Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCK9_LEIMA

TriTrypDb:

LmjF.21.0070 , LMJLV39_210005800 , LMJSD75_210005800

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.425
CLV_NRD_NRD_1	223	225	PF00675	0.491
CLV_PCSK_KEX2_1	108	110	PF00082	0.429
CLV_PCSK_KEX2_1	223	225	PF00082	0.491
CLV_PCSK_SKI1_1	145	149	PF00082	0.476
CLV_PCSK_SKI1_1	22	26	PF00082	0.398
CLV_PCSK_SKI1_1	264	268	PF00082	0.590
CLV_PCSK_SKI1_1	28	32	PF00082	0.396
CLV_PCSK_SKI1_1	281	285	PF00082	0.615
CLV_PCSK_SKI1_1	46	50	PF00082	0.361
DEG_MDM2_SWIB_1	89	96	PF02201	0.551
DEG_Nend_UBRbox_2	1	3	PF02207	0.616
DOC_CKS1_1	159	164	PF01111	0.600
DOC_CYCLIN_RxL_1	10	21	PF00134	0.553
DOC_MAPK_gen_1	264	272	PF00069	0.392
DOC_MAPK_MEF2A_6	129	136	PF00069	0.492
DOC_MAPK_MEF2A_6	244	253	PF00069	0.320
DOC_PP1_RVXF_1	242	249	PF00149	0.311
DOC_PP1_RVXF_1	44	51	PF00149	0.504
DOC_USP7_MATH_1	139	143	PF00917	0.527
DOC_USP7_MATH_1	192	196	PF00917	0.667
DOC_USP7_MATH_1	198	202	PF00917	0.650
DOC_USP7_MATH_1	230	234	PF00917	0.703
DOC_USP7_MATH_1	265	269	PF00917	0.358
DOC_WW_Pin1_4	158	163	PF00397	0.599
LIG_14-3-3_CanoR_1	22	30	PF00244	0.594
LIG_14-3-3_CanoR_1	264	270	PF00244	0.362
LIG_14-3-3_CanoR_1	279	284	PF00244	0.452
LIG_14-3-3_CanoR_1	46	51	PF00244	0.579
LIG_14-3-3_CterR_2	281	285	PF00244	0.425
LIG_Actin_WH2_2	242	258	PF00022	0.353
LIG_AP2alpha_2	105	107	PF02296	0.578
LIG_Clathr_ClatBox_1	133	137	PF01394	0.492
LIG_FHA_1	121	127	PF00498	0.545
LIG_FHA_1	19	25	PF00498	0.573
LIG_FHA_1	89	95	PF00498	0.532
LIG_FHA_2	162	168	PF00498	0.594
LIG_FHA_2	216	222	PF00498	0.695
LIG_GBD_Chelix_1	246	254	PF00786	0.435
LIG_GBD_Chelix_1	262	270	PF00786	0.539
LIG_LIR_Gen_1	91	100	PF02991	0.578
LIG_LIR_Nem_3	56	61	PF02991	0.629
LIG_LIR_Nem_3	91	96	PF02991	0.558
LIG_NRBOX	245	251	PF00104	0.353
LIG_PCNA_PIPBox_1	30	39	PF02747	0.559
LIG_PDZ_Class_2	280	285	PF00595	0.448
LIG_Pex14_2	107	111	PF04695	0.621
LIG_Pex14_2	124	128	PF04695	0.449
LIG_Pex14_2	89	93	PF04695	0.545
LIG_Pex3_1	246	257	PF04882	0.311
LIG_SH2_STAT3	151	154	PF00017	0.593
LIG_SH2_STAT5	85	88	PF00017	0.504
LIG_SH3_3	186	192	PF00018	0.615
LIG_SxIP_EBH_1	228	239	PF03271	0.572
LIG_TRAF2_1	164	167	PF00917	0.578
LIG_WRC_WIRS_1	47	52	PF05994	0.559
MOD_CDK_SPxxK_3	158	165	PF00069	0.598
MOD_CK1_1	200	206	PF00069	0.701
MOD_CK2_1	161	167	PF00069	0.568
MOD_CK2_1	215	221	PF00069	0.700
MOD_GlcNHglycan	141	144	PF01048	0.377
MOD_GlcNHglycan	194	197	PF01048	0.421
MOD_GlcNHglycan	2	5	PF01048	0.418
MOD_GlcNHglycan	203	206	PF01048	0.479
MOD_GlcNHglycan	232	235	PF01048	0.497
MOD_GlcNHglycan	68	71	PF01048	0.337
MOD_GlcNHglycan	78	82	PF01048	0.340
MOD_GSK3_1	18	25	PF00069	0.576
MOD_GSK3_1	197	204	PF00069	0.698
MOD_GSK3_1	211	218	PF00069	0.664
MOD_LATS_1	44	50	PF00433	0.644
MOD_NEK2_1	270	275	PF00069	0.400
MOD_NEK2_1	36	41	PF00069	0.645
MOD_NEK2_2	120	125	PF00069	0.553
MOD_PIKK_1	150	156	PF00454	0.585
MOD_PIKK_1	211	217	PF00454	0.730
MOD_PIKK_1	22	28	PF00454	0.635
MOD_PKA_2	113	119	PF00069	0.582
MOD_PKA_2	215	221	PF00069	0.811
MOD_PKA_2	54	60	PF00069	0.474
MOD_PKB_1	112	120	PF00069	0.562
MOD_Plk_1	171	177	PF00069	0.576
MOD_Plk_4	184	190	PF00069	0.593
MOD_Plk_4	265	271	PF00069	0.381
MOD_Plk_4	28	34	PF00069	0.526
MOD_ProDKin_1	158	164	PF00069	0.601
TRG_ER_diArg_1	107	110	PF00400	0.623
TRG_ER_diArg_1	222	224	PF00400	0.632
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4B3	Leptomonas seymouri	48%	80%
A0A3Q8IA76	Leishmania donovani	93%	100%
A4HBK4	Leishmania braziliensis	74%	82%
A4HZL1	Leishmania infantum	92%	100%
E9AUX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%