RNA-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCM8_LEIMA

TriTrypDb:

LmjF.20.1740 , LMJLV39_200023500 , LMJSD75_200023400

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.505
CLV_NRD_NRD_1	245	247	PF00675	0.568
CLV_PCSK_FUR_1	243	247	PF00082	0.613
CLV_PCSK_KEX2_1	122	124	PF00082	0.592
CLV_PCSK_KEX2_1	171	173	PF00082	0.524
CLV_PCSK_KEX2_1	245	247	PF00082	0.622
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.641
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.524
CLV_PCSK_PC7_1	167	173	PF00082	0.569
CLV_PCSK_SKI1_1	268	272	PF00082	0.567
CLV_PCSK_SKI1_1	7	11	PF00082	0.701
DEG_Nend_UBRbox_1	1	4	PF02207	0.506
DOC_MAPK_gen_1	125	134	PF00069	0.640
DOC_MAPK_gen_1	171	180	PF00069	0.557
DOC_MAPK_gen_1	292	299	PF00069	0.587
DOC_MAPK_RevD_3	158	172	PF00069	0.651
DOC_MAPK_RevD_3	280	295	PF00069	0.522
DOC_USP7_MATH_1	99	103	PF00917	0.712
DOC_WW_Pin1_4	170	175	PF00397	0.653
DOC_WW_Pin1_4	49	54	PF00397	0.577
DOC_WW_Pin1_4	97	102	PF00397	0.705
LIG_14-3-3_CanoR_1	128	132	PF00244	0.522
LIG_14-3-3_CanoR_1	2	10	PF00244	0.575
LIG_Actin_WH2_2	187	204	PF00022	0.535
LIG_APCC_ABBA_1	262	267	PF00400	0.369
LIG_BIR_III_2	184	188	PF00653	0.535
LIG_Clathr_ClatBox_1	71	75	PF01394	0.505
LIG_FHA_1	106	112	PF00498	0.645
LIG_FHA_2	58	64	PF00498	0.550
LIG_FXI_DFP_1	272	276	PF00024	0.504
LIG_LIR_Apic_2	106	112	PF02991	0.607
LIG_LIR_Gen_1	231	239	PF02991	0.392
LIG_LIR_Nem_3	130	134	PF02991	0.558
LIG_LIR_Nem_3	231	235	PF02991	0.380
LIG_LIR_Nem_3	260	265	PF02991	0.450
LIG_LIR_Nem_3	45	51	PF02991	0.599
LIG_NRBOX	39	45	PF00104	0.577
LIG_SH2_CRK	109	113	PF00017	0.419
LIG_SH2_STAP1	265	269	PF00017	0.369
LIG_SH2_STAT5	109	112	PF00017	0.547
LIG_SH2_STAT5	136	139	PF00017	0.441
LIG_SH2_STAT5	232	235	PF00017	0.496
LIG_SH2_STAT5	281	284	PF00017	0.387
LIG_SH3_3	207	213	PF00018	0.490
LIG_SH3_3	279	285	PF00018	0.389
LIG_SUMO_SIM_anti_2	203	211	PF11976	0.534
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.527
LIG_SUMO_SIM_anti_2	267	274	PF11976	0.566
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.496
LIG_SUMO_SIM_par_1	70	76	PF11976	0.593
LIG_UBA3_1	287	295	PF00899	0.569
LIG_WRC_WIRS_1	48	53	PF05994	0.527
MOD_CDK_SPK_2	170	175	PF00069	0.653
MOD_CDK_SPxxK_3	97	104	PF00069	0.559
MOD_CK1_1	100	106	PF00069	0.709
MOD_CK1_1	205	211	PF00069	0.456
MOD_CK1_1	33	39	PF00069	0.568
MOD_CK2_1	49	55	PF00069	0.566
MOD_CK2_1	57	63	PF00069	0.503
MOD_GlcNHglycan	217	221	PF01048	0.502
MOD_GlcNHglycan	32	35	PF01048	0.486
MOD_GSK3_1	201	208	PF00069	0.461
MOD_GSK3_1	212	219	PF00069	0.365
MOD_GSK3_1	47	54	PF00069	0.623
MOD_GSK3_1	99	106	PF00069	0.735
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	201	206	PF00069	0.476
MOD_NEK2_1	35	40	PF00069	0.595
MOD_NEK2_2	57	62	PF00069	0.450
MOD_PIKK_1	257	263	PF00454	0.507
MOD_PIKK_1	35	41	PF00454	0.497
MOD_PIKK_1	75	81	PF00454	0.613
MOD_PIKK_1	91	97	PF00454	0.741
MOD_PK_1	202	208	PF00069	0.592
MOD_PKA_2	1	7	PF00069	0.645
MOD_PKA_2	127	133	PF00069	0.545
MOD_PKA_2	86	92	PF00069	0.580
MOD_Plk_1	202	208	PF00069	0.493
MOD_Plk_1	216	222	PF00069	0.355
MOD_Plk_2-3	70	76	PF00069	0.515
MOD_Plk_4	127	133	PF00069	0.638
MOD_Plk_4	202	208	PF00069	0.510
MOD_Plk_4	228	234	PF00069	0.486
MOD_Plk_4	283	289	PF00069	0.563
MOD_ProDKin_1	170	176	PF00069	0.640
MOD_ProDKin_1	49	55	PF00069	0.578
MOD_ProDKin_1	97	103	PF00069	0.705
TRG_ENDOCYTIC_2	131	134	PF00928	0.477
TRG_ENDOCYTIC_2	232	235	PF00928	0.384
TRG_ER_diArg_1	123	126	PF00400	0.539
TRG_ER_diArg_1	242	245	PF00400	0.563
TRG_ER_diArg_1	84	87	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB90	Leptomonas seymouri	62%	100%
A0A1X0NW23	Trypanosomatidae	39%	100%
A0A3Q8IBV6	Leishmania donovani	94%	100%
A0A422NTN5	Trypanosoma rangeli	42%	88%
A4HZ03	Leishmania infantum	94%	100%
C9ZIL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	81%
E9AIM2	Leishmania braziliensis	83%	100%
E9AUV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BHE7	Trypanosoma cruzi	39%	80%