Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TBC1 domain family member 20/GTPase, putative

Species:

Leishmania major

UniProt:

Q4QCN9_LEIMA

TriTrypDb:

LmjF.20.1630 , LMJLV39_200022300 , LMJSD75_200022300

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCN9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0043087	regulation of GTPase activity	5	7
GO:0043547	positive regulation of GTPase activity	6	7
GO:0044093	positive regulation of molecular function	3	7
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0050790	regulation of catalytic activity	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051336	regulation of hydrolase activity	4	7
GO:0051345	positive regulation of hydrolase activity	5	7
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.827
CLV_NRD_NRD_1	150	152	PF00675	0.615
CLV_NRD_NRD_1	184	186	PF00675	0.587
CLV_NRD_NRD_1	226	228	PF00675	0.555
CLV_NRD_NRD_1	234	236	PF00675	0.532
CLV_NRD_NRD_1	306	308	PF00675	0.349
CLV_NRD_NRD_1	38	40	PF00675	0.420
CLV_NRD_NRD_1	572	574	PF00675	0.346
CLV_NRD_NRD_1	77	79	PF00675	0.410
CLV_PCSK_FUR_1	359	363	PF00082	0.418
CLV_PCSK_KEX2_1	184	186	PF00082	0.587
CLV_PCSK_KEX2_1	225	227	PF00082	0.561
CLV_PCSK_KEX2_1	234	236	PF00082	0.532
CLV_PCSK_KEX2_1	305	307	PF00082	0.349
CLV_PCSK_KEX2_1	361	363	PF00082	0.362
CLV_PCSK_KEX2_1	37	39	PF00082	0.417
CLV_PCSK_KEX2_1	572	574	PF00082	0.346
CLV_PCSK_KEX2_1	64	66	PF00082	0.398
CLV_PCSK_KEX2_1	79	81	PF00082	0.435
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.418
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.398
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.435
CLV_PCSK_PC7_1	301	307	PF00082	0.346
CLV_PCSK_SKI1_1	226	230	PF00082	0.599
CLV_PCSK_SKI1_1	234	238	PF00082	0.524
CLV_PCSK_SKI1_1	245	249	PF00082	0.390
CLV_PCSK_SKI1_1	306	310	PF00082	0.312
CLV_PCSK_SKI1_1	314	318	PF00082	0.290
CLV_PCSK_SKI1_1	366	370	PF00082	0.318
CLV_PCSK_SKI1_1	572	576	PF00082	0.349
CLV_PCSK_SKI1_1	79	83	PF00082	0.443
CLV_Separin_Metazoa	192	196	PF03568	0.812
DEG_APCC_DBOX_1	225	233	PF00400	0.773
DEG_APCC_DBOX_1	304	312	PF00400	0.574
DOC_ANK_TNKS_1	71	78	PF00023	0.578
DOC_CYCLIN_RxL_1	309	321	PF00134	0.546
DOC_CYCLIN_RxL_1	567	578	PF00134	0.669
DOC_MAPK_gen_1	305	315	PF00069	0.520
DOC_MAPK_MEF2A_6	306	315	PF00069	0.519
DOC_MAPK_MEF2A_6	462	469	PF00069	0.689
DOC_PP1_RVXF_1	570	577	PF00149	0.572
DOC_PP2B_LxvP_1	191	194	PF13499	0.861
DOC_USP7_MATH_1	565	569	PF00917	0.774
DOC_USP7_MATH_1	6	10	PF00917	0.776
DOC_WW_Pin1_4	123	128	PF00397	0.784
DOC_WW_Pin1_4	20	25	PF00397	0.727
DOC_WW_Pin1_4	253	258	PF00397	0.819
DOC_WW_Pin1_4	337	342	PF00397	0.509
DOC_WW_Pin1_4	561	566	PF00397	0.663
LIG_14-3-3_CanoR_1	164	169	PF00244	0.797
LIG_14-3-3_CanoR_1	226	236	PF00244	0.739
LIG_14-3-3_CanoR_1	289	295	PF00244	0.594
LIG_14-3-3_CanoR_1	362	368	PF00244	0.549
LIG_14-3-3_CanoR_1	520	524	PF00244	0.641
LIG_14-3-3_CanoR_1	78	87	PF00244	0.667
LIG_Actin_WH2_2	229	247	PF00022	0.635
LIG_APCC_ABBA_1	339	344	PF00400	0.546
LIG_CaM_IQ_9	92	107	PF13499	0.679
LIG_Clathr_ClatBox_1	431	435	PF01394	0.486
LIG_EH1_1	375	383	PF00400	0.574
LIG_eIF4E_1	441	447	PF01652	0.530
LIG_FHA_1	198	204	PF00498	0.808
LIG_FHA_1	409	415	PF00498	0.546
LIG_FHA_1	441	447	PF00498	0.539
LIG_FHA_1	583	589	PF00498	0.406
LIG_FHA_2	341	347	PF00498	0.574
LIG_FHA_2	41	47	PF00498	0.609
LIG_FHA_2	451	457	PF00498	0.501
LIG_LIR_Apic_2	270	275	PF02991	0.665
LIG_LIR_Apic_2	561	565	PF02991	0.691
LIG_LIR_Gen_1	343	351	PF02991	0.574
LIG_LIR_Gen_1	452	461	PF02991	0.556
LIG_LIR_Gen_1	513	523	PF02991	0.590
LIG_LIR_LC3C_4	443	448	PF02991	0.486
LIG_LIR_Nem_3	270	274	PF02991	0.702
LIG_LIR_Nem_3	290	295	PF02991	0.383
LIG_LIR_Nem_3	343	348	PF02991	0.569
LIG_LIR_Nem_3	358	363	PF02991	0.475
LIG_LIR_Nem_3	394	398	PF02991	0.538
LIG_LIR_Nem_3	428	432	PF02991	0.618
LIG_LIR_Nem_3	44	50	PF02991	0.603
LIG_LIR_Nem_3	452	458	PF02991	0.551
LIG_LIR_Nem_3	513	518	PF02991	0.589
LIG_MYND_1	189	193	PF01753	0.827
LIG_NRBOX	312	318	PF00104	0.546
LIG_NRBOX	504	510	PF00104	0.585
LIG_Rb_LxCxE_1	27	46	PF01857	0.632
LIG_Rb_pABgroove_1	421	429	PF01858	0.546
LIG_SH2_CRK	325	329	PF00017	0.531
LIG_SH2_CRK	486	490	PF00017	0.580
LIG_SH2_CRK	515	519	PF00017	0.625
LIG_SH2_GRB2like	47	50	PF00017	0.632
LIG_SH2_SRC	413	416	PF00017	0.545
LIG_SH2_STAP1	376	380	PF00017	0.546
LIG_SH2_STAP1	404	408	PF00017	0.618
LIG_SH2_STAT5	342	345	PF00017	0.543
LIG_SH2_STAT5	413	416	PF00017	0.546
LIG_SH2_STAT5	429	432	PF00017	0.546
LIG_SH2_STAT5	441	444	PF00017	0.546
LIG_SH2_STAT5	50	53	PF00017	0.533
LIG_SH2_STAT5	515	518	PF00017	0.644
LIG_SH3_3	190	196	PF00018	0.843
LIG_SH3_3	262	268	PF00018	0.782
LIG_SUMO_SIM_anti_2	418	424	PF11976	0.530
LIG_SUMO_SIM_anti_2	475	483	PF11976	0.672
LIG_SUMO_SIM_par_1	346	353	PF11976	0.546
LIG_SUMO_SIM_par_1	430	435	PF11976	0.530
LIG_TRAF2_1	461	464	PF00917	0.640
LIG_TRFH_1	337	341	PF08558	0.411
LIG_UBA3_1	454	462	PF00899	0.473
LIG_WW_3	192	196	PF00397	0.804
MOD_CDC14_SPxK_1	564	567	PF00782	0.598
MOD_CDK_SPxK_1	561	567	PF00069	0.580
MOD_CK1_1	120	126	PF00069	0.778
MOD_CK1_1	155	161	PF00069	0.784
MOD_CK1_1	167	173	PF00069	0.735
MOD_CK1_1	230	236	PF00069	0.759
MOD_CK1_1	290	296	PF00069	0.512
MOD_CK1_1	340	346	PF00069	0.450
MOD_CK1_1	416	422	PF00069	0.394
MOD_CK1_1	9	15	PF00069	0.741
MOD_CK2_1	20	26	PF00069	0.493
MOD_CK2_1	249	255	PF00069	0.689
MOD_CK2_1	340	346	PF00069	0.438
MOD_CK2_1	40	46	PF00069	0.369
MOD_CK2_1	446	452	PF00069	0.370
MOD_Cter_Amidation	76	79	PF01082	0.492
MOD_GlcNHglycan	117	120	PF01048	0.736
MOD_GlcNHglycan	15	18	PF01048	0.698
MOD_GlcNHglycan	153	157	PF01048	0.771
MOD_GlcNHglycan	260	264	PF01048	0.705
MOD_GlcNHglycan	297	300	PF01048	0.430
MOD_GlcNHglycan	363	366	PF01048	0.411
MOD_GlcNHglycan	435	439	PF01048	0.500
MOD_GlcNHglycan	56	59	PF01048	0.629
MOD_GSK3_1	104	111	PF00069	0.659
MOD_GSK3_1	152	159	PF00069	0.808
MOD_GSK3_1	163	170	PF00069	0.705
MOD_GSK3_1	249	256	PF00069	0.683
MOD_GSK3_1	295	302	PF00069	0.475
MOD_GSK3_1	4	11	PF00069	0.748
MOD_GSK3_1	404	411	PF00069	0.471
MOD_GSK3_1	446	453	PF00069	0.312
MOD_GSK3_1	465	472	PF00069	0.458
MOD_GSK3_1	50	57	PF00069	0.370
MOD_GSK3_1	539	546	PF00069	0.541
MOD_GSK3_1	561	568	PF00069	0.595
MOD_GSK3_1	96	103	PF00069	0.667
MOD_LATS_1	110	116	PF00433	0.709
MOD_N-GLC_1	108	113	PF02516	0.740
MOD_N-GLC_1	253	258	PF02516	0.790
MOD_N-GLC_2	49	51	PF02516	0.367
MOD_NEK2_1	163	168	PF00069	0.748
MOD_NEK2_1	174	179	PF00069	0.653
MOD_NEK2_1	261	266	PF00069	0.658
MOD_NEK2_1	355	360	PF00069	0.411
MOD_NEK2_1	446	451	PF00069	0.350
MOD_NEK2_1	54	59	PF00069	0.496
MOD_NEK2_1	575	580	PF00069	0.415
MOD_NEK2_1	8	13	PF00069	0.728
MOD_PIKK_1	227	233	PF00454	0.770
MOD_PIKK_1	446	452	PF00454	0.401
MOD_PKA_1	361	367	PF00069	0.372
MOD_PKA_1	79	85	PF00069	0.585
MOD_PKA_2	115	121	PF00069	0.676
MOD_PKA_2	163	169	PF00069	0.740
MOD_PKA_2	361	367	PF00069	0.433
MOD_PKA_2	450	456	PF00069	0.380
MOD_PKA_2	519	525	PF00069	0.602
MOD_PKA_2	79	85	PF00069	0.585
MOD_PKB_1	185	193	PF00069	0.747
MOD_PKB_1	225	233	PF00069	0.690
MOD_Plk_1	159	165	PF00069	0.770
MOD_Plk_1	287	293	PF00069	0.411
MOD_Plk_1	96	102	PF00069	0.711
MOD_Plk_2-3	347	353	PF00069	0.411
MOD_Plk_4	261	267	PF00069	0.654
MOD_Plk_4	404	410	PF00069	0.512
MOD_Plk_4	450	456	PF00069	0.339
MOD_ProDKin_1	123	129	PF00069	0.744
MOD_ProDKin_1	20	26	PF00069	0.657
MOD_ProDKin_1	253	259	PF00069	0.793
MOD_ProDKin_1	337	343	PF00069	0.359
MOD_ProDKin_1	561	567	PF00069	0.580
MOD_SUMO_for_1	461	464	PF00179	0.436
MOD_SUMO_for_1	566	569	PF00179	0.606
TRG_DiLeu_BaEn_1	26	31	PF01217	0.431
TRG_DiLeu_BaEn_2	525	531	PF01217	0.497
TRG_DiLeu_BaEn_4	526	532	PF01217	0.499
TRG_ENDOCYTIC_2	325	328	PF00928	0.390
TRG_ENDOCYTIC_2	429	432	PF00928	0.512
TRG_ENDOCYTIC_2	486	489	PF00928	0.458
TRG_ENDOCYTIC_2	515	518	PF00928	0.528
TRG_ER_diArg_1	183	185	PF00400	0.750
TRG_ER_diArg_1	224	227	PF00400	0.714
TRG_ER_diArg_1	234	236	PF00400	0.672
TRG_ER_diArg_1	305	307	PF00400	0.415
TRG_ER_diArg_1	37	39	PF00400	0.510
TRG_ER_diArg_1	571	573	PF00400	0.597
TRG_ER_diArg_1	78	81	PF00400	0.593
TRG_NES_CRM1_1	421	435	PF08389	0.512
TRG_NLS_Bipartite_1	64	82	PF00514	0.375
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.724
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P406	Leptomonas seymouri	55%	100%
A0A3S7WWA9	Leishmania donovani	93%	100%
A4HYZ3	Leishmania infantum	93%	100%
E9AIL1	Leishmania braziliensis	75%	100%
E9AUU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%