Cell division cycle protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle protein-like protein

Species:

Leishmania major

UniProt:

Q4QCP1_LEIMA

TriTrypDb:

LmjF.20.1530 , LMJLV39_200022000 , LMJSD75_200022000

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4QCP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCP1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0051301	cell division	2	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.472
CLV_C14_Caspase3-7	511	515	PF00656	0.503
CLV_C14_Caspase3-7	668	672	PF00656	0.279
CLV_C14_Caspase3-7	697	701	PF00656	0.279
CLV_C14_Caspase3-7	806	810	PF00656	0.732
CLV_C14_Caspase3-7	841	845	PF00656	0.564
CLV_MEL_PAP_1	430	436	PF00089	0.529
CLV_NRD_NRD_1	331	333	PF00675	0.344
CLV_NRD_NRD_1	455	457	PF00675	0.501
CLV_NRD_NRD_1	526	528	PF00675	0.509
CLV_NRD_NRD_1	618	620	PF00675	0.320
CLV_NRD_NRD_1	626	628	PF00675	0.352
CLV_NRD_NRD_1	765	767	PF00675	0.622
CLV_PCSK_KEX2_1	331	333	PF00082	0.399
CLV_PCSK_KEX2_1	455	457	PF00082	0.501
CLV_PCSK_KEX2_1	528	530	PF00082	0.623
CLV_PCSK_KEX2_1	618	620	PF00082	0.319
CLV_PCSK_KEX2_1	626	628	PF00082	0.351
CLV_PCSK_KEX2_1	764	766	PF00082	0.608
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.623
CLV_PCSK_PC1ET2_1	764	766	PF00082	0.557
CLV_PCSK_PC7_1	761	767	PF00082	0.519
CLV_PCSK_SKI1_1	218	222	PF00082	0.521
CLV_PCSK_SKI1_1	228	232	PF00082	0.438
CLV_PCSK_SKI1_1	250	254	PF00082	0.477
CLV_PCSK_SKI1_1	304	308	PF00082	0.527
CLV_PCSK_SKI1_1	489	493	PF00082	0.573
CLV_PCSK_SKI1_1	597	601	PF00082	0.336
CLV_PCSK_SKI1_1	609	613	PF00082	0.265
DEG_APCC_DBOX_1	303	311	PF00400	0.523
DEG_APCC_DBOX_1	331	339	PF00400	0.513
DEG_SPOP_SBC_1	363	367	PF00917	0.533
DEG_SPOP_SBC_1	47	51	PF00917	0.408
DOC_CKS1_1	424	429	PF01111	0.308
DOC_CYCLIN_RxL_1	615	624	PF00134	0.412
DOC_CYCLIN_yClb5_NLxxxL_5	331	339	PF00134	0.405
DOC_MAPK_gen_1	527	533	PF00069	0.597
DOC_MAPK_gen_1	626	633	PF00069	0.377
DOC_MAPK_gen_1	729	739	PF00069	0.279
DOC_MAPK_JIP1_4	729	735	PF00069	0.279
DOC_MAPK_MEF2A_6	729	737	PF00069	0.279
DOC_PP2B_LxvP_1	354	357	PF13499	0.516
DOC_PP2B_LxvP_1	591	594	PF13499	0.542
DOC_PP2B_LxvP_1	620	623	PF13499	0.410
DOC_PP2B_LxvP_1	673	676	PF13499	0.279
DOC_PP2B_LxvP_1	77	80	PF13499	0.531
DOC_USP7_MATH_1	113	117	PF00917	0.659
DOC_USP7_MATH_1	363	367	PF00917	0.579
DOC_USP7_MATH_1	462	466	PF00917	0.613
DOC_USP7_MATH_1	541	545	PF00917	0.663
DOC_USP7_MATH_1	604	608	PF00917	0.320
DOC_USP7_MATH_1	62	66	PF00917	0.455
DOC_USP7_MATH_1	816	820	PF00917	0.687
DOC_USP7_MATH_1	860	864	PF00917	0.539
