WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCM1_LEIMA

TriTrypDb:

LmjF.20.1600 , LMJLV39_200024100 , LMJSD75_200024300

Length:

1006

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	419	421	PF00675	0.582
CLV_NRD_NRD_1	615	617	PF00675	0.561
CLV_NRD_NRD_1	9	11	PF00675	0.732
CLV_PCSK_KEX2_1	504	506	PF00082	0.619
CLV_PCSK_KEX2_1	615	617	PF00082	0.601
CLV_PCSK_KEX2_1	8	10	PF00082	0.765
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.619
CLV_PCSK_SKI1_1	367	371	PF00082	0.533
CLV_PCSK_SKI1_1	411	415	PF00082	0.639
CLV_PCSK_SKI1_1	515	519	PF00082	0.514
CLV_PCSK_SKI1_1	623	627	PF00082	0.537
CLV_PCSK_SKI1_1	715	719	PF00082	0.585
CLV_PCSK_SKI1_1	727	731	PF00082	0.369
CLV_PCSK_SKI1_1	759	763	PF00082	0.518
CLV_PCSK_SKI1_1	88	92	PF00082	0.581
CLV_PCSK_SKI1_1	9	13	PF00082	0.658
DEG_APCC_DBOX_1	514	522	PF00400	0.522
DEG_APCC_DBOX_1	622	630	PF00400	0.581
DEG_Nend_Nbox_1	1	3	PF02207	0.716
DOC_MAPK_gen_1	420	427	PF00069	0.549
DOC_MAPK_MEF2A_6	306	314	PF00069	0.368
DOC_MAPK_MEF2A_6	804	811	PF00069	0.535
DOC_MAPK_MEF2A_6	970	978	PF00069	0.594
DOC_PP2B_LxvP_1	369	372	PF13499	0.580
DOC_PP2B_PxIxI_1	804	810	PF00149	0.485
DOC_PP4_FxxP_1	3	6	PF00568	0.735
DOC_PP4_FxxP_1	447	450	PF00568	0.461
DOC_PP4_FxxP_1	993	996	PF00568	0.500
DOC_USP7_MATH_1	272	276	PF00917	0.565
DOC_USP7_MATH_1	400	404	PF00917	0.492
DOC_USP7_MATH_1	573	577	PF00917	0.358
DOC_USP7_MATH_1	749	753	PF00917	0.456
DOC_USP7_MATH_1	867	871	PF00917	0.375
DOC_USP7_MATH_1	938	942	PF00917	0.656
DOC_USP7_MATH_1	963	967	PF00917	0.608
DOC_WW_Pin1_4	2	7	PF00397	0.736
DOC_WW_Pin1_4	405	410	PF00397	0.498
DOC_WW_Pin1_4	446	451	PF00397	0.508
DOC_WW_Pin1_4	615	620	PF00397	0.581
DOC_WW_Pin1_4	651	656	PF00397	0.468
DOC_WW_Pin1_4	694	699	PF00397	0.656
DOC_WW_Pin1_4	934	939	PF00397	0.581
DOC_WW_Pin1_4	984	989	PF00397	0.427
DOC_WW_Pin1_4	992	997	PF00397	0.425
LIG_14-3-3_CanoR_1	237	243	PF00244	0.639
LIG_14-3-3_CanoR_1	333	340	PF00244	0.421
LIG_14-3-3_CanoR_1	411	418	PF00244	0.636
LIG_14-3-3_CanoR_1	505	509	PF00244	0.635
LIG_14-3-3_CanoR_1	610	615	PF00244	0.611
LIG_14-3-3_CanoR_1	704	709	PF00244	0.571
LIG_14-3-3_CanoR_1	727	732	PF00244	0.614
LIG_14-3-3_CanoR_1	860	869	PF00244	0.486
LIG_14-3-3_CanoR_1	88	93	PF00244	0.572
LIG_Actin_WH2_2	489	506	PF00022	0.517
LIG_Actin_WH2_2	600	617	PF00022	0.552
LIG_APCC_ABBA_1	425	430	PF00400	0.565
LIG_BRCT_BRCA1_1	952	956	PF00533	0.594
LIG_Clathr_ClatBox_1	311	315	PF01394	0.565
LIG_DLG_GKlike_1	970	977	PF00625	0.428
LIG_EH_1	747	751	PF12763	0.369
LIG_eIF4E_1	288	294	PF01652	0.503
LIG_FAT_LD_1	489	497	PF03623	0.557
