Putative N-acyl-L-amino acid amidohydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amidohydrolase, putative

Species:

Leishmania major

UniProt:

Q4QCM4_LEIMA

TriTrypDb:

LmjF.20.1570 , LMJLV39_200023800 , LMJSD75_200024000

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCM4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004046	aminoacylase activity	5	18
GO:0016787	hydrolase activity	2	21
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	18
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.367
CLV_C14_Caspase3-7	323	327	PF00656	0.456
CLV_MEL_PAP_1	245	251	PF00089	0.420
CLV_NRD_NRD_1	247	249	PF00675	0.347
CLV_NRD_NRD_1	40	42	PF00675	0.407
CLV_NRD_NRD_1	74	76	PF00675	0.478
CLV_PCSK_KEX2_1	117	119	PF00082	0.457
CLV_PCSK_KEX2_1	247	249	PF00082	0.345
CLV_PCSK_KEX2_1	40	42	PF00082	0.407
CLV_PCSK_KEX2_1	74	76	PF00082	0.415
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.457
CLV_PCSK_SKI1_1	153	157	PF00082	0.328
CLV_PCSK_SKI1_1	343	347	PF00082	0.457
CLV_PCSK_SKI1_1	74	78	PF00082	0.415
DEG_APCC_DBOX_1	278	286	PF00400	0.347
DEG_COP1_1	286	296	PF00400	0.382
DOC_MAPK_gen_1	145	154	PF00069	0.328
DOC_MAPK_MEF2A_6	168	175	PF00069	0.328
DOC_PP2B_LxvP_1	252	255	PF13499	0.359
DOC_USP7_MATH_1	113	117	PF00917	0.328
DOC_USP7_MATH_1	379	383	PF00917	0.369
DOC_WW_Pin1_4	74	79	PF00397	0.410
LIG_14-3-3_CanoR_1	247	256	PF00244	0.455
LIG_BIR_III_2	102	106	PF00653	0.328
LIG_BRCT_BRCA1_1	179	183	PF00533	0.427
LIG_BRCT_BRCA1_1	24	28	PF00533	0.449
LIG_BRCT_BRCA1_1	387	391	PF00533	0.349
LIG_FHA_1	129	135	PF00498	0.328
LIG_FHA_1	258	264	PF00498	0.293
LIG_FHA_2	321	327	PF00498	0.399
LIG_LIR_Apic_2	313	319	PF02991	0.328
LIG_LIR_Gen_1	208	217	PF02991	0.304
LIG_LIR_Gen_1	266	276	PF02991	0.344
LIG_LIR_Gen_1	360	370	PF02991	0.391
LIG_LIR_Nem_3	208	213	PF02991	0.311
LIG_LIR_Nem_3	266	272	PF02991	0.344
LIG_LIR_Nem_3	357	362	PF02991	0.343
LIG_LIR_Nem_3	377	383	PF02991	0.375
LIG_LIR_Nem_3	45	51	PF02991	0.522
LIG_LYPXL_yS_3	46	49	PF13949	0.445
LIG_SH2_CRK	269	273	PF00017	0.347
LIG_SH2_CRK	362	366	PF00017	0.395
LIG_SH2_NCK_1	269	273	PF00017	0.347
LIG_SH2_STAP1	312	316	PF00017	0.457
LIG_SH2_STAP1	95	99	PF00017	0.328
LIG_SH2_STAT3	51	54	PF00017	0.534
LIG_SH2_STAT5	384	387	PF00017	0.394
LIG_SH2_STAT5	48	51	PF00017	0.443
LIG_SH2_STAT5	59	62	PF00017	0.424
LIG_SH3_5	55	59	PF00018	0.432
LIG_SUMO_SIM_par_1	229	236	PF11976	0.441
LIG_SUMO_SIM_par_1	255	260	PF11976	0.330
LIG_TRAF2_1	105	108	PF00917	0.328
LIG_TRAF2_1	50	53	PF00917	0.441
LIG_UBA3_1	300	306	PF00899	0.414
MOD_CK1_1	243	249	PF00069	0.353
MOD_CK1_1	382	388	PF00069	0.330
MOD_CK2_1	219	225	PF00069	0.345
MOD_CK2_1	292	298	PF00069	0.382
MOD_CK2_1	312	318	PF00069	0.233
MOD_CK2_1	332	338	PF00069	0.185
MOD_GlcNHglycan	108	112	PF01048	0.328
MOD_GlcNHglycan	164	167	PF01048	0.328
MOD_GlcNHglycan	249	252	PF01048	0.427
MOD_GlcNHglycan	394	398	PF01048	0.521
MOD_GSK3_1	18	25	PF00069	0.395
MOD_GSK3_1	195	202	PF00069	0.327
MOD_GSK3_1	243	250	PF00069	0.384
MOD_GSK3_1	382	389	PF00069	0.326
MOD_LATS_1	16	22	PF00433	0.426
MOD_NEK2_1	257	262	PF00069	0.373
MOD_NEK2_1	278	283	PF00069	0.347
MOD_NEK2_2	379	384	PF00069	0.360
MOD_PIKK_1	219	225	PF00454	0.345
MOD_PIKK_1	257	263	PF00454	0.287
MOD_PIKK_1	286	292	PF00454	0.427
MOD_PKA_1	247	253	PF00069	0.427
MOD_PKA_2	148	154	PF00069	0.373
MOD_PKA_2	247	253	PF00069	0.427
MOD_PKA_2	278	284	PF00069	0.322
MOD_PKA_2	286	292	PF00069	0.347
MOD_Plk_1	312	318	PF00069	0.349
MOD_Plk_1	393	399	PF00069	0.477
MOD_Plk_4	10	16	PF00069	0.604
MOD_Plk_4	177	183	PF00069	0.491
MOD_Plk_4	240	246	PF00069	0.345
MOD_Plk_4	292	298	PF00069	0.382
MOD_Plk_4	312	318	PF00069	0.233
MOD_Plk_4	379	385	PF00069	0.382
MOD_Plk_4	405	411	PF00069	0.440
MOD_Plk_4	77	83	PF00069	0.429
MOD_ProDKin_1	74	80	PF00069	0.405
MOD_SUMO_for_1	32	35	PF00179	0.334
MOD_SUMO_for_1	348	351	PF00179	0.332
TRG_ENDOCYTIC_2	269	272	PF00928	0.347
TRG_ENDOCYTIC_2	330	333	PF00928	0.339
TRG_ENDOCYTIC_2	362	365	PF00928	0.375
TRG_ENDOCYTIC_2	46	49	PF00928	0.445
TRG_ER_diArg_1	247	249	PF00400	0.345
TRG_ER_diArg_1	276	279	PF00400	0.382
TRG_ER_diArg_1	39	41	PF00400	0.394
TRG_ER_diArg_1	73	75	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	283	288	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N6	Leptomonas seymouri	44%	100%
A0A0N0P327	Leptomonas seymouri	27%	100%
A0A1X0NW20	Trypanosomatidae	76%	100%
A0A1X0NW36	Trypanosomatidae	70%	100%
A0A1X0NWQ6	Trypanosomatidae	61%	100%
A0A3Q8IBS0	Leishmania donovani	81%	100%
A0A3Q8IIH2	Leishmania donovani	44%	100%
A0A3Q8IJC1	Leishmania donovani	42%	94%
A0A3S7WW66	Leishmania donovani	89%	100%
A0A3S7WW80	Leishmania donovani	98%	77%
A0A422NTM4	Trypanosoma rangeli	76%	100%
A0AHD2	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	31%	100%
A0RHZ2	Bacillus thuringiensis (strain Al Hakam)	34%	100%
A1S647	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	23%	100%
A2RI06	Lactococcus lactis subsp. cremoris (strain MG1363)	27%	100%
A3CQT4	Streptococcus sanguinis (strain SK36)	28%	100%
A4HJ93	Leishmania braziliensis	43%	100%
A4HZ10	Leishmania infantum	81%	100%
A4HZ11	Leishmania infantum	98%	77%
A4I5G9	Leishmania infantum	42%	94%
A4I6N7	Leishmania infantum	44%	100%
A4I6N8	Leishmania infantum	44%	100%
A4ILT6	Geobacillus thermodenitrificans (strain NG80-2)	33%	100%
A4VY21	Streptococcus suis (strain 05ZYH33)	28%	100%
A4W4B4	Streptococcus suis (strain 98HAH33)	28%	100%
A5VJ57	Limosilactobacillus reuteri (strain DSM 20016)	30%	100%
A7GS08	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	34%	100%
A7Z433	Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)	32%	100%
A8AUM0	Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)	28%	100%
A8FCN2	Bacillus pumilus (strain SAFR-032)	32%	100%
A8YUT2	Lactobacillus helveticus (strain DPC 4571)	28%	100%
A9VUE2	Bacillus mycoides (strain KBAB4)	33%	100%
B1I9G2	Streptococcus pneumoniae (strain Hungary19A-6)	30%	100%
B1MZM9	Leuconostoc citreum (strain KM20)	33%	100%
B1YJ90	Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)	30%	100%
B2G6M8	Limosilactobacillus reuteri (strain JCM 1112)	30%	100%
B2GC10	Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251)	29%	100%
B2IN14	Streptococcus pneumoniae (strain CGSP14)	30%	100%
