BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCL4_LEIMA

TriTrypDb:

LmjF.21.0030 , LMJLV39_210005300 , LMJSD75_210005300

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QCL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.439
CLV_NRD_NRD_1	1	3	PF00675	0.459
CLV_NRD_NRD_1	126	128	PF00675	0.367
CLV_NRD_NRD_1	148	150	PF00675	0.643
CLV_NRD_NRD_1	166	168	PF00675	0.585
CLV_NRD_NRD_1	222	224	PF00675	0.443
CLV_PCSK_KEX2_1	126	128	PF00082	0.580
CLV_PCSK_KEX2_1	166	168	PF00082	0.515
CLV_PCSK_KEX2_1	222	224	PF00082	0.597
CLV_PCSK_SKI1_1	101	105	PF00082	0.526
CLV_PCSK_SKI1_1	179	183	PF00082	0.488
CLV_PCSK_SKI1_1	3	7	PF00082	0.476
CLV_PCSK_SKI1_1	9	13	PF00082	0.458
DEG_Nend_UBRbox_1	1	4	PF02207	0.516
DOC_MAPK_gen_1	222	230	PF00069	0.463
DOC_MAPK_gen_1	91	100	PF00069	0.401
DOC_USP7_MATH_1	125	129	PF00917	0.415
DOC_USP7_MATH_1	205	209	PF00917	0.503
DOC_USP7_MATH_1	57	61	PF00917	0.541
LIG_14-3-3_CanoR_1	48	55	PF00244	0.557
LIG_FHA_1	205	211	PF00498	0.557
LIG_FHA_2	140	146	PF00498	0.601
LIG_FHA_2	182	188	PF00498	0.605
LIG_FHA_2	34	40	PF00498	0.604
LIG_FHA_2	54	60	PF00498	0.530
LIG_LIR_Gen_1	183	193	PF02991	0.496
LIG_LIR_Gen_1	84	92	PF02991	0.434
LIG_LIR_Nem_3	133	137	PF02991	0.485
LIG_LIR_Nem_3	183	188	PF02991	0.490
LIG_PCNA_PIPBox_1	197	206	PF02747	0.367
LIG_PDZ_Class_2	225	230	PF00595	0.604
LIG_Pex14_2	96	100	PF04695	0.408
LIG_SH2_NCK_1	161	165	PF00017	0.420
LIG_SH2_SRC	161	164	PF00017	0.468
LIG_SH2_STAT5	203	206	PF00017	0.554
LIG_TRAF2_1	43	46	PF00917	0.556
LIG_UBA3_1	210	216	PF00899	0.481
LIG_UBA3_1	54	63	PF00899	0.367
MOD_CK2_1	106	112	PF00069	0.510
MOD_CK2_1	139	145	PF00069	0.573
MOD_CK2_1	181	187	PF00069	0.464
MOD_CK2_1	39	45	PF00069	0.577
MOD_CK2_1	53	59	PF00069	0.460
MOD_GlcNHglycan	41	44	PF01048	0.556
MOD_GSK3_1	108	115	PF00069	0.501
MOD_GSK3_1	162	169	PF00069	0.555
MOD_GSK3_1	199	206	PF00069	0.472
MOD_GSK3_1	29	36	PF00069	0.480
MOD_GSK3_1	44	51	PF00069	0.509
MOD_GSK3_1	53	60	PF00069	0.432
MOD_N-GLC_1	33	38	PF02516	0.437
MOD_NEK2_1	155	160	PF00069	0.550
MOD_NEK2_1	181	186	PF00069	0.510
MOD_NEK2_1	204	209	PF00069	0.541
MOD_NEK2_1	210	215	PF00069	0.567
MOD_NEK2_1	218	223	PF00069	0.605
MOD_NEK2_1	5	10	PF00069	0.513
MOD_PIKK_1	205	211	PF00454	0.398
MOD_PIKK_1	48	54	PF00454	0.389
MOD_PKA_1	166	172	PF00069	0.489
MOD_PKA_2	125	131	PF00069	0.558
MOD_PKA_2	166	172	PF00069	0.493
MOD_PKA_2	47	53	PF00069	0.585
MOD_Plk_1	106	112	PF00069	0.539
MOD_Plk_1	33	39	PF00069	0.623
MOD_Plk_2-3	106	112	PF00069	0.575
MOD_Plk_4	192	198	PF00069	0.586
MOD_Plk_4	199	205	PF00069	0.525
MOD_Plk_4	57	63	PF00069	0.430
MOD_SUMO_rev_2	106	116	PF00179	0.526
MOD_SUMO_rev_2	154	160	PF00179	0.623
MOD_SUMO_rev_2	178	184	PF00179	0.538
MOD_SUMO_rev_2	187	193	PF00179	0.510
MOD_SUMO_rev_2	20	27	PF00179	0.517
MOD_SUMO_rev_2	38	43	PF00179	0.371
MOD_SUMO_rev_2	95	103	PF00179	0.490
TRG_ENDOCYTIC_2	185	188	PF00928	0.396
TRG_NES_CRM1_1	52	66	PF08389	0.373
TRG_NLS_MonoExtC_3	148	153	PF00514	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	29%	97%
A0A0N1PD85	Leptomonas seymouri	47%	100%
A0A1X0NXA6	Trypanosomatidae	29%	76%
A0A1X0NXA8	Trypanosomatidae	39%	98%
A0A3Q8IKU7	Leishmania donovani	93%	100%
A0A3S5H792	Leishmania donovani	32%	94%
A0A3S5H7I1	Leishmania donovani	27%	68%
A0A422MZP2	Trypanosoma rangeli	28%	76%
A4HBJ9	Leishmania braziliensis	54%	100%
A4HBK0	Leishmania braziliensis	30%	95%
A4HFU7	Leishmania braziliensis	27%	68%
A4HZL5	Leishmania infantum	32%	94%
A4HZL6	Leishmania infantum	92%	100%
A4I2W4	Leishmania infantum	27%	68%
E9ADF0	Leishmania major	27%	68%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	94%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	68%
Q4QCL3	Leishmania major	31%	100%
V5BG41	Trypanosoma cruzi	34%	98%
V5BKK3	Trypanosoma cruzi	28%	76%