RNA methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA (Uracil-5-)-methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QCN1_LEIMA

TriTrypDb:

LmjF.20.1710 , LMJLV39_200023200 , LMJSD75_200023100

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCN1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	592	596	PF00656	0.670
CLV_NRD_NRD_1	125	127	PF00675	0.662
CLV_NRD_NRD_1	161	163	PF00675	0.410
CLV_NRD_NRD_1	274	276	PF00675	0.350
CLV_NRD_NRD_1	441	443	PF00675	0.413
CLV_NRD_NRD_1	504	506	PF00675	0.311
CLV_NRD_NRD_1	561	563	PF00675	0.492
CLV_PCSK_KEX2_1	123	125	PF00082	0.646
CLV_PCSK_KEX2_1	153	155	PF00082	0.490
CLV_PCSK_KEX2_1	161	163	PF00082	0.460
CLV_PCSK_KEX2_1	425	427	PF00082	0.344
CLV_PCSK_KEX2_1	441	443	PF00082	0.231
CLV_PCSK_KEX2_1	504	506	PF00082	0.311
CLV_PCSK_KEX2_1	561	563	PF00082	0.506
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.646
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.490
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.327
CLV_PCSK_SKI1_1	161	165	PF00082	0.445
CLV_PCSK_SKI1_1	259	263	PF00082	0.289
CLV_PCSK_SKI1_1	354	358	PF00082	0.407
CLV_PCSK_SKI1_1	389	393	PF00082	0.357
CLV_PCSK_SKI1_1	422	426	PF00082	0.288
DEG_APCC_DBOX_1	153	161	PF00400	0.455
DEG_APCC_DBOX_1	306	314	PF00400	0.510
DEG_SCF_FBW7_2	382	388	PF00400	0.384
DEG_SPOP_SBC_1	295	299	PF00917	0.531
DOC_CDC14_PxL_1	357	365	PF14671	0.466
DOC_CKS1_1	382	387	PF01111	0.384
DOC_CKS1_1	81	86	PF01111	0.449
DOC_MAPK_gen_1	152	159	PF00069	0.383
DOC_MAPK_gen_1	422	432	PF00069	0.311
DOC_MAPK_MEF2A_6	191	198	PF00069	0.385
DOC_MAPK_MEF2A_6	284	293	PF00069	0.382
DOC_MAPK_MEF2A_6	425	432	PF00069	0.311
DOC_MAPK_MEF2A_6	475	482	PF00069	0.423
DOC_PP2B_LxvP_1	350	353	PF13499	0.508
DOC_PP2B_LxvP_1	482	485	PF13499	0.311
DOC_PP2B_LxvP_1	5	8	PF13499	0.690
DOC_PP4_FxxP_1	81	84	PF00568	0.454
DOC_USP7_MATH_1	202	206	PF00917	0.522
DOC_USP7_MATH_1	333	337	PF00917	0.462
DOC_USP7_MATH_1	88	92	PF00917	0.504
DOC_USP7_UBL2_3	119	123	PF12436	0.678
DOC_USP7_UBL2_3	389	393	PF12436	0.222
DOC_USP7_UBL2_3	43	47	PF12436	0.481
DOC_USP7_UBL2_3	525	529	PF12436	0.309
DOC_WW_Pin1_4	107	112	PF00397	0.529
DOC_WW_Pin1_4	181	186	PF00397	0.396
DOC_WW_Pin1_4	203	208	PF00397	0.456
DOC_WW_Pin1_4	372	377	PF00397	0.308
DOC_WW_Pin1_4	381	386	PF00397	0.311
DOC_WW_Pin1_4	531	536	PF00397	0.381
DOC_WW_Pin1_4	80	85	PF00397	0.451
LIG_14-3-3_CanoR_1	102	111	PF00244	0.516
LIG_14-3-3_CanoR_1	561	569	PF00244	0.432
LIG_14-3-3_CanoR_1	87	97	PF00244	0.509
LIG_AP2alpha_1	174	178	PF02296	0.520
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BIR_III_4	595	599	PF00653	0.672
