MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania major

UniProt:

Q4QCK8_LEIMA

TriTrypDb:

LmjF.21.0080 , LMJLV39_210005900 , LMJSD75_210005900

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QCK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCK8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.528
CLV_PCSK_KEX2_1	47	49	PF00082	0.347
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.347
CLV_PCSK_SKI1_1	166	170	PF00082	0.261
CLV_PCSK_SKI1_1	410	414	PF00082	0.261
CLV_PCSK_SKI1_1	505	509	PF00082	0.611
CLV_PCSK_SKI1_1	60	64	PF00082	0.362
DEG_Nend_UBRbox_4	1	3	PF02207	0.519
DOC_CDC14_PxL_1	258	266	PF14671	0.387
DOC_CYCLIN_RxL_1	139	151	PF00134	0.364
DOC_CYCLIN_RxL_1	263	274	PF00134	0.341
DOC_CYCLIN_RxL_1	56	67	PF00134	0.554
DOC_MAPK_gen_1	105	112	PF00069	0.460
DOC_MAPK_gen_1	410	418	PF00069	0.476
DOC_MAPK_MEF2A_6	105	114	PF00069	0.456
DOC_MAPK_MEF2A_6	170	178	PF00069	0.519
DOC_PP1_RVXF_1	264	271	PF00149	0.341
DOC_PP1_RVXF_1	411	418	PF00149	0.461
DOC_USP7_MATH_1	198	202	PF00917	0.341
DOC_USP7_MATH_1	64	68	PF00917	0.548
DOC_WW_Pin1_4	216	221	PF00397	0.314
DOC_WW_Pin1_4	431	436	PF00397	0.426
DOC_WW_Pin1_4	62	67	PF00397	0.553
LIG_14-3-3_CanoR_1	239	249	PF00244	0.461
LIG_14-3-3_CanoR_1	41	47	PF00244	0.527
LIG_14-3-3_CanoR_1	533	539	PF00244	0.538
LIG_Actin_WH2_2	160	177	PF00022	0.334
LIG_APCC_ABBA_1	366	371	PF00400	0.387
LIG_BRCT_BRCA1_1	358	362	PF00533	0.361
LIG_BRCT_BRCA1_1	377	381	PF00533	0.176
LIG_BRCT_BRCA1_1	447	451	PF00533	0.225
LIG_BRCT_BRCA1_1	503	507	PF00533	0.398
LIG_FHA_1	11	17	PF00498	0.502
LIG_FHA_1	200	206	PF00498	0.341
LIG_FHA_1	221	227	PF00498	0.334
LIG_FHA_1	23	29	PF00498	0.492
LIG_FHA_1	263	269	PF00498	0.305
LIG_FHA_1	519	525	PF00498	0.316
LIG_FHA_1	57	63	PF00498	0.558
LIG_FHA_2	167	173	PF00498	0.492
LIG_FHA_2	180	186	PF00498	0.357
LIG_FHA_2	230	236	PF00498	0.426
LIG_FHA_2	272	278	PF00498	0.334
LIG_FHA_2	432	438	PF00498	0.426
LIG_FHA_2	93	99	PF00498	0.446
LIG_LIR_Apic_2	230	236	PF02991	0.357
LIG_LIR_Apic_2	32	37	PF02991	0.517
LIG_LIR_Apic_2	341	346	PF02991	0.541
LIG_LIR_Gen_1	13	21	PF02991	0.500
LIG_LIR_Gen_1	255	264	PF02991	0.325
LIG_LIR_Gen_1	269	278	PF02991	0.271
LIG_LIR_Gen_1	286	297	PF02991	0.264
LIG_LIR_Gen_1	363	373	PF02991	0.389
LIG_LIR_Gen_1	448	456	PF02991	0.459
LIG_LIR_Gen_1	98	104	PF02991	0.637
LIG_LIR_Nem_3	13	18	PF02991	0.500
LIG_LIR_Nem_3	150	155	PF02991	0.314
LIG_LIR_Nem_3	160	164	PF02991	0.314
LIG_LIR_Nem_3	169	174	PF02991	0.461
LIG_LIR_Nem_3	201	206	PF02991	0.256
LIG_LIR_Nem_3	255	261	PF02991	0.325
LIG_LIR_Nem_3	269	273	PF02991	0.271
LIG_LIR_Nem_3	274	279	PF02991	0.290
LIG_LIR_Nem_3	363	368	PF02991	0.421
LIG_LIR_Nem_3	371	376	PF02991	0.289
LIG_LIR_Nem_3	378	384	PF02991	0.275
LIG_LIR_Nem_3	386	391	PF02991	0.347
