Putative Qb-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4QCL2_LEIMA

TriTrypDb:

LmjF.21.0050 , LMJLV39_210005500 , LMJSD75_210005500

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	12
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QCL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCL2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0006886	intracellular protein transport	4	2
GO:0006887	exocytosis	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0016192	vesicle-mediated transport	4	5
GO:0022406	membrane docking	2	2
GO:0032940	secretion by cell	3	2
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046903	secretion	4	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0140352	export from cell	2	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.570
CLV_PCSK_SKI1_1	43	47	PF00082	0.396
CLV_PCSK_SKI1_1	57	61	PF00082	0.356
CLV_Separin_Metazoa	58	62	PF03568	0.620
DEG_Nend_Nbox_1	1	3	PF02207	0.717
DOC_MAPK_gen_1	160	169	PF00069	0.605
DOC_MAPK_gen_1	211	219	PF00069	0.410
DOC_MAPK_MEF2A_6	185	194	PF00069	0.515
DOC_MAPK_MEF2A_6	213	221	PF00069	0.251
DOC_PP1_RVXF_1	152	158	PF00149	0.617
DOC_USP7_MATH_1	122	126	PF00917	0.697
DOC_USP7_UBL2_3	69	73	PF12436	0.647
DOC_WW_Pin1_4	118	123	PF00397	0.707
DOC_WW_Pin1_4	32	37	PF00397	0.607
LIG_14-3-3_CanoR_1	154	158	PF00244	0.607
LIG_Actin_WH2_2	148	165	PF00022	0.610
LIG_Actin_WH2_2	180	197	PF00022	0.515
LIG_AP2alpha_2	5	7	PF02296	0.518
LIG_APCC_ABBA_1	167	172	PF00400	0.695
LIG_BRCT_BRCA1_1	3	7	PF00533	0.597
LIG_CaM_IQ_9	187	202	PF13499	0.498
LIG_FAT_LD_1	201	209	PF03623	0.382
LIG_FHA_1	154	160	PF00498	0.632
LIG_FHA_1	173	179	PF00498	0.710
LIG_FHA_1	214	220	PF00498	0.383
LIG_FHA_2	46	52	PF00498	0.592
LIG_LIR_Gen_1	99	109	PF02991	0.576
LIG_LIR_Nem_3	99	104	PF02991	0.581
LIG_PCNA_yPIPBox_3	193	205	PF02747	0.464
LIG_Pex14_2	222	226	PF04695	0.360
LIG_SH2_NCK_1	101	105	PF00017	0.575
LIG_SH2_STAP1	101	105	PF00017	0.631
LIG_SH3_3	116	122	PF00018	0.705
LIG_SH3_3	30	36	PF00018	0.611
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.336
LIG_TRAF2_1	48	51	PF00917	0.555
LIG_UBA3_1	204	213	PF00899	0.470
LIG_UBA3_1	52	57	PF00899	0.607
MOD_CK1_1	35	41	PF00069	0.614
MOD_CK2_1	118	124	PF00069	0.712
MOD_CK2_1	35	41	PF00069	0.600
MOD_CK2_1	45	51	PF00069	0.533
MOD_CK2_1	7	13	PF00069	0.583
MOD_CK2_1	73	79	PF00069	0.551
MOD_CK2_1	96	102	PF00069	0.565
MOD_GlcNHglycan	106	109	PF01048	0.404
MOD_GlcNHglycan	134	137	PF01048	0.467
MOD_GlcNHglycan	186	190	PF01048	0.263
MOD_GlcNHglycan	75	78	PF01048	0.409
MOD_GSK3_1	118	125	PF00069	0.688
MOD_N-GLC_1	7	12	PF02516	0.431
MOD_NEK2_1	162	167	PF00069	0.612
MOD_NEK2_1	204	209	PF00069	0.470
MOD_NEK2_1	7	12	PF00069	0.544
MOD_PIKK_1	172	178	PF00454	0.677
MOD_PIKK_1	26	32	PF00454	0.617
MOD_PKA_2	153	159	PF00069	0.600
MOD_PKA_2	162	168	PF00069	0.586
MOD_Plk_1	7	13	PF00069	0.551
MOD_Plk_2-3	96	102	PF00069	0.601
MOD_ProDKin_1	118	124	PF00069	0.709
MOD_ProDKin_1	32	38	PF00069	0.603
MOD_SUMO_rev_2	143	147	PF00179	0.684
MOD_SUMO_rev_2	38	48	PF00179	0.597
TRG_DiLeu_BaEn_3	50	56	PF01217	0.590
TRG_ENDOCYTIC_2	101	104	PF00928	0.617
TRG_ER_diArg_1	111	114	PF00400	0.637
TRG_ER_diArg_1	192	195	PF00400	0.501
TRG_NES_CRM1_1	50	65	PF08389	0.560
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.362
TRG_PTS2	1	28	PF00400	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C8	Leptomonas seymouri	74%	98%
A0A0S4J237	Bodo saltans	29%	81%
A0A0S4JJL1	Bodo saltans	30%	95%
A0A1X0NSP4	Trypanosomatidae	30%	97%
A0A1X0NXA4	Trypanosomatidae	46%	100%
A0A3Q8IBW4	Leishmania donovani	95%	100%
A0A3R7M3G3	Trypanosoma rangeli	42%	100%
A4HBK1	Leishmania braziliensis	83%	100%
A4HZL4	Leishmania infantum	95%	100%
D0A1J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AUX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q54IX6	Dictyostelium discoideum	25%	93%
V5BUP0	Trypanosoma cruzi	28%	98%