Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCP4_LEIMA

TriTrypDb:

LmjF.20.1500 , LMJLV39_200021700 , LMJSD75_200021700

Length:

953

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	416	420	PF00656	0.729
CLV_C14_Caspase3-7	851	855	PF00656	0.657
CLV_C14_Caspase3-7	888	892	PF00656	0.702
CLV_NRD_NRD_1	154	156	PF00675	0.637
CLV_NRD_NRD_1	332	334	PF00675	0.480
CLV_NRD_NRD_1	358	360	PF00675	0.553
CLV_NRD_NRD_1	718	720	PF00675	0.663
CLV_NRD_NRD_1	866	868	PF00675	0.621
CLV_NRD_NRD_1	923	925	PF00675	0.567
CLV_PCSK_FUR_1	450	454	PF00082	0.419
CLV_PCSK_KEX2_1	154	156	PF00082	0.637
CLV_PCSK_KEX2_1	332	334	PF00082	0.486
CLV_PCSK_KEX2_1	358	360	PF00082	0.553
CLV_PCSK_KEX2_1	452	454	PF00082	0.553
CLV_PCSK_KEX2_1	718	720	PF00082	0.678
CLV_PCSK_KEX2_1	868	870	PF00082	0.638
CLV_PCSK_KEX2_1	923	925	PF00082	0.570
CLV_PCSK_KEX2_1	949	951	PF00082	0.801
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.422
CLV_PCSK_PC1ET2_1	868	870	PF00082	0.638
CLV_PCSK_PC1ET2_1	949	951	PF00082	0.801
CLV_PCSK_SKI1_1	244	248	PF00082	0.403
CLV_PCSK_SKI1_1	438	442	PF00082	0.363
CLV_PCSK_SKI1_1	62	66	PF00082	0.373
CLV_PCSK_SKI1_1	647	651	PF00082	0.389
CLV_PCSK_SKI1_1	676	680	PF00082	0.474
CLV_PCSK_SKI1_1	86	90	PF00082	0.454
CLV_PCSK_SKI1_1	878	882	PF00082	0.714
CLV_PCSK_SKI1_1	923	927	PF00082	0.632
CLV_PCSK_SKI1_1	949	953	PF00082	0.685
DEG_APCC_DBOX_1	437	445	PF00400	0.355
DEG_COP1_1	467	476	PF00400	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.468
DEG_SCF_FBW7_2	110	117	PF00400	0.383
DEG_SPOP_SBC_1	505	509	PF00917	0.433
DEG_SPOP_SBC_1	870	874	PF00917	0.649
DOC_CDC14_PxL_1	264	272	PF14671	0.362
DOC_CKS1_1	111	116	PF01111	0.375
DOC_CKS1_1	797	802	PF01111	0.608
DOC_CYCLIN_RxL_1	432	443	PF00134	0.365
DOC_CYCLIN_RxL_1	633	643	PF00134	0.530
DOC_CYCLIN_RxL_1	83	90	PF00134	0.434
DOC_CYCLIN_RxL_1	875	883	PF00134	0.669
DOC_CYCLIN_yClb1_LxF_4	454	460	PF00134	0.441
DOC_CYCLIN_yCln2_LP_2	638	644	PF00134	0.513
DOC_MAPK_DCC_7	86	96	PF00069	0.482
DOC_MAPK_gen_1	139	148	PF00069	0.431
DOC_MAPK_gen_1	202	212	PF00069	0.501
DOC_MAPK_gen_1	450	460	PF00069	0.482
DOC_MAPK_gen_1	533	543	PF00069	0.483
DOC_MAPK_gen_1	615	623	PF00069	0.473
DOC_MAPK_gen_1	62	70	PF00069	0.358
DOC_MAPK_gen_1	84	91	PF00069	0.403
DOC_MAPK_MEF2A_6	205	212	PF00069	0.418
DOC_MAPK_MEF2A_6	536	545	PF00069	0.497
DOC_MAPK_NFAT4_5	205	213	PF00069	0.390
DOC_PP1_RVXF_1	242	248	PF00149	0.415
DOC_PP1_RVXF_1	803	810	PF00149	0.579
DOC_PP2B_LxvP_1	252	255	PF13499	0.402
DOC_PP2B_LxvP_1	638	641	PF13499	0.452
DOC_PP2B_LxvP_1	89	92	PF13499	0.482
DOC_PP4_FxxP_1	544	547	PF00568	0.533
DOC_USP7_MATH_1	102	106	PF00917	0.546
DOC_USP7_MATH_1	142	146	PF00917	0.472
DOC_USP7_MATH_1	191	195	PF00917	0.505
DOC_USP7_MATH_1	229	233	PF00917	0.407
DOC_USP7_MATH_1	260	264	PF00917	0.382
DOC_USP7_MATH_1	344	348	PF00917	0.727
DOC_USP7_MATH_1	411	415	PF00917	0.646
DOC_USP7_MATH_1	47	51	PF00917	0.463
DOC_USP7_MATH_1	488	492	PF00917	0.479
DOC_USP7_MATH_1	496	500	PF00917	0.476
DOC_USP7_MATH_1	505	509	PF00917	0.589
DOC_USP7_MATH_1	526	530	PF00917	0.364
DOC_USP7_MATH_1	567	571	PF00917	0.455
DOC_USP7_MATH_1	656	660	PF00917	0.505
DOC_USP7_MATH_1	701	705	PF00917	0.471
DOC_USP7_MATH_1	714	718	PF00917	0.456
DOC_USP7_MATH_1	857	861	PF00917	0.762
DOC_USP7_MATH_1	862	866	PF00917	0.672
DOC_USP7_MATH_1	870	874	PF00917	0.595
DOC_USP7_MATH_1	889	893	PF00917	0.640
DOC_USP7_MATH_1	915	919	PF00917	0.553
DOC_USP7_MATH_2	641	647	PF00917	0.535
DOC_USP7_UBL2_3	815	819	PF12436	0.654
DOC_WW_Pin1_4	110	115	PF00397	0.396
DOC_WW_Pin1_4	189	194	PF00397	0.459
DOC_WW_Pin1_4	679	684	PF00397	0.563
DOC_WW_Pin1_4	796	801	PF00397	0.649
DOC_WW_Pin1_4	871	876	PF00397	0.712
DOC_WW_Pin1_4	941	946	PF00397	0.734
LIG_14-3-3_CanoR_1	202	212	PF00244	0.501
LIG_14-3-3_CanoR_1	332	338	PF00244	0.508
LIG_14-3-3_CanoR_1	497	501	PF00244	0.483
LIG_14-3-3_CanoR_1	539	544	PF00244	0.370
LIG_14-3-3_CanoR_1	711	721	PF00244	0.486
LIG_14-3-3_CanoR_1	869	875	PF00244	0.827
LIG_APCC_ABBA_1	396	401	PF00400	0.517
LIG_BRCT_BRCA1_1	490	494	PF00533	0.462
LIG_DLG_GKlike_1	333	341	PF00625	0.424
LIG_eIF4E_1	434	440	PF01652	0.371
LIG_FHA_1	10	16	PF00498	0.506
LIG_FHA_1	106	112	PF00498	0.443
LIG_FHA_1	20	26	PF00498	0.354
LIG_FHA_1	475	481	PF00498	0.589
LIG_FHA_1	505	511	PF00498	0.476
LIG_FHA_1	538	544	PF00498	0.374
LIG_FHA_1	693	699	PF00498	0.460
LIG_FHA_1	848	854	PF00498	0.696
LIG_FHA_2	318	324	PF00498	0.523
LIG_FHA_2	424	430	PF00498	0.477
LIG_FHA_2	615	621	PF00498	0.490
LIG_LIR_Apic_2	542	547	PF02991	0.414
LIG_LIR_Gen_1	105	114	PF02991	0.469
LIG_LIR_Gen_1	16	25	PF02991	0.388
LIG_LIR_Gen_1	499	505	PF02991	0.398
LIG_LIR_Gen_1	52	61	PF02991	0.507
LIG_LIR_Gen_1	66	74	PF02991	0.264
LIG_LIR_Nem_3	105	109	PF02991	0.504
LIG_LIR_Nem_3	16	20	PF02991	0.415
LIG_LIR_Nem_3	336	341	PF02991	0.437
LIG_LIR_Nem_3	388	393	PF02991	0.479
LIG_LIR_Nem_3	499	504	PF02991	0.403
LIG_LIR_Nem_3	52	57	PF02991	0.408
LIG_LIR_Nem_3	66	70	PF02991	0.360
LIG_LYPXL_S_1	433	437	PF13949	0.435
LIG_LYPXL_yS_3	390	393	PF13949	0.415
LIG_LYPXL_yS_3	434	437	PF13949	0.436
LIG_NRBOX	392	398	PF00104	0.510
LIG_NRBOX	436	442	PF00104	0.453
LIG_NRBOX	526	532	PF00104	0.483
LIG_NRP_CendR_1	950	953	PF00754	0.658
LIG_PCNA_yPIPBox_3	524	536	PF02747	0.483
LIG_REV1ctd_RIR_1	335	343	PF16727	0.539
LIG_REV1ctd_RIR_1	457	466	PF16727	0.451
LIG_SH2_CRK	2	6	PF00017	0.425
LIG_SH2_NCK_1	46	50	PF00017	0.383
LIG_SH2_NCK_1	758	762	PF00017	0.451
LIG_SH2_PTP2	67	70	PF00017	0.339
LIG_SH2_SRC	758	761	PF00017	0.533
LIG_SH2_STAP1	301	305	PF00017	0.384
LIG_SH2_STAT3	664	667	PF00017	0.422
LIG_SH2_STAT5	136	139	PF00017	0.422
LIG_SH2_STAT5	2	5	PF00017	0.360
LIG_SH2_STAT5	436	439	PF00017	0.459
LIG_SH2_STAT5	603	606	PF00017	0.478
LIG_SH2_STAT5	664	667	PF00017	0.461
LIG_SH2_STAT5	67	70	PF00017	0.339
LIG_SH3_1	719	725	PF00018	0.611
LIG_SH3_3	104	110	PF00018	0.454
LIG_SH3_3	159	165	PF00018	0.534
LIG_SH3_3	190	196	PF00018	0.460
LIG_SH3_3	719	725	PF00018	0.611
LIG_SH3_3	794	800	PF00018	0.633
LIG_SH3_3	873	879	PF00018	0.706
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.456
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.343
LIG_SUMO_SIM_anti_2	704	710	PF11976	0.455
LIG_SUMO_SIM_anti_2	903	908	PF11976	0.697
LIG_SUMO_SIM_par_1	208	213	PF11976	0.359
LIG_TRAF2_1	487	490	PF00917	0.566
LIG_TRAF2_1	515	518	PF00917	0.441
LIG_TRAF2_1	595	598	PF00917	0.488
LIG_UBA3_1	921	929	PF00899	0.560
LIG_WRC_WIRS_1	1	6	PF05994	0.391
LIG_WRC_WIRS_1	334	339	PF05994	0.564
LIG_WW_1	724	727	PF00397	0.641
MOD_CDK_SPK_2	110	115	PF00069	0.396
MOD_CDK_SPxxK_3	871	878	PF00069	0.671
MOD_CK1_1	105	111	PF00069	0.578
MOD_CK1_1	150	156	PF00069	0.556
MOD_CK1_1	192	198	PF00069	0.524
MOD_CK1_1	231	237	PF00069	0.439
MOD_CK1_1	259	265	PF00069	0.517
MOD_CK1_1	361	367	PF00069	0.570
MOD_CK1_1	45	51	PF00069	0.458
MOD_CK1_1	503	509	PF00069	0.510
MOD_CK1_1	682	688	PF00069	0.535
MOD_CK1_1	7	13	PF00069	0.424
MOD_CK1_1	717	723	PF00069	0.546
MOD_CK1_1	730	736	PF00069	0.640
MOD_CK1_1	811	817	PF00069	0.556
MOD_CK1_1	858	864	PF00069	0.752
MOD_CK1_1	892	898	PF00069	0.625
MOD_CK2_1	317	323	PF00069	0.500
MOD_CK2_1	368	374	PF00069	0.682
MOD_CK2_1	614	620	PF00069	0.475
MOD_CK2_1	701	707	PF00069	0.502
MOD_Cter_Amidation	330	333	PF01082	0.469
MOD_GlcNHglycan	196	199	PF01048	0.484
MOD_GlcNHglycan	220	223	PF01048	0.435
MOD_GlcNHglycan	231	234	PF01048	0.419
MOD_GlcNHglycan	258	261	PF01048	0.446
MOD_GlcNHglycan	284	287	PF01048	0.557
MOD_GlcNHglycan	346	349	PF01048	0.628
MOD_GlcNHglycan	403	406	PF01048	0.680
MOD_GlcNHglycan	489	493	PF01048	0.613
MOD_GlcNHglycan	49	52	PF01048	0.379
MOD_GlcNHglycan	647	650	PF01048	0.457
MOD_GlcNHglycan	667	670	PF01048	0.309
MOD_GlcNHglycan	7	10	PF01048	0.410
MOD_GlcNHglycan	703	706	PF01048	0.469
MOD_GlcNHglycan	729	732	PF01048	0.617
MOD_GlcNHglycan	783	786	PF01048	0.525
MOD_GlcNHglycan	835	838	PF01048	0.703
MOD_GlcNHglycan	850	853	PF01048	0.577
MOD_GlcNHglycan	917	920	PF01048	0.676
MOD_GlcNHglycan	937	940	PF01048	0.576
MOD_GSK3_1	142	149	PF00069	0.466
MOD_GSK3_1	228	235	PF00069	0.434
MOD_GSK3_1	256	263	PF00069	0.459
MOD_GSK3_1	278	285	PF00069	0.495
MOD_GSK3_1	301	308	PF00069	0.462
MOD_GSK3_1	385	392	PF00069	0.502
MOD_GSK3_1	411	418	PF00069	0.714
MOD_GSK3_1	496	503	PF00069	0.454
MOD_GSK3_1	5	12	PF00069	0.445
MOD_GSK3_1	710	717	PF00069	0.430
MOD_GSK3_1	858	865	PF00069	0.651
MOD_GSK3_1	887	894	PF00069	0.682
MOD_GSK3_1	935	942	PF00069	0.847
MOD_N-GLC_1	123	128	PF02516	0.423
MOD_N-GLC_1	150	155	PF02516	0.569
MOD_N-GLC_1	55	60	PF02516	0.485
MOD_NEK2_1	123	128	PF00069	0.531
MOD_NEK2_1	147	152	PF00069	0.629
MOD_NEK2_1	271	276	PF00069	0.509
MOD_NEK2_1	42	47	PF00069	0.366
MOD_NEK2_1	500	505	PF00069	0.427
MOD_NEK2_1	614	619	PF00069	0.454
MOD_NEK2_1	810	815	PF00069	0.542
MOD_NEK2_2	496	501	PF00069	0.491
MOD_PIKK_1	317	323	PF00454	0.520
MOD_PIKK_1	339	345	PF00454	0.572
MOD_PIKK_1	893	899	PF00454	0.609
MOD_PIKK_1	9	15	PF00454	0.530
MOD_PKA_1	358	364	PF00069	0.541
MOD_PKA_2	183	189	PF00069	0.405
MOD_PKA_2	358	364	PF00069	0.658
MOD_PKA_2	496	502	PF00069	0.479
MOD_PKA_2	701	707	PF00069	0.616
MOD_PKA_2	710	716	PF00069	0.488
MOD_PKA_2	717	723	PF00069	0.511
MOD_PKA_2	727	733	PF00069	0.594
MOD_PKA_2	735	741	PF00069	0.583
MOD_PKA_2	833	839	PF00069	0.610
MOD_PKA_2	858	864	PF00069	0.705
MOD_PKB_1	867	875	PF00069	0.642
MOD_Plk_1	123	129	PF00069	0.420
MOD_Plk_1	142	148	PF00069	0.518
MOD_Plk_1	376	382	PF00069	0.651
MOD_Plk_1	488	494	PF00069	0.424
MOD_Plk_4	102	108	PF00069	0.507
MOD_Plk_4	123	129	PF00069	0.420
MOD_Plk_4	142	148	PF00069	0.555
MOD_Plk_4	16	22	PF00069	0.456
MOD_Plk_4	266	272	PF00069	0.436
MOD_Plk_4	278	284	PF00069	0.370
MOD_Plk_4	301	307	PF00069	0.459
MOD_Plk_4	333	339	PF00069	0.484
MOD_Plk_4	36	42	PF00069	0.485
MOD_Plk_4	376	382	PF00069	0.632
MOD_Plk_4	496	502	PF00069	0.494
MOD_Plk_4	526	532	PF00069	0.452
MOD_Plk_4	539	545	PF00069	0.571
MOD_Plk_4	774	780	PF00069	0.368
MOD_Plk_4	839	845	PF00069	0.673
MOD_Plk_4	917	923	PF00069	0.621
MOD_ProDKin_1	110	116	PF00069	0.388
MOD_ProDKin_1	189	195	PF00069	0.455
MOD_ProDKin_1	679	685	PF00069	0.564
MOD_ProDKin_1	796	802	PF00069	0.650
MOD_ProDKin_1	871	877	PF00069	0.713
MOD_ProDKin_1	941	947	PF00069	0.734
MOD_SUMO_rev_2	894	904	PF00179	0.697
TRG_DiLeu_BaEn_1	66	71	PF01217	0.343
TRG_DiLeu_BaEn_2	116	122	PF01217	0.344
TRG_DiLeu_BaEn_2	455	461	PF01217	0.446
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.377
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.519
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.675
TRG_ENDOCYTIC_2	2	5	PF00928	0.429
TRG_ENDOCYTIC_2	390	393	PF00928	0.454
TRG_ENDOCYTIC_2	434	437	PF00928	0.368
TRG_ENDOCYTIC_2	67	70	PF00928	0.339
TRG_ER_diArg_1	154	156	PF00400	0.637
TRG_ER_diArg_1	332	334	PF00400	0.479
TRG_ER_diArg_1	357	359	PF00400	0.622
TRG_ER_diArg_1	83	86	PF00400	0.400
TRG_ER_diArg_1	922	924	PF00400	0.573
TRG_NLS_MonoExtC_3	948	953	PF00514	0.658
TRG_NLS_MonoExtN_4	946	953	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB01	Leptomonas seymouri	50%	100%
A0A3S5H790	Leishmania donovani	93%	100%
A4HZ05	Leishmania infantum	92%	100%
E9AIK7	Leishmania braziliensis	77%	98%
E9AUT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%