LIG_BRCT_BRCA1_1	196	200	PF00533	0.469
LIG_Clathr_ClatBox_1	26	30	PF01394	0.421
LIG_FHA_1	204	210	PF00498	0.431
LIG_FHA_1	218	224	PF00498	0.357
LIG_FHA_1	297	303	PF00498	0.444
LIG_FHA_1	329	335	PF00498	0.370
LIG_FHA_1	362	368	PF00498	0.356
LIG_FHA_1	402	408	PF00498	0.338
LIG_FHA_1	411	417	PF00498	0.393
LIG_FHA_1	548	554	PF00498	0.311
LIG_FHA_2	136	142	PF00498	0.548
LIG_FHA_2	225	231	PF00498	0.526
LIG_FHA_2	296	302	PF00498	0.513
LIG_FHA_2	313	319	PF00498	0.333
LIG_FHA_2	360	366	PF00498	0.361
LIG_FHA_2	403	409	PF00498	0.311
LIG_FHA_2	448	454	PF00498	0.418
LIG_FHA_2	532	538	PF00498	0.378
LIG_FHA_2	590	596	PF00498	0.723
LIG_FHA_2	81	87	PF00498	0.471
LIG_Integrin_RGD_1	475	477	PF01839	0.456
LIG_LIR_Apic_2	355	361	PF02991	0.522
LIG_LIR_Gen_1	138	145	PF02991	0.487
LIG_LIR_Gen_1	263	273	PF02991	0.479
LIG_LIR_Gen_1	301	311	PF02991	0.450
LIG_LIR_Gen_1	33	41	PF02991	0.478
LIG_LIR_Nem_3	138	143	PF02991	0.453
LIG_LIR_Nem_3	176	181	PF02991	0.395
LIG_LIR_Nem_3	253	257	PF02991	0.386
LIG_LIR_Nem_3	263	268	PF02991	0.434
LIG_LIR_Nem_3	271	277	PF02991	0.404
LIG_LIR_Nem_3	301	306	PF02991	0.450
LIG_LIR_Nem_3	33	38	PF02991	0.466
LIG_LIR_Nem_3	377	382	PF02991	0.301
LIG_PCNA_yPIPBox_3	486	497	PF02747	0.456
LIG_PCNA_yPIPBox_3	54	66	PF02747	0.625
LIG_Pex14_2	174	178	PF04695	0.520
LIG_PTB_Apo_2	448	455	PF02174	0.295
LIG_SH2_CRK	35	39	PF00017	0.496
LIG_SH2_CRK	358	362	PF00017	0.485
LIG_SH2_NCK_1	35	39	PF00017	0.496
LIG_SH2_STAT5	366	369	PF00017	0.520
LIG_SH2_STAT5	508	511	PF00017	0.305
LIG_SH2_STAT5	76	79	PF00017	0.508
LIG_SH3_1	54	60	PF00018	0.652
LIG_SH3_3	379	385	PF00018	0.384
LIG_SH3_3	54	60	PF00018	0.556
LIG_SH3_4	525	532	PF00018	0.330
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.313
LIG_SUMO_SIM_anti_2	554	560	PF11976	0.311
LIG_SUMO_SIM_par_1	309	318	PF11976	0.362
LIG_SUMO_SIM_par_1	404	411	PF11976	0.389
LIG_SUMO_SIM_par_1	477	483	PF11976	0.313
LIG_SUMO_SIM_par_1	554	560	PF11976	0.384
LIG_TRAF2_1	315	318	PF00917	0.458
LIG_TRAF2_1	50	53	PF00917	0.415
LIG_TRAF2_1	588	591	PF00917	0.769
LIG_TRFH_1	372	376	PF08558	0.311
LIG_UBA3_1	61	70	PF00899	0.537
LIG_WW_3	483	487	PF00397	0.311
MOD_CDK_SPK_2	107	112	PF00069	0.569
MOD_CDK_SPxxK_3	80	87	PF00069	0.498
MOD_CK1_1	135	141	PF00069	0.448
MOD_CK1_1	184	190	PF00069	0.448
MOD_CK1_1	401	407	PF00069	0.423
MOD_CK1_1	465	471	PF00069	0.368
MOD_CK1_1	527	533	PF00069	0.222
MOD_CK2_1	135	141	PF00069	0.489
MOD_CK2_1	212	218	PF00069	0.607
MOD_CK2_1	312	318	PF00069	0.359
MOD_CK2_1	359	365	PF00069	0.379
MOD_CK2_1	447	453	PF00069	0.404
MOD_CK2_1	531	537	PF00069	0.378
MOD_GlcNHglycan	237	240	PF01048	0.481
MOD_GlcNHglycan	270	273	PF01048	0.515
MOD_GlcNHglycan	410	413	PF01048	0.408
MOD_GlcNHglycan	434	437	PF01048	0.311
MOD_GlcNHglycan	564	567	PF01048	0.668
MOD_GlcNHglycan	576	579	PF01048	0.576
MOD_GlcNHglycan	582	585	PF01048	0.651
MOD_GlcNHglycan	90	93	PF01048	0.463
MOD_GSK3_1	131	138	PF00069	0.686
MOD_GSK3_1	180	187	PF00069	0.385
MOD_GSK3_1	324	331	PF00069	0.407
MOD_GSK3_1	340	347	PF00069	0.441
MOD_GSK3_1	398	405	PF00069	0.342
MOD_GSK3_1	408	415	PF00069	0.295
MOD_GSK3_1	462	469	PF00069	0.222
MOD_GSK3_1	521	528	PF00069	0.313
MOD_N-GLC_1	131	136	PF02516	0.473
MOD_N-GLC_1	194	199	PF02516	0.510
MOD_N-GLC_1	489	494	PF02516	0.456
MOD_NEK2_1	1	6	PF00069	0.701
MOD_NEK2_1	114	119	PF00069	0.555
MOD_NEK2_1	418	423	PF00069	0.410
MOD_NEK2_1	432	437	PF00069	0.214
MOD_NEK2_1	536	541	PF00069	0.372
MOD_NEK2_2	499	504	PF00069	0.354
MOD_PIKK_1	135	141	PF00454	0.472
MOD_PKB_1	100	108	PF00069	0.526
MOD_Plk_1	194	200	PF00069	0.510
MOD_Plk_1	489	495	PF00069	0.456
MOD_Plk_1	589	595	PF00069	0.566
MOD_Plk_2-3	589	595	PF00069	0.566
MOD_Plk_4	212	218	PF00069	0.574
MOD_Plk_4	402	408	PF00069	0.233
MOD_Plk_4	462	468	PF00069	0.384
MOD_Plk_4	489	495	PF00069	0.311
MOD_ProDKin_1	107	113	PF00069	0.524
MOD_ProDKin_1	181	187	PF00069	0.396
MOD_ProDKin_1	203	209	PF00069	0.449
MOD_ProDKin_1	372	378	PF00069	0.308
MOD_ProDKin_1	381	387	PF00069	0.311
MOD_ProDKin_1	531	537	PF00069	0.381
MOD_ProDKin_1	80	86	PF00069	0.445
MOD_SUMO_for_1	283	286	PF00179	0.466
MOD_SUMO_rev_2	510	516	PF00179	0.300
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.603
TRG_ENDOCYTIC_2	140	143	PF00928	0.508
TRG_ENDOCYTIC_2	171	174	PF00928	0.453
TRG_ENDOCYTIC_2	35	38	PF00928	0.492
TRG_ENDOCYTIC_2	76	79	PF00928	0.508
TRG_ER_diArg_1	100	103	PF00400	0.525
TRG_ER_diArg_1	124	126	PF00400	0.695
TRG_ER_diArg_1	160	162	PF00400	0.503
TRG_ER_diArg_1	306	309	PF00400	0.489
TRG_ER_diArg_1	503	505	PF00400	0.311
TRG_ER_diArg_1	561	563	PF00400	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V8	Leptomonas seymouri	75%	100%
A0A1X0NXG3	Trypanosomatidae	58%	100%
A0A3Q8IAY6	Leishmania donovani	93%	100%
A0A3R7L6W3	Trypanosoma rangeli	62%	100%
A4HZ00	Leishmania infantum	93%	100%
A4QP75	Danio rerio	31%	100%
A5IBU7	Legionella pneumophila (strain Corby)	25%	100%
C9ZIM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AIL9	Leishmania braziliensis	85%	100%
E9AUV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O31503	Bacillus subtilis (strain 168)	26%	100%
P0DG16	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	25%	100%
P0DG17	Streptococcus pyogenes serotype M3 (strain SSI-1)	25%	100%
