LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase 2
Gene product:
phosphoglycan beta 1,3 galactosyltransferase 2
Species:
Leishmania major
UniProt:
Q4QCL8_LEIMA
TriTrypDb:
LmjF.21.0010 , LMJLV39_310043200 , LMJSD75_020006900
Length:
814

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 15
GO:0016020 membrane 2 53
GO:0031090 organelle membrane 3 15
GO:0098588 bounding membrane of organelle 4 15
GO:0110165 cellular anatomical entity 1 53

Expansion

Sequence features

Q4QCL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCL8

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 53
GO:0006807 nitrogen compound metabolic process 2 53
GO:0008152 metabolic process 1 53
GO:0019538 protein metabolic process 3 53
GO:0036211 protein modification process 4 53
GO:0043170 macromolecule metabolic process 3 53
GO:0043412 macromolecule modification 4 53
GO:0043413 macromolecule glycosylation 3 53
GO:0044238 primary metabolic process 2 53
GO:0070085 glycosylation 2 53
GO:0071704 organic substance metabolic process 2 53
GO:1901564 organonitrogen compound metabolic process 3 53
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 53
GO:0008194 UDP-glycosyltransferase activity 4 15
GO:0016740 transferase activity 2 53
GO:0016757 glycosyltransferase activity 3 53
GO:0016758 hexosyltransferase activity 4 53

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 107 109 PF00675 0.422
CLV_NRD_NRD_1 284 286 PF00675 0.600
CLV_NRD_NRD_1 490 492 PF00675 0.644
CLV_NRD_NRD_1 611 613 PF00675 0.551
CLV_NRD_NRD_1 682 684 PF00675 0.512
CLV_NRD_NRD_1 801 803 PF00675 0.553
CLV_NRD_NRD_1 93 95 PF00675 0.450
CLV_PCSK_FUR_1 105 109 PF00082 0.379
CLV_PCSK_KEX2_1 107 109 PF00082 0.431
CLV_PCSK_KEX2_1 284 286 PF00082 0.592
CLV_PCSK_KEX2_1 611 613 PF00082 0.541
CLV_PCSK_KEX2_1 64 66 PF00082 0.471
CLV_PCSK_KEX2_1 674 676 PF00082 0.597
CLV_PCSK_KEX2_1 682 684 PF00082 0.531
CLV_PCSK_KEX2_1 730 732 PF00082 0.542
CLV_PCSK_KEX2_1 800 802 PF00082 0.548
CLV_PCSK_KEX2_1 93 95 PF00082 0.450
CLV_PCSK_PC1ET2_1 64 66 PF00082 0.467
CLV_PCSK_PC1ET2_1 674 676 PF00082 0.548
CLV_PCSK_PC1ET2_1 730 732 PF00082 0.542
CLV_PCSK_PC7_1 796 802 PF00082 0.500
CLV_PCSK_SKI1_1 401 405 PF00082 0.576
CLV_PCSK_SKI1_1 516 520 PF00082 0.579
CLV_PCSK_SKI1_1 563 567 PF00082 0.546
CLV_PCSK_SKI1_1 630 634 PF00082 0.515
CLV_PCSK_SKI1_1 693 697 PF00082 0.497
CLV_Separin_Metazoa 269 273 PF03568 0.330
DEG_Kelch_Keap1_1 292 297 PF01344 0.410
DEG_Nend_UBRbox_1 1 4 PF02207 0.670
DEG_SCF_FBW7_1 452 459 PF00400 0.462
DEG_SPOP_SBC_1 438 442 PF00917 0.337
DOC_CKS1_1 453 458 PF01111 0.466
DOC_CYCLIN_yCln2_LP_2 24 27 PF00134 0.634