LIG_FHA_1	103	109	PF00498	0.545
LIG_FHA_1	156	162	PF00498	0.520
LIG_FHA_1	244	250	PF00498	0.567
LIG_FHA_1	272	278	PF00498	0.506
LIG_FHA_1	307	313	PF00498	0.494
LIG_FHA_1	320	326	PF00498	0.409
LIG_FHA_1	378	384	PF00498	0.532
LIG_FHA_1	40	46	PF00498	0.634
LIG_FHA_1	412	418	PF00498	0.557
LIG_FHA_1	430	436	PF00498	0.388
LIG_FHA_1	438	444	PF00498	0.473
LIG_FHA_1	588	594	PF00498	0.610
LIG_FHA_1	674	680	PF00498	0.380
LIG_FHA_1	789	795	PF00498	0.575
LIG_FHA_1	861	867	PF00498	0.442
LIG_FHA_1	915	921	PF00498	0.501
LIG_FHA_2	146	152	PF00498	0.546
LIG_FHA_2	73	79	PF00498	0.540
LIG_FHA_2	826	832	PF00498	0.422
LIG_FHA_2	922	928	PF00498	0.508
LIG_HCF-1_HBM_1	316	319	PF13415	0.603
LIG_LIR_Apic_2	302	307	PF02991	0.610
LIG_LIR_Apic_2	444	450	PF02991	0.452
LIG_LIR_Apic_2	992	996	PF02991	0.521
LIG_LIR_Gen_1	379	389	PF02991	0.485
LIG_LIR_Gen_1	423	428	PF02991	0.549
LIG_LIR_Gen_1	553	562	PF02991	0.529
LIG_LIR_Gen_1	672	682	PF02991	0.563
LIG_LIR_Gen_1	697	708	PF02991	0.566
LIG_LIR_Gen_1	747	758	PF02991	0.492
LIG_LIR_Gen_1	821	830	PF02991	0.396
LIG_LIR_LC3C_4	541	546	PF02991	0.672
LIG_LIR_Nem_3	255	261	PF02991	0.591
LIG_LIR_Nem_3	287	291	PF02991	0.520
LIG_LIR_Nem_3	423	427	PF02991	0.549
LIG_LIR_Nem_3	553	559	PF02991	0.517
LIG_LIR_Nem_3	609	614	PF02991	0.604
LIG_LIR_Nem_3	672	678	PF02991	0.571
LIG_LIR_Nem_3	697	703	PF02991	0.576
LIG_LIR_Nem_3	747	753	PF02991	0.506
LIG_LIR_Nem_3	821	826	PF02991	0.429
LIG_LIR_Nem_3	953	959	PF02991	0.530
LIG_NRBOX	457	463	PF00104	0.703
LIG_NRBOX	561	567	PF00104	0.574
LIG_NRBOX	677	683	PF00104	0.458
LIG_PCNA_PIPBox_1	605	614	PF02747	0.408
LIG_PCNA_yPIPBox_3	599	612	PF02747	0.392
LIG_Pex14_1	26	30	PF04695	0.639
LIG_Pex14_2	169	173	PF04695	0.495
LIG_Pex14_2	810	814	PF04695	0.472
LIG_Pex14_2	981	985	PF04695	0.499
LIG_PTB_Apo_2	814	821	PF02174	0.492
LIG_PTB_Phospho_1	814	820	PF10480	0.493
LIG_SH2_CRK	195	199	PF00017	0.487
LIG_SH2_CRK	245	249	PF00017	0.648
LIG_SH2_CRK	288	292	PF00017	0.508
LIG_SH2_CRK	304	308	PF00017	0.579
LIG_SH2_CRK	334	338	PF00017	0.527
LIG_SH2_CRK	424	428	PF00017	0.542
LIG_SH2_CRK	475	479	PF00017	0.617
LIG_SH2_NCK_1	304	308	PF00017	0.633
LIG_SH2_PTP2	806	809	PF00017	0.491
LIG_SH2_SRC	127	130	PF00017	0.534
LIG_SH2_SRC	806	809	PF00017	0.545
LIG_SH2_STAP1	195	199	PF00017	0.487
LIG_SH2_STAP1	245	249	PF00017	0.648
LIG_SH2_STAP1	334	338	PF00017	0.456
LIG_SH2_STAP1	483	487	PF00017	0.588
LIG_SH2_STAP1	510	514	PF00017	0.614
LIG_SH2_STAP1	691	695	PF00017	0.631
LIG_SH2_STAT3	691	694	PF00017	0.545
LIG_SH2_STAT5	245	248	PF00017	0.624
LIG_SH2_STAT5	612	615	PF00017	0.599
