Putative ribosome biogenesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome biogenesis protein, putative

Species:

Leishmania major

UniProt:

Q4QCN5_LEIMA

TriTrypDb:

LmjF.20.1670 , LMJLV39_200022800 , LMJSD75_200022700

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCN5

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	11
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0019843	rRNA binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.552
CLV_NRD_NRD_1	275	277	PF00675	0.400
CLV_NRD_NRD_1	281	283	PF00675	0.410
CLV_PCSK_KEX2_1	275	277	PF00082	0.400
CLV_PCSK_KEX2_1	281	283	PF00082	0.410
CLV_PCSK_KEX2_1	7	9	PF00082	0.590
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.590
CLV_PCSK_SKI1_1	171	175	PF00082	0.221
CLV_PCSK_SKI1_1	187	191	PF00082	0.306
CLV_PCSK_SKI1_1	264	268	PF00082	0.461
CLV_PCSK_SKI1_1	61	65	PF00082	0.477
CLV_PCSK_SKI1_1	75	79	PF00082	0.278
CLV_PCSK_SKI1_1	82	86	PF00082	0.233
DEG_APCC_DBOX_1	81	89	PF00400	0.412
DOC_CKS1_1	197	202	PF01111	0.412
DOC_CYCLIN_RxL_1	168	177	PF00134	0.412
DOC_CYCLIN_RxL_1	62	76	PF00134	0.408
DOC_MAPK_DCC_7	244	252	PF00069	0.507
DOC_MAPK_gen_1	168	176	PF00069	0.412
DOC_MAPK_gen_1	187	197	PF00069	0.412
DOC_MAPK_gen_1	80	88	PF00069	0.443
DOC_MAPK_MEF2A_6	168	176	PF00069	0.412
DOC_MAPK_MEF2A_6	80	88	PF00069	0.445
DOC_PP4_FxxP_1	125	128	PF00568	0.507
DOC_PP4_FxxP_1	197	200	PF00568	0.412
DOC_SPAK_OSR1_1	244	248	PF12202	0.365
DOC_USP7_MATH_1	304	308	PF00917	0.511
DOC_WW_Pin1_4	196	201	PF00397	0.412
DOC_WW_Pin1_4	231	236	PF00397	0.507
LIG_14-3-3_CanoR_1	10	18	PF00244	0.533
LIG_14-3-3_CanoR_1	103	108	PF00244	0.507
LIG_14-3-3_CanoR_1	187	193	PF00244	0.412
LIG_14-3-3_CanoR_1	212	217	PF00244	0.507
LIG_14-3-3_CanoR_1	244	248	PF00244	0.412
LIG_14-3-3_CanoR_1	75	84	PF00244	0.539
LIG_APCC_ABBAyCdc20_2	171	177	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BIR_III_3	1	5	PF00653	0.676
LIG_BRCT_BRCA1_1	121	125	PF00533	0.426
LIG_BRCT_BRCA1_1	205	209	PF00533	0.412
LIG_Clathr_ClatBox_1	173	177	PF01394	0.412
LIG_CtBP_PxDLS_1	310	314	PF00389	0.443
LIG_DLG_GKlike_1	212	219	PF00625	0.507
LIG_FHA_1	102	108	PF00498	0.443
LIG_FHA_2	104	110	PF00498	0.507
LIG_FHA_2	154	160	PF00498	0.426
LIG_FHA_2	76	82	PF00498	0.479
LIG_LIR_Apic_2	122	128	PF02991	0.507
LIG_LIR_Gen_1	132	142	PF02991	0.412
LIG_LIR_Gen_1	215	223	PF02991	0.479
LIG_LIR_Nem_3	132	138	PF02991	0.412
LIG_LIR_Nem_3	215	219	PF02991	0.479
LIG_Pex14_1	224	228	PF04695	0.412
LIG_Pex14_2	176	180	PF04695	0.412
LIG_SH2_CRK	169	173	PF00017	0.443
LIG_SH2_CRK	228	232	PF00017	0.459
LIG_SH2_SRC	228	231	PF00017	0.426