DOC_CYCLIN_yCln2_LP_2 249 255 PF00134 0.336
DOC_CYCLIN_yCln2_LP_2 450 456 PF00134 0.509
DOC_CYCLIN_yCln2_LP_2 632 638 PF00134 0.328
DOC_MAPK_DCC_7 14 24 PF00069 0.663
DOC_MAPK_DCC_7 572 581 PF00069 0.341
DOC_MAPK_gen_1 105 114 PF00069 0.538
DOC_MAPK_gen_1 298 307 PF00069 0.367
DOC_MAPK_gen_1 496 503 PF00069 0.348
DOC_MAPK_gen_1 561 569 PF00069 0.294
DOC_MAPK_gen_1 639 647 PF00069 0.283
DOC_MAPK_gen_1 693 702 PF00069 0.272
DOC_MAPK_JIP1_4 298 304 PF00069 0.346
DOC_MAPK_JIP1_4 561 567 PF00069 0.302
DOC_MAPK_MEF2A_6 107 116 PF00069 0.569
DOC_MAPK_MEF2A_6 298 307 PF00069 0.316
DOC_MAPK_MEF2A_6 480 487 PF00069 0.423
DOC_MAPK_MEF2A_6 536 545 PF00069 0.294
DOC_MAPK_MEF2A_6 561 569 PF00069 0.310
DOC_MAPK_MEF2A_6 572 581 PF00069 0.330
DOC_MAPK_MEF2A_6 642 649 PF00069 0.295
DOC_MAPK_NFAT4_5 300 308 PF00069 0.268
DOC_MAPK_NFAT4_5 480 488 PF00069 0.333
DOC_MAPK_NFAT4_5 642 650 PF00069 0.287
DOC_PP1_RVXF_1 514 521 PF00149 0.418
DOC_PP1_RVXF_1 588 594 PF00149 0.304
DOC_PP1_RVXF_1 694 700 PF00149 0.309
DOC_PP2B_LxvP_1 24 27 PF13499 0.634
DOC_PP2B_LxvP_1 305 308 PF13499 0.266
DOC_PP2B_LxvP_1 450 453 PF13499 0.514
DOC_PP2B_LxvP_1 543 546 PF13499 0.303
DOC_USP7_MATH_1 222 226 PF00917 0.466
DOC_USP7_MATH_1 241 245 PF00917 0.488
DOC_USP7_MATH_1 256 260 PF00917 0.348
DOC_USP7_MATH_1 37 41 PF00917 0.701
DOC_USP7_MATH_1 371 375 PF00917 0.394
DOC_USP7_MATH_1 438 442 PF00917 0.382
DOC_USP7_MATH_1 92 96 PF00917 0.640
DOC_USP7_UBL2_3 492 496 PF12436 0.352
DOC_USP7_UBL2_3 654 658 PF12436 0.264
DOC_USP7_UBL2_3 720 724 PF12436 0.316
DOC_WW_Pin1_4 152 157 PF00397 0.459
DOC_WW_Pin1_4 418 423 PF00397 0.462
DOC_WW_Pin1_4 452 457 PF00397 0.440
DOC_WW_Pin1_4 80 85 PF00397 0.639
LIG_14-3-3_CanoR_1 169 177 PF00244 0.425
LIG_14-3-3_CanoR_1 323 327 PF00244 0.445
LIG_14-3-3_CanoR_1 427 431 PF00244 0.392
LIG_14-3-3_CanoR_1 480 484 PF00244 0.305
LIG_14-3-3_CanoR_1 563 568 PF00244 0.367
LIG_14-3-3_CanoR_1 779 785 PF00244 0.343
LIG_14-3-3_CanoR_1 93 100 PF00244 0.665
LIG_Actin_WH2_2 538 555 PF00022 0.273
LIG_APCC_ABBA_1 618 623 PF00400 0.279
LIG_BRCT_BRCA1_1 153 157 PF00533 0.424
LIG_EH_1 618 622 PF12763 0.332
LIG_FHA_1 128 134 PF00498 0.445
LIG_FHA_1 14 20 PF00498 0.702
LIG_FHA_1 195 201 PF00498 0.520
LIG_FHA_1 259 265 PF00498 0.466
LIG_FHA_1 338 344 PF00498 0.341
LIG_FHA_1 364 370 PF00498 0.369
LIG_FHA_1 426 432 PF00498 0.361
LIG_FHA_1 438 444 PF00498 0.402
LIG_FHA_1 564 570 PF00498 0.340
LIG_FHA_1 576 582 PF00498 0.369
LIG_FHA_1 65 71 PF00498 0.666
LIG_FHA_2 326 332 PF00498 0.394
LIG_FHA_2 370 376 PF00498 0.484
LIG_FHA_2 739 745 PF00498 0.301
LIG_FHA_2 781 787 PF00498 0.337
LIG_IBAR_NPY_1 634 636 PF08397 0.303
LIG_Integrin_RGD_1 775 777 PF01839 0.579
LIG_LIR_Apic_2 416 422 PF02991 0.334
LIG_LIR_Apic_2 504 508 PF02991 0.415
LIG_LIR_Gen_1 154 161 PF02991 0.496
LIG_LIR_Gen_1 206 217 PF02991 0.396
LIG_LIR_Gen_1 482 488 PF02991 0.368
LIG_LIR_Gen_1 539 549 PF02991 0.345
LIG_LIR_Gen_1 622 632 PF02991 0.285
LIG_LIR_Gen_1 641 649 PF02991 0.369
LIG_LIR_Gen_1 698 706 PF02991 0.346
LIG_LIR_Nem_3 154 160 PF02991 0.498
LIG_LIR_Nem_3 206 212 PF02991 0.403
LIG_LIR_Nem_3 325 329 PF02991 0.448
LIG_LIR_Nem_3 406 411 PF02991 0.356
LIG_LIR_Nem_3 482 487 PF02991 0.333
LIG_LIR_Nem_3 517 523 PF02991 0.365
LIG_LIR_Nem_3 526 531 PF02991 0.392
LIG_LIR_Nem_3 539 545 PF02991 0.310
LIG_LIR_Nem_3 622 627 PF02991 0.298
LIG_LIR_Nem_3 641 647 PF02991 0.391
LIG_LIR_Nem_3 698 702 PF02991 0.349
LIG_NRBOX 111 117 PF00104 0.299
LIG_NRBOX 627 633 PF00104 0.333
LIG_NRP_CendR_1 813 814 PF00754 0.576
LIG_PCNA_yPIPBox_3 625 639 PF02747 0.286
LIG_Pex14_2 769 773 PF04695 0.272
LIG_PTB_Apo_2 208 215 PF02174 0.408
LIG_PTB_Phospho_1 208 214 PF10480 0.406
LIG_RPA_C_Fungi 678 690 PF08784 0.301
LIG_SH2_NCK_1 376 380 PF00017 0.484
LIG_SH2_NCK_1 782 786 PF00017 0.400
LIG_SH2_STAP1 214 218 PF00017 0.522
LIG_SH2_STAP1 358 362 PF00017 0.388
LIG_SH2_STAP1 523 527 PF00017 0.534
LIG_SH2_STAP1 636 640 PF00017 0.412
LIG_SH2_STAP1 793 797 PF00017 0.433
LIG_SH2_STAT3 280 283 PF00017 0.425
LIG_SH2_STAT3 358 361 PF00017 0.394
LIG_SH2_STAT5 347 350 PF00017 0.482
LIG_SH2_STAT5 358 361 PF00017 0.501
LIG_SH2_STAT5 362 365 PF00017 0.431
LIG_SH2_STAT5 397 400 PF00017 0.410
LIG_SH2_STAT5 464 467 PF00017 0.357
LIG_SH2_STAT5 525 528 PF00017 0.403
LIG_SH2_STAT5 533 536 PF00017 0.368
LIG_SH2_STAT5 542 545 PF00017 0.381
LIG_SH2_STAT5 548 551 PF00017 0.378
LIG_SH2_STAT5 607 610 PF00017 0.292
LIG_SH2_STAT5 644 647 PF00017 0.412
LIG_SH2_STAT5 714 717 PF00017 0.513
LIG_SH2_STAT5 782 785 PF00017 0.446
LIG_SH3_3 450 456 PF00018 0.596
LIG_SH3_3 526 532 PF00018 0.445
LIG_SH3_3 564 570 PF00018 0.435
LIG_SH3_3 571 577 PF00018 0.446
LIG_SH3_4 492 499 PF00018 0.409
LIG_SUMO_SIM_anti_2 139 146 PF11976 0.534
LIG_SUMO_SIM_anti_2 698 704 PF11976 0.282
LIG_SUMO_SIM_par_1 577 583 PF11976 0.356
LIG_TRAF2_1 741 744 PF00917 0.376
LIG_TYR_ITIM 327 332 PF00017 0.514
MOD_CK1_1 127 133 PF00069 0.495
MOD_CK1_1 155 161 PF00069 0.555
MOD_CK1_1 292 298 PF00069 0.546
MOD_CK1_1 356 362 PF00069 0.554
MOD_CK1_1 441 447 PF00069 0.411
MOD_CK1_1 514 520 PF00069 0.263
MOD_CK1_1 66 72 PF00069 0.610
MOD_CK2_1 136 142 PF00069 0.546
MOD_CK2_1 162 168 PF00069 0.501
MOD_CK2_1 291 297 PF00069 0.516
MOD_CK2_1 325 331 PF00069 0.467
MOD_CK2_1 33 39 PF00069 0.585
MOD_CK2_1 369 375 PF00069 0.620
MOD_CK2_1 738 744 PF00069 0.397
MOD_CK2_1 780 786 PF00069 0.369
MOD_CMANNOS 275 278 PF00535 0.306
MOD_Cter_Amidation 62 65 PF01082 0.571
MOD_GlcNHglycan 164 167 PF01048 0.487
MOD_GlcNHglycan 179 182 PF01048 0.532
MOD_GlcNHglycan 215 218 PF01048 0.579
MOD_GlcNHglycan 243 246 PF01048 0.601
MOD_GlcNHglycan 35 38 PF01048 0.633
MOD_GlcNHglycan 39 42 PF01048 0.605
MOD_GlcNHglycan 446 449 PF01048 0.523
MOD_GlcNHglycan 468 471 PF01048 0.502
MOD_GlcNHglycan 60 63 PF01048 0.666
MOD_GlcNHglycan 708 711 PF01048 0.266
MOD_GlcNHglycan 94 97 PF01048 0.522
MOD_GSK3_1 124 131 PF00069 0.451
MOD_GSK3_1 151 158 PF00069 0.591
MOD_GSK3_1 177 184 PF00069 0.565
MOD_GSK3_1 222 229 PF00069 0.615
MOD_GSK3_1 235 242 PF00069 0.484
MOD_GSK3_1 287 294 PF00069 0.550
MOD_GSK3_1 33 40 PF00069 0.638
MOD_GSK3_1 425 432 PF00069 0.495
MOD_GSK3_1 437 444 PF00069 0.456
MOD_GSK3_1 448 455 PF00069 0.494
MOD_GSK3_1 53 60 PF00069 0.636
MOD_GSK3_1 66 73 PF00069 0.597
MOD_GSK3_1 753 760 PF00069 0.397
MOD_N-GLC_1 210 215 PF02516 0.506
MOD_N-GLC_1 226 231 PF02516 0.502
MOD_N-GLC_1 337 342 PF02516 0.384
MOD_N-GLC_1 563 568 PF02516 0.409
MOD_N-GLC_1 744 749 PF02516 0.433
MOD_N-GLC_2 87 89 PF02516 0.520
MOD_NEK2_1 170 175 PF00069 0.569
MOD_NEK2_1 177 182 PF00069 0.499
MOD_NEK2_1 240 245 PF00069 0.544
MOD_NEK2_1 286 291 PF00069 0.472
MOD_NEK2_1 363 368 PF00069 0.396
MOD_NEK2_1 501 506 PF00069 0.438
MOD_NEK2_1 565 570 PF00069 0.416
MOD_NEK2_1 594 599 PF00069 0.351
MOD_NEK2_1 706 711 PF00069 0.272
MOD_NEK2_1 85 90 PF00069 0.567
MOD_NEK2_2 194 199 PF00069 0.670
MOD_PIKK_1 124 130 PF00454 0.436
MOD_PIKK_1 170 176 PF00454 0.493
MOD_PIKK_1 25 31 PF00454 0.564
MOD_PIKK_1 287 293 PF00454 0.561
MOD_PIKK_1 511 517 PF00454 0.525
MOD_PIKK_1 744 750 PF00454 0.411
MOD_PIKK_1 753 759 PF00454 0.375
MOD_PK_1 235 241 PF00069 0.461
MOD_PKA_1 491 497 PF00069 0.571
MOD_PKA_1 64 70 PF00069 0.553
MOD_PKA_2 13 19 PF00069 0.617
MOD_PKA_2 168 174 PF00069 0.502
MOD_PKA_2 223 229 PF00069 0.608
MOD_PKA_2 292 298 PF00069 0.555
MOD_PKA_2 322 328 PF00069 0.547
MOD_PKA_2 353 359 PF00069 0.446
MOD_PKA_2 426 432 PF00069 0.484
MOD_PKA_2 479 485 PF00069 0.424
MOD_PKA_2 57 63 PF00069 0.593
MOD_PKA_2 64 70 PF00069 0.558
MOD_PKA_2 92 98 PF00069 0.542
MOD_Plk_1 203 209 PF00069 0.496
MOD_Plk_1 210 216 PF00069 0.477
MOD_Plk_1 563 569 PF00069 0.339
MOD_Plk_2-3 738 744 PF00069 0.335
MOD_Plk_4 235 241 PF00069 0.487
MOD_Plk_4 322 328 PF00069 0.471
MOD_Plk_4 426 432 PF00069 0.435
MOD_Plk_4 479 485 PF00069 0.363
MOD_Plk_4 514 520 PF00069 0.276
MOD_Plk_4 695 701 PF00069 0.462
MOD_Plk_4 758 764 PF00069 0.369
MOD_ProDKin_1 152 158 PF00069 0.561
MOD_ProDKin_1 418 424 PF00069 0.575
MOD_ProDKin_1 452 458 PF00069 0.530
MOD_ProDKin_1 80 86 PF00069 0.537
MOD_SUMO_rev_2 486 494 PF00179 0.407
MOD_SUMO_rev_2 646 656 PF00179 0.305
MOD_SUMO_rev_2 722 732 PF00179 0.337
TRG_DiLeu_BaEn_1 728 733 PF01217 0.356
TRG_DiLeu_BaLyEn_6 609 614 PF01217 0.390
TRG_DiLeu_LyEn_5 728 733 PF01217 0.354
TRG_ENDOCYTIC_2 329 332 PF00928 0.551
TRG_ENDOCYTIC_2 525 528 PF00928 0.550
TRG_ENDOCYTIC_2 542 545 PF00928 0.264
TRG_ENDOCYTIC_2 644 647 PF00928 0.467
TRG_ER_diArg_1 105 108 PF00400 0.532
TRG_ER_diArg_1 284 286 PF00400 0.470
TRG_ER_diArg_1 611 613 PF00400 0.389
TRG_ER_diArg_1 682 684 PF00400 0.359
TRG_ER_diArg_1 799 802 PF00400 0.406
TRG_ER_diArg_1 92 94 PF00400 0.550
TRG_NLS_MonoExtN_4 493 500 PF00514 0.427
TRG_NLS_MonoExtN_4 672 677 PF00514 0.346
TRG_Pf-PMV_PEXEL_1 199 203 PF00026 0.494
TRG_Pf-PMV_PEXEL_1 611 615 PF00026 0.428
TRG_Pf-PMV_PEXEL_1 731 735 PF00026 0.372

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 82% 100%
A0A3S5H4Y6 Leishmania donovani 40% 100%
A0A3S5H4Y9 Leishmania donovani 32% 82%
A0A3S7WT86 Leishmania donovani 35% 79%
A0A3S7WWA6 Leishmania donovani 82% 100%
A0A451EJD9 Leishmania donovani 73% 100%
A0A451EJF4 Leishmania donovani 41% 100%
A0A451EJF6 Leishmania donovani 41% 100%
A0A451EJF8 Leishmania donovani 37% 100%
A0A451EJF9 Leishmania donovani 41% 94%
A4H3A9 Leishmania braziliensis 42% 100%
A4H3B4 Leishmania braziliensis 41% 100%
A4H3B6 Leishmania braziliensis 38% 100%
A4H3B8 Leishmania braziliensis 40% 98%
A4H3B9 Leishmania braziliensis 33% 91%
A4H4W8 Leishmania braziliensis 62% 100%
A4HJ20 Leishmania braziliensis 39% 100%
A4HNK3 Leishmania braziliensis 71% 100%
A4HNK6 Leishmania braziliensis 62% 100%
A4HRL9 Leishmania infantum 41% 100%
A4HRM0 Leishmania infantum 39% 100%
A4HRM1 Leishmania infantum 41% 100%
A4HRS1 Leishmania infantum 41% 94%
A4HRS3 Leishmania infantum 32% 82%
A4HRS5 Leishmania infantum 37% 100%
A4HZM0 Leishmania infantum 73% 100%
A4I7C7 Leishmania infantum 74% 100%
A4IAQ2 Leishmania infantum 71% 100%
E9AC91 Leishmania major 42% 100%
E9AC92 Leishmania major 43% 100%
E9AC94 Leishmania major 31% 69%
E9AC95 Leishmania major 39% 100%
E9AC96 Leishmania major 41% 100%
E9AC98 Leishmania major 32% 100%
E9AEH8 Leishmania major 81% 100%
E9AHA6 Leishmania infantum 72% 100%
E9AIP8 Leishmania braziliensis 64% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 82%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4Q5T6 Leishmania major 82% 100%
Q4QFJ3 Leishmania major 36% 79%
Q4QIG9 Leishmania major 96% 100%
Q7YXU9 Leishmania major 95% 100%
Q7YXV1 Leishmania major 95% 96%
Q7YXV2 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS