Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCK7_LEIMA

TriTrypDb:

LmjF.21.0090 , LMJLV39_210006000 , LMJSD75_210006000

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QCK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.304
CLV_PCSK_KEX2_1	87	89	PF00082	0.302
CLV_PCSK_SKI1_1	88	92	PF00082	0.323
DEG_APCC_DBOX_1	13	21	PF00400	0.518
DEG_Nend_UBRbox_2	1	3	PF02207	0.692
DEG_SPOP_SBC_1	174	178	PF00917	0.579
DOC_MAPK_gen_1	87	95	PF00069	0.478
DOC_MAPK_gen_1	9	19	PF00069	0.597
DOC_MAPK_HePTP_8	85	97	PF00069	0.539
DOC_MAPK_MEF2A_6	12	21	PF00069	0.481
DOC_MAPK_MEF2A_6	87	95	PF00069	0.488
DOC_MAPK_NFAT4_5	88	96	PF00069	0.518
DOC_USP7_MATH_1	161	165	PF00917	0.701
DOC_USP7_MATH_1	174	178	PF00917	0.686
DOC_USP7_MATH_1	65	69	PF00917	0.330
DOC_WW_Pin1_4	80	85	PF00397	0.597
LIG_14-3-3_CanoR_1	175	183	PF00244	0.714
LIG_deltaCOP1_diTrp_1	110	119	PF00928	0.339
LIG_EH1_1	22	30	PF00400	0.446
LIG_FHA_1	118	124	PF00498	0.355
LIG_LIR_Gen_1	116	126	PF02991	0.361
LIG_LIR_Gen_1	127	137	PF02991	0.344
LIG_LIR_Gen_1	50	61	PF02991	0.324
LIG_LIR_Nem_3	116	122	PF02991	0.358
LIG_LIR_Nem_3	127	132	PF02991	0.322
LIG_LIR_Nem_3	142	146	PF02991	0.302
LIG_LIR_Nem_3	41	47	PF02991	0.367
LIG_LIR_Nem_3	50	56	PF02991	0.277
LIG_PDZ_Class_2	178	183	PF00595	0.693
LIG_Pex14_2	104	108	PF04695	0.348
LIG_Pex14_2	135	139	PF04695	0.346
LIG_SH2_SRC	76	79	PF00017	0.597
LIG_SH2_STAP1	146	150	PF00017	0.554
LIG_SH2_STAT5	34	37	PF00017	0.444
LIG_SH2_STAT5	53	56	PF00017	0.232
LIG_SH3_3	64	70	PF00018	0.385
LIG_WRC_WIRS_1	114	119	PF05994	0.443
LIG_WRC_WIRS_1	53	58	PF05994	0.439
LIG_WRC_WIRS_1	96	101	PF05994	0.434
MOD_CDK_SPxxK_3	80	87	PF00069	0.620
MOD_CK1_1	166	172	PF00069	0.629
MOD_CK1_1	177	183	PF00069	0.710
MOD_CK1_1	83	89	PF00069	0.614
MOD_GlcNHglycan	165	168	PF01048	0.528
MOD_GlcNHglycan	67	70	PF01048	0.350
MOD_GSK3_1	113	120	PF00069	0.353
MOD_GSK3_1	124	131	PF00069	0.301
MOD_GSK3_1	144	151	PF00069	0.231
MOD_GSK3_1	173	180	PF00069	0.704
MOD_NEK2_1	113	118	PF00069	0.382
MOD_NEK2_1	128	133	PF00069	0.313
MOD_NEK2_1	139	144	PF00069	0.298
MOD_NEK2_1	173	178	PF00069	0.678
MOD_PIKK_1	161	167	PF00454	0.688
MOD_PKA_2	174	180	PF00069	0.695
MOD_Plk_4	128	134	PF00069	0.362
MOD_Plk_4	139	145	PF00069	0.342
MOD_ProDKin_1	80	86	PF00069	0.595
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.351
TRG_ENDOCYTIC_2	44	47	PF00928	0.394
TRG_ENDOCYTIC_2	53	56	PF00928	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT5	Leptomonas seymouri	27%	100%
A0A0N1PC80	Leptomonas seymouri	69%	100%
A0A0S4J4Y6	Bodo saltans	37%	100%
A0A0S4JQJ3	Bodo saltans	31%	100%
A0A1X0NXC4	Trypanosomatidae	41%	100%
A0A3Q8IF10	Leishmania donovani	97%	100%
A0A422N768	Trypanosoma rangeli	39%	100%
A4HBK6	Leishmania braziliensis	80%	99%
A4HZL0	Leishmania infantum	97%	100%
E9AUX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AZH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%