LIG_SH2_STAT5	135	138	PF00017	0.468
LIG_SH3_3	139	145	PF00018	0.412
LIG_SH3_3	229	235	PF00018	0.507
LIG_SH3_3	24	30	PF00018	0.786
LIG_SUMO_SIM_anti_2	309	315	PF11976	0.556
LIG_TRFH_1	180	184	PF08558	0.507
LIG_TYR_ITIM	133	138	PF00017	0.398
LIG_WRC_WIRS_1	213	218	PF05994	0.468
MOD_CDK_SPK_2	196	201	PF00069	0.412
MOD_CK1_1	11	17	PF00069	0.612
MOD_CK1_1	143	149	PF00069	0.507
MOD_CK1_1	234	240	PF00069	0.507
MOD_CK1_1	76	82	PF00069	0.505
MOD_CK2_1	153	159	PF00069	0.426
MOD_CK2_1	234	240	PF00069	0.448
MOD_Cter_Amidation	4	7	PF01082	0.678
MOD_GlcNHglycan	10	13	PF01048	0.684
MOD_GlcNHglycan	142	145	PF01048	0.307
MOD_GlcNHglycan	264	267	PF01048	0.377
MOD_GlcNHglycan	306	309	PF01048	0.554
MOD_GSK3_1	230	237	PF00069	0.468
MOD_GSK3_1	57	64	PF00069	0.516
MOD_N-GLC_2	254	256	PF02516	0.297
MOD_NEK2_1	167	172	PF00069	0.453
MOD_NEK2_1	262	267	PF00069	0.481
MOD_PKA_1	6	12	PF00069	0.717
MOD_PKA_1	61	67	PF00069	0.441
MOD_PKA_2	243	249	PF00069	0.412
MOD_Plk_1	131	137	PF00069	0.471
MOD_Plk_4	119	125	PF00069	0.421
MOD_Plk_4	131	137	PF00069	0.406
MOD_Plk_4	188	194	PF00069	0.426
MOD_Plk_4	212	218	PF00069	0.468
MOD_Plk_4	234	240	PF00069	0.468
MOD_Plk_4	257	263	PF00069	0.429
MOD_ProDKin_1	196	202	PF00069	0.412
MOD_ProDKin_1	231	237	PF00069	0.507
MOD_SUMO_rev_2	273	280	PF00179	0.421
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.412
TRG_ENDOCYTIC_2	135	138	PF00928	0.443
TRG_ENDOCYTIC_2	228	231	PF00928	0.443
TRG_ER_diArg_1	280	282	PF00400	0.423
TRG_NLS_MonoExtC_3	5	10	PF00514	0.717
TRG_NLS_MonoExtN_4	6	11	PF00514	0.673
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X5	Leptomonas seymouri	83%	98%
A0A0S4IP78	Bodo saltans	59%	100%
A0A1X0P6M8	Trypanosomatidae	70%	100%
A0A3S7WW54	Leishmania donovani	97%	100%
A4HYZ6	Leishmania infantum	97%	100%
D0A0C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AIL5	Leishmania braziliensis	91%	100%
E9AUU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13823	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P34524	Caenorhabditis elegans	39%	90%
Q08235	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
Q3SZZ0	Bos taurus	36%	90%
Q4QQT6	Rattus norvegicus	37%	90%
Q54JN0	Dictyostelium discoideum	40%	97%
Q5RAN2	Pongo abelii	40%	90%
Q755T8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
Q8TDN6	Homo sapiens	41%	90%
Q8UVY2	Xenopus laevis	37%	94%
Q9C928	Arabidopsis thaliana	32%	99%
Q9DCA5	Mus musculus	36%	90%
Q9HGL6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
Q9LE16	Arabidopsis thaliana	36%	100%
Q9VZE6	Drosophila melanogaster	40%	88%
V5C1R2	Trypanosoma cruzi	71%	100%