LIG_SH2_STAT5	792	795	PF00017	0.492
LIG_SH2_STAT5	806	809	PF00017	0.377
LIG_SH2_STAT5	823	826	PF00017	0.316
LIG_SH2_STAT5	980	983	PF00017	0.463
LIG_SH3_3	1000	1006	PF00018	0.567
LIG_SH3_3	136	142	PF00018	0.487
LIG_SH3_3	212	218	PF00018	0.582
LIG_SH3_3	406	412	PF00018	0.483
LIG_SH3_3	44	50	PF00018	0.653
LIG_SH3_3	524	530	PF00018	0.635
LIG_SUMO_SIM_anti_2	104	112	PF11976	0.647
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.334
LIG_SUMO_SIM_anti_2	273	280	PF11976	0.606
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.566
LIG_SUMO_SIM_anti_2	676	683	PF11976	0.415
LIG_SUMO_SIM_anti_2	972	978	PF11976	0.521
LIG_SUMO_SIM_par_1	104	112	PF11976	0.661
LIG_SUMO_SIM_par_1	273	280	PF11976	0.445
LIG_SUMO_SIM_par_1	309	316	PF11976	0.581
LIG_SUMO_SIM_par_1	676	683	PF11976	0.367
LIG_SUMO_SIM_par_1	917	924	PF11976	0.512
LIG_TRAF2_1	313	316	PF00917	0.524
LIG_TRAF2_1	765	768	PF00917	0.545
LIG_TYR_ITIM	193	198	PF00017	0.484
LIG_TYR_ITIM	422	427	PF00017	0.556
LIG_TYR_ITIM	473	478	PF00017	0.601
LIG_TYR_ITIM	978	983	PF00017	0.469
LIG_UBA3_1	368	373	PF00899	0.575
LIG_UBA3_1	581	588	PF00899	0.468
LIG_UBA3_1	807	816	PF00899	0.417
LIG_WRC_WIRS_1	750	755	PF05994	0.486
LIG_WRC_WIRS_1	944	949	PF05994	0.648
MOD_CDC14_SPxK_1	408	411	PF00782	0.574
MOD_CDC14_SPxK_1	5	8	PF00782	0.747
MOD_CDK_SPxK_1	2	8	PF00069	0.742
MOD_CDK_SPxK_1	405	411	PF00069	0.547
MOD_CDK_SPxxK_3	2	9	PF00069	0.544
MOD_CK1_1	107	113	PF00069	0.628
MOD_CK1_1	132	138	PF00069	0.513
MOD_CK1_1	238	244	PF00069	0.715
MOD_CK1_1	270	276	PF00069	0.550
MOD_CK1_1	302	308	PF00069	0.377
MOD_CK1_1	384	390	PF00069	0.472
MOD_CK1_1	39	45	PF00069	0.634
MOD_CK1_1	429	435	PF00069	0.525
MOD_CK1_1	468	474	PF00069	0.648
MOD_CK1_1	567	573	PF00069	0.496
MOD_CK1_1	634	640	PF00069	0.575
MOD_CK1_1	66	72	PF00069	0.539
MOD_CK1_1	673	679	PF00069	0.483
MOD_CK1_1	683	689	PF00069	0.588
MOD_CK1_1	725	731	PF00069	0.526
MOD_CK1_1	737	743	PF00069	0.568
MOD_CK1_1	835	841	PF00069	0.495
MOD_CK1_1	865	871	PF00069	0.508
MOD_CK1_1	896	902	PF00069	0.461
MOD_CK1_1	914	920	PF00069	0.371
MOD_CK1_1	942	948	PF00069	0.552
MOD_CK1_1	951	957	PF00069	0.464
MOD_CK1_1	97	103	PF00069	0.594
MOD_CK2_1	145	151	PF00069	0.541
MOD_CK2_1	248	254	PF00069	0.597
MOD_CK2_1	292	298	PF00069	0.476
MOD_CK2_1	503	509	PF00069	0.678
MOD_CK2_1	70	76	PF00069	0.377
MOD_CK2_1	703	709	PF00069	0.611
MOD_CK2_1	762	768	PF00069	0.573
MOD_CK2_1	921	927	PF00069	0.482
MOD_GlcNHglycan	131	134	PF01048	0.407
MOD_GlcNHglycan	237	240	PF01048	0.681
MOD_GlcNHglycan	264	267	PF01048	0.672
MOD_GlcNHglycan	467	470	PF01048	0.562
MOD_GlcNHglycan	493	496	PF01048	0.641
MOD_GlcNHglycan	511	514	PF01048	0.378
MOD_GlcNHglycan	575	578	PF01048	0.431
MOD_GlcNHglycan	672	675	PF01048	0.531
MOD_GlcNHglycan	727	730	PF01048	0.567
MOD_GlcNHglycan	764	767	PF01048	0.514
MOD_GlcNHglycan	834	837	PF01048	0.497
MOD_GlcNHglycan	904	907	PF01048	0.524
MOD_GlcNHglycan	913	916	PF01048	0.432
MOD_GlcNHglycan	948	951	PF01048	0.570
MOD_GlcNHglycan	96	99	PF01048	0.656
MOD_GSK3_1	267	274	PF00069	0.577
MOD_GSK3_1	302	309	PF00069	0.491
MOD_GSK3_1	37	44	PF00069	0.546
MOD_GSK3_1	377	384	PF00069	0.495
MOD_GSK3_1	407	414	PF00069	0.496
MOD_GSK3_1	446	453	PF00069	0.536
MOD_GSK3_1	499	506	PF00069	0.625
MOD_GSK3_1	521	528	PF00069	0.603
MOD_GSK3_1	544	551	PF00069	0.664
MOD_GSK3_1	606	613	PF00069	0.583
MOD_GSK3_1	66	73	PF00069	0.590
MOD_GSK3_1	694	701	PF00069	0.529
MOD_GSK3_1	762	769	PF00069	0.454
MOD_GSK3_1	788	795	PF00069	0.490
MOD_GSK3_1	821	828	PF00069	0.509
MOD_GSK3_1	835	842	PF00069	0.450
MOD_GSK3_1	84	91	PF00069	0.340
MOD_GSK3_1	846	853	PF00069	0.522
MOD_GSK3_1	867	874	PF00069	0.462
MOD_GSK3_1	911	918	PF00069	0.466
MOD_GSK3_1	921	928	PF00069	0.410
MOD_GSK3_1	934	941	PF00069	0.431
MOD_GSK3_1	942	949	PF00069	0.573
MOD_N-GLC_1	374	379	PF02516	0.625
MOD_N-GLC_1	88	93	PF02516	0.504
MOD_N-GLC_1	915	920	PF02516	0.461
MOD_N-GLC_1	938	943	PF02516	0.559
MOD_NEK2_1	12	17	PF00069	0.675
MOD_NEK2_1	154	159	PF00069	0.568
MOD_NEK2_1	165	170	PF00069	0.533
MOD_NEK2_1	199	204	PF00069	0.486
MOD_NEK2_1	248	253	PF00069	0.562
MOD_NEK2_1	271	276	PF00069	0.533
MOD_NEK2_1	381	386	PF00069	0.505
MOD_NEK2_1	503	508	PF00069	0.663
MOD_NEK2_1	521	526	PF00069	0.461
MOD_NEK2_1	544	549	PF00069	0.594
MOD_NEK2_1	589	594	PF00069	0.563
MOD_NEK2_1	614	619	PF00069	0.590
MOD_NEK2_1	628	633	PF00069	0.423
MOD_NEK2_1	644	649	PF00069	0.373
MOD_NEK2_1	703	708	PF00069	0.608
MOD_NEK2_1	734	739	PF00069	0.523
MOD_NEK2_1	744	749	PF00069	0.572
MOD_NEK2_1	788	793	PF00069	0.483
MOD_NEK2_1	859	864	PF00069	0.458
MOD_NEK2_1	871	876	PF00069	0.490
MOD_NEK2_1	948	953	PF00069	0.629
MOD_NEK2_2	299	304	PF00069	0.468
MOD_NEK2_2	499	504	PF00069	0.463
MOD_NEK2_2	952	957	PF00069	0.616
MOD_OFUCOSY	520	525	PF10250	0.633
MOD_PIKK_1	683	689	PF00454	0.594
MOD_PIKK_1	70	76	PF00454	0.610
MOD_PIKK_1	853	859	PF00454	0.494
MOD_PK_1	893	899	PF00069	0.580
MOD_PKA_1	504	510	PF00069	0.594
MOD_PKA_2	243	249	PF00069	0.637
MOD_PKA_2	267	273	PF00069	0.631
MOD_PKA_2	332	338	PF00069	0.484
MOD_PKA_2	504	510	PF00069	0.601
MOD_PKA_2	567	573	PF00069	0.481
MOD_PKA_2	614	620	PF00069	0.618
MOD_PKA_2	703	709	PF00069	0.533
