Guanylate cyclase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Guanylate cyclase

Gene product:

STE/STE11 serine/threonine-protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QCK2_LEIMA

TriTrypDb:

LmjF.21.0130 , LMJLV39_210006500 , LMJSD75_210006500

Length:

1722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QCK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006163	purine nucleotide metabolic process	5	6
GO:0006164	purine nucleotide biosynthetic process	6	6
GO:0006171	cAMP biosynthetic process	8	6
GO:0006182	cGMP biosynthetic process	8	6
GO:0006468	protein phosphorylation	5	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006753	nucleoside phosphate metabolic process	4	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009117	nucleotide metabolic process	5	6
GO:0009150	purine ribonucleotide metabolic process	6	6
GO:0009152	purine ribonucleotide biosynthetic process	7	6
GO:0009165	nucleotide biosynthetic process	6	6
GO:0009187	cyclic nucleotide metabolic process	6	6
GO:0009190	cyclic nucleotide biosynthetic process	7	6
GO:0009259	ribonucleotide metabolic process	5	6
GO:0009260	ribonucleotide biosynthetic process	6	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6
GO:0019538	protein metabolic process	3	6
GO:0019637	organophosphate metabolic process	3	6
GO:0019693	ribose phosphate metabolic process	4	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034654	nucleobase-containing compound biosynthetic process	4	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0046058	cAMP metabolic process	7	6
GO:0046068	cGMP metabolic process	7	6
GO:0046390	ribose phosphate biosynthetic process	5	6
GO:0046483	heterocycle metabolic process	3	6
GO:0052652	cyclic purine nucleotide metabolic process	6	6
GO:0055086	nucleobase-containing small molecule metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0072521	purine-containing compound metabolic process	4	6
GO:0072522	purine-containing compound biosynthetic process	5	6
GO:0090407	organophosphate biosynthetic process	4	6
GO:1901135	carbohydrate derivative metabolic process	3	6
GO:1901137	carbohydrate derivative biosynthetic process	4	6
GO:1901293	nucleoside phosphate biosynthetic process	5	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1091	1095	PF00656	0.584
CLV_C14_Caspase3-7	1408	1412	PF00656	0.612
CLV_C14_Caspase3-7	1690	1694	PF00656	0.496
CLV_C14_Caspase3-7	770	774	PF00656	0.683