DOC_USP7_UBL2_3	803	807	PF12436	0.464
DOC_WW_Pin1_4	297	302	PF00397	0.500
DOC_WW_Pin1_4	311	316	PF00397	0.573
DOC_WW_Pin1_4	423	428	PF00397	0.593
DOC_WW_Pin1_4	818	823	PF00397	0.629
DOC_WW_Pin1_4	842	847	PF00397	0.695
LIG_14-3-3_CanoR_1	191	197	PF00244	0.656
LIG_14-3-3_CanoR_1	209	217	PF00244	0.610
LIG_14-3-3_CanoR_1	440	450	PF00244	0.416
LIG_14-3-3_CanoR_1	690	696	PF00244	0.290
LIG_14-3-3_CanoR_1	765	772	PF00244	0.607
LIG_Actin_WH2_2	29	47	PF00022	0.358
LIG_BRCT_BRCA1_1	286	290	PF00533	0.508
LIG_BRCT_BRCA1_1	292	296	PF00533	0.361
LIG_Clathr_ClatBox_1	341	345	PF01394	0.502
LIG_Clathr_ClatBox_1	376	380	PF01394	0.303
LIG_CSL_BTD_1	82	85	PF09270	0.467
LIG_FHA_1	124	130	PF00498	0.620
LIG_FHA_1	191	197	PF00498	0.651
LIG_FHA_1	227	233	PF00498	0.615
LIG_FHA_1	312	318	PF00498	0.520
LIG_FHA_1	37	43	PF00498	0.497
LIG_FHA_1	395	401	PF00498	0.419
LIG_FHA_1	418	424	PF00498	0.370
LIG_FHA_1	452	458	PF00498	0.516
LIG_FHA_1	471	477	PF00498	0.468
LIG_FHA_1	48	54	PF00498	0.402
LIG_FHA_1	507	513	PF00498	0.649
LIG_FHA_1	581	587	PF00498	0.419
LIG_FHA_1	594	600	PF00498	0.373
LIG_FHA_1	608	614	PF00498	0.245
LIG_FHA_1	638	644	PF00498	0.478
LIG_FHA_1	70	76	PF00498	0.495
LIG_FHA_1	778	784	PF00498	0.528
LIG_FHA_1	824	830	PF00498	0.532
LIG_FHA_2	195	201	PF00498	0.694
LIG_FHA_2	443	449	PF00498	0.488
LIG_FHA_2	678	684	PF00498	0.351
LIG_FHA_2	695	701	PF00498	0.187
LIG_Integrin_isoDGR_2	189	191	PF01839	0.581
LIG_Integrin_RGD_1	842	844	PF01839	0.565
LIG_LIR_Gen_1	139	148	PF02991	0.585
LIG_LIR_Gen_1	243	252	PF02991	0.483
LIG_LIR_Gen_1	39	48	PF02991	0.360
LIG_LIR_Gen_1	559	567	PF02991	0.454
LIG_LIR_Nem_3	139	145	PF02991	0.565
LIG_LIR_Nem_3	243	248	PF02991	0.497
LIG_LIR_Nem_3	369	375	PF02991	0.381
LIG_LIR_Nem_3	39	44	PF02991	0.541
LIG_LIR_Nem_3	559	564	PF02991	0.410
LIG_LYPXL_S_1	371	375	PF13949	0.314
LIG_LYPXL_yS_3	372	375	PF13949	0.299
LIG_MYND_1	818	822	PF01753	0.575
LIG_NRBOX	290	296	PF00104	0.411
LIG_NRBOX	305	311	PF00104	0.468
LIG_NRBOX	691	697	PF00104	0.279
LIG_PTAP_UEV_1	502	507	PF05743	0.514
LIG_Rb_pABgroove_1	648	656	PF01858	0.306
LIG_SH2_CRK	168	172	PF00017	0.478
LIG_SH2_CRK	245	249	PF00017	0.596
LIG_SH2_CRK	561	565	PF00017	0.397
LIG_SH2_STAP1	561	565	PF00017	0.454
LIG_SH2_STAT5	41	44	PF00017	0.328
LIG_SH2_STAT5	452	455	PF00017	0.450
LIG_SH2_STAT5	796	799	PF00017	0.567
LIG_SH3_3	155	161	PF00018	0.467
LIG_SH3_3	350	356	PF00018	0.446
LIG_SH3_3	367	373	PF00018	0.641
LIG_SH3_3	500	506	PF00018	0.649
LIG_SH3_3	550	556	PF00018	0.521
LIG_SH3_3	724	730	PF00018	0.410