B3W7E6	Lacticaseibacillus casei (strain BL23)	28%	100%
B5E3A3	Streptococcus pneumoniae serotype 19F (strain G54)	30%	100%
B7GIC0	Anoxybacillus flavithermus (strain DSM 21510 / WK1)	32%	100%
B7H6W7	Bacillus cereus (strain B4264)	33%	100%
B7HMV1	Bacillus cereus (strain AH187)	34%	100%
B7IVL7	Bacillus cereus (strain G9842)	33%	100%
B7JKV4	Bacillus cereus (strain AH820)	34%	100%
B8DEC3	Listeria monocytogenes serotype 4a (strain HCC23)	32%	100%
B8ZPL8	Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)	30%	100%
B9DVY6	Streptococcus uberis (strain ATCC BAA-854 / 0140J)	28%	100%
B9IW60	Bacillus cereus (strain Q1)	34%	100%
C0ZGH7	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)	31%	100%
C1CAS3	Streptococcus pneumoniae (strain 70585)	30%	100%
C1CH24	Streptococcus pneumoniae (strain JJA)	30%	100%
C1CN42	Streptococcus pneumoniae (strain P1031)	30%	100%
C1CTZ9	Streptococcus pneumoniae (strain Taiwan19F-14)	30%	100%
C1EPZ4	Bacillus cereus (strain 03BB102)	34%	100%
C1L1T3	Listeria monocytogenes serotype 4b (strain CLIP80459)	32%	100%
C3LI46	Bacillus anthracis (strain CDC 684 / NRRL 3495)	34%	100%
C3P6Y7	Bacillus anthracis (strain A0248)	34%	100%
C5D827	Geobacillus sp. (strain WCH70)	33%	100%
C9ZIL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
D5E0A1	Priestia megaterium (strain ATCC 12872 / QMB1551)	31%	100%
E9AGU3	Leishmania infantum	89%	100%
E9AIM3	Leishmania braziliensis	78%	100%
E9AIM4	Leishmania braziliensis	79%	92%
E9AIM5	Leishmania braziliensis	90%	100%
E9AUV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9AUV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AUV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B0R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B1R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
O04373	Arabidopsis thaliana	38%	94%
O07598	Bacillus subtilis (strain 168)	38%	100%
O34916	Bacillus subtilis (strain 168)	32%	100%
O34980	Bacillus subtilis (strain 168)	35%	100%
O50173	Enterobacter agglomerans	30%	95%
O81641	Arabidopsis thaliana	36%	97%
P37112	Geobacillus stearothermophilus	49%	100%
P44765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	98%
P45493	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	33%	100%
P54955	Bacillus subtilis (strain 168)	39%	100%
P54968	Arabidopsis thaliana	37%	94%
P54969	Arabidopsis thaliana	38%	95%
P54970	Arabidopsis thaliana	39%	95%
P54984	Synechocystis sp. (strain PCC 6803 / Kazusa)	39%	100%
P55663	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	30%	100%
P58156	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	38%	100%
P80092	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	38%	100%
Q032G8	Lactococcus lactis subsp. cremoris (strain SK11)	27%	100%
Q03CW2	Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441)	28%	100%
Q03HT1	Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)	30%	100%
Q03IN1	Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)	28%	100%
Q03YE3	Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)	33%	100%
Q04FS2	Oenococcus oeni (strain ATCC BAA-331 / PSU-1)	28%	100%
Q04I78	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)	30%	100%
Q1WUQ7	Ligilactobacillus salivarius (strain UCC118)	30%	100%
Q2FH40	Staphylococcus aureus (strain USA300)	29%	100%
Q2FYN6	Staphylococcus aureus (strain NCTC 8325 / PS 47)	29%	100%
Q2YY21	Staphylococcus aureus (strain bovine RF122 / ET3-1)	29%	100%
Q49XK0	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	29%	100%
Q4L6A3	Staphylococcus haemolyticus (strain JCSC1435)	28%	100%
Q4Q6F0	Leishmania major	44%	100%
Q4Q7G6	Leishmania major	42%	100%
Q4QCM5	Leishmania major	89%	100%
Q4QCM6	Leishmania major	81%	100%
Q5FKR0	Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)	30%	100%
Q5HG22	Staphylococcus aureus (strain COL)	29%	100%
Q5HPE4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	29%	100%
Q5L145	Geobacillus kaustophilus (strain HTA426)	33%	100%
Q5LXY3	Streptococcus thermophilus (strain CNRZ 1066)	27%	100%
Q5M2I5	Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)	27%	100%
Q5N8F2	Oryza sativa subsp. japonica	39%	91%
Q5WF94	Alkalihalobacillus clausii (strain KSM-K16)	32%	100%
Q5Z678	Oryza sativa subsp. japonica	39%	81%
Q635U8	Bacillus cereus (strain ZK / E33L)	34%	100%
Q65K84	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	32%	100%
Q6G9G3	Staphylococcus aureus (strain MSSA476)	29%	100%
Q6GH10	Staphylococcus aureus (strain MRSA252)	29%	100%
Q6HEI5	Bacillus thuringiensis subsp. konkukian (strain 97-27)	34%	100%
Q6LAN3	Listeria ivanovii	30%	100%
Q721F4	Listeria monocytogenes serotype 4b (strain F2365)	32%	100%
Q731Y6	Bacillus cereus (strain ATCC 10987 / NRS 248)	34%	100%
Q7A5P6	Staphylococcus aureus (strain N315)	29%	100%
Q7XUA8	Oryza sativa subsp. japonica	40%	97%
Q819J6	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	33%	100%
Q81MQ3	Bacillus anthracis	34%	100%
Q836H7	Enterococcus faecalis (strain ATCC 700802 / V583)	32%	100%
Q84XG9	Oryza sativa subsp. indica	38%	94%
Q851L5	Oryza sativa subsp. japonica	38%	100%
Q851L6	Oryza sativa subsp. japonica	38%	100%
Q88V24	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	30%	100%
Q8CSM6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	29%	100%
Q8DN55	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	30%	100%
Q8DVY6	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	28%	100%
Q8ERA3	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	30%	100%
Q8GGD4	Corynebacterium striatum	33%	100%
Q8H3C7	Oryza sativa subsp. japonica	39%	94%
Q8H3C8	Oryza sativa subsp. japonica	41%	93%
Q8H3C9	Oryza sativa subsp. japonica	40%	91%
Q8NWS3	Staphylococcus aureus (strain MW2)	29%	100%
Q8S9S4	Oryza sativa subsp. japonica	38%	94%
Q8VYX0	Arabidopsis thaliana	37%	89%
Q8Y8A0	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	32%	100%
Q92D10	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	33%	100%
Q97NE7	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	30%	100%
Q99U87	Staphylococcus aureus (strain Mu50 / ATCC 700699)	29%	100%
Q9CIS4	Lactococcus lactis subsp. lactis (strain IL1403)	27%	100%
Q9K9H9	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	34%	100%
Q9SWX9	Arabidopsis thaliana	38%	95%