DUF1279 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCM0_LEIMA

TriTrypDb:

LmjF.20.1610 , LMJLV39_200024200 , LMJSD75_200024400

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QCM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.670
CLV_NRD_NRD_1	242	244	PF00675	0.535
CLV_NRD_NRD_1	249	251	PF00675	0.549
CLV_NRD_NRD_1	56	58	PF00675	0.501
CLV_PCSK_KEX2_1	236	238	PF00082	0.460
CLV_PCSK_KEX2_1	249	251	PF00082	0.463
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.460
CLV_PCSK_SKI1_1	236	240	PF00082	0.456
DEG_Nend_UBRbox_3	1	3	PF02207	0.425
DOC_ANK_TNKS_1	127	134	PF00023	0.506
DOC_CYCLIN_RxL_1	231	240	PF00134	0.464
DOC_CYCLIN_yClb5_NLxxxL_5	172	181	PF00134	0.557
DOC_MAPK_HePTP_8	162	174	PF00069	0.396
DOC_MAPK_MEF2A_6	165	174	PF00069	0.500
DOC_MIT_MIM_1	233	241	PF04212	0.422
DOC_PP4_FxxP_1	216	219	PF00568	0.580
DOC_USP7_UBL2_3	125	129	PF12436	0.631
DOC_USP7_UBL2_3	58	62	PF12436	0.460
DOC_WW_Pin1_4	110	115	PF00397	0.506
LIG_14-3-3_CanoR_1	154	160	PF00244	0.551
LIG_14-3-3_CanoR_1	193	198	PF00244	0.546
LIG_14-3-3_CanoR_1	77	85	PF00244	0.430
LIG_DLG_GKlike_1	193	201	PF00625	0.564
LIG_FHA_1	121	127	PF00498	0.478
LIG_FHA_1	134	140	PF00498	0.506
LIG_FHA_1	150	156	PF00498	0.507
LIG_FHA_1	196	202	PF00498	0.580
LIG_FHA_1	233	239	PF00498	0.545
LIG_LIR_Apic_2	215	219	PF02991	0.535
LIG_LIR_Gen_1	10	20	PF02991	0.418
LIG_LIR_Gen_1	22	31	PF02991	0.451
LIG_LIR_Nem_3	10	15	PF02991	0.422
LIG_LIR_Nem_3	22	28	PF02991	0.553
LIG_PCNA_yPIPBox_3	165	178	PF02747	0.405
LIG_Pex14_2	8	12	PF04695	0.424
LIG_PTB_Apo_2	101	108	PF02174	0.560
LIG_PTB_Phospho_1	101	107	PF10480	0.566
LIG_RPA_C_Fungi	238	250	PF08784	0.436
LIG_SH2_CRK	64	68	PF00017	0.510
LIG_SH2_STAP1	191	195	PF00017	0.472
LIG_SH2_STAT5	107	110	PF00017	0.518
LIG_SH2_STAT5	23	26	PF00017	0.681
LIG_SH2_STAT5	37	40	PF00017	0.551
LIG_SH2_STAT5	59	62	PF00017	0.442
LIG_SH3_3	163	169	PF00018	0.511
LIG_UBA3_1	140	148	PF00899	0.561
LIG_UBA3_1	167	173	PF00899	0.524
LIG_UBA3_1	238	244	PF00899	0.547
MOD_CDK_SPxxK_3	110	117	PF00069	0.556
MOD_CK1_1	149	155	PF00069	0.513
MOD_CK1_1	39	45	PF00069	0.440
MOD_CK1_1	52	58	PF00069	0.405
MOD_CK1_1	96	102	PF00069	0.634
MOD_CK2_1	155	161	PF00069	0.553
MOD_Cter_Amidation	55	58	PF01082	0.506
MOD_GlcNHglycan	38	41	PF01048	0.450
MOD_GlcNHglycan	54	57	PF01048	0.501
MOD_GlcNHglycan	97	101	PF01048	0.635
MOD_GSK3_1	106	113	PF00069	0.409
MOD_GSK3_1	116	123	PF00069	0.385
MOD_GSK3_1	142	149	PF00069	0.500
MOD_GSK3_1	15	22	PF00069	0.411
MOD_GSK3_1	89	96	PF00069	0.583
MOD_N-GLC_1	193	198	PF02516	0.544
MOD_NEK2_1	15	20	PF00069	0.399
MOD_NEK2_1	7	12	PF00069	0.425
MOD_NEK2_1	88	93	PF00069	0.421
MOD_PIKK_1	120	126	PF00454	0.537
MOD_PIKK_1	133	139	PF00454	0.513
MOD_PIKK_1	41	47	PF00454	0.541
MOD_PKA_1	243	249	PF00069	0.587
MOD_PKA_2	248	254	PF00069	0.657
MOD_PKA_2	76	82	PF00069	0.582
MOD_Plk_1	193	199	PF00069	0.684
MOD_Plk_1	2	8	PF00069	0.477
MOD_Plk_4	155	161	PF00069	0.414
MOD_Plk_4	19	25	PF00069	0.408
MOD_Plk_4	2	8	PF00069	0.423
MOD_ProDKin_1	110	116	PF00069	0.505
MOD_SUMO_rev_2	145	149	PF00179	0.535
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.425
TRG_ENDOCYTIC_2	107	110	PF00928	0.470
TRG_ENDOCYTIC_2	23	26	PF00928	0.580
TRG_ENDOCYTIC_2	64	67	PF00928	0.487
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT0	Leptomonas seymouri	39%	100%
A0A3Q8IEZ9	Leishmania donovani	81%	100%
A4HZ15	Leishmania infantum	80%	100%
C9ZIL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AUW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
V5D8U8	Trypanosoma cruzi	27%	91%