LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative N-acyl-L-amino acid amidohydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative N-acyl-L-amino acid amidohydrolase
Gene product:
amidohydrolase, putative
Species:
Leishmania major
UniProt:
Q4QCM4_LEIMA
TriTrypDb:
LmjF.20.1570 * , LMJLV39_200023800 * , LMJSD75_200024000 *
Length:
415

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCM4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCM4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 21
GO:0004046 aminoacylase activity 5 18
GO:0016787 hydrolase activity 2 21
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 18
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 27 31 PF00656 0.367
CLV_C14_Caspase3-7 323 327 PF00656 0.456
CLV_MEL_PAP_1 245 251 PF00089 0.420
CLV_NRD_NRD_1 247 249 PF00675 0.347
CLV_NRD_NRD_1 40 42 PF00675 0.407
CLV_NRD_NRD_1 74 76 PF00675 0.478
CLV_PCSK_KEX2_1 117 119 PF00082 0.457
CLV_PCSK_KEX2_1 247 249 PF00082 0.345
CLV_PCSK_KEX2_1 40 42 PF00082 0.407
CLV_PCSK_KEX2_1 74 76 PF00082 0.415
CLV_PCSK_PC1ET2_1 117 119 PF00082 0.457
CLV_PCSK_SKI1_1 153 157 PF00082 0.328
CLV_PCSK_SKI1_1 343 347 PF00082 0.457
CLV_PCSK_SKI1_1 74 78 PF00082 0.415
DEG_APCC_DBOX_1 278 286 PF00400 0.347
DEG_COP1_1 286 296 PF00400 0.382
DOC_MAPK_gen_1 145 154 PF00069 0.328
DOC_MAPK_MEF2A_6 168 175 PF00069 0.328
DOC_PP2B_LxvP_1 252 255 PF13499 0.359
DOC_USP7_MATH_1 113 117 PF00917 0.328
DOC_USP7_MATH_1 379 383 PF00917 0.369
DOC_WW_Pin1_4 74 79 PF00397 0.410
LIG_14-3-3_CanoR_1 247 256 PF00244 0.455
LIG_BIR_III_2 102 106 PF00653 0.328
LIG_BRCT_BRCA1_1 179 183 PF00533 0.427
LIG_BRCT_BRCA1_1 24 28 PF00533 0.449
LIG_BRCT_BRCA1_1 387 391 PF00533 0.349
LIG_FHA_1 129 135 PF00498 0.328
LIG_FHA_1 258 264 PF00498 0.293
LIG_FHA_2 321 327 PF00498 0.399
LIG_LIR_Apic_2 313 319 PF02991 0.328
LIG_LIR_Gen_1 208 217 PF02991 0.304
LIG_LIR_Gen_1 266 276 PF02991 0.344
LIG_LIR_Gen_1 360 370 PF02991 0.391
LIG_LIR_Nem_3 208 213 PF02991 0.311
LIG_LIR_Nem_3 266 272 PF02991 0.344
LIG_LIR_Nem_3 357 362 PF02991 0.343
LIG_LIR_Nem_3 377 383 PF02991 0.375
LIG_LIR_Nem_3 45 51 PF02991 0.522
LIG_LYPXL_yS_3 46 49 PF13949 0.445
LIG_SH2_CRK 269 273 PF00017 0.347
LIG_SH2_CRK 362 366 PF00017 0.395
LIG_SH2_NCK_1 269 273 PF00017 0.347
LIG_SH2_STAP1 312 316 PF00017 0.457
LIG_SH2_STAP1 95 99 PF00017 0.328
LIG_SH2_STAT3 51 54 PF00017 0.534
LIG_SH2_STAT5 384 387 PF00017 0.394
LIG_SH2_STAT5 48 51 PF00017 0.443
LIG_SH2_STAT5 59 62 PF00017 0.424
LIG_SH3_5 55 59 PF00018 0.432
LIG_SUMO_SIM_par_1 229 236 PF11976 0.441
LIG_SUMO_SIM_par_1 255 260 PF11976 0.330
LIG_TRAF2_1 105 108 PF00917 0.328
LIG_TRAF2_1 50 53 PF00917 0.441
LIG_UBA3_1 300 306 PF00899 0.414
MOD_CK1_1 243 249 PF00069 0.353
MOD_CK1_1 382 388 PF00069 0.330
MOD_CK2_1 219 225 PF00069 0.345
MOD_CK2_1 292 298 PF00069 0.382
MOD_CK2_1 312 318 PF00069 0.233
MOD_CK2_1 332 338 PF00069 0.185
MOD_GlcNHglycan 108 112 PF01048 0.328
MOD_GlcNHglycan 164 167 PF01048 0.328
MOD_GlcNHglycan 249 252 PF01048 0.427
MOD_GlcNHglycan 394 398 PF01048 0.521
MOD_GSK3_1 18 25 PF00069 0.395
MOD_GSK3_1 195 202 PF00069 0.327
MOD_GSK3_1 243 250 PF00069 0.384
MOD_GSK3_1 382 389 PF00069 0.326
MOD_LATS_1 16 22 PF00433 0.426
MOD_NEK2_1 257 262 PF00069 0.373
MOD_NEK2_1 278 283 PF00069 0.347
MOD_NEK2_2 379 384 PF00069 0.360
MOD_PIKK_1 219 225 PF00454 0.345
MOD_PIKK_1 257 263 PF00454 0.287
MOD_PIKK_1 286 292 PF00454 0.427
MOD_PKA_1 247 253 PF00069 0.427
MOD_PKA_2 148 154 PF00069 0.373
MOD_PKA_2 247 253 PF00069 0.427
MOD_PKA_2 278 284 PF00069 0.322
MOD_PKA_2 286 292 PF00069 0.347
MOD_Plk_1 312 318 PF00069 0.349
MOD_Plk_1 393 399 PF00069 0.477
MOD_Plk_4 10 16 PF00069 0.604
MOD_Plk_4 177 183 PF00069 0.491
MOD_Plk_4 240 246 PF00069 0.345
MOD_Plk_4 292 298 PF00069 0.382
MOD_Plk_4 312 318 PF00069 0.233
MOD_Plk_4 379 385 PF00069 0.382
MOD_Plk_4 405 411 PF00069 0.440
MOD_Plk_4 77 83 PF00069 0.429
MOD_ProDKin_1 74 80 PF00069 0.405
MOD_SUMO_for_1 32 35 PF00179 0.334
MOD_SUMO_for_1 348 351 PF00179 0.332
TRG_ENDOCYTIC_2 269 272 PF00928 0.347
TRG_ENDOCYTIC_2 330 333 PF00928 0.339
TRG_ENDOCYTIC_2 362 365 PF00928 0.375
TRG_ENDOCYTIC_2 46 49 PF00928 0.445
TRG_ER_diArg_1 247 249 PF00400 0.345
TRG_ER_diArg_1 276 279 PF00400 0.382
TRG_ER_diArg_1 39 41 PF00400 0.394
TRG_ER_diArg_1 73 75 PF00400 0.495
TRG_Pf-PMV_PEXEL_1 283 288 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2N6 Leptomonas seymouri 44% 100%
A0A0N0P327 Leptomonas seymouri 27% 100%
A0A1X0NW20 Trypanosomatidae 76% 100%
A0A1X0NW36 Trypanosomatidae 70% 100%
A0A1X0NWQ6 Trypanosomatidae 61% 100%
A0A3Q8IBS0 Leishmania donovani 81% 100%
A0A3Q8IIH2 Leishmania donovani 44% 100%
A0A3Q8IJC1 Leishmania donovani 42% 94%
A0A3S7WW66 Leishmania donovani 89% 100%
A0A3S7WW80 Leishmania donovani 98% 77%
A0A422NTM4 Trypanosoma rangeli 76% 100%
A0AHD2 Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8) 31% 100%
A0RHZ2 Bacillus thuringiensis (strain Al Hakam) 34% 100%
A1S647 Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) 23% 100%
A2RI06 Lactococcus lactis subsp. cremoris (strain MG1363) 27% 100%
A3CQT4 Streptococcus sanguinis (strain SK36) 28% 100%
A4HJ93 Leishmania braziliensis 43% 100%
A4HZ10 Leishmania infantum 81% 100%
A4HZ11 Leishmania infantum 98% 77%
A4I5G9 Leishmania infantum 42% 94%
A4I6N7 Leishmania infantum 44% 100%
A4I6N8 Leishmania infantum 44% 100%
A4ILT6 Geobacillus thermodenitrificans (strain NG80-2) 33% 100%
A4VY21 Streptococcus suis (strain 05ZYH33) 28% 100%
A4W4B4 Streptococcus suis (strain 98HAH33) 28% 100%
A5VJ57 Limosilactobacillus reuteri (strain DSM 20016) 30% 100%
A7GS08 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) 34% 100%
A7Z433 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) 32% 100%
A8AUM0 Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288) 28% 100%
A8FCN2 Bacillus pumilus (strain SAFR-032) 32% 100%
A8YUT2 Lactobacillus helveticus (strain DPC 4571) 28% 100%
A9VUE2 Bacillus mycoides (strain KBAB4) 33% 100%
B1I9G2 Streptococcus pneumoniae (strain Hungary19A-6) 30% 100%
B1MZM9 Leuconostoc citreum (strain KM20) 33% 100%
B1YJ90 Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15) 30% 100%
B2G6M8 Limosilactobacillus reuteri (strain JCM 1112) 30% 100%
B2GC10 Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251) 29% 100%
B2IN14 Streptococcus pneumoniae (strain CGSP14) 30% 100%
B3W7E6 Lacticaseibacillus casei (strain BL23) 28% 100%
B5E3A3 Streptococcus pneumoniae serotype 19F (strain G54) 30% 100%
B7GIC0 Anoxybacillus flavithermus (strain DSM 21510 / WK1) 32% 100%
B7H6W7 Bacillus cereus (strain B4264) 33% 100%
B7HMV1 Bacillus cereus (strain AH187) 34% 100%
B7IVL7 Bacillus cereus (strain G9842) 33% 100%
B7JKV4 Bacillus cereus (strain AH820) 34% 100%
B8DEC3 Listeria monocytogenes serotype 4a (strain HCC23) 32% 100%
B8ZPL8 Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) 30% 100%
B9DVY6 Streptococcus uberis (strain ATCC BAA-854 / 0140J) 28% 100%
B9IW60 Bacillus cereus (strain Q1) 34% 100%
C0ZGH7 Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) 31% 100%
C1CAS3 Streptococcus pneumoniae (strain 70585) 30% 100%
C1CH24 Streptococcus pneumoniae (strain JJA) 30% 100%
C1CN42 Streptococcus pneumoniae (strain P1031) 30% 100%
C1CTZ9 Streptococcus pneumoniae (strain Taiwan19F-14) 30% 100%
C1EPZ4 Bacillus cereus (strain 03BB102) 34% 100%
C1L1T3 Listeria monocytogenes serotype 4b (strain CLIP80459) 32% 100%
C3LI46 Bacillus anthracis (strain CDC 684 / NRRL 3495) 34% 100%
C3P6Y7 Bacillus anthracis (strain A0248) 34% 100%
C5D827 Geobacillus sp. (strain WCH70) 33% 100%
C9ZIL8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
D5E0A1 Priestia megaterium (strain ATCC 12872 / QMB1551) 31% 100%
E9AGU3 Leishmania infantum 89% 100%
E9AIM3 Leishmania braziliensis 78% 100%
E9AIM4 Leishmania braziliensis 79% 92%
E9AIM5 Leishmania braziliensis 90% 100%
E9AUV6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
E9AUV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AUV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B0R7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9B1R0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
O04373 Arabidopsis thaliana 38% 94%
O07598 Bacillus subtilis (strain 168) 38% 100%
O34916 Bacillus subtilis (strain 168) 32% 100%
O34980 Bacillus subtilis (strain 168) 35% 100%
O50173 Enterobacter agglomerans 30% 95%
O81641 Arabidopsis thaliana 36% 97%
P37112 Geobacillus stearothermophilus 49% 100%
P44765 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 24% 98%
P45493 Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) 33% 100%
P54955 Bacillus subtilis (strain 168) 39% 100%
P54968 Arabidopsis thaliana 37% 94%
P54969 Arabidopsis thaliana 38% 95%
P54970 Arabidopsis thaliana 39% 95%
P54984 Synechocystis sp. (strain PCC 6803 / Kazusa) 39% 100%
P55663 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 30% 100%
P58156 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 38% 100%
P80092 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 38% 100%
Q032G8 Lactococcus lactis subsp. cremoris (strain SK11) 27% 100%
Q03CW2 Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441) 28% 100%
Q03HT1 Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) 30% 100%
Q03IN1 Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) 28% 100%
Q03YE3 Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y) 33% 100%
Q04FS2 Oenococcus oeni (strain ATCC BAA-331 / PSU-1) 28% 100%
Q04I78 Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 30% 100%
Q1WUQ7 Ligilactobacillus salivarius (strain UCC118) 30% 100%
Q2FH40 Staphylococcus aureus (strain USA300) 29% 100%
Q2FYN6 Staphylococcus aureus (strain NCTC 8325 / PS 47) 29% 100%
Q2YY21 Staphylococcus aureus (strain bovine RF122 / ET3-1) 29% 100%
Q49XK0 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 29% 100%
Q4L6A3 Staphylococcus haemolyticus (strain JCSC1435) 28% 100%
Q4Q6F0 Leishmania major 44% 100%
Q4Q7G6 Leishmania major 42% 100%
Q4QCM5 Leishmania major 89% 100%
Q4QCM6 Leishmania major 81% 100%
Q5FKR0 Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) 30% 100%
Q5HG22 Staphylococcus aureus (strain COL) 29% 100%
Q5HPE4 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 29% 100%
Q5L145 Geobacillus kaustophilus (strain HTA426) 33% 100%
Q5LXY3 Streptococcus thermophilus (strain CNRZ 1066) 27% 100%
Q5M2I5 Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) 27% 100%
Q5N8F2 Oryza sativa subsp. japonica 39% 91%
Q5WF94 Alkalihalobacillus clausii (strain KSM-K16) 32% 100%
Q5Z678 Oryza sativa subsp. japonica 39% 81%
Q635U8 Bacillus cereus (strain ZK / E33L) 34% 100%
Q65K84 Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) 32% 100%
Q6G9G3 Staphylococcus aureus (strain MSSA476) 29% 100%
Q6GH10 Staphylococcus aureus (strain MRSA252) 29% 100%
Q6HEI5 Bacillus thuringiensis subsp. konkukian (strain 97-27) 34% 100%
Q6LAN3 Listeria ivanovii 30% 100%
Q721F4 Listeria monocytogenes serotype 4b (strain F2365) 32% 100%
Q731Y6 Bacillus cereus (strain ATCC 10987 / NRS 248) 34% 100%
Q7A5P6 Staphylococcus aureus (strain N315) 29% 100%
Q7XUA8 Oryza sativa subsp. japonica 40% 97%
Q819J6 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 33% 100%
Q81MQ3 Bacillus anthracis 34% 100%
Q836H7 Enterococcus faecalis (strain ATCC 700802 / V583) 32% 100%
Q84XG9 Oryza sativa subsp. indica 38% 94%
Q851L5 Oryza sativa subsp. japonica 38% 100%
Q851L6 Oryza sativa subsp. japonica 38% 100%
Q88V24 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 30% 100%
Q8CSM6 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 29% 100%
Q8DN55 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 30% 100%
Q8DVY6 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) 28% 100%
Q8ERA3 Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) 30% 100%
Q8GGD4 Corynebacterium striatum 33% 100%
Q8H3C7 Oryza sativa subsp. japonica 39% 94%
Q8H3C8 Oryza sativa subsp. japonica 41% 93%
Q8H3C9 Oryza sativa subsp. japonica 40% 91%
Q8NWS3 Staphylococcus aureus (strain MW2) 29% 100%
Q8S9S4 Oryza sativa subsp. japonica 38% 94%
Q8VYX0 Arabidopsis thaliana 37% 89%
Q8Y8A0 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) 32% 100%
Q92D10 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) 33% 100%
Q97NE7 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 30% 100%
Q99U87 Staphylococcus aureus (strain Mu50 / ATCC 700699) 29% 100%
Q9CIS4 Lactococcus lactis subsp. lactis (strain IL1403) 27% 100%
Q9K9H9 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 34% 100%
Q9SWX9 Arabidopsis thaliana 38% 95%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS