PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCM3_LEIMA

TriTrypDb:

LmjF.20.1580 , LMJLV39_200023900 , LMJSD75_200024100

Length:

1018

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCM3

Function

Biological processes
Term	Name	Level	Count
GO:0000966	RNA 5'-end processing	7	2
GO:0001682	tRNA 5'-leader removal	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0099116	tRNA 5'-end processing	8	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004519	endonuclease activity	5	2
GO:0004521	RNA endonuclease activity	5	2
GO:0004526	ribonuclease P activity	6	2
GO:0004540	RNA nuclease activity	4	2
GO:0004549	tRNA-specific ribonuclease activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140101	catalytic activity, acting on a tRNA	4	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	700	704	PF00656	0.452
CLV_NRD_NRD_1	1003	1005	PF00675	0.524
CLV_NRD_NRD_1	1013	1015	PF00675	0.511
CLV_NRD_NRD_1	472	474	PF00675	0.405
CLV_NRD_NRD_1	567	569	PF00675	0.356
CLV_NRD_NRD_1	626	628	PF00675	0.405
CLV_NRD_NRD_1	629	631	PF00675	0.421
CLV_NRD_NRD_1	640	642	PF00675	0.417
CLV_NRD_NRD_1	925	927	PF00675	0.482
CLV_NRD_NRD_1	975	977	PF00675	0.526
CLV_PCSK_FUR_1	1009	1013	PF00082	0.552
CLV_PCSK_FUR_1	627	631	PF00082	0.404
CLV_PCSK_KEX2_1	1011	1013	PF00082	0.521
CLV_PCSK_KEX2_1	44	46	PF00082	0.537
CLV_PCSK_KEX2_1	472	474	PF00082	0.424
CLV_PCSK_KEX2_1	567	569	PF00082	0.341
CLV_PCSK_KEX2_1	621	623	PF00082	0.415
CLV_PCSK_KEX2_1	625	627	PF00082	0.420
CLV_PCSK_KEX2_1	629	631	PF00082	0.428
CLV_PCSK_KEX2_1	975	977	PF00082	0.600
CLV_PCSK_PC1ET2_1	1011	1013	PF00082	0.522
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.369
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.401
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.408
CLV_PCSK_PC7_1	1009	1015	PF00082	0.561
CLV_PCSK_PC7_1	622	628	PF00082	0.390
CLV_PCSK_PC7_1	971	977	PF00082	0.562
CLV_PCSK_SKI1_1	1004	1008	PF00082	0.507
CLV_PCSK_SKI1_1	122	126	PF00082	0.425
CLV_PCSK_SKI1_1	131	135	PF00082	0.433
CLV_PCSK_SKI1_1	224	228	PF00082	0.330
CLV_PCSK_SKI1_1	268	272	PF00082	0.347
CLV_PCSK_SKI1_1	622	626	PF00082	0.399
CLV_Separin_Metazoa	279	283	PF03568	0.321
DEG_COP1_1	359	368	PF00400	0.492
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_ODPH_VHL_1	873	884	PF01847	0.500
DEG_SCF_FBW7_2	150	157	PF00400	0.596
DOC_CKS1_1	727	732	PF01111	0.528
DOC_CYCLIN_RxL_1	116	129	PF00134	0.418
DOC_MAPK_gen_1	413	421	PF00069	0.406
DOC_MAPK_gen_1	567	575	PF00069	0.332
DOC_MAPK_gen_1	641	648	PF00069	0.496
DOC_MAPK_MEF2A_6	415	423	PF00069	0.403
DOC_PP2B_LxvP_1	133	136	PF13499	0.670
DOC_PP2B_LxvP_1	672	675	PF13499	0.586
DOC_PP2B_LxvP_1	945	948	PF13499	0.467
DOC_PP4_FxxP_1	727	730	PF00568	0.564
DOC_USP7_MATH_1	7	11	PF00917	0.598
DOC_USP7_MATH_1	875	879	PF00917	0.416
DOC_USP7_MATH_1	883	887	PF00917	0.446
DOC_USP7_UBL2_3	243	247	PF12436	0.493
DOC_USP7_UBL2_3	621	625	PF12436	0.386
DOC_WW_Pin1_4	103	108	PF00397	0.428
DOC_WW_Pin1_4	11	16	PF00397	0.376
DOC_WW_Pin1_4	150	155	PF00397	0.646
DOC_WW_Pin1_4	268	273	PF00397	0.286
DOC_WW_Pin1_4	360	365	PF00397	0.387
DOC_WW_Pin1_4	650	655	PF00397	0.626
DOC_WW_Pin1_4	702	707	PF00397	0.441
DOC_WW_Pin1_4	726	731	PF00397	0.572
DOC_WW_Pin1_4	824	829	PF00397	0.378
DOC_WW_Pin1_4	955	960	PF00397	0.550
DOC_WW_Pin1_4	977	982	PF00397	0.544
LIG_14-3-3_CanoR_1	102	107	PF00244	0.535
LIG_14-3-3_CanoR_1	116	124	PF00244	0.600
LIG_14-3-3_CanoR_1	567	571	PF00244	0.351
LIG_14-3-3_CanoR_1	604	608	PF00244	0.529
LIG_14-3-3_CterR_2	1013	1018	PF00244	0.574
LIG_APCC_ABBA_1	507	512	PF00400	0.422
LIG_APCC_ABBAyCdc20_2	693	699	PF00400	0.449
LIG_BRCT_BRCA1_1	859	863	PF00533	0.524
LIG_deltaCOP1_diTrp_1	65	73	PF00928	0.407
LIG_deltaCOP1_diTrp_1	774	781	PF00928	0.498
LIG_EVH1_2	951	955	PF00568	0.556
LIG_FHA_1	269	275	PF00498	0.306
LIG_FHA_1	310	316	PF00498	0.286
LIG_FHA_1	387	393	PF00498	0.423
LIG_FHA_1	490	496	PF00498	0.517
LIG_FHA_1	900	906	PF00498	0.623
LIG_FHA_2	151	157	PF00498	0.696
LIG_FHA_2	519	525	PF00498	0.370
LIG_FHA_2	708	714	PF00498	0.460
LIG_FHA_2	727	733	PF00498	0.412
LIG_FHA_2	82	88	PF00498	0.559
LIG_FHA_2	887	893	PF00498	0.638
LIG_LIR_Apic_2	51	55	PF02991	0.426
LIG_LIR_Apic_2	724	730	PF02991	0.561
LIG_LIR_Gen_1	137	147	PF02991	0.563
LIG_LIR_Gen_1	289	297	PF02991	0.383
LIG_LIR_Gen_1	389	398	PF02991	0.362
LIG_LIR_Gen_1	441	447	PF02991	0.431
LIG_LIR_Gen_1	535	542	PF02991	0.323
LIG_LIR_Gen_1	551	559	PF02991	0.327
LIG_LIR_Gen_1	569	578	PF02991	0.324
LIG_LIR_Gen_1	803	811	PF02991	0.544
LIG_LIR_Gen_1	889	899	PF02991	0.493
LIG_LIR_Gen_1	928	934	PF02991	0.423
LIG_LIR_LC3C_4	204	209	PF02991	0.497
LIG_LIR_Nem_3	118	124	PF02991	0.380
LIG_LIR_Nem_3	137	143	PF02991	0.539
LIG_LIR_Nem_3	240	245	PF02991	0.353
LIG_LIR_Nem_3	289	293	PF02991	0.306
LIG_LIR_Nem_3	341	347	PF02991	0.375
LIG_LIR_Nem_3	389	394	PF02991	0.364
LIG_LIR_Nem_3	462	467	PF02991	0.326
LIG_LIR_Nem_3	533	537	PF02991	0.352
LIG_LIR_Nem_3	569	573	PF02991	0.340
LIG_LIR_Nem_3	790	794	PF02991	0.422
LIG_LIR_Nem_3	833	837	PF02991	0.470
LIG_LIR_Nem_3	889	894	PF02991	0.488
LIG_LIR_Nem_3	928	933	PF02991	0.417
