Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4QCL0_LEIMA

TriTrypDb:

LmjF.21.0060 , LMJLV39_210005700 , LMJSD75_210005700

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005840	ribosome	5	17
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	19
GO:0043226	organelle	2	17
GO:0043228	non-membrane-bounded organelle	3	17
GO:0043229	intracellular organelle	3	17
GO:0043232	intracellular non-membrane-bounded organelle	4	17
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	17
GO:1990904	ribonucleoprotein complex	2	19
GO:0015935	small ribosomal subunit	4	2
GO:0044391	ribosomal subunit	3	2
GO:0005730	nucleolus	5	1

Expansion

Sequence features

Q4QCL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCL0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0043022	ribosome binding	4	2
GO:0044877	protein-containing complex binding	2	2
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.644
CLV_PCSK_KEX2_1	23	25	PF00082	0.669
CLV_PCSK_KEX2_1	311	313	PF00082	0.477
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.723
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.477
CLV_PCSK_SKI1_1	110	114	PF00082	0.534
CLV_PCSK_SKI1_1	162	166	PF00082	0.317
CLV_PCSK_SKI1_1	312	316	PF00082	0.386
CLV_PCSK_SKI1_1	53	57	PF00082	0.670
CLV_PCSK_SKI1_1	85	89	PF00082	0.535
CLV_PCSK_SKI1_1	95	99	PF00082	0.465
DEG_SCF_FBW7_1	146	152	PF00400	0.567
DOC_CKS1_1	146	151	PF01111	0.567
DOC_MAPK_DCC_7	405	415	PF00069	0.448
DOC_MAPK_gen_1	414	423	PF00069	0.543
DOC_MAPK_gen_1	93	100	PF00069	0.543
DOC_MAPK_MEF2A_6	69	76	PF00069	0.495
DOC_PP4_FxxP_1	370	373	PF00568	0.559
DOC_USP7_MATH_1	149	153	PF00917	0.489
DOC_USP7_MATH_1	156	160	PF00917	0.506
DOC_USP7_MATH_1	321	325	PF00917	0.504
DOC_USP7_MATH_1	70	74	PF00917	0.664
DOC_USP7_MATH_1	99	103	PF00917	0.411
DOC_USP7_UBL2_3	31	35	PF12436	0.747
DOC_WW_Pin1_4	145	150	PF00397	0.520
DOC_WW_Pin1_4	38	43	PF00397	0.730
LIG_14-3-3_CanoR_1	231	237	PF00244	0.506
LIG_14-3-3_CanoR_1	376	381	PF00244	0.411
LIG_14-3-3_CanoR_1	85	91	PF00244	0.515
LIG_Actin_WH2_2	385	403	PF00022	0.430
LIG_Actin_WH2_2	54	71	PF00022	0.607
LIG_BRCT_BRCA1_1	151	155	PF00533	0.480
LIG_CtBP_PxDLS_1	243	249	PF00389	0.381
LIG_FHA_1	126	132	PF00498	0.488
LIG_FHA_1	161	167	PF00498	0.549
LIG_FHA_1	203	209	PF00498	0.509
LIG_FHA_1	345	351	PF00498	0.565
LIG_FHA_1	6	12	PF00498	0.729
LIG_FHA_2	184	190	PF00498	0.539
LIG_FHA_2	256	262	PF00498	0.562
LIG_FHA_2	278	284	PF00498	0.420
LIG_FHA_2	339	345	PF00498	0.569
LIG_FHA_2	376	382	PF00498	0.381
LIG_IBAR_NPY_1	284	286	PF08397	0.420
LIG_LIR_Apic_2	30	36	PF02991	0.595
LIG_LIR_Apic_2	367	373	PF02991	0.569
LIG_LIR_Gen_1	258	264	PF02991	0.296
LIG_LIR_Nem_3	258	262	PF02991	0.294
LIG_LIR_Nem_3	283	289	PF02991	0.423
LIG_LIR_Nem_3	82	87	PF02991	0.502
LIG_NRBOX	75	81	PF00104	0.474
LIG_Pex14_2	87	91	PF04695	0.417
LIG_PTB_Apo_2	333	340	PF02174	0.558
LIG_SH2_CRK	286	290	PF00017	0.464
LIG_SH2_NCK_1	33	37	PF00017	0.809
LIG_SH2_PTP2	417	420	PF00017	0.431
LIG_SH2_STAT3	301	304	PF00017	0.472