LIG_SH3_3	812	818	PF00018	0.645
LIG_SH3_3	843	849	PF00018	0.579
LIG_SH3_3	88	94	PF00018	0.597
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.483
LIG_SUMO_SIM_anti_2	345	351	PF11976	0.426
LIG_SUMO_SIM_anti_2	583	590	PF11976	0.509
LIG_SUMO_SIM_anti_2	634	640	PF11976	0.288
LIG_SUMO_SIM_anti_2	708	714	PF11976	0.395
LIG_SUMO_SIM_anti_2	782	788	PF11976	0.503
LIG_SUMO_SIM_par_1	337	343	PF11976	0.431
LIG_SUMO_SIM_par_1	374	381	PF11976	0.317
LIG_SUMO_SIM_par_1	489	495	PF11976	0.419
LIG_SUMO_SIM_par_1	583	590	PF11976	0.438
LIG_SUMO_SIM_par_1	710	716	PF11976	0.409
LIG_SUMO_SIM_par_1	780	788	PF11976	0.553
LIG_TRAF2_1	436	439	PF00917	0.407
LIG_TYR_ITIM	370	375	PF00017	0.325
LIG_WRC_WIRS_1	416	421	PF05994	0.457
LIG_WW_3	674	678	PF00397	0.279
MOD_CDK_SPxxK_3	297	304	PF00069	0.474
MOD_CK1_1	179	185	PF00069	0.703
MOD_CK1_1	192	198	PF00069	0.696
MOD_CK1_1	362	368	PF00069	0.631
MOD_CK1_1	544	550	PF00069	0.561
MOD_CK1_1	607	613	PF00069	0.279
MOD_CK1_1	637	643	PF00069	0.306
MOD_CK1_1	716	722	PF00069	0.386
MOD_CK2_1	114	120	PF00069	0.582
MOD_CK2_1	192	198	PF00069	0.715
MOD_CK2_1	213	219	PF00069	0.613
MOD_CK2_1	415	421	PF00069	0.456
MOD_CK2_1	441	447	PF00069	0.421
MOD_CK2_1	677	683	PF00069	0.410
MOD_CK2_1	818	824	PF00069	0.525
MOD_Cter_Amidation	616	619	PF01082	0.306
MOD_GlcNHglycan	16	19	PF01048	0.642
MOD_GlcNHglycan	181	184	PF01048	0.612
MOD_GlcNHglycan	280	283	PF01048	0.620
MOD_GlcNHglycan	286	289	PF01048	0.555
MOD_GlcNHglycan	361	364	PF01048	0.666
MOD_GlcNHglycan	503	506	PF01048	0.542
MOD_GlcNHglycan	543	546	PF01048	0.738
MOD_GlcNHglycan	604	607	PF01048	0.282
MOD_GlcNHglycan	715	718	PF01048	0.317
MOD_GlcNHglycan	744	747	PF01048	0.578
MOD_GlcNHglycan	861	865	PF01048	0.469
MOD_GSK3_1	115	122	PF00069	0.669
MOD_GSK3_1	123	130	PF00069	0.490
MOD_GSK3_1	132	139	PF00069	0.390
MOD_GSK3_1	190	197	PF00069	0.776
MOD_GSK3_1	22	29	PF00069	0.544
MOD_GSK3_1	226	233	PF00069	0.619
MOD_GSK3_1	274	281	PF00069	0.565
MOD_GSK3_1	359	366	PF00069	0.601
MOD_GSK3_1	36	43	PF00069	0.483
MOD_GSK3_1	388	395	PF00069	0.540
MOD_GSK3_1	479	486	PF00069	0.446
MOD_GSK3_1	497	504	PF00069	0.554
MOD_GSK3_1	506	513	PF00069	0.680
MOD_GSK3_1	540	547	PF00069	0.674
MOD_GSK3_1	607	614	PF00069	0.312
MOD_GSK3_1	656	663	PF00069	0.407
MOD_GSK3_1	677	684	PF00069	0.294
MOD_GSK3_1	690	697	PF00069	0.248
MOD_GSK3_1	737	744	PF00069	0.504
MOD_N-GLC_1	684	689	PF02516	0.402
MOD_NEK2_1	123	128	PF00069	0.547
MOD_NEK2_1	132	137	PF00069	0.458
MOD_NEK2_1	274	279	PF00069	0.511
MOD_NEK2_1	290	295	PF00069	0.226
MOD_NEK2_1	310	315	PF00069	0.560
MOD_NEK2_1	359	364	PF00069	0.588
MOD_NEK2_1	36	41	PF00069	0.378
MOD_NEK2_1	392	397	PF00069	0.417
MOD_NEK2_1	407	412	PF00069	0.533
MOD_NEK2_1	441	446	PF00069	0.527
MOD_NEK2_1	478	483	PF00069	0.330
MOD_NEK2_1	653	658	PF00069	0.357
MOD_PIKK_1	299	305	PF00454	0.447
MOD_PIKK_1	6	12	PF00454	0.462
MOD_PIKK_1	694	700	PF00454	0.410
MOD_PKA_1	765	771	PF00069	0.603
MOD_PKA_2	190	196	PF00069	0.655
MOD_PKA_2	210	216	PF00069	0.619
MOD_PKA_2	278	284	PF00069	0.607
MOD_PKA_2	678	684	PF00069	0.322
MOD_PKA_2	765	771	PF00069	0.603
MOD_Plk_1	140	146	PF00069	0.557
MOD_Plk_1	688	694	PF00069	0.279
MOD_Plk_1	810	816	PF00069	0.736
MOD_Plk_4	119	125	PF00069	0.655
MOD_Plk_4	27	33	PF00069	0.458
MOD_Plk_4	290	296	PF00069	0.336
MOD_Plk_4	313	319	PF00069	0.494
MOD_Plk_4	36	42	PF00069	0.402
MOD_Plk_4	366	372	PF00069	0.500
MOD_Plk_4	388	394	PF00069	0.404
MOD_Plk_4	497	503	PF00069	0.532
MOD_Plk_4	634	640	PF00069	0.297
MOD_Plk_4	691	697	PF00069	0.279
MOD_ProDKin_1	297	303	PF00069	0.497
MOD_ProDKin_1	311	317	PF00069	0.576
MOD_ProDKin_1	423	429	PF00069	0.597
MOD_ProDKin_1	818	824	PF00069	0.628
MOD_ProDKin_1	842	848	PF00069	0.699
TRG_DiLeu_BaEn_1	243	248	PF01217	0.473
TRG_DiLeu_BaEn_1	337	342	PF01217	0.380
TRG_DiLeu_BaEn_1	380	385	PF01217	0.360
TRG_DiLeu_BaEn_1	788	793	PF01217	0.498
TRG_DiLeu_BaEn_2	96	102	PF01217	0.453
TRG_DiLeu_BaEn_4	243	249	PF01217	0.470
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.446
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.511
TRG_ENDOCYTIC_2	168	171	PF00928	0.543
TRG_ENDOCYTIC_2	245	248	PF00928	0.534
TRG_ENDOCYTIC_2	372	375	PF00928	0.305
TRG_ENDOCYTIC_2	41	44	PF00928	0.328
TRG_ENDOCYTIC_2	561	564	PF00928	0.379
TRG_ER_diArg_1	209	212	PF00400	0.594
TRG_ER_diArg_1	331	333	PF00400	0.478
TRG_ER_diArg_1	455	457	PF00400	0.437
TRG_ER_diArg_1	618	620	PF00400	0.321
TRG_ER_diArg_1	626	628	PF00400	0.355
TRG_ER_diArg_1	676	679	PF00400	0.297
TRG_NES_CRM1_1	576	590	PF08389	0.520
TRG_NLS_MonoExtC_3	763	769	PF00514	0.555
TRG_NLS_MonoExtN_4	761	768	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	202	207	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E7	Leptomonas seymouri	49%	100%
A0A1X0NXH5	Trypanosomatidae	35%	100%
A0A3Q8IBN9	Leishmania donovani	93%	100%
A0A3R7NWG6	Trypanosoma rangeli	35%	100%
A4HZ08	Leishmania infantum	92%	100%
C9ZIP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AIL0	Leishmania braziliensis	76%	100%
E9AUU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BCV9	Trypanosoma cruzi	34%	100%