LIG_MYND_1	132	136	PF01753	0.582
LIG_NRP_CendR_1	1016	1018	PF00754	0.694
LIG_PCNA_yPIPBox_3	21	29	PF02747	0.476
LIG_Pex14_1	518	522	PF04695	0.349
LIG_Pex14_1	936	940	PF04695	0.404
LIG_Rb_LxCxE_1	367	380	PF01857	0.384
LIG_SH2_CRK	121	125	PF00017	0.612
LIG_SH2_CRK	242	246	PF00017	0.347
LIG_SH2_CRK	290	294	PF00017	0.383
LIG_SH2_CRK	344	348	PF00017	0.361
LIG_SH2_CRK	353	357	PF00017	0.321
LIG_SH2_CRK	52	56	PF00017	0.428
LIG_SH2_CRK	791	795	PF00017	0.489
LIG_SH2_GRB2like	303	306	PF00017	0.286
LIG_SH2_GRB2like	391	394	PF00017	0.301
LIG_SH2_NCK_1	290	294	PF00017	0.376
LIG_SH2_NCK_1	303	307	PF00017	0.212
LIG_SH2_NCK_1	467	471	PF00017	0.274
LIG_SH2_NCK_1	891	895	PF00017	0.485
LIG_SH2_PTP2	537	540	PF00017	0.311
LIG_SH2_SRC	303	306	PF00017	0.286
LIG_SH2_SRC	592	595	PF00017	0.361
LIG_SH2_SRC	842	845	PF00017	0.545
LIG_SH2_STAP1	16	20	PF00017	0.355
LIG_SH2_STAP1	290	294	PF00017	0.438
LIG_SH2_STAP1	353	357	PF00017	0.336
LIG_SH2_STAP1	453	457	PF00017	0.487
LIG_SH2_STAP1	467	471	PF00017	0.226
LIG_SH2_STAP1	534	538	PF00017	0.326
LIG_SH2_STAP1	570	574	PF00017	0.341
LIG_SH2_STAP1	69	73	PF00017	0.414
LIG_SH2_STAT3	69	72	PF00017	0.413
LIG_SH2_STAT5	177	180	PF00017	0.435
LIG_SH2_STAT5	391	394	PF00017	0.301
LIG_SH2_STAT5	537	540	PF00017	0.311
LIG_SH2_STAT5	592	595	PF00017	0.387
LIG_SH2_STAT5	638	641	PF00017	0.413
LIG_SH2_STAT5	932	935	PF00017	0.396
LIG_SH3_2	872	877	PF14604	0.437
LIG_SH3_3	646	652	PF00018	0.654
LIG_SH3_3	665	671	PF00018	0.535
LIG_SH3_3	869	875	PF00018	0.585
LIG_SH3_3	945	951	PF00018	0.477
LIG_SUMO_SIM_anti_2	190	195	PF11976	0.460
LIG_SUMO_SIM_anti_2	203	212	PF11976	0.317
LIG_SUMO_SIM_par_1	131	137	PF11976	0.706
LIG_SUMO_SIM_par_1	203	212	PF11976	0.365
LIG_SUMO_SIM_par_1	492	498	PF11976	0.479
LIG_TRAF2_1	154	157	PF00917	0.720
LIG_TRAF2_1	580	583	PF00917	0.359
LIG_TRAF2_1	634	637	PF00917	0.407
LIG_TRAF2_1	74	77	PF00917	0.438
LIG_TRAF2_1	878	881	PF00917	0.425
LIG_TRAF2_1	997	1000	PF00917	0.578
LIG_TRAF2_2	136	141	PF00917	0.609
LIG_TRFH_1	648	652	PF08558	0.658
LIG_TYR_ITSM	887	894	PF00017	0.566
LIG_UBA3_1	261	266	PF00899	0.302
LIG_WRC_WIRS_1	281	286	PF05994	0.347
MOD_CDK_SPK_2	268	273	PF00069	0.286
MOD_CDK_SPK_2	702	707	PF00069	0.441
MOD_CK1_1	106	112	PF00069	0.460
MOD_CK1_1	168	174	PF00069	0.443
MOD_CK1_1	182	188	PF00069	0.398
MOD_CK1_1	321	327	PF00069	0.513
MOD_CK1_1	566	572	PF00069	0.353
MOD_CK1_1	823	829	PF00069	0.523
MOD_CK1_1	886	892	PF00069	0.595
MOD_CK1_1	965	971	PF00069	0.521
MOD_CK2_1	150	156	PF00069	0.700
MOD_CK2_1	31	37	PF00069	0.419
MOD_CK2_1	326	332	PF00069	0.410