LIG_SH2_STAT5	301	304	PF00017	0.363
LIG_SH2_STAT5	417	420	PF00017	0.458
LIG_SH3_3	103	109	PF00018	0.495
LIG_SH3_3	143	149	PF00018	0.517
LIG_SH3_3	279	285	PF00018	0.550
LIG_SH3_3	36	42	PF00018	0.764
LIG_SH3_3	396	402	PF00018	0.389
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.463
LIG_SUMO_SIM_par_1	387	393	PF11976	0.467
LIG_TYR_ITIM	415	420	PF00017	0.430
LIG_WRC_WIRS_1	377	382	PF05994	0.345
MOD_CK1_1	16	22	PF00069	0.709
MOD_CK1_1	171	177	PF00069	0.473
MOD_CK1_1	187	193	PF00069	0.392
MOD_CK1_1	338	344	PF00069	0.563
MOD_CK2_1	171	177	PF00069	0.500
MOD_CK2_1	277	283	PF00069	0.480
MOD_CK2_1	375	381	PF00069	0.526
MOD_Cter_Amidation	309	312	PF01082	0.500
MOD_GlcNHglycan	151	154	PF01048	0.278
MOD_GlcNHglycan	19	22	PF01048	0.738
MOD_GlcNHglycan	198	201	PF01048	0.251
MOD_GlcNHglycan	357	361	PF01048	0.442
MOD_GSK3_1	1	8	PF00069	0.722
MOD_GSK3_1	13	20	PF00069	0.718
MOD_GSK3_1	144	151	PF00069	0.476
MOD_GSK3_1	156	163	PF00069	0.493
MOD_GSK3_1	167	174	PF00069	0.539
MOD_GSK3_1	183	190	PF00069	0.485
MOD_GSK3_1	198	205	PF00069	0.510
MOD_GSK3_1	335	342	PF00069	0.537
MOD_GSK3_1	405	412	PF00069	0.508
MOD_GSK3_1	70	77	PF00069	0.579
MOD_N-GLC_1	13	18	PF02516	0.709
MOD_N-GLC_1	167	172	PF02516	0.433
MOD_N-GLC_1	335	340	PF02516	0.382
MOD_N-GLC_2	296	298	PF02516	0.609
MOD_N-GLC_2	3	5	PF02516	0.742
MOD_N-GLC_2	394	396	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	183	188	PF00069	0.532
MOD_NEK2_1	196	201	PF00069	0.510
MOD_NEK2_1	232	237	PF00069	0.533
MOD_NEK2_1	262	267	PF00069	0.420
MOD_NEK2_1	287	292	PF00069	0.489
MOD_NEK2_2	335	340	PF00069	0.481
MOD_NMyristoyl	1	7	PF02799	0.747
MOD_PK_1	405	411	PF00069	0.570
MOD_PKA_1	53	59	PF00069	0.495
MOD_PKA_2	375	381	PF00069	0.386
MOD_Plk_1	117	123	PF00069	0.401
MOD_Plk_1	160	166	PF00069	0.481
MOD_Plk_1	171	177	PF00069	0.381
MOD_Plk_1	202	208	PF00069	0.475
MOD_Plk_4	297	303	PF00069	0.503
MOD_Plk_4	329	335	PF00069	0.533
MOD_Plk_4	405	411	PF00069	0.512
MOD_Plk_4	53	59	PF00069	0.622
MOD_Plk_4	70	76	PF00069	0.584
MOD_Plk_4	86	92	PF00069	0.490
MOD_ProDKin_1	145	151	PF00069	0.520
MOD_ProDKin_1	38	44	PF00069	0.726
MOD_SUMO_for_1	34	37	PF00179	0.594
MOD_SUMO_rev_2	215	224	PF00179	0.478
MOD_SUMO_rev_2	47	55	PF00179	0.524
TRG_DiLeu_BaEn_1	393	398	PF01217	0.340
TRG_ENDOCYTIC_2	259	262	PF00928	0.299
TRG_ENDOCYTIC_2	273	276	PF00928	0.392
TRG_ENDOCYTIC_2	286	289	PF00928	0.335
TRG_ENDOCYTIC_2	417	420	PF00928	0.475
TRG_ER_diArg_1	413	416	PF00400	0.564
TRG_NES_CRM1_1	65	78	PF08389	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X3	Leptomonas seymouri	26%	95%
A0A0N1I307	Leptomonas seymouri	66%	98%
A0A0S4J1I0	Bodo saltans	40%	94%
A0A1X0NQ96	Trypanosomatidae	23%	100%
A0A1X0NQI7	Trypanosomatidae	26%	100%
A0A1X0NYQ0	Trypanosomatidae	46%	94%
A0A1X0P551	Trypanosomatidae	24%	95%
A0A3Q8IBR2	Leishmania donovani	98%	100%
A0A3R7KUH0	Trypanosoma rangeli	24%	100%
A0A3S7WR72	Leishmania donovani	27%	100%
A0A3S7X9Q7	Leishmania donovani	25%	95%
A0A422N793	Trypanosoma rangeli	44%	95%
A1CUD6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	91%
A2RRU3	Rattus norvegicus	24%	80%
A4H666	Leishmania braziliensis	23%	100%
A4HBK3	Leishmania braziliensis	78%	100%
A4HGX7	Leishmania braziliensis	25%	100%
A4HN59	Leishmania braziliensis	26%	95%
A4HUJ0	Leishmania infantum	27%	100%
A4HZL2	Leishmania infantum	98%	100%
A4IBS6	Leishmania infantum	25%	95%
A4R3M4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	92%
B0XM00	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	24%	91%
B2B766	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	25%	91%
B8M0Q1	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	26%	92%
B8P4B0	Postia placenta (strain ATCC 44394 / Madison 698-R)	24%	97%
B8PD53	Postia placenta (strain ATCC 44394 / Madison 698-R)	24%	99%
C4JPW9	Uncinocarpus reesii (strain UAMH 1704)	26%	92%
C4JZS6	Uncinocarpus reesii (strain UAMH 1704)	23%	95%
C4YFX2	Candida albicans (strain WO-1)	24%	83%
C5FWH1	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	24%	92%
C9ZVL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A1J9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
D0A8Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D4AZ50	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	23%	92%
D4DG66	Trichophyton verrucosum (strain HKI 0517)	23%	92%
E8NHN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AFL2	Leishmania major	25%	95%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AUX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B6R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	95%
O74319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	66%
O74855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	84%
P0CY34	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	83%
P39014	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	66%
P49027	Oryza sativa subsp. japonica	24%	100%
P61964	Homo sapiens	25%	100%
P61965	Mus musculus	25%	100%
P62884	Leishmania infantum	25%	100%
P69103	Trypanosoma brucei brucei	28%	100%
P69104	Trypanosoma brucei rhodesiense	28%	100%
Q2KIG2	Bos taurus	25%	100%
Q3KQ62	Xenopus laevis	25%	100%
Q3Y8L7	Chlamydomonas reinhardtii	25%	95%
Q498M4	Rattus norvegicus	25%	100%
Q4ICM0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	92%
Q4P9P9	Ustilago maydis (strain 521 / FGSC 9021)	23%	94%
Q4Q0T1	Leishmania major	21%	83%
Q4Q7Y7	Leishmania major	25%	100%
Q4QHD6	Leishmania major	26%	100%
Q4R8E7	Macaca fascicularis	23%	100%
Q4WLM7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	91%
Q5BK30	Rattus norvegicus	23%	100%
Q5M786	Xenopus tropicalis	24%	100%
Q5XGI5	Xenopus tropicalis	23%	100%
Q6CB13	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	75%
Q6DH44	Danio rerio	25%	100%
Q6L4F8	Oryza sativa subsp. japonica	24%	100%
Q76LS6	Leishmania donovani	25%	100%
Q8I0F4	Dictyostelium discoideum	24%	100%
Q9M2Z2	Arabidopsis thaliana	22%	100%
Q9V3J8	Drosophila melanogaster	25%	100%
V5BDQ2	Trypanosoma cruzi	25%	100%
V5BFZ8	Trypanosoma cruzi	44%	100%
V5BP59	Trypanosoma cruzi	26%	100%