P33753	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	94%
P73374	Synechocystis sp. (strain PCC 6803 / Kazusa)	26%	100%
Q02I93	Pseudomonas aeruginosa (strain UCBPP-PA14)	26%	100%
Q5HEM5	Staphylococcus aureus (strain COL)	26%	100%
Q5HN37	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5WW81	Legionella pneumophila (strain Lens)	24%	100%
Q5X5A8	Legionella pneumophila (strain Paris)	25%	100%
Q5XAU1	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	25%	100%
Q5ZVI4	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	25%	100%
Q6G836	Staphylococcus aureus (strain MSSA476)	26%	100%
Q6GFG0	Staphylococcus aureus (strain MRSA252)	26%	100%
Q73E18	Bacillus cereus (strain ATCC 10987 / NRS 248)	26%	100%
Q73EJ5	Bacillus cereus (strain ATCC 10987 / NRS 248)	26%	100%
Q74I68	Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)	26%	100%
Q74N58	Nanoarchaeum equitans (strain Kin4-M)	25%	100%
Q7A4Q9	Staphylococcus aureus (strain N315)	26%	100%
Q7MVG9	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	28%	100%
Q7NGN4	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	28%	100%
Q814A6	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	27%	100%
Q81Z48	Bacillus anthracis	26%	100%
Q81ZD6	Bacillus anthracis	27%	100%
Q830R6	Enterococcus faecalis (strain ATCC 700802 / V583)	28%	100%
Q891A0	Clostridium tetani (strain Massachusetts / E88)	24%	100%
Q892Z2	Clostridium tetani (strain Massachusetts / E88)	27%	100%
Q8AA22	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	27%	100%
Q8BNV1	Mus musculus	32%	98%
Q8CRU6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8IZ69	Homo sapiens	31%	96%
Q8L7S3	Arabidopsis thaliana	30%	74%
Q8NVT4	Staphylococcus aureus (strain MW2)	26%	100%
Q8P017	Streptococcus pyogenes serotype M18 (strain MGAS8232)	24%	100%
Q8R5Z8	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	25%	100%
Q8R933	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	31%	100%
Q8XIK5	Clostridium perfringens (strain 13 / Type A)	29%	100%
Q8YR05	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	28%	100%
Q97J51	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	28%	100%
Q97LN4	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	28%	100%
Q99SY9	Staphylococcus aureus (strain Mu50 / ATCC 700699)	26%	100%
Q99YP3	Streptococcus pyogenes serotype M1	25%	100%
Q9CDP0	Lactococcus lactis subsp. lactis (strain IL1403)	26%	100%
Q9CGB9	Lactococcus lactis subsp. lactis (strain IL1403)	27%	100%
Q9I525	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
V5ASX3	Trypanosoma cruzi	61%	100%