Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCL5_LEIMA

TriTrypDb:

LmjF.21.0027 , LMJLV39_210005200 , LMJSD75_210005200

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_Separin_Metazoa	212	216	PF03568	0.490
DEG_APCC_DBOX_1	113	121	PF00400	0.544
DOC_MAPK_MEF2A_6	101	109	PF00069	0.517
DOC_USP7_MATH_1	127	131	PF00917	0.596
DOC_USP7_MATH_1	22	26	PF00917	0.654
DOC_USP7_MATH_1	243	247	PF00917	0.342
DOC_WW_Pin1_4	161	166	PF00397	0.600
DOC_WW_Pin1_4	194	199	PF00397	0.510
DOC_WW_Pin1_4	65	70	PF00397	0.687
LIG_14-3-3_CanoR_1	244	250	PF00244	0.546
LIG_14-3-3_CanoR_1	43	48	PF00244	0.510
LIG_14-3-3_CanoR_1	5	11	PF00244	0.691
LIG_APCC_ABBA_1	45	50	PF00400	0.503
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	190	194	PF00533	0.465
LIG_FHA_1	104	110	PF00498	0.496
LIG_FHA_2	129	135	PF00498	0.616
LIG_LIR_Gen_1	240	250	PF02991	0.527
LIG_LIR_Gen_1	42	52	PF02991	0.499
LIG_LIR_LC3C_4	157	160	PF02991	0.389
LIG_LIR_Nem_3	240	245	PF02991	0.519
LIG_LIR_Nem_3	42	48	PF02991	0.415
LIG_MYND_3	250	254	PF01753	0.627
LIG_PDZ_Class_3	251	256	PF00595	0.512
LIG_SH2_CRK	145	149	PF00017	0.446
LIG_SH2_STAT5	226	229	PF00017	0.405
LIG_SH3_3	162	168	PF00018	0.543
LIG_SUMO_SIM_par_1	102	108	PF11976	0.501
MOD_CDK_SPK_2	65	70	PF00069	0.421
MOD_CK1_1	14	20	PF00069	0.613
MOD_CK1_1	164	170	PF00069	0.376
MOD_CK1_1	188	194	PF00069	0.525
MOD_CK1_1	65	71	PF00069	0.458
MOD_CK2_1	128	134	PF00069	0.561
MOD_Cter_Amidation	80	83	PF01082	0.491
MOD_GlcNHglycan	180	183	PF01048	0.519
MOD_GlcNHglycan	84	87	PF01048	0.551
MOD_GSK3_1	185	192	PF00069	0.504
MOD_GSK3_1	194	201	PF00069	0.429
MOD_GSK3_1	39	46	PF00069	0.438
MOD_GSK3_1	99	106	PF00069	0.454
MOD_N-GLC_1	150	155	PF02516	0.574
MOD_N-GLC_1	52	57	PF02516	0.534
MOD_N-GLC_2	98	100	PF02516	0.564
MOD_NEK2_1	105	110	PF00069	0.458
MOD_NEK2_1	11	16	PF00069	0.582
MOD_NEK2_1	150	155	PF00069	0.508
MOD_NEK2_1	186	191	PF00069	0.426
MOD_NEK2_1	23	28	PF00069	0.602
MOD_NEK2_1	36	41	PF00069	0.502
MOD_NEK2_1	4	9	PF00069	0.605
MOD_NEK2_1	99	104	PF00069	0.522
MOD_NEK2_2	198	203	PF00069	0.536
MOD_OFUCOSY	12	18	PF10250	0.623
MOD_PKA_1	82	88	PF00069	0.562
MOD_PKA_2	243	249	PF00069	0.487
MOD_PKA_2	4	10	PF00069	0.707
MOD_Plk_1	150	156	PF00069	0.581
MOD_Plk_4	128	134	PF00069	0.567
MOD_Plk_4	189	195	PF00069	0.562
MOD_Plk_4	245	251	PF00069	0.517
MOD_ProDKin_1	161	167	PF00069	0.595
MOD_ProDKin_1	194	200	PF00069	0.510
MOD_ProDKin_1	65	71	PF00069	0.687
MOD_SUMO_for_1	202	205	PF00179	0.571
MOD_SUMO_for_1	69	72	PF00179	0.449
MOD_SUMO_rev_2	225	231	PF00179	0.543
TRG_NES_CRM1_1	208	221	PF08389	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IYT2	Bodo saltans	28%	80%
A0A1X0NXA5	Trypanosomatidae	31%	94%
A0A3Q8IB00	Leishmania donovani	90%	100%
A0A3R7N8W3	Trypanosoma rangeli	34%	97%
A4HBJ8	Leishmania braziliensis	65%	100%
D0A1J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	85%
E9AGU4	Leishmania infantum	91%	100%
E9AUW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%