MOD_CK2_1	518	524	PF00069	0.365
MOD_CK2_1	576	582	PF00069	0.340
MOD_CK2_1	689	695	PF00069	0.406
MOD_CK2_1	707	713	PF00069	0.440
MOD_CK2_1	81	87	PF00069	0.550
MOD_CK2_1	824	830	PF00069	0.343
MOD_CK2_1	875	881	PF00069	0.412
MOD_CK2_1	886	892	PF00069	0.460
MOD_CK2_1	994	1000	PF00069	0.592
MOD_CMANNOS	683	686	PF00535	0.407
MOD_GlcNHglycan	113	116	PF01048	0.466
MOD_GlcNHglycan	289	293	PF01048	0.383
MOD_GlcNHglycan	33	36	PF01048	0.434
MOD_GlcNHglycan	396	399	PF01048	0.338
MOD_GlcNHglycan	579	582	PF01048	0.351
MOD_GlcNHglycan	724	727	PF01048	0.476
MOD_GlcNHglycan	768	771	PF01048	0.648
MOD_GlcNHglycan	821	825	PF01048	0.510
MOD_GlcNHglycan	859	862	PF01048	0.461
MOD_GSK3_1	102	109	PF00069	0.438
MOD_GSK3_1	111	118	PF00069	0.440
MOD_GSK3_1	185	192	PF00069	0.484
MOD_GSK3_1	318	325	PF00069	0.391
MOD_GSK3_1	326	333	PF00069	0.393
MOD_GSK3_1	356	363	PF00069	0.480
MOD_GSK3_1	489	496	PF00069	0.411
MOD_GSK3_1	7	14	PF00069	0.559
MOD_GSK3_1	722	729	PF00069	0.418
MOD_GSK3_1	820	827	PF00069	0.348
MOD_GSK3_1	895	902	PF00069	0.417
MOD_GSK3_1	918	925	PF00069	0.705
MOD_GSK3_1	962	969	PF00069	0.509
MOD_GSK3_1	995	1002	PF00069	0.631
MOD_N-GLC_1	148	153	PF02516	0.715
MOD_N-GLC_1	185	190	PF02516	0.397
MOD_N-GLC_1	255	260	PF02516	0.382
MOD_N-GLC_1	386	391	PF02516	0.428
MOD_N-GLC_2	461	463	PF02516	0.472
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	1007	1012	PF00069	0.552
MOD_NEK2_1	246	251	PF00069	0.494
MOD_NEK2_1	280	285	PF00069	0.347
MOD_NEK2_1	330	335	PF00069	0.432
MOD_NEK2_1	356	361	PF00069	0.393
MOD_NEK2_1	394	399	PF00069	0.336
MOD_NEK2_1	424	429	PF00069	0.439
MOD_NEK2_1	576	581	PF00069	0.332
MOD_NEK2_1	752	757	PF00069	0.438
MOD_NEK2_1	966	971	PF00069	0.525
MOD_PIKK_1	134	140	PF00454	0.635
MOD_PIKK_1	165	171	PF00454	0.593
MOD_PIKK_1	322	328	PF00454	0.401
MOD_PIKK_1	358	364	PF00454	0.367
MOD_PIKK_1	918	924	PF00454	0.664
MOD_PK_1	189	195	PF00069	0.531
MOD_PKA_1	44	50	PF00069	0.460
MOD_PKA_1	687	693	PF00069	0.417
MOD_PKA_2	115	121	PF00069	0.590
MOD_PKA_2	2	8	PF00069	0.657
MOD_PKA_2	44	50	PF00069	0.629
MOD_PKA_2	566	572	PF00069	0.353
MOD_PKA_2	603	609	PF00069	0.400
MOD_PKA_2	925	931	PF00069	0.447
MOD_PKA_2	995	1001	PF00069	0.558
MOD_Plk_1	189	195	PF00069	0.499
MOD_Plk_1	255	261	PF00069	0.376
MOD_Plk_1	288	294	PF00069	0.383
MOD_Plk_1	309	315	PF00069	0.286
MOD_Plk_1	322	328	PF00069	0.423
MOD_Plk_1	386	392	PF00069	0.425
MOD_Plk_1	60	66	PF00069	0.390
MOD_Plk_1	676	682	PF00069	0.553
MOD_Plk_1	886	892	PF00069	0.465
MOD_Plk_2-3	530	536	PF00069	0.342
MOD_Plk_4	189	195	PF00069	0.539