LIG_LIR_Nem_3	448	452	PF02991	0.413
LIG_LIR_Nem_3	537	541	PF02991	0.536
LIG_LIR_Nem_3	98	103	PF02991	0.611
LIG_MLH1_MIPbox_1	503	507	PF16413	0.398
LIG_OCRL_FandH_1	102	114	PF00620	0.425
LIG_PDZ_Class_3	545	550	PF00595	0.608
LIG_Pex14_1	34	38	PF04695	0.522
LIG_Pex14_1	365	369	PF04695	0.314
LIG_Pex14_2	157	161	PF04695	0.334
LIG_Pex14_2	99	103	PF04695	0.584
LIG_PTB_Apo_2	424	431	PF02174	0.334
LIG_SH2_CRK	171	175	PF00017	0.541
LIG_SH2_CRK	500	504	PF00017	0.314
LIG_SH2_NCK_1	469	473	PF00017	0.461
LIG_SH2_PTP2	15	18	PF00017	0.504
LIG_SH2_PTP2	258	261	PF00017	0.357
LIG_SH2_STAP1	276	280	PF00017	0.314
LIG_SH2_STAP1	373	377	PF00017	0.296
LIG_SH2_STAP1	469	473	PF00017	0.461
LIG_SH2_STAT3	541	544	PF00017	0.619
LIG_SH2_STAT5	15	18	PF00017	0.504
LIG_SH2_STAT5	258	261	PF00017	0.304
LIG_SH2_STAT5	393	396	PF00017	0.327
LIG_SH2_STAT5	402	405	PF00017	0.308
LIG_SH2_STAT5	407	410	PF00017	0.437
LIG_SH2_STAT5	414	417	PF00017	0.295
LIG_SH2_STAT5	541	544	PF00017	0.553
LIG_SH3_3	214	220	PF00018	0.314
LIG_SH3_3	287	293	PF00018	0.413
LIG_SH3_3	34	40	PF00018	0.521
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.542
LIG_SxIP_EBH_1	155	166	PF03271	0.342
LIG_TRAF2_1	478	481	PF00917	0.541
LIG_TYR_ITIM	256	261	PF00017	0.314
LIG_TYR_ITIM	353	358	PF00017	0.420
LIG_TYR_ITIM	467	472	PF00017	0.314
LIG_TYR_ITIM	498	503	PF00017	0.357
LIG_WRC_WIRS_1	158	163	PF05994	0.342
LIG_WRC_WIRS_1	384	389	PF05994	0.334
MOD_CDK_SPxxK_3	431	438	PF00069	0.426
MOD_CK1_1	227	233	PF00069	0.314
MOD_CK1_1	271	277	PF00069	0.459
MOD_CK1_1	314	320	PF00069	0.398
MOD_CK1_1	334	340	PF00069	0.202
MOD_CK1_1	341	347	PF00069	0.312
MOD_CK1_1	50	56	PF00069	0.436
MOD_CK2_1	179	185	PF00069	0.413
MOD_CK2_1	229	235	PF00069	0.392
MOD_CK2_1	271	277	PF00069	0.314
MOD_CK2_1	486	492	PF00069	0.314
MOD_GlcNHglycan	214	217	PF01048	0.357
MOD_GlcNHglycan	226	229	PF01048	0.314
MOD_GlcNHglycan	270	273	PF01048	0.421
MOD_GlcNHglycan	297	300	PF01048	0.424
MOD_GlcNHglycan	313	316	PF01048	0.206
MOD_GlcNHglycan	358	361	PF01048	0.352
MOD_GlcNHglycan	362	365	PF01048	0.364
MOD_GlcNHglycan	483	486	PF01048	0.314
MOD_GSK3_1	20	27	PF00069	0.349
MOD_GSK3_1	212	219	PF00069	0.377
MOD_GSK3_1	220	227	PF00069	0.314
MOD_GSK3_1	248	255	PF00069	0.349
MOD_GSK3_1	262	269	PF00069	0.294
MOD_GSK3_1	302	309	PF00069	0.370
MOD_GSK3_1	314	321	PF00069	0.267
MOD_GSK3_1	334	341	PF00069	0.299
MOD_GSK3_1	356	363	PF00069	0.334
MOD_GSK3_1	371	378	PF00069	0.304
MOD_GSK3_1	48	55	PF00069	0.435
MOD_GSK3_1	501	508	PF00069	0.418
MOD_GSK3_1	510	517	PF00069	0.316
MOD_GSK3_1	6	13	PF00069	0.379
MOD_GSK3_1	62	69	PF00069	0.428
MOD_N-GLC_1	534	539	PF02516	0.399
MOD_NEK2_1	148	153	PF00069	0.377
MOD_NEK2_1	157	162	PF00069	0.387
MOD_NEK2_1	229	234	PF00069	0.390
MOD_NEK2_1	248	253	PF00069	0.155
MOD_NEK2_1	268	273	PF00069	0.376
MOD_NEK2_1	311	316	PF00069	0.438
MOD_NEK2_1	369	374	PF00069	0.356
MOD_NEK2_1	406	411	PF00069	0.349
MOD_NEK2_1	418	423	PF00069	0.438
MOD_NEK2_1	445	450	PF00069	0.438
MOD_NEK2_1	451	456	PF00069	0.360
MOD_NEK2_1	518	523	PF00069	0.336
MOD_NEK2_2	364	369	PF00069	0.327
MOD_NEK2_2	383	388	PF00069	0.314
MOD_PIKK_1	334	340	PF00454	0.426
MOD_PIKK_1	50	56	PF00454	0.436
MOD_PKA_1	266	272	PF00069	0.459
MOD_PKA_1	47	53	PF00069	0.435
MOD_PKA_2	240	246	PF00069	0.314
MOD_PKA_2	40	46	PF00069	0.403
MOD_PKA_2	47	53	PF00069	0.428
MOD_PKA_2	71	77	PF00069	0.448
MOD_Plk_1	10	16	PF00069	0.372
MOD_Plk_1	306	312	PF00069	0.445
MOD_Plk_1	331	337	PF00069	0.255
MOD_Plk_1	436	442	PF00069	0.426
MOD_Plk_1	473	479	PF00069	0.314
MOD_Plk_1	534	540	PF00069	0.403
MOD_Plk_2-3	318	324	PF00069	0.407
MOD_Plk_4	157	163	PF00069	0.342
MOD_Plk_4	229	235	PF00069	0.426
MOD_Plk_4	271	277	PF00069	0.334
MOD_Plk_4	306	312	PF00069	0.362
MOD_Plk_4	383	389	PF00069	0.385
MOD_Plk_4	398	404	PF00069	0.235
MOD_Plk_4	438	444	PF00069	0.357
MOD_Plk_4	445	451	PF00069	0.357
MOD_ProDKin_1	216	222	PF00069	0.314
MOD_ProDKin_1	431	437	PF00069	0.426
MOD_ProDKin_1	62	68	PF00069	0.443
MOD_SUMO_rev_2	314	321	PF00179	0.370
TRG_DiLeu_BaEn_1	331	336	PF01217	0.387
TRG_DiLeu_BaEn_3	379	385	PF01217	0.459
TRG_ENDOCYTIC_2	15	18	PF00928	0.374
TRG_ENDOCYTIC_2	171	174	PF00928	0.426
TRG_ENDOCYTIC_2	258	261	PF00928	0.306
TRG_ENDOCYTIC_2	276	279	PF00928	0.317
TRG_ENDOCYTIC_2	355	358	PF00928	0.389
TRG_ENDOCYTIC_2	373	376	PF00928	0.182
TRG_ENDOCYTIC_2	414	417	PF00928	0.319
TRG_ENDOCYTIC_2	469	472	PF00928	0.314
TRG_ENDOCYTIC_2	500	503	PF00928	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJH4	Leptomonas seymouri	80%	100%
A0A0N1ILZ7	Leptomonas seymouri	22%	100%
A0A0S4J692	Bodo saltans	23%	91%
A0A0S4J989	Bodo saltans	50%	100%
A0A1X0NWR8	Trypanosomatidae	24%	100%
A0A1X0NXK8	Trypanosomatidae	65%	100%
A0A3R7NE20	Trypanosoma rangeli	61%	100%
A0A3S7WUW1	Leishmania donovani	23%	100%
A0A3S7WW86	Leishmania donovani	96%	100%
A4H9A1	Leishmania braziliensis	23%	100%
A4HBK5	Leishmania braziliensis	89%	100%
A4HXM1	Leishmania infantum	23%	100%
B2RXV4	Mus musculus	23%	98%
E9AGU5	Leishmania infantum	96%	100%
E9ARB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AUX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O01735	Caenorhabditis elegans	24%	94%
P60815	Rattus norvegicus	22%	100%
Q4QE46	Leishmania major	24%	100%
Q66H95	Rattus norvegicus	22%	100%
Q6GNV7	Xenopus laevis	22%	100%
Q6UXD7	Homo sapiens	24%	98%
Q8BFQ6	Mus musculus	22%	100%
Q91X85	Mus musculus	22%	100%
Q96SL1	Homo sapiens	22%	100%
Q9ES43	Mus terricolor	23%	98%
Q9N1F2	Felis catus	22%	98%
Q9UPI3	Homo sapiens	21%	100%
Q9Y5Y0	Homo sapiens	23%	99%
V5BQV3	Trypanosoma cruzi	24%	100%
V5DGX2	Trypanosoma cruzi	60%	100%