Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCP7_LEIMA

TriTrypDb:

LmjF.20.1470 , LMJLV39_200021300 , LMJSD75_200021300

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.568
CLV_NRD_NRD_1	352	354	PF00675	0.760
CLV_NRD_NRD_1	44	46	PF00675	0.620
CLV_NRD_NRD_1	446	448	PF00675	0.665
CLV_PCSK_FUR_1	42	46	PF00082	0.585
CLV_PCSK_KEX2_1	256	258	PF00082	0.568
CLV_PCSK_KEX2_1	352	354	PF00082	0.760
CLV_PCSK_KEX2_1	44	46	PF00082	0.620
CLV_PCSK_KEX2_1	446	448	PF00082	0.665
CLV_PCSK_SKI1_1	102	106	PF00082	0.557
CLV_PCSK_SKI1_1	152	156	PF00082	0.540
CLV_PCSK_SKI1_1	341	345	PF00082	0.771
CLV_PCSK_SKI1_1	417	421	PF00082	0.445
CLV_Separin_Metazoa	253	257	PF03568	0.736
DEG_APCC_DBOX_1	151	159	PF00400	0.725
DEG_Nend_Nbox_1	1	3	PF02207	0.791
DEG_SPOP_SBC_1	215	219	PF00917	0.751
DEG_SPOP_SBC_1	454	458	PF00917	0.696
DOC_CKS1_1	382	387	PF01111	0.477
DOC_CKS1_1	420	425	PF01111	0.445
DOC_CKS1_1	438	443	PF01111	0.736
DOC_CYCLIN_RxL_1	338	347	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.724
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.766
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.797
DOC_MAPK_DCC_7	61	69	PF00069	0.695
DOC_MAPK_gen_1	352	358	PF00069	0.558
DOC_MAPK_MEF2A_6	61	69	PF00069	0.695
DOC_PP2B_LxvP_1	512	515	PF13499	0.546
DOC_PP2B_LxvP_1	67	70	PF13499	0.824
DOC_USP7_MATH_1	213	217	PF00917	0.748
DOC_USP7_MATH_1	238	242	PF00917	0.715
DOC_USP7_MATH_1	301	305	PF00917	0.631
DOC_USP7_MATH_1	33	37	PF00917	0.769
DOC_USP7_MATH_1	400	404	PF00917	0.552
DOC_WW_Pin1_4	208	213	PF00397	0.839
DOC_WW_Pin1_4	267	272	PF00397	0.758
DOC_WW_Pin1_4	381	386	PF00397	0.572
DOC_WW_Pin1_4	419	424	PF00397	0.386
DOC_WW_Pin1_4	437	442	PF00397	0.717
DOC_WW_Pin1_4	550	555	PF00397	0.499
DOC_WW_Pin1_4	60	65	PF00397	0.806
LIG_14-3-3_CanoR_1	132	141	PF00244	0.774
LIG_14-3-3_CanoR_1	257	265	PF00244	0.851
LIG_14-3-3_CanoR_1	329	335	PF00244	0.518
LIG_BIR_III_4	185	189	PF00653	0.871
LIG_BRCT_BRCA1_1	290	294	PF00533	0.717
LIG_FAT_LD_1	557	565	PF03623	0.563
LIG_FHA_1	134	140	PF00498	0.726
LIG_FHA_1	410	416	PF00498	0.606
LIG_FHA_1	420	426	PF00498	0.401
LIG_FHA_1	540	546	PF00498	0.545
LIG_FHA_1	7	13	PF00498	0.721
LIG_FHA_2	197	203	PF00498	0.711
LIG_LIR_Gen_1	138	149	PF02991	0.815
LIG_LIR_Gen_1	199	208	PF02991	0.748
LIG_LIR_Gen_1	26	35	PF02991	0.768
LIG_LIR_Gen_1	291	301	PF02991	0.767
LIG_LIR_Gen_1	566	575	PF02991	0.543
LIG_LIR_Nem_3	138	144	PF02991	0.698
LIG_LIR_Nem_3	199	203	PF02991	0.743
LIG_LIR_Nem_3	26	31	PF02991	0.755
LIG_LIR_Nem_3	291	297	PF02991	0.703
LIG_LIR_Nem_3	566	571	PF02991	0.485
LIG_LIR_Nem_3	576	581	PF02991	0.464
LIG_MLH1_MIPbox_1	290	294	PF16413	0.717
LIG_Pex14_1	290	294	PF04695	0.690
LIG_Pex14_1	428	432	PF04695	0.445
LIG_Pex14_2	203	207	PF04695	0.751
LIG_Pex14_2	294	298	PF04695	0.687
LIG_Pex14_2	487	491	PF04695	0.692
LIG_SH2_CRK	313	317	PF00017	0.546
LIG_SH2_CRK	568	572	PF00017	0.580
LIG_SH2_CRK	62	66	PF00017	0.806
LIG_SH2_NCK_1	62	66	PF00017	0.806
LIG_SH2_PTP2	191	194	PF00017	0.780
LIG_SH2_STAP1	313	317	PF00017	0.546
LIG_SH2_STAP1	391	395	PF00017	0.519
LIG_SH2_STAT5	191	194	PF00017	0.780
LIG_SH2_STAT5	374	377	PF00017	0.540
LIG_SH2_STAT5	486	489	PF00017	0.655
LIG_SH2_STAT5	574	577	PF00017	0.484
LIG_SH2_STAT5	62	65	PF00017	0.807
LIG_SH3_1	191	197	PF00018	0.775
LIG_SH3_1	232	238	PF00018	0.743
LIG_SH3_3	142	148	PF00018	0.689
LIG_SH3_3	189	195	PF00018	0.745
LIG_SH3_3	232	238	PF00018	0.743
LIG_SH3_3	379	385	PF00018	0.586
LIG_SH3_3	439	445	PF00018	0.797
LIG_SUMO_SIM_par_1	225	230	PF11976	0.801
LIG_TRAF2_1	16	19	PF00917	0.833
LIG_TRFH_1	191	195	PF08558	0.851
MOD_CDK_SPxK_1	550	556	PF00069	0.498
MOD_CK1_1	216	222	PF00069	0.681
MOD_CK1_1	267	273	PF00069	0.762
MOD_CK1_1	370	376	PF00069	0.580
MOD_CK1_1	396	402	PF00069	0.556
MOD_CK1_1	403	409	PF00069	0.575
MOD_CK1_1	455	461	PF00069	0.792
MOD_CK1_1	48	54	PF00069	0.786
MOD_CK1_1	517	523	PF00069	0.436
MOD_CK1_1	6	12	PF00069	0.758
MOD_CK2_1	260	266	PF00069	0.835
MOD_CK2_1	478	484	PF00069	0.705
MOD_Cter_Amidation	350	353	PF01082	0.729
MOD_GlcNHglycan	229	232	PF01048	0.615
MOD_GlcNHglycan	262	265	PF01048	0.592
MOD_GlcNHglycan	266	269	PF01048	0.592
MOD_GlcNHglycan	290	293	PF01048	0.406
MOD_GlcNHglycan	349	352	PF01048	0.743
MOD_GlcNHglycan	395	398	PF01048	0.784
MOD_GlcNHglycan	405	408	PF01048	0.766
MOD_GlcNHglycan	442	445	PF01048	0.576
MOD_GlcNHglycan	47	50	PF01048	0.581
MOD_GlcNHglycan	481	484	PF01048	0.507
MOD_GSK3_1	198	205	PF00069	0.744
MOD_GSK3_1	2	9	PF00069	0.766
MOD_GSK3_1	260	267	PF00069	0.800
MOD_GSK3_1	33	40	PF00069	0.767
MOD_GSK3_1	343	350	PF00069	0.596
MOD_GSK3_1	387	394	PF00069	0.573
MOD_GSK3_1	396	403	PF00069	0.623
MOD_GSK3_1	405	412	PF00069	0.477
MOD_GSK3_1	44	51	PF00069	0.835
MOD_GSK3_1	452	459	PF00069	0.814
MOD_N-GLC_1	71	76	PF02516	0.514
MOD_N-GLC_2	355	357	PF02516	0.647
MOD_NEK2_1	1	6	PF00069	0.774
MOD_NEK2_1	260	265	PF00069	0.859
MOD_NEK2_1	293	298	PF00069	0.660
MOD_NEK2_1	367	372	PF00069	0.526
MOD_NEK2_1	395	400	PF00069	0.653
MOD_NEK2_1	50	55	PF00069	0.826
MOD_NEK2_2	238	243	PF00069	0.712
MOD_NEK2_2	33	38	PF00069	0.787
MOD_OFUCOSY	511	518	PF10250	0.504
MOD_PIKK_1	139	145	PF00454	0.816
MOD_PIKK_1	37	43	PF00454	0.774
MOD_PIKK_1	527	533	PF00454	0.518
MOD_PIKK_1	6	12	PF00454	0.749
MOD_PKA_1	168	174	PF00069	0.751
MOD_PKA_1	44	50	PF00069	0.783
MOD_PKA_2	301	307	PF00069	0.629
MOD_PKA_2	328	334	PF00069	0.526
MOD_PKA_2	409	415	PF00069	0.554
MOD_PKA_2	44	50	PF00069	0.797
MOD_PKA_2	539	545	PF00069	0.548
MOD_PKA_2	86	92	PF00069	0.851
MOD_PKB_1	42	50	PF00069	0.783
MOD_Plk_1	100	106	PF00069	0.832
MOD_Plk_1	51	57	PF00069	0.791
MOD_Plk_4	113	119	PF00069	0.798
MOD_Plk_4	293	299	PF00069	0.682
MOD_Plk_4	33	39	PF00069	0.788
MOD_Plk_4	573	579	PF00069	0.528
MOD_ProDKin_1	208	214	PF00069	0.840
MOD_ProDKin_1	267	273	PF00069	0.757
MOD_ProDKin_1	381	387	PF00069	0.575
MOD_ProDKin_1	419	425	PF00069	0.386
MOD_ProDKin_1	437	443	PF00069	0.718
MOD_ProDKin_1	550	556	PF00069	0.498
MOD_ProDKin_1	60	66	PF00069	0.805
TRG_DiLeu_BaEn_3	337	343	PF01217	0.519
TRG_ENDOCYTIC_2	313	316	PF00928	0.445
TRG_ENDOCYTIC_2	568	571	PF00928	0.529
TRG_ER_diArg_1	255	257	PF00400	0.757
TRG_ER_diArg_1	352	354	PF00400	0.564
TRG_ER_diArg_1	445	447	PF00400	0.836
TRG_ER_diArg_1	82	85	PF00400	0.816
TRG_NES_CRM1_1	138	153	PF08389	0.696
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ42	Leptomonas seymouri	52%	100%
A0A3Q8IAX6	Leishmania donovani	89%	100%
A4HYZ0	Leishmania infantum	90%	98%
E9AIK4	Leishmania braziliensis	76%	100%
E9AUT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%