CHORD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CHORD, putative

Species:

Leishmania major

UniProt:

Q4QCL9_LEIMA

TriTrypDb:

LmjF.20.1620 , LMJLV39_200024300 , LMJSD75_200024500

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCL9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0022402	cell cycle process	2	2
GO:0051298	centrosome duplication	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.435
CLV_C14_Caspase3-7	226	230	PF00656	0.353
CLV_PCSK_KEX2_1	206	208	PF00082	0.569
CLV_PCSK_KEX2_1	53	55	PF00082	0.454
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.534
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.454
CLV_PCSK_SKI1_1	10	14	PF00082	0.449
CLV_PCSK_SKI1_1	149	153	PF00082	0.217
CLV_PCSK_SKI1_1	41	45	PF00082	0.355
CLV_PCSK_SKI1_1	48	52	PF00082	0.376
DEG_Nend_UBRbox_1	1	4	PF02207	0.338
DOC_CYCLIN_RxL_1	35	49	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.465
DOC_MAPK_FxFP_2	175	178	PF00069	0.558
DOC_MAPK_gen_1	48	58	PF00069	0.453
DOC_MAPK_MEF2A_6	179	187	PF00069	0.529
DOC_PP1_RVXF_1	274	281	PF00149	0.515
DOC_PP1_RVXF_1	39	46	PF00149	0.393
DOC_PP2B_LxvP_1	183	186	PF13499	0.524
DOC_PP4_FxxP_1	175	178	PF00568	0.514
DOC_USP7_MATH_1	193	197	PF00917	0.538
DOC_USP7_UBL2_3	93	97	PF12436	0.449
LIG_14-3-3_CanoR_1	167	176	PF00244	0.550
LIG_14-3-3_CanoR_1	41	46	PF00244	0.328
LIG_Actin_WH2_2	91	109	PF00022	0.490
LIG_APCC_ABBAyCdc20_2	132	138	PF00400	0.473
LIG_deltaCOP1_diTrp_1	153	157	PF00928	0.413
LIG_FHA_1	42	48	PF00498	0.328
LIG_LIR_Gen_1	153	161	PF02991	0.411
LIG_LIR_Gen_1	279	287	PF02991	0.413
LIG_LIR_Gen_1	83	91	PF02991	0.316
LIG_LIR_Nem_3	153	157	PF02991	0.435
LIG_LIR_Nem_3	279	283	PF02991	0.413
LIG_LIR_Nem_3	83	88	PF02991	0.326
LIG_REV1ctd_RIR_1	43	52	PF16727	0.399
LIG_SH2_STAT5	4	7	PF00017	0.302
LIG_SH3_3	281	287	PF00018	0.413
LIG_SUMO_SIM_anti_2	87	92	PF11976	0.423
LIG_TRAF2_1	178	181	PF00917	0.583
LIG_UBA3_1	90	97	PF00899	0.376
LIG_WRC_WIRS_1	42	47	PF05994	0.361
MOD_CK1_1	196	202	PF00069	0.601
MOD_CK1_1	77	83	PF00069	0.371
MOD_CK2_1	30	36	PF00069	0.454
MOD_Cter_Amidation	147	150	PF01082	0.235
MOD_Cter_Amidation	204	207	PF01082	0.654
MOD_GlcNHglycan	187	190	PF01048	0.491
MOD_GlcNHglycan	195	198	PF01048	0.553
MOD_GlcNHglycan	199	202	PF01048	0.557
MOD_GlcNHglycan	67	70	PF01048	0.378
MOD_GSK3_1	193	200	PF00069	0.589
MOD_N-GLC_2	125	127	PF02516	0.235
MOD_NEK2_1	106	111	PF00069	0.321
MOD_NEK2_1	187	192	PF00069	0.504
MOD_NEK2_1	20	25	PF00069	0.487
MOD_NEK2_1	219	224	PF00069	0.453
MOD_NEK2_1	262	267	PF00069	0.413
MOD_NEK2_1	46	51	PF00069	0.300
MOD_NEK2_1	65	70	PF00069	0.231
MOD_NEK2_1	74	79	PF00069	0.324
MOD_PIKK_1	187	193	PF00454	0.572
MOD_PIKK_1	219	225	PF00454	0.389
MOD_PKA_1	206	212	PF00069	0.626
MOD_PKA_2	166	172	PF00069	0.576
MOD_PKA_2	206	212	PF00069	0.512
MOD_PKA_2	74	80	PF00069	0.329
MOD_Plk_2-3	153	159	PF00069	0.471
MOD_Plk_4	41	47	PF00069	0.354
MOD_SUMO_for_1	12	15	PF00179	0.530
MOD_SUMO_for_1	178	181	PF00179	0.532
MOD_SUMO_rev_2	199	208	PF00179	0.530
MOD_SUMO_rev_2	226	232	PF00179	0.386
MOD_SUMO_rev_2	99	109	PF00179	0.403
TRG_DiLeu_BaEn_2	278	284	PF01217	0.424
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.444
TRG_ENDOCYTIC_2	85	88	PF00928	0.313
TRG_ER_diArg_1	72	75	PF00400	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I9	Leptomonas seymouri	68%	100%
A0A0S4J9B3	Bodo saltans	50%	98%
A0A1X0NW45	Trypanosomatidae	49%	97%
A0A3Q8IAQ6	Leishmania donovani	92%	100%
A0A3R7MVQ5	Trypanosoma rangeli	54%	99%
A4HZ16	Leishmania infantum	92%	100%
A9YUB1	Sus scrofa	27%	89%
C9ZIN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
D4A4T9	Rattus norvegicus	27%	89%
E9AIN0	Leishmania braziliensis	75%	100%
E9AUW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
G5EEI8	Caenorhabditis elegans	30%	92%
Q29RL2	Bos taurus	27%	89%
Q462R2	Sus scrofa	28%	86%
Q4R7U2	Macaca fascicularis	27%	89%
Q5RD91	Pongo abelii	28%	89%
Q5ZML4	Gallus gallus	26%	89%
Q6EPW7	Oryza sativa subsp. japonica	31%	100%
Q6NUA0	Xenopus laevis	29%	89%
Q7T3F7	Danio rerio	29%	87%
Q9D1P4	Mus musculus	27%	89%
Q9R000	Mus musculus	30%	85%
Q9SE33	Arabidopsis thaliana	30%	100%
Q9UHD1	Homo sapiens	27%	89%
Q9UKP3	Homo sapiens	28%	85%
Q9VCC0	Drosophila melanogaster	28%	84%
V5D8W5	Trypanosoma cruzi	52%	86%