Translation initiation factor if-2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCN2_LEIMA

TriTrypDb:

LmjF.20.1700 , LMJLV39_200023100 , LMJSD75_200023000

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	37	39	PF00082	0.735
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.735
DEG_SPOP_SBC_1	150	154	PF00917	0.703
DOC_CKS1_1	217	222	PF01111	0.653
DOC_CKS1_1	62	67	PF01111	0.671
DOC_CYCLIN_yClb5_NLxxxL_5	7	13	PF00134	0.665
DOC_MAPK_gen_1	37	43	PF00069	0.741
DOC_PP2B_LxvP_1	97	100	PF13499	0.590
DOC_USP7_MATH_1	39	43	PF00917	0.740
DOC_USP7_MATH_1	60	64	PF00917	0.708
DOC_WW_Pin1_4	16	21	PF00397	0.698
DOC_WW_Pin1_4	216	221	PF00397	0.651
DOC_WW_Pin1_4	61	66	PF00397	0.812
LIG_14-3-3_CanoR_1	200	208	PF00244	0.645
LIG_14-3-3_CanoR_1	223	233	PF00244	0.640
LIG_14-3-3_CanoR_1	38	44	PF00244	0.742
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_FHA_1	64	70	PF00498	0.570
LIG_FHA_1	76	82	PF00498	0.502
LIG_FHA_2	29	35	PF00498	0.676
LIG_FHA_2	62	68	PF00498	0.608
LIG_LIR_Apic_2	216	220	PF02991	0.651
LIG_LIR_Gen_1	79	90	PF02991	0.684
LIG_LIR_Nem_3	79	85	PF02991	0.695
LIG_PCNA_yPIPBox_3	175	184	PF02747	0.685
LIG_PCNA_yPIPBox_3	6	17	PF02747	0.593
LIG_RPA_C_Insects	2	17	PF08784	0.673
LIG_SH2_CRK	174	178	PF00017	0.635
LIG_SH2_CRK	217	221	PF00017	0.651
LIG_SH2_CRK	82	86	PF00017	0.689
LIG_SH2_NCK_1	82	86	PF00017	0.689
LIG_SH2_STAP1	226	230	PF00017	0.757
LIG_SH2_STAT3	208	211	PF00017	0.697
LIG_SH2_STAT3	244	247	PF00017	0.697
LIG_SH2_STAT5	181	184	PF00017	0.611
LIG_SH2_STAT5	82	85	PF00017	0.696
LIG_SH3_1	262	268	PF00018	0.669
LIG_SH3_1	47	53	PF00018	0.546
LIG_SH3_2	261	266	PF14604	0.678
LIG_SH3_3	106	112	PF00018	0.626
LIG_SH3_3	135	141	PF00018	0.709
LIG_SH3_3	166	172	PF00018	0.697
LIG_SH3_3	209	215	PF00018	0.785
LIG_SH3_3	258	264	PF00018	0.674
LIG_SH3_3	33	39	PF00018	0.674
LIG_SH3_3	42	48	PF00018	0.637
LIG_SH3_3	59	65	PF00018	0.610
LIG_SH3_3	85	91	PF00018	0.571
LIG_SH3_5	177	181	PF00018	0.631
LIG_SUMO_SIM_par_1	39	44	PF11976	0.660
LIG_TYR_ITIM	80	85	PF00017	0.691
LIG_WW_1	260	263	PF00397	0.679
LIG_WW_3	263	267	PF00397	0.678
MOD_CDK_SPxxK_3	216	223	PF00069	0.653
MOD_CK1_1	19	25	PF00069	0.527
MOD_CK1_1	2	8	PF00069	0.671
MOD_CK1_1	224	230	PF00069	0.612
MOD_CK1_1	242	248	PF00069	0.481
MOD_CK1_1	63	69	PF00069	0.722
MOD_CK2_1	61	67	PF00069	0.651
MOD_CK2_1	73	79	PF00069	0.625
MOD_GlcNHglycan	1	4	PF01048	0.680
MOD_GlcNHglycan	228	231	PF01048	0.656
MOD_GlcNHglycan	244	247	PF01048	0.513
MOD_GlcNHglycan	71	74	PF01048	0.657
MOD_GlcNHglycan	75	78	PF01048	0.613
MOD_GSK3_1	146	153	PF00069	0.721
MOD_GSK3_1	221	228	PF00069	0.672
MOD_GSK3_1	69	76	PF00069	0.559
MOD_NEK2_1	156	161	PF00069	0.566
MOD_NEK2_1	239	244	PF00069	0.637
MOD_PIKK_1	120	126	PF00454	0.551
MOD_PIKK_1	158	164	PF00454	0.587
MOD_PKA_2	222	228	PF00069	0.539
MOD_Plk_2-3	28	34	PF00069	0.574
MOD_Plk_4	19	25	PF00069	0.640
MOD_ProDKin_1	16	22	PF00069	0.701
MOD_ProDKin_1	216	222	PF00069	0.653
MOD_ProDKin_1	61	67	PF00069	0.810
MOD_SUMO_rev_2	42	48	PF00179	0.621
TRG_ENDOCYTIC_2	236	239	PF00928	0.637
TRG_ENDOCYTIC_2	82	85	PF00928	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW51	Leishmania donovani	86%	100%
A4HYZ9	Leishmania infantum	86%	100%
E9AIL8	Leishmania braziliensis	68%	100%
E9AUV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%