MOD_Plk_4	387	393	PF00069	0.359
MOD_Plk_4	419	425	PF00069	0.493
MOD_Plk_4	603	609	PF00069	0.381
MOD_Plk_4	752	758	PF00069	0.434
MOD_Plk_4	886	892	PF00069	0.487
MOD_ProDKin_1	103	109	PF00069	0.430
MOD_ProDKin_1	11	17	PF00069	0.371
MOD_ProDKin_1	150	156	PF00069	0.648
MOD_ProDKin_1	268	274	PF00069	0.286
MOD_ProDKin_1	360	366	PF00069	0.395
MOD_ProDKin_1	650	656	PF00069	0.622
MOD_ProDKin_1	702	708	PF00069	0.442
MOD_ProDKin_1	726	732	PF00069	0.571
MOD_ProDKin_1	824	830	PF00069	0.378
MOD_ProDKin_1	955	961	PF00069	0.537
MOD_ProDKin_1	977	983	PF00069	0.545
MOD_SUMO_for_1	706	709	PF00179	0.472
MOD_SUMO_for_1	787	790	PF00179	0.383
MOD_SUMO_rev_2	258	267	PF00179	0.321
MOD_SUMO_rev_2	441	450	PF00179	0.533
MOD_SUMO_rev_2	709	716	PF00179	0.521
MOD_SUMO_rev_2	790	800	PF00179	0.534
TRG_DiLeu_BaEn_2	570	576	PF01217	0.420
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.445
TRG_DiLeu_LyEn_5	129	134	PF01217	0.503
TRG_ENDOCYTIC_2	121	124	PF00928	0.376
TRG_ENDOCYTIC_2	140	143	PF00928	0.498
TRG_ENDOCYTIC_2	242	245	PF00928	0.349
TRG_ENDOCYTIC_2	290	293	PF00928	0.286
TRG_ENDOCYTIC_2	303	306	PF00928	0.286
TRG_ENDOCYTIC_2	344	347	PF00928	0.374
TRG_ENDOCYTIC_2	353	356	PF00928	0.321
TRG_ENDOCYTIC_2	391	394	PF00928	0.301
TRG_ENDOCYTIC_2	442	445	PF00928	0.404
TRG_ENDOCYTIC_2	467	470	PF00928	0.341
TRG_ENDOCYTIC_2	537	540	PF00928	0.311
TRG_ENDOCYTIC_2	570	573	PF00928	0.328
TRG_ENDOCYTIC_2	791	794	PF00928	0.502
TRG_ENDOCYTIC_2	891	894	PF00928	0.613
TRG_ENDOCYTIC_2	930	933	PF00928	0.440
TRG_ER_diArg_1	1012	1014	PF00400	0.518
TRG_ER_diArg_1	1015	1018	PF00400	0.547
TRG_ER_diArg_1	368	371	PF00400	0.383
TRG_ER_diArg_1	626	629	PF00400	0.407
TRG_ER_diArg_1	974	976	PF00400	0.561
TRG_NES_CRM1_1	326	338	PF08389	0.508
TRG_NLS_Bipartite_1	609	629	PF00514	0.385
TRG_NLS_MonoCore_2	1010	1015	PF00514	0.548
TRG_NLS_MonoExtC_3	624	629	PF00514	0.390
TRG_NLS_MonoExtC_3	925	931	PF00514	0.532
TRG_NLS_MonoExtN_4	1009	1015	PF00514	0.528
TRG_NLS_MonoExtN_4	622	629	PF00514	0.393
TRG_NLS_MonoExtN_4	924	930	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	903	907	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS7	Leptomonas seymouri	81%	100%
A0A0S4JPI2	Bodo saltans	50%	94%
A0A1X0NWA5	Trypanosomatidae	67%	100%
A0A3Q8IBP6	Leishmania donovani	96%	100%
A0A422NTN1	Trypanosoma rangeli	66%	100%
A4HZ12	Leishmania infantum	96%	100%
C9ZIL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9AIM6	Leishmania braziliensis	90%	100%
E9AUV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B8D4	Trypanosoma cruzi	66%	98%