Adaptin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCP5_LEIMA

TriTrypDb:

LmjF.20.1490 , LMJLV39_200021600 , LMJSD75_200021600

Length:

966

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QCP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.753
CLV_C14_Caspase3-7	388	392	PF00656	0.688
CLV_C14_Caspase3-7	819	823	PF00656	0.707
CLV_NRD_NRD_1	138	140	PF00675	0.601
CLV_NRD_NRD_1	162	164	PF00675	0.625
CLV_NRD_NRD_1	312	314	PF00675	0.375
CLV_NRD_NRD_1	467	469	PF00675	0.449
CLV_NRD_NRD_1	55	57	PF00675	0.513
CLV_NRD_NRD_1	945	947	PF00675	0.577
CLV_PCSK_KEX2_1	138	140	PF00082	0.601
CLV_PCSK_KEX2_1	312	314	PF00082	0.375
CLV_PCSK_KEX2_1	467	469	PF00082	0.449
CLV_PCSK_KEX2_1	557	559	PF00082	0.392
CLV_PCSK_KEX2_1	674	676	PF00082	0.365
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.392
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.413
CLV_PCSK_SKI1_1	60	64	PF00082	0.602
CLV_PCSK_SKI1_1	634	638	PF00082	0.633
DEG_APCC_DBOX_1	641	649	PF00400	0.336
DEG_MDM2_SWIB_1	551	559	PF02201	0.540
DEG_SPOP_SBC_1	269	273	PF00917	0.563
DEG_SPOP_SBC_1	375	379	PF00917	0.630
DEG_SPOP_SBC_1	782	786	PF00917	0.670
DOC_CDC14_PxL_1	295	303	PF14671	0.600
DOC_CDC14_PxL_1	872	880	PF14671	0.755
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.519
DOC_MAPK_DCC_7	561	571	PF00069	0.626
DOC_MAPK_gen_1	15	23	PF00069	0.357
DOC_MAPK_gen_1	312	319	PF00069	0.560
DOC_MAPK_gen_1	53	63	PF00069	0.376
DOC_MAPK_gen_1	69	78	PF00069	0.249
DOC_MAPK_gen_1	946	954	PF00069	0.726
DOC_MAPK_HePTP_8	54	66	PF00069	0.376
DOC_MAPK_JIP1_4	313	319	PF00069	0.532
DOC_MAPK_MEF2A_6	440	449	PF00069	0.512
DOC_MAPK_MEF2A_6	57	66	PF00069	0.356
DOC_MAPK_MEF2A_6	69	78	PF00069	0.259
DOC_MAPK_MEF2A_6	904	912	PF00069	0.712
DOC_MAPK_RevD_3	150	164	PF00069	0.406
DOC_MAPK_RevD_3	452	468	PF00069	0.605
DOC_PP1_RVXF_1	794	801	PF00149	0.680
DOC_PP1_RVXF_1	88	95	PF00149	0.348
DOC_PP1_SILK_1	823	828	PF00149	0.689
DOC_PP2B_LxvP_1	243	246	PF13499	0.554
DOC_PP4_FxxP_1	932	935	PF00568	0.648
DOC_PP4_MxPP_1	370	373	PF00568	0.548
DOC_PP4_MxPP_1	906	909	PF00568	0.615
DOC_USP7_MATH_1	3	7	PF00917	0.512
DOC_USP7_MATH_1	436	440	PF00917	0.654
DOC_USP7_MATH_1	506	510	PF00917	0.676
DOC_USP7_MATH_1	620	624	PF00917	0.542
DOC_USP7_MATH_1	781	785	PF00917	0.706
DOC_USP7_MATH_1	808	812	PF00917	0.674
DOC_USP7_MATH_1	828	832	PF00917	0.679
DOC_USP7_UBL2_3	13	17	PF12436	0.459
DOC_USP7_UBL2_3	557	561	PF12436	0.592
DOC_WW_Pin1_4	237	242	PF00397	0.690
DOC_WW_Pin1_4	439	444	PF00397	0.666
DOC_WW_Pin1_4	531	536	PF00397	0.730
DOC_WW_Pin1_4	564	569	PF00397	0.564
DOC_WW_Pin1_4	635	640	PF00397	0.421
DOC_WW_Pin1_4	904	909	PF00397	0.724
LIG_14-3-3_CanoR_1	127	132	PF00244	0.375
LIG_14-3-3_CanoR_1	412	416	PF00244	0.608
LIG_14-3-3_CanoR_1	471	479	PF00244	0.569
LIG_14-3-3_CanoR_1	634	639	PF00244	0.425
LIG_14-3-3_CanoR_1	705	715	PF00244	0.647
LIG_14-3-3_CanoR_1	73	79	PF00244	0.311
LIG_14-3-3_CanoR_1	817	821	PF00244	0.678
LIG_14-3-3_CanoR_1	961	966	PF00244	0.790
LIG_Actin_RPEL_3	66	85	PF02755	0.328
LIG_Actin_WH2_2	399	414	PF00022	0.607
LIG_Actin_WH2_2	444	462	PF00022	0.605
LIG_APCC_ABBA_1	21	26	PF00400	0.401
LIG_APCC_ABBA_1	878	883	PF00400	0.735
LIG_BRCT_BRCA1_1	299	303	PF00533	0.569
LIG_BRCT_BRCA1_1	796	800	PF00533	0.728
LIG_BRCT_BRCA1_1	893	897	PF00533	0.664
LIG_BRCT_BRCA1_1	928	932	PF00533	0.657
LIG_deltaCOP1_diTrp_1	739	749	PF00928	0.636
LIG_EH1_1	645	653	PF00400	0.432
LIG_EVH1_1	872	876	PF00568	0.753
LIG_FHA_1	253	259	PF00498	0.575
LIG_FHA_1	271	277	PF00498	0.563
LIG_FHA_1	282	288	PF00498	0.601
LIG_FHA_1	405	411	PF00498	0.606
LIG_FHA_1	444	450	PF00498	0.558
LIG_FHA_1	471	477	PF00498	0.619
LIG_FHA_1	537	543	PF00498	0.727
LIG_FHA_1	561	567	PF00498	0.604
LIG_FHA_1	622	628	PF00498	0.538
LIG_FHA_1	635	641	PF00498	0.327
LIG_FHA_1	859	865	PF00498	0.670
LIG_FHA_1	867	873	PF00498	0.682
LIG_FHA_2	542	548	PF00498	0.655
LIG_FHA_2	6	12	PF00498	0.490
LIG_GBD_Chelix_1	182	190	PF00786	0.530
LIG_GBD_Chelix_1	574	582	PF00786	0.406
LIG_IRF3_LxIS_1	685	692	PF10401	0.489
LIG_IRF3_LxIS_1	813	819	PF10401	0.672
LIG_LIR_Apic_2	929	935	PF02991	0.696
LIG_LIR_Gen_1	171	179	PF02991	0.355
LIG_LIR_Gen_1	429	437	PF02991	0.580
LIG_LIR_Gen_1	641	652	PF02991	0.336
LIG_LIR_Gen_1	729	738	PF02991	0.541
LIG_LIR_Gen_1	739	749	PF02991	0.577
LIG_LIR_Nem_3	171	176	PF02991	0.357
LIG_LIR_Nem_3	300	306	PF02991	0.574
LIG_LIR_Nem_3	429	434	PF02991	0.572
LIG_LIR_Nem_3	729	733	PF02991	0.550
LIG_LIR_Nem_3	739	745	PF02991	0.580
LIG_NRBOX	429	435	PF00104	0.546
LIG_PCNA_PIPBox_1	424	433	PF02747	0.570
LIG_PCNA_yPIPBox_3	199	212	PF02747	0.397
LIG_PCNA_yPIPBox_3	417	431	PF02747	0.574
LIG_PDZ_Class_1	961	966	PF00595	0.730
LIG_Pex14_2	551	555	PF04695	0.606
LIG_Pex14_2	592	596	PF04695	0.358
LIG_SH2_CRK	173	177	PF00017	0.313
LIG_SH2_CRK	322	326	PF00017	0.587
LIG_SH2_CRK	659	663	PF00017	0.507
LIG_SH2_GRB2like	479	482	PF00017	0.610
LIG_SH2_SRC	479	482	PF00017	0.610
LIG_SH2_SRC	659	662	PF00017	0.499
LIG_SH2_STAP1	173	177	PF00017	0.308
LIG_SH2_STAT5	415	418	PF00017	0.676
LIG_SH2_STAT5	43	46	PF00017	0.322
LIG_SH2_STAT5	458	461	PF00017	0.524
LIG_SH2_STAT5	479	482	PF00017	0.582
LIG_SH2_STAT5	699	702	PF00017	0.614
LIG_SH2_STAT5	732	735	PF00017	0.570
LIG_SH2_STAT5	911	914	PF00017	0.720
LIG_SH2_STAT5	962	965	PF00017	0.688
LIG_SH3_3	235	241	PF00018	0.658
LIG_SH3_3	293	299	PF00018	0.560
LIG_SH3_3	366	372	PF00018	0.587
LIG_SH3_3	451	457	PF00018	0.571
LIG_SH3_3	530	536	PF00018	0.719
LIG_SH3_3	860	866	PF00018	0.739
LIG_SH3_3	870	876	PF00018	0.770
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.555
LIG_SUMO_SIM_anti_2	744	749	PF11976	0.631
LIG_SUMO_SIM_par_1	205	211	PF11976	0.372
LIG_SUMO_SIM_par_1	401	408	PF11976	0.559
LIG_SUMO_SIM_par_1	567	573	PF11976	0.545
LIG_SUMO_SIM_par_1	77	83	PF11976	0.384
LIG_SxIP_EBH_1	103	112	PF03271	0.266
LIG_TRAF2_1	544	547	PF00917	0.697
LIG_TRAF2_1	752	755	PF00917	0.688
LIG_TYR_ITIM	320	325	PF00017	0.524
LIG_TYR_ITSM	169	176	PF00017	0.362
LIG_UBA3_1	61	69	PF00899	0.364
LIG_WRC_WIRS_1	727	732	PF05994	0.552
LIG_WW_1	908	911	PF00397	0.754
LIG_WW_2	873	876	PF00397	0.753
MOD_CDK_SPxxK_3	237	244	PF00069	0.614
MOD_CDK_SPxxK_3	635	642	PF00069	0.413
MOD_CK1_1	218	224	PF00069	0.703
MOD_CK1_1	237	243	PF00069	0.717
MOD_CK1_1	333	339	PF00069	0.606
MOD_CK1_1	439	445	PF00069	0.623
MOD_CK1_1	534	540	PF00069	0.759
MOD_CK1_1	560	566	PF00069	0.653
MOD_CK1_1	621	627	PF00069	0.523
MOD_CK1_1	638	644	PF00069	0.345
MOD_CK1_1	709	715	PF00069	0.670
MOD_CK1_1	731	737	PF00069	0.638
MOD_CK1_1	770	776	PF00069	0.653
MOD_CK1_1	794	800	PF00069	0.745
MOD_CK1_1	858	864	PF00069	0.772
MOD_CK1_1	892	898	PF00069	0.740
MOD_CK2_1	43	49	PF00069	0.365
MOD_CK2_1	5	11	PF00069	0.524
MOD_CK2_1	506	512	PF00069	0.688
MOD_CK2_1	518	524	PF00069	0.725
MOD_CK2_1	541	547	PF00069	0.712
MOD_CK2_1	65	71	PF00069	0.444
MOD_CK2_1	680	686	PF00069	0.584
MOD_CK2_1	749	755	PF00069	0.620
MOD_CK2_1	80	86	PF00069	0.311
MOD_GlcNHglycan	135	138	PF01048	0.616
MOD_GlcNHglycan	307	310	PF01048	0.380
MOD_GlcNHglycan	391	394	PF01048	0.504
MOD_GlcNHglycan	482	485	PF01048	0.450
MOD_GlcNHglycan	508	511	PF01048	0.469
MOD_GlcNHglycan	587	590	PF01048	0.406
MOD_GlcNHglycan	610	613	PF01048	0.732
MOD_GlcNHglycan	620	623	PF01048	0.789
MOD_GlcNHglycan	630	633	PF01048	0.690
MOD_GlcNHglycan	691	694	PF01048	0.463
MOD_GlcNHglycan	701	704	PF01048	0.344
MOD_GlcNHglycan	837	840	PF01048	0.513
MOD_GlcNHglycan	857	860	PF01048	0.501
MOD_GlcNHglycan	884	890	PF01048	0.580
MOD_GlcNHglycan	922	925	PF01048	0.625
MOD_GlcNHglycan	928	931	PF01048	0.552
MOD_GSK3_1	127	134	PF00069	0.405
MOD_GSK3_1	233	240	PF00069	0.750
MOD_GSK3_1	264	271	PF00069	0.535
MOD_GSK3_1	3	10	PF00069	0.514
MOD_GSK3_1	329	336	PF00069	0.622
MOD_GSK3_1	418	425	PF00069	0.646
MOD_GSK3_1	439	446	PF00069	0.657
MOD_GSK3_1	560	567	PF00069	0.591
MOD_GSK3_1	616	623	PF00069	0.587
MOD_GSK3_1	626	633	PF00069	0.518
MOD_GSK3_1	634	641	PF00069	0.238
MOD_GSK3_1	65	72	PF00069	0.280
MOD_GSK3_1	722	729	PF00069	0.564
MOD_GSK3_1	770	777	PF00069	0.617
MOD_GSK3_1	794	801	PF00069	0.714
MOD_GSK3_1	808	815	PF00069	0.645
MOD_GSK3_1	885	892	PF00069	0.752
MOD_GSK3_1	916	923	PF00069	0.708
MOD_N-GLC_1	418	423	PF02516	0.439
MOD_N-GLC_1	480	485	PF02516	0.400
