	74	PF00069	0.433
MOD_NEK2_1	84	89	PF00069	0.454
MOD_PIKK_1	182	188	PF00454	0.410
MOD_PIKK_1	284	290	PF00454	0.676
MOD_PIKK_1	306	312	PF00454	0.681
MOD_PIKK_1	327	333	PF00454	0.728
MOD_PK_1	335	341	PF00069	0.666
MOD_PKA_1	167	173	PF00069	0.387
MOD_PKA_1	218	224	PF00069	0.454
MOD_PKA_2	124	130	PF00069	0.505
MOD_PKA_2	167	173	PF00069	0.505
MOD_PKA_2	218	224	PF00069	0.454
MOD_Plk_1	109	115	PF00069	0.360
MOD_Plk_1	204	210	PF00069	0.484
MOD_Plk_1	335	341	PF00069	0.666
MOD_Plk_4	109	115	PF00069	0.356
MOD_ProDKin_1	224	230	PF00069	0.394
MOD_ProDKin_1	23	29	PF00069	0.366
MOD_ProDKin_1	254	260	PF00069	0.589
MOD_ProDKin_1	325	331	PF00069	0.634
MOD_ProDKin_1	75	81	PF00069	0.420
MOD_ProDKin_1	90	96	PF00069	0.391
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.357
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.439
TRG_ENDOCYTIC_2	131	134	PF00928	0.365
TRG_ENDOCYTIC_2	25	28	PF00928	0.358
TRG_ENDOCYTIC_2	305	308	PF00928	0.621
TRG_ENDOCYTIC_2	56	59	PF00928	0.371
TRG_ENDOCYTIC_2	99	102	PF00928	0.388
TRG_ER_diArg_1	167	169	PF00400	0.473
TRG_ER_diArg_1	171	174	PF00400	0.425
TRG_ER_diArg_1	33	36	PF00400	0.367
TRG_ER_diArg_1	45	48	PF00400	0.384
TRG_ER_diLys_1	343	347	PF00400	0.657
TRG_NES_CRM1_1	240	251	PF08389	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P409	Leptomonas seymouri	51%	100%
A0A3Q8IDQ9	Leishmania donovani	89%	100%
A4HYY9	Leishmania infantum	90%	100%
E9AIK3	Leishmania braziliensis	66%	100%
E9AUT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%