MOD_PKA_2	762	768	PF00069	0.514
MOD_PKA_2	859	865	PF00069	0.560
MOD_Plk_1	377	383	PF00069	0.567
MOD_Plk_1	499	505	PF00069	0.468
MOD_Plk_1	689	695	PF00069	0.598
MOD_Plk_1	720	726	PF00069	0.637
MOD_Plk_1	838	844	PF00069	0.518
MOD_Plk_1	88	94	PF00069	0.514
MOD_Plk_1	915	921	PF00069	0.534
MOD_Plk_2-3	921	927	PF00069	0.482
MOD_Plk_4	104	110	PF00069	0.597
MOD_Plk_4	122	128	PF00069	0.517
MOD_Plk_4	132	138	PF00069	0.478
MOD_Plk_4	272	278	PF00069	0.536
MOD_Plk_4	299	305	PF00069	0.441
MOD_Plk_4	306	312	PF00069	0.454
MOD_Plk_4	377	383	PF00069	0.543
MOD_Plk_4	41	47	PF00069	0.580
MOD_Plk_4	468	474	PF00069	0.643
MOD_Plk_4	727	733	PF00069	0.514
MOD_Plk_4	749	755	PF00069	0.487
MOD_Plk_4	788	794	PF00069	0.565
MOD_Plk_4	821	827	PF00069	0.433
MOD_Plk_4	846	852	PF00069	0.493
MOD_Plk_4	88	94	PF00069	0.531
MOD_Plk_4	893	899	PF00069	0.512
MOD_Plk_4	943	949	PF00069	0.611
MOD_Plk_4	972	978	PF00069	0.472
MOD_ProDKin_1	2	8	PF00069	0.742
MOD_ProDKin_1	405	411	PF00069	0.506
MOD_ProDKin_1	446	452	PF00069	0.512
MOD_ProDKin_1	615	621	PF00069	0.572
MOD_ProDKin_1	651	657	PF00069	0.474
MOD_ProDKin_1	694	700	PF00069	0.653
MOD_ProDKin_1	934	940	PF00069	0.591
MOD_ProDKin_1	984	990	PF00069	0.424
MOD_ProDKin_1	992	998	PF00069	0.429
MOD_SUMO_for_1	161	164	PF00179	0.488
MOD_SUMO_rev_2	251	258	PF00179	0.580
MOD_SUMO_rev_2	765	772	PF00179	0.562
MOD_SUMO_rev_2	883	888	PF00179	0.471
MOD_SUMO_rev_2	927	934	PF00179	0.521
TRG_DiLeu_BaEn_1	104	109	PF01217	0.522
TRG_DiLeu_BaEn_1	151	156	PF01217	0.612
TRG_DiLeu_BaEn_1	972	977	PF01217	0.529
TRG_DiLeu_BaEn_2	228	234	PF01217	0.608
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.589
TRG_DiLeu_BaLyEn_6	664	669	PF01217	0.615
TRG_ENDOCYTIC_2	195	198	PF00928	0.486
TRG_ENDOCYTIC_2	245	248	PF00928	0.650
TRG_ENDOCYTIC_2	288	291	PF00928	0.513
TRG_ENDOCYTIC_2	334	337	PF00928	0.529
TRG_ENDOCYTIC_2	424	427	PF00928	0.541
TRG_ENDOCYTIC_2	475	478	PF00928	0.635
TRG_ENDOCYTIC_2	806	809	PF00928	0.463
TRG_ENDOCYTIC_2	823	826	PF00928	0.266
TRG_ENDOCYTIC_2	980	983	PF00928	0.463
TRG_ER_diArg_1	614	616	PF00400	0.624
TRG_ER_diArg_1	645	648	PF00400	0.566
TRG_ER_diArg_1	8	10	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	648	653	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY6	Leptomonas seymouri	54%	100%
A0A1X0NXF3	Trypanosomatidae	25%	88%
A0A3S7WWC6	Leishmania donovani	91%	100%
A4HZ14	Leishmania infantum	91%	100%
C9ZIL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	85%
E9AIM8	Leishmania braziliensis	76%	100%
E9AUW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%