MOD_N-GLC_1	855	860	PF02516	0.505
MOD_N-GLC_2	5	7	PF02516	0.676
MOD_NEK2_1	104	109	PF00069	0.342
MOD_NEK2_1	19	24	PF00069	0.421
MOD_NEK2_1	258	263	PF00069	0.572
MOD_NEK2_1	286	291	PF00069	0.593
MOD_NEK2_1	374	379	PF00069	0.749
MOD_NEK2_1	410	415	PF00069	0.552
MOD_NEK2_1	480	485	PF00069	0.562
MOD_NEK2_1	630	635	PF00069	0.494
MOD_NEK2_1	689	694	PF00069	0.622
MOD_NEK2_1	798	803	PF00069	0.785
MOD_NEK2_1	80	85	PF00069	0.424
MOD_NEK2_1	816	821	PF00069	0.619
MOD_NMyristoyl	1	7	PF02799	0.516
MOD_PIKK_1	127	133	PF00454	0.428
MOD_PIKK_1	286	292	PF00454	0.501
MOD_PIKK_1	418	424	PF00454	0.625
MOD_PIKK_1	791	797	PF00454	0.704
MOD_PIKK_1	858	864	PF00454	0.684
MOD_PK_1	783	789	PF00069	0.592
MOD_PK_1	950	956	PF00069	0.603
MOD_PKA_1	557	563	PF00069	0.611
MOD_PKA_1	69	75	PF00069	0.405
MOD_PKA_2	126	132	PF00069	0.382
MOD_PKA_2	281	287	PF00069	0.603
MOD_PKA_2	411	417	PF00069	0.628
MOD_PKA_2	470	476	PF00069	0.611
MOD_PKA_2	557	563	PF00069	0.611
MOD_PKA_2	689	695	PF00069	0.666
MOD_PKA_2	782	788	PF00069	0.657
MOD_PKA_2	816	822	PF00069	0.676
MOD_Plk_1	218	224	PF00069	0.631
MOD_Plk_1	233	239	PF00069	0.768
MOD_Plk_1	252	258	PF00069	0.435
MOD_Plk_1	770	776	PF00069	0.658
MOD_Plk_1	821	827	PF00069	0.728
MOD_Plk_2-3	518	524	PF00069	0.641
MOD_Plk_4	19	25	PF00069	0.394
MOD_Plk_4	297	303	PF00069	0.637
MOD_Plk_4	365	371	PF00069	0.631
MOD_Plk_4	411	417	PF00069	0.572
MOD_Plk_4	422	428	PF00069	0.588
MOD_Plk_4	443	449	PF00069	0.590
MOD_Plk_4	567	573	PF00069	0.595
MOD_Plk_4	74	80	PF00069	0.365
MOD_Plk_4	775	781	PF00069	0.745
MOD_Plk_4	821	827	PF00069	0.718
MOD_ProDKin_1	237	243	PF00069	0.682
MOD_ProDKin_1	439	445	PF00069	0.658
MOD_ProDKin_1	531	537	PF00069	0.732
MOD_ProDKin_1	564	570	PF00069	0.559
MOD_ProDKin_1	635	641	PF00069	0.417
MOD_ProDKin_1	904	910	PF00069	0.725
MOD_SUMO_rev_2	752	757	PF00179	0.545
MOD_SUMO_rev_2	801	811	PF00179	0.706
TRG_DiLeu_BaEn_2	927	933	PF01217	0.656
TRG_DiLeu_BaEn_3	754	760	PF01217	0.600
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.331
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.541
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.596
TRG_ENDOCYTIC_2	173	176	PF00928	0.311
TRG_ENDOCYTIC_2	322	325	PF00928	0.590
TRG_ENDOCYTIC_2	962	965	PF00928	0.688
TRG_ER_diArg_1	138	140	PF00400	0.401
TRG_ER_diArg_1	312	314	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	713	718	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU24	Leptomonas seymouri	62%	98%
A0A3R7NMU6	Trypanosoma rangeli	32%	100%
A0A3S7WW45	Leishmania donovani	91%	100%
A4HYZ2	Leishmania infantum	91%	100%
C9ZIP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
E9AIK6	Leishmania braziliensis	78%	99%
E9AUT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%