Phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Suppressor of G2 allele of SKP1, putative

Species:

Leishmania major

UniProt:

Q4QCN8_LEIMA

TriTrypDb:

LmjF.20.1640 , LMJLV39_200022400 , LMJSD75_200022400

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCN8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0051087	protein-folding chaperone binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.550
CLV_NRD_NRD_1	171	173	PF00675	0.269
CLV_NRD_NRD_1	98	100	PF00675	0.657
CLV_PCSK_KEX2_1	171	173	PF00082	0.279
CLV_PCSK_SKI1_1	124	128	PF00082	0.619
CLV_PCSK_SKI1_1	176	180	PF00082	0.293
CLV_PCSK_SKI1_1	39	43	PF00082	0.345
CLV_PCSK_SKI1_1	78	82	PF00082	0.326
DOC_MAPK_gen_1	132	141	PF00069	0.339
DOC_MAPK_gen_1	28	37	PF00069	0.498
DOC_MAPK_gen_1	78	86	PF00069	0.479
DOC_MAPK_HePTP_8	36	48	PF00069	0.487
DOC_MAPK_MEF2A_6	134	143	PF00069	0.520
DOC_MAPK_MEF2A_6	39	48	PF00069	0.501
DOC_MAPK_MEF2A_6	78	86	PF00069	0.485
LIG_14-3-3_CanoR_1	99	108	PF00244	0.551
LIG_BIR_III_2	146	150	PF00653	0.520
LIG_FHA_1	22	28	PF00498	0.454
LIG_FHA_1	5	11	PF00498	0.657
LIG_FHA_2	120	126	PF00498	0.612
LIG_FHA_2	186	192	PF00498	0.477
LIG_FHA_2	29	35	PF00498	0.554
LIG_FHA_2	40	46	PF00498	0.507
LIG_Integrin_isoDGR_2	53	55	PF01839	0.303
LIG_LIR_Gen_1	13	23	PF02991	0.571
LIG_LIR_Gen_1	135	143	PF02991	0.511
LIG_LIR_Gen_1	187	198	PF02991	0.469
LIG_LIR_Gen_1	62	73	PF02991	0.544
LIG_LIR_Nem_3	13	18	PF02991	0.513
LIG_LIR_Nem_3	135	139	PF02991	0.493
LIG_LIR_Nem_3	187	193	PF02991	0.469
LIG_LIR_Nem_3	58	64	PF02991	0.494
LIG_SH2_CRK	61	65	PF00017	0.490
LIG_SH2_STAP1	57	61	PF00017	0.548
LIG_SH2_STAT5	26	29	PF00017	0.493
LIG_SH3_3	104	110	PF00018	0.672
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.534
LIG_SUMO_SIM_anti_2	83	88	PF11976	0.437
LIG_WRC_WIRS_1	175	180	PF05994	0.469
MOD_CK1_1	181	187	PF00069	0.478
MOD_CK2_1	174	180	PF00069	0.469
MOD_CK2_1	207	213	PF00069	0.492
MOD_CK2_1	39	45	PF00069	0.515
MOD_GlcNHglycan	101	104	PF01048	0.642
MOD_GlcNHglycan	135	139	PF01048	0.303
MOD_GlcNHglycan	180	183	PF01048	0.371
MOD_GSK3_1	174	181	PF00069	0.469
MOD_GSK3_1	35	42	PF00069	0.481
MOD_NEK2_1	174	179	PF00069	0.469
MOD_NEK2_2	73	78	PF00069	0.494
MOD_PKA_1	99	105	PF00069	0.680
MOD_Plk_1	134	140	PF00069	0.508
MOD_Plk_1	28	34	PF00069	0.571
MOD_Plk_1	82	88	PF00069	0.493
MOD_Plk_2-3	207	213	PF00069	0.571
MOD_Plk_4	181	187	PF00069	0.485
MOD_Plk_4	82	88	PF00069	0.437
MOD_SUMO_for_1	139	142	PF00179	0.515
MOD_SUMO_for_1	147	150	PF00179	0.469
MOD_SUMO_for_1	80	83	PF00179	0.493
MOD_SUMO_rev_2	142	149	PF00179	0.479
TRG_ENDOCYTIC_2	15	18	PF00928	0.582
TRG_ENDOCYTIC_2	61	64	PF00928	0.505
TRG_NLS_MonoCore_2	193	198	PF00514	0.520
TRG_NLS_MonoExtC_3	193	199	PF00514	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVR6	Leptomonas seymouri	70%	98%
A0A0S4JRF8	Bodo saltans	54%	73%
A0A1X0NW51	Trypanosomatidae	58%	96%
A0A3Q8IEZ0	Leishmania donovani	95%	100%
A0A3R7M4C8	Trypanosoma rangeli	55%	99%
A4HYZ4	Leishmania infantum	94%	100%
C9ZIN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	96%
E9AIL2	Leishmania braziliensis	87%	100%
E9AUU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BCX0	Trypanosoma cruzi	54%	99%