LeishMANIAdb
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BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
BAR domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QCL4_LEIMA
TriTrypDb:
LmjF.21.0030 * , LMJLV39_210005300 * , LMJSD75_210005300 *
Length:
230

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0031253 cell projection membrane 4 1
GO:0060170 ciliary membrane 5 1
GO:0098588 bounding membrane of organelle 4 1
GO:0098590 plasma membrane region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

Q4QCL4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCL4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 165 169 PF00656 0.439
CLV_NRD_NRD_1 1 3 PF00675 0.459
CLV_NRD_NRD_1 126 128 PF00675 0.367
CLV_NRD_NRD_1 148 150 PF00675 0.643
CLV_NRD_NRD_1 166 168 PF00675 0.585
CLV_NRD_NRD_1 222 224 PF00675 0.443
CLV_PCSK_KEX2_1 126 128 PF00082 0.580
CLV_PCSK_KEX2_1 166 168 PF00082 0.515
CLV_PCSK_KEX2_1 222 224 PF00082 0.597
CLV_PCSK_SKI1_1 101 105 PF00082 0.526
CLV_PCSK_SKI1_1 179 183 PF00082 0.488
CLV_PCSK_SKI1_1 3 7 PF00082 0.476
CLV_PCSK_SKI1_1 9 13 PF00082 0.458
DEG_Nend_UBRbox_1 1 4 PF02207 0.516
DOC_MAPK_gen_1 222 230 PF00069 0.463
DOC_MAPK_gen_1 91 100 PF00069 0.401
DOC_USP7_MATH_1 125 129 PF00917 0.415
DOC_USP7_MATH_1 205 209 PF00917 0.503
DOC_USP7_MATH_1 57 61 PF00917 0.541
LIG_14-3-3_CanoR_1 48 55 PF00244 0.557
LIG_FHA_1 205 211 PF00498 0.557
LIG_FHA_2 140 146 PF00498 0.601
LIG_FHA_2 182 188 PF00498 0.605
LIG_FHA_2 34 40 PF00498 0.604
LIG_FHA_2 54 60 PF00498 0.530
LIG_LIR_Gen_1 183 193 PF02991 0.496
LIG_LIR_Gen_1 84 92 PF02991 0.434
LIG_LIR_Nem_3 133 137 PF02991 0.485
LIG_LIR_Nem_3 183 188 PF02991 0.490
LIG_PCNA_PIPBox_1 197 206 PF02747 0.367
LIG_PDZ_Class_2 225 230 PF00595 0.604
LIG_Pex14_2 96 100 PF04695 0.408
LIG_SH2_NCK_1 161 165 PF00017 0.420
LIG_SH2_SRC 161 164 PF00017 0.468
LIG_SH2_STAT5 203 206 PF00017 0.554
LIG_TRAF2_1 43 46 PF00917 0.556
LIG_UBA3_1 210 216 PF00899 0.481
LIG_UBA3_1 54 63 PF00899 0.367
MOD_CK2_1 106 112 PF00069 0.510
MOD_CK2_1 139 145 PF00069 0.573
MOD_CK2_1 181 187 PF00069 0.464
MOD_CK2_1 39 45 PF00069 0.577
MOD_CK2_1 53 59 PF00069 0.460
MOD_GlcNHglycan 41 44 PF01048 0.556
MOD_GSK3_1 108 115 PF00069 0.501
MOD_GSK3_1 162 169 PF00069 0.555
MOD_GSK3_1 199 206 PF00069 0.472
MOD_GSK3_1 29 36 PF00069 0.480
MOD_GSK3_1 44 51 PF00069 0.509
MOD_GSK3_1 53 60 PF00069 0.432
MOD_N-GLC_1 33 38 PF02516 0.437
MOD_NEK2_1 155 160 PF00069 0.550
MOD_NEK2_1 181 186 PF00069 0.510
MOD_NEK2_1 204 209 PF00069 0.541
MOD_NEK2_1 210 215 PF00069 0.567
MOD_NEK2_1 218 223 PF00069 0.605
MOD_NEK2_1 5 10 PF00069 0.513
MOD_PIKK_1 205 211 PF00454 0.398
MOD_PIKK_1 48 54 PF00454 0.389
MOD_PKA_1 166 172 PF00069 0.489
MOD_PKA_2 125 131 PF00069 0.558
MOD_PKA_2 166 172 PF00069 0.493
MOD_PKA_2 47 53 PF00069 0.585
MOD_Plk_1 106 112 PF00069 0.539
MOD_Plk_1 33 39 PF00069 0.623
MOD_Plk_2-3 106 112 PF00069 0.575
MOD_Plk_4 192 198 PF00069 0.586
MOD_Plk_4 199 205 PF00069 0.525
MOD_Plk_4 57 63 PF00069 0.430
MOD_SUMO_rev_2 106 116 PF00179 0.526
MOD_SUMO_rev_2 154 160 PF00179 0.623
MOD_SUMO_rev_2 178 184 PF00179 0.538
MOD_SUMO_rev_2 187 193 PF00179 0.510
MOD_SUMO_rev_2 20 27 PF00179 0.517
MOD_SUMO_rev_2 38 43 PF00179 0.371
MOD_SUMO_rev_2 95 103 PF00179 0.490
TRG_ENDOCYTIC_2 185 188 PF00928 0.396
TRG_NES_CRM1_1 52 66 PF08389 0.373
TRG_NLS_MonoExtC_3 148 153 PF00514 0.637

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4S1 Leptomonas seymouri 29% 97%
A0A0N1PD85 Leptomonas seymouri 47% 100%
A0A1X0NXA6 Trypanosomatidae 29% 76%
A0A1X0NXA8 Trypanosomatidae 39% 98%
A0A3Q8IKU7 Leishmania donovani 93% 100%
A0A3S5H792 Leishmania donovani 32% 94%
A0A3S5H7I1 Leishmania donovani 27% 68%
A0A422MZP2 Trypanosoma rangeli 28% 76%
A4HBJ9 Leishmania braziliensis 54% 100%
A4HBK0 Leishmania braziliensis 30% 95%
A4HFU7 Leishmania braziliensis 27% 68%
A4HZL5 Leishmania infantum 32% 94%
A4HZL6 Leishmania infantum 92% 100%
A4I2W4 Leishmania infantum 27% 68%
E9ADF0 Leishmania major 27% 68%
E9AUW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9AUW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 94%
E9AZ74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 68%
Q4QCL3 Leishmania major 31% 100%
V5BG41 Trypanosoma cruzi 34% 98%
V5BKK3 Trypanosoma cruzi 28% 76%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS