BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCL3_LEIMA

TriTrypDb:

LmjF.21.0040 , LMJLV39_210005400 , LMJSD75_210005400

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QCL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.303
CLV_C14_Caspase3-7	72	76	PF00656	0.374
CLV_NRD_NRD_1	150	152	PF00675	0.574
CLV_NRD_NRD_1	168	170	PF00675	0.542
CLV_NRD_NRD_1	24	26	PF00675	0.521
CLV_NRD_NRD_1	51	53	PF00675	0.540
CLV_PCSK_FUR_1	24	28	PF00082	0.525
CLV_PCSK_KEX2_1	127	129	PF00082	0.500
CLV_PCSK_KEX2_1	168	170	PF00082	0.472
CLV_PCSK_KEX2_1	24	26	PF00082	0.429
CLV_PCSK_KEX2_1	51	53	PF00082	0.502
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.498
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.446
CLV_PCSK_PC7_1	123	129	PF00082	0.320
CLV_PCSK_SKI1_1	154	158	PF00082	0.459
CLV_PCSK_SKI1_1	194	198	PF00082	0.439
CLV_PCSK_SKI1_1	27	31	PF00082	0.517
CLV_PCSK_SKI1_1	8	12	PF00082	0.533
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DOC_CYCLIN_RxL_1	151	159	PF00134	0.356
DOC_MAPK_gen_1	6	13	PF00069	0.593
DOC_USP7_MATH_1	102	106	PF00917	0.550
DOC_USP7_MATH_1	175	179	PF00917	0.477
DOC_USP7_MATH_1	35	39	PF00917	0.475
DOC_USP7_MATH_1	46	50	PF00917	0.481
DOC_USP7_MATH_1	63	67	PF00917	0.573
DOC_USP7_UBL2_3	154	158	PF12436	0.547
DOC_USP7_UBL2_3	26	30	PF12436	0.525
DOC_USP7_UBL2_3	8	12	PF12436	0.610
LIG_14-3-3_CanoR_1	151	157	PF00244	0.381
LIG_14-3-3_CanoR_1	194	202	PF00244	0.347
LIG_Actin_WH2_2	209	226	PF00022	0.500
LIG_BRCT_BRCA1_1	216	220	PF00533	0.472
LIG_BRCT_BRCA1_1	60	64	PF00533	0.432
LIG_FHA_1	109	115	PF00498	0.518
LIG_FHA_1	197	203	PF00498	0.527
LIG_FHA_2	15	21	PF00498	0.466
LIG_FHA_2	195	201	PF00498	0.559
LIG_FHA_2	39	45	PF00498	0.499
LIG_LIR_Apic_2	226	232	PF02991	0.400
LIG_LIR_Gen_1	61	71	PF02991	0.520
LIG_LIR_Nem_3	134	138	PF02991	0.468
LIG_LIR_Nem_3	180	186	PF02991	0.442
LIG_LIR_Nem_3	217	223	PF02991	0.436
LIG_LIR_Nem_3	61	67	PF02991	0.398
LIG_LIR_Nem_3	93	99	PF02991	0.465
LIG_LYPXL_yS_3	70	73	PF13949	0.364
LIG_OCRL_FandH_1	182	194	PF00620	0.391
LIG_Rb_pABgroove_1	112	120	PF01858	0.349
LIG_SH2_PTP2	229	232	PF00017	0.404
LIG_SH2_SRC	229	232	PF00017	0.359
LIG_SH2_STAP1	162	166	PF00017	0.412
LIG_SH2_STAP1	39	43	PF00017	0.302
LIG_SH2_STAT5	149	152	PF00017	0.501
LIG_SH2_STAT5	229	232	PF00017	0.550
LIG_SH3_3	68	74	PF00018	0.537
LIG_UBA3_1	4	12	PF00899	0.608
MOD_CK1_1	207	213	PF00069	0.347
MOD_CK1_1	38	44	PF00069	0.418
MOD_CK2_1	14	20	PF00069	0.501
MOD_CK2_1	38	44	PF00069	0.536
MOD_Cter_Amidation	125	128	PF01082	0.289
MOD_GlcNHglycan	177	180	PF01048	0.448
MOD_GlcNHglycan	214	219	PF01048	0.369
MOD_GlcNHglycan	33	36	PF01048	0.408
MOD_GSK3_1	102	109	PF00069	0.426
MOD_GSK3_1	152	159	PF00069	0.547
MOD_GSK3_1	190	197	PF00069	0.411
MOD_GSK3_1	31	38	PF00069	0.460
MOD_GSK3_1	69	76	PF00069	0.551
MOD_NEK2_1	103	108	PF00069	0.467
MOD_NEK2_1	150	155	PF00069	0.483
MOD_NEK2_1	156	161	PF00069	0.466
MOD_NEK2_1	190	195	PF00069	0.526
MOD_NEK2_1	84	89	PF00069	0.456
MOD_NEK2_2	46	51	PF00069	0.313
MOD_PIKK_1	188	194	PF00454	0.317
MOD_PKA_2	150	156	PF00069	0.516
MOD_Plk_1	103	109	PF00069	0.470
MOD_Plk_1	91	97	PF00069	0.410
MOD_Plk_4	103	109	PF00069	0.389
MOD_Plk_4	152	158	PF00069	0.629
MOD_SUMO_for_1	143	146	PF00179	0.402
MOD_SUMO_rev_2	177	183	PF00179	0.537
TRG_ENDOCYTIC_2	70	73	PF00928	0.477
TRG_ER_diArg_1	24	27	PF00400	0.527
TRG_ER_diArg_1	50	52	PF00400	0.333
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	54%	100%
A0A0N1PD85	Leptomonas seymouri	33%	100%
A0A1X0NXA6	Trypanosomatidae	25%	81%
A0A1X0NXA8	Trypanosomatidae	36%	100%
A0A3Q8IKU7	Leishmania donovani	31%	100%
A0A3S5H792	Leishmania donovani	87%	100%
A0A3S5H7I1	Leishmania donovani	22%	72%
A0A422MZP2	Trypanosoma rangeli	26%	81%
A4HBJ9	Leishmania braziliensis	34%	100%
A4HBK0	Leishmania braziliensis	60%	100%
A4HFU7	Leishmania braziliensis	22%	72%
A4HZL5	Leishmania infantum	87%	100%
A4HZL6	Leishmania infantum	32%	100%
A4I2W4	Leishmania infantum	22%	72%
E9ADF0	Leishmania major	21%	72%
E9AHL0	Leishmania infantum	25%	79%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	72%
Q4Q6I6	Leishmania major	27%	82%
Q4QCL4	Leishmania major	31%	100%
V5BG41	Trypanosoma cruzi	37%	100%
V5BKK3	Trypanosoma cruzi	24%	81%