CLV_NRD_NRD_1	1144	1146	PF00675	0.306
CLV_NRD_NRD_1	1232	1234	PF00675	0.422
CLV_NRD_NRD_1	133	135	PF00675	0.368
CLV_NRD_NRD_1	1613	1615	PF00675	0.259
CLV_NRD_NRD_1	190	192	PF00675	0.311
CLV_NRD_NRD_1	342	344	PF00675	0.477
CLV_NRD_NRD_1	427	429	PF00675	0.278
CLV_NRD_NRD_1	697	699	PF00675	0.297
CLV_NRD_NRD_1	749	751	PF00675	0.291
CLV_NRD_NRD_1	905	907	PF00675	0.286
CLV_NRD_NRD_1	936	938	PF00675	0.301
CLV_NRD_NRD_1	947	949	PF00675	0.274
CLV_PCSK_FUR_1	945	949	PF00082	0.279
CLV_PCSK_KEX2_1	1144	1146	PF00082	0.312
CLV_PCSK_KEX2_1	1232	1234	PF00082	0.422
CLV_PCSK_KEX2_1	133	135	PF00082	0.370
CLV_PCSK_KEX2_1	159	161	PF00082	0.404
CLV_PCSK_KEX2_1	1707	1709	PF00082	0.259
CLV_PCSK_KEX2_1	190	192	PF00082	0.375
CLV_PCSK_KEX2_1	342	344	PF00082	0.477
CLV_PCSK_KEX2_1	427	429	PF00082	0.278
CLV_PCSK_KEX2_1	597	599	PF00082	0.340
CLV_PCSK_KEX2_1	748	750	PF00082	0.331
CLV_PCSK_KEX2_1	792	794	PF00082	0.349
CLV_PCSK_KEX2_1	905	907	PF00082	0.286
CLV_PCSK_KEX2_1	936	938	PF00082	0.301
CLV_PCSK_KEX2_1	947	949	PF00082	0.274
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.348
CLV_PCSK_PC1ET2_1	1707	1709	PF00082	0.259
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.340
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.349
CLV_PCSK_PC7_1	155	161	PF00082	0.423
CLV_PCSK_PC7_1	593	599	PF00082	0.354
CLV_PCSK_SKI1_1	1017	1021	PF00082	0.292
CLV_PCSK_SKI1_1	1029	1033	PF00082	0.297
CLV_PCSK_SKI1_1	1053	1057	PF00082	0.407
CLV_PCSK_SKI1_1	1221	1225	PF00082	0.355
CLV_PCSK_SKI1_1	1566	1570	PF00082	0.368
CLV_PCSK_SKI1_1	1583	1587	PF00082	0.196
CLV_PCSK_SKI1_1	342	346	PF00082	0.537
CLV_PCSK_SKI1_1	347	351	PF00082	0.533
CLV_PCSK_SKI1_1	792	796	PF00082	0.357
CLV_PCSK_SKI1_1	940	944	PF00082	0.315
CLV_PCSK_SKI1_1	950	954	PF00082	0.274
DEG_APCC_DBOX_1	1565	1573	PF00400	0.496
DEG_APCC_DBOX_1	76	84	PF00400	0.574
DEG_APCC_DBOX_1	939	947	PF00400	0.538
DEG_Nend_UBRbox_1	1	4	PF02207	0.607
DEG_SCF_FBW7_1	1097	1103	PF00400	0.516
DEG_SCF_FBW7_2	588	595	PF00400	0.585
DEG_SPOP_SBC_1	582	586	PF00917	0.554
DOC_CDC14_PxL_1	1207	1215	PF14671	0.566
DOC_CKS1_1	1097	1102	PF01111	0.521
DOC_CKS1_1	589	594	PF01111	0.588
DOC_CKS1_1	692	697	PF01111	0.508
DOC_CYCLIN_RxL_1	1487	1500	PF00134	0.496
DOC_CYCLIN_RxL_1	305	316	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	1271	1277	PF00134	0.629
DOC_MAPK_gen_1	1144	1151	PF00069	0.480
DOC_MAPK_gen_1	133	139	PF00069	0.523
DOC_MAPK_gen_1	1583	1592	PF00069	0.459
DOC_MAPK_gen_1	179	185	PF00069	0.618
DOC_MAPK_gen_1	698	709	PF00069	0.501
DOC_MAPK_gen_1	936	943	PF00069	0.546
DOC_MAPK_MEF2A_6	1317	1324	PF00069	0.628
DOC_MAPK_MEF2A_6	1586	1594	PF00069	0.459
DOC_MAPK_MEF2A_6	717	726	PF00069	0.483
DOC_MAPK_MEF2A_6	73	82	PF00069	0.524
DOC_MAPK_MEF2A_6	936	943	PF00069	0.512
DOC_MAPK_MEF2A_6	993	1001	PF00069	0.485
DOC_PP1_RVXF_1	312	318	PF00149	0.459
DOC_PP1_RVXF_1	697	704	PF00149	0.466
DOC_PP2B_LxvP_1	1271	1274	PF13499	0.628
DOC_PP2B_LxvP_1	1494	1497	PF13499	0.459
DOC_PP2B_LxvP_1	3	6	PF13499	0.609
DOC_PP4_FxxP_1	268	271	PF00568	0.657
DOC_PP4_FxxP_1	507	510	PF00568	0.520
DOC_PP4_FxxP_1	623	626	PF00568	0.466
DOC_USP7_MATH_1	1088	1092	PF00917	0.633
DOC_USP7_MATH_1	1124	1128	PF00917	0.545
DOC_USP7_MATH_1	1197	1201	PF00917	0.533
DOC_USP7_MATH_1	1265	1269	PF00917	0.670
DOC_USP7_MATH_1	1309	1313	PF00917	0.654
DOC_USP7_MATH_1	132	136	PF00917	0.560
DOC_USP7_MATH_1	1360	1364	PF00917	0.705
DOC_USP7_MATH_1	1369	1373	PF00917	0.580
DOC_USP7_MATH_1	1422	1426	PF00917	0.563
DOC_USP7_MATH_1	149	153	PF00917	0.617
DOC_USP7_MATH_1	1495	1499	PF00917	0.459
DOC_USP7_MATH_1	271	275	PF00917	0.642
DOC_USP7_MATH_1	65	69	PF00917	0.506
DOC_USP7_MATH_1	686	690	PF00917	0.529
DOC_USP7_MATH_1	811	815	PF00917	0.590
DOC_USP7_MATH_1	840	844	PF00917	0.640
DOC_USP7_MATH_1	89	93	PF00917	0.617
DOC_USP7_MATH_1	991	995	PF00917	0.557
DOC_WW_Pin1_4	1084	1089	PF00397	0.571
DOC_WW_Pin1_4	1096	1101	PF00397	0.647
DOC_WW_Pin1_4	120	125	PF00397	0.639
DOC_WW_Pin1_4	1233	1238	PF00397	0.683
DOC_WW_Pin1_4	1243	1248	PF00397	0.642
DOC_WW_Pin1_4	1251	1256	PF00397	0.597
DOC_WW_Pin1_4	1266	1271	PF00397	0.603
DOC_WW_Pin1_4	1292	1297	PF00397	0.550
DOC_WW_Pin1_4	1361	1366	PF00397	0.655
DOC_WW_Pin1_4	1389	1394	PF00397	0.546
DOC_WW_Pin1_4	16	21	PF00397	0.676
DOC_WW_Pin1_4	1621	1626	PF00397	0.459
DOC_WW_Pin1_4	1633	1638	PF00397	0.459
DOC_WW_Pin1_4	1658	1663	PF00397	0.478
DOC_WW_Pin1_4	178	183	PF00397	0.697
DOC_WW_Pin1_4	254	259	PF00397	0.650
DOC_WW_Pin1_4	267	272	PF00397	0.541
DOC_WW_Pin1_4	48	53	PF00397	0.664
DOC_WW_Pin1_4	534	539	PF00397	0.667
DOC_WW_Pin1_4	552	557	PF00397	0.447
DOC_WW_Pin1_4	571	576	PF00397	0.542
DOC_WW_Pin1_4	588	593	PF00397	0.551
DOC_WW_Pin1_4	691	696	PF00397	0.529
DOC_WW_Pin1_4	775	780	PF00397	0.646
DOC_WW_Pin1_4	827	832	PF00397	0.620
DOC_WW_Pin1_4	87	92	PF00397	0.618
DOC_WW_Pin1_4	99	104	PF00397	0.751
LIG_14-3-3_CanoR_1	1090	1097	PF00244	0.575
LIG_14-3-3_CanoR_1	1132	1142	PF00244	0.514
LIG_14-3-3_CanoR_1	133	140	PF00244	0.557
LIG_14-3-3_CanoR_1	1708	1715	PF00244	0.459
LIG_14-3-3_CanoR_1	263	269	PF00244	0.691
LIG_14-3-3_CanoR_1	314	318	PF00244	0.278
LIG_14-3-3_CanoR_1	462	471	PF00244	0.486
LIG_14-3-3_CanoR_1	511	520	PF00244	0.520
LIG_14-3-3_CanoR_1	529	538	PF00244	0.550
LIG_14-3-3_CanoR_1	702	706	PF00244	0.546
LIG_14-3-3_CanoR_1	819	826	PF00244	0.585
LIG_Actin_WH2_2	1304	1319	PF00022	0.592
LIG_APCC_ABBA_1	1534	1539	PF00400	0.496
LIG_APCC_ABBA_1	411	416	PF00400	0.452
LIG_BRCT_BRCA1_1	1525	1529	PF00533	0.459
LIG_BRCT_BRCA1_1	233	237	PF00533	0.554
LIG_BRCT_BRCA1_1	722	726	PF00533	0.454
LIG_Clathr_ClatBox_1	1077	1081	PF01394	0.522
LIG_deltaCOP1_diTrp_1	1642	1650	PF00928	0.459
LIG_eIF4E_1	369	375	PF01652	0.504
LIG_eIF4E_1	678	684	PF01652	0.388
LIG_FHA_1	1016	1022	PF00498	0.528
LIG_FHA_1	1047	1053	PF00498	0.479
LIG_FHA_1	1376	1382	PF00498	0.535
LIG_FHA_1	1390	1396	PF00498	0.592
LIG_FHA_1	1408	1414	PF00498	0.504
LIG_FHA_1	1458	1464	PF00498	0.526
LIG_FHA_1	1517	1523	PF00498	0.459
LIG_FHA_1	1531	1537	PF00498	0.459
LIG_FHA_1	1558	1564	PF00498	0.459
LIG_FHA_1	1653	1659	PF00498	0.459
LIG_FHA_1	242	248	PF00498	0.583
LIG_FHA_1	314	320	PF00498	0.278
LIG_FHA_1	348	354	PF00498	0.484
LIG_FHA_1	390	396	PF00498	0.504
LIG_FHA_1	415	421	PF00498	0.499
LIG_FHA_1	471	477	PF00498	0.562
LIG_FHA_1	512	518	PF00498	0.520
LIG_FHA_1	530	536	PF00498	0.480
LIG_FHA_1	584	590	PF00498	0.601
LIG_FHA_1	644	650	PF00498	0.519
LIG_FHA_1	671	677	PF00498	0.311
LIG_FHA_1	702	708	PF00498	0.464
LIG_FHA_1	73	79	PF00498	0.505
LIG_FHA_1	908	914	PF00498	0.515
LIG_FHA_2	1099	1105	PF00498	0.606
LIG_FHA_2	1356	1362	PF00498	0.684
LIG_FHA_2	1406	1412	PF00498	0.605
LIG_FHA_2	17	23	PF00498	0.628
LIG_FHA_2	281	287	PF00498	0.603
LIG_FHA_2	35	41	PF00498	0.638
LIG_FHA_2	476	482	PF00498	0.571
LIG_FHA_2	768	774	PF00498	0.607
LIG_FHA_2	823	829	PF00498	0.610
LIG_FHA_2	840	846	PF00498	0.598
LIG_IRF3_LxIS_1	1279	1284	PF10401	0.566
LIG_LIR_Apic_2	1624	1630	PF02991	0.459
LIG_LIR_Apic_2	266	271	PF02991	0.670
LIG_LIR_Apic_2	505	510	PF02991	0.520
LIG_LIR_Apic_2	595	599	PF02991	0.494
LIG_LIR_Apic_2	622	626	PF02991	0.448
LIG_LIR_Gen_1	167	176	PF02991	0.725
LIG_LIR_Gen_1	372	383	PF02991	0.326
LIG_LIR_Gen_1	44	54	PF02991	0.644
LIG_LIR_Gen_1	445	454	PF02991	0.590
LIG_LIR_Gen_1	472	481	PF02991	0.529
LIG_LIR_Gen_1	518	527	PF02991	0.554
LIG_LIR_Gen_1	546	552	PF02991	0.480
LIG_LIR_Gen_1	662	670	PF02991	0.217
LIG_LIR_Gen_1	825	834	PF02991	0.577
LIG_LIR_Nem_3	1473	1477	PF02991	0.459
LIG_LIR_Nem_3	167	171	PF02991	0.722
LIG_LIR_Nem_3	316	320	PF02991	0.311
LIG_LIR_Nem_3	372	378	PF02991	0.262
LIG_LIR_Nem_3	44	50	PF02991	0.648
LIG_LIR_Nem_3	445	451	PF02991	0.609
LIG_LIR_Nem_3	453	457	PF02991	0.452
LIG_LIR_Nem_3	518	524	PF02991	0.516
LIG_LIR_Nem_3	546	550	PF02991	0.484
LIG_LIR_Nem_3	627	633	PF02991	0.476
LIG_LIR_Nem_3	662	666	PF02991	0.217
LIG_LIR_Nem_3	825	829	PF02991	0.566
LIG_MYND_1	1314	1318	PF01753	0.758
LIG_NRBOX	314	320	PF00104	0.290
LIG_PCNA_PIPBox_1	368	377	PF02747	0.342
LIG_PCNA_PIPBox_1	501	510	PF02747	0.502
LIG_PCNA_yPIPBox_3	1221	1235	PF02747	0.616
LIG_PCNA_yPIPBox_3	368	382	PF02747	0.318
LIG_PCNA_yPIPBox_3	501	511	PF02747	0.501
LIG_PDZ_Class_2	1717	1722	PF00595	0.466
LIG_Pex14_2	1020	1024	PF04695	0.504
LIG_Pex14_2	164	168	PF04695	0.609
LIG_Pex14_2	448	452	PF04695	0.432
LIG_Pex14_2	508	512	PF04695	0.515
LIG_Pex14_2	794	798	PF04695	0.524
LIG_PTB_Apo_2	1115	1122	PF02174	0.491
LIG_Rb_pABgroove_1	1054	1062	PF01858	0.476
LIG_SH2_CRK	1207	1211	PF00017	0.528
LIG_SH2_CRK	320	324	PF00017	0.342
LIG_SH2_CRK	454	458	PF00017	0.481
LIG_SH2_NCK_1	1109	1113	PF00017	0.501
LIG_SH2_NCK_1	1174	1178	PF00017	0.512
LIG_SH2_NCK_1	495	499	PF00017	0.541
LIG_SH2_PTP2	1301	1304	PF00017	0.618
LIG_SH2_SRC	1301	1304	PF00017	0.618
LIG_SH2_SRC	1674	1677	PF00017	0.496
LIG_SH2_SRC	924	927	PF00017	0.439
LIG_SH2_STAP1	1015	1019	PF00017	0.522
LIG_SH2_STAP1	1060	1064	PF00017	0.476
LIG_SH2_STAP1	1109	1113	PF00017	0.501
LIG_SH2_STAP1	1174	1178	PF00017	0.552
LIG_SH2_STAP1	531	535	PF00017	0.521
LIG_SH2_STAP1	567	571	PF00017	0.467
LIG_SH2_STAP1	908	912	PF00017	0.517
LIG_SH2_STAT3	1153	1156	PF00017	0.534
LIG_SH2_STAT5	1301	1304	PF00017	0.636
LIG_SH2_STAT5	1462	1465	PF00017	0.518
LIG_SH2_STAT5	1478	1481	PF00017	0.459
LIG_SH2_STAT5	1627	1630	PF00017	0.459
LIG_SH2_STAT5	465	468	PF00017	0.475
LIG_SH2_STAT5	474	477	PF00017	0.542
LIG_SH2_STAT5	531	534	PF00017	0.547
LIG_SH2_STAT5	552	555	PF00017	0.460
LIG_SH2_STAT5	557	560	PF00017	0.477
LIG_SH2_STAT5	669	672	PF00017	0.329
LIG_SH2_STAT5	678	681	PF00017	0.324
LIG_SH2_STAT5	70	73	PF00017	0.542
LIG_SH2_STAT5	705	708	PF00017	0.443
LIG_SH2_STAT5	720	723	PF00017	0.500
LIG_SH2_STAT5	732	735	PF00017	0.437
LIG_SH2_STAT5	924	927	PF00017	0.474
LIG_SH3_3	1045	1051	PF00018	0.493
LIG_SH3_3	1293	1299	PF00018	0.591
LIG_SH3_3	1312	1318	PF00018	0.762
LIG_SH3_3	1321	1327	PF00018	0.592
LIG_SH3_3	1359	1365	PF00018	0.704
LIG_SH3_3	1656	1662	PF00018	0.478
LIG_SH3_3	1680	1686	PF00018	0.459
LIG_SH3_3	252	258	PF00018	0.641
LIG_SH3_3	270	276	PF00018	0.691
LIG_SH3_3	433	439	PF00018	0.510
LIG_SH3_3	783	789	PF00018	0.558
LIG_SH3_3	829	835	PF00018	0.577
LIG_SH3_3	843	849	PF00018	0.714
LIG_SH3_3	857	863	PF00018	0.525
LIG_SH3_3	88	94	PF00018	0.603
LIG_SH3_CIN85_PxpxPR_1	1157	1162	PF14604	0.537
LIG_SH3_CIN85_PxpxPR_1	588	593	PF14604	0.517
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.593
LIG_SUMO_SIM_anti_2	1399	1405	PF11976	0.519
LIG_SUMO_SIM_anti_2	1509	1514	PF11976	0.459
LIG_SUMO_SIM_anti_2	645	651	PF11976	0.342
LIG_SUMO_SIM_par_1	1075	1081	PF11976	0.512
LIG_SUMO_SIM_par_1	123	130	PF11976	0.640
LIG_SUMO_SIM_par_1	1279	1284	PF11976	0.619
LIG_SxIP_EBH_1	159	171	PF03271	0.613
LIG_TRAF2_1	126	129	PF00917	0.635
LIG_TRAF2_1	1345	1348	PF00917	0.619
LIG_TRAF2_1	1433	1436	PF00917	0.526
LIG_TRAF2_1	20	23	PF00917	0.681
LIG_TRAF2_1	881	884	PF00917	0.528
LIG_TRFH_1	237	241	PF08558	0.582
LIG_TYR_ITIM	1172	1177	PF00017	0.507
LIG_TYR_ITIM	1205	1210	PF00017	0.532
LIG_TYR_ITIM	318	323	PF00017	0.348
LIG_TYR_ITIM	667	672	PF00017	0.290
LIG_UBA3_1	185	192	PF00899	0.564
LIG_UBA3_1	374	382	PF00899	0.518
LIG_UBA3_1	520	526	PF00899	0.521
LIG_UBA3_1	942	950	PF00899	0.516
LIG_WRC_WIRS_1	1591	1596	PF05994	0.496
LIG_WRC_WIRS_1	161	166	PF05994	0.612
LIG_WRC_WIRS_1	544	549	PF05994	0.451
LIG_WRC_WIRS_1	660	665	PF05994	0.232
MOD_CDC14_SPxK_1	1236	1239	PF00782	0.687
MOD_CDC14_SPxK_1	1636	1639	PF00782	0.496
MOD_CDK_SPK_2	588	593	PF00069	0.571
MOD_CDK_SPxK_1	1084	1090	PF00069	0.554
MOD_CDK_SPxK_1	1096	1102	PF00069	0.524
MOD_CDK_SPxK_1	1233	1239	PF00069	0.679
MOD_CDK_SPxK_1	1292	1298	PF00069	0.556
MOD_CDK_SPxK_1	1633	1639	PF00069	0.496
MOD_CDK_SPxxK_3	691	698	PF00069	0.525
MOD_CK1_1	102	108	PF00069	0.712
MOD_CK1_1	116	122	PF00069	0.674
MOD_CK1_1	1292	1298	PF00069	0.720
MOD_CK1_1	1405	1411	PF00069	0.599
MOD_CK1_1	1412	1418	PF00069	0.648
MOD_CK1_1	1446	1452	PF00069	0.557
MOD_CK1_1	1498	1504	PF00069	0.459
MOD_CK1_1	1706	1712	PF00069	0.496
MOD_CK1_1	233	239	PF00069	0.552
MOD_CK1_1	266	272	PF00069	0.646
MOD_CK1_1	278	284	PF00069	0.634
MOD_CK1_1	287	293	PF00069	0.609
MOD_CK1_1	45	51	PF00069	0.649
MOD_CK1_1	496	502	PF00069	0.492
MOD_CK1_1	64	70	PF00069	0.550
MOD_CK1_1	642	648	PF00069	0.496
MOD_CK2_1	1098	1104	PF00069	0.577
MOD_CK2_1	1188	1194	PF00069	0.657
MOD_CK2_1	123	129	PF00069	0.606
MOD_CK2_1	1326	1332	PF00069	0.539
MOD_CK2_1	1355	1361	PF00069	0.681
MOD_CK2_1	1430	1436	PF00069	0.532
MOD_CK2_1	1498	1504	PF00069	0.459
MOD_CK2_1	16	22	PF00069	0.624
MOD_CK2_1	1614	1620	PF00069	0.496
MOD_CK2_1	166	172	PF00069	0.612
MOD_CK2_1	213	219	PF00069	0.630
MOD_CK2_1	280	286	PF00069	0.609
MOD_CK2_1	345	351	PF00069	0.381
MOD_CK2_1	475	481	PF00069	0.583
MOD_CK2_1	50	56	PF00069	0.626
MOD_CK2_1	527	533	PF00069	0.520
MOD_CK2_1	769	775	PF00069	0.617
MOD_CK2_1	822	828	PF00069	0.609
MOD_CK2_1	839	845	PF00069	0.594
MOD_GlcNHglycan	1056	1059	PF01048	0.286
MOD_GlcNHglycan	1072	1075	PF01048	0.373
MOD_GlcNHglycan	1081	1085	PF01048	0.369
MOD_GlcNHglycan	1153	1156	PF01048	0.334
MOD_GlcNHglycan	1275	1278	PF01048	0.396
MOD_GlcNHglycan	1282	1286	PF01048	0.373
MOD_GlcNHglycan	1291	1294	PF01048	0.366
MOD_GlcNHglycan	134	137	PF01048	0.365
MOD_GlcNHglycan	1404	1407	PF01048	0.380
MOD_GlcNHglycan	1415	1418	PF01048	0.319
MOD_GlcNHglycan	1428	1431	PF01048	0.301
MOD_GlcNHglycan	147	150	PF01048	0.433
MOD_GlcNHglycan	1484	1487	PF01048	0.259
MOD_GlcNHglycan	1499	1503	PF01048	0.259
MOD_GlcNHglycan	152	155	PF01048	0.510
MOD_GlcNHglycan	1605	1608	PF01048	0.259
MOD_GlcNHglycan	1677	1680	PF01048	0.314
MOD_GlcNHglycan	1709	1712	PF01048	0.296
MOD_GlcNHglycan	199	202	PF01048	0.358
MOD_GlcNHglycan	215	218	PF01048	0.510
MOD_GlcNHglycan	226	229	PF01048	0.411
MOD_GlcNHglycan	233	236	PF01048	0.292
MOD_GlcNHglycan	252	255	PF01048	0.471
MOD_GlcNHglycan	277	280	PF01048	0.498
MOD_GlcNHglycan	288	292	PF01048	0.436
MOD_GlcNHglycan	347	350	PF01048	0.585
MOD_GlcNHglycan	42	47	PF01048	0.440
MOD_GlcNHglycan	467	470	PF01048	0.279
MOD_GlcNHglycan	496	499	PF01048	0.279
MOD_GlcNHglycan	52	55	PF01048	0.497
MOD_GlcNHglycan	538	541	PF01048	0.336
MOD_GlcNHglycan	614	617	PF01048	0.344
MOD_GlcNHglycan	63	66	PF01048	0.324
MOD_GlcNHglycan	813	816	PF01048	0.420
MOD_GlcNHglycan	884	888	PF01048	0.296
MOD_GlcNHglycan	928	931	PF01048	0.277
MOD_GlcNHglycan	956	959	PF01048	0.286
MOD_GSK3_1	1009	1016	PF00069	0.499
MOD_GSK3_1	1080	1087	PF00069	0.624
MOD_GSK3_1	1096	1103	PF00069	0.573
MOD_GSK3_1	1130	1137	PF00069	0.526
MOD_GSK3_1	116	123	PF00069	0.568
MOD_GSK3_1	1186	1193	PF00069	0.654
MOD_GSK3_1	1233	1240	PF00069	0.699
MOD_GSK3_1	1281	1288	PF00069	0.608
MOD_GSK3_1	1405	1412	PF00069	0.661
MOD_GSK3_1	1422	1429	PF00069	0.469
MOD_GSK3_1	1430	1437	PF00069	0.536
MOD_GSK3_1	1446	1453	PF00069	0.558
MOD_GSK3_1	145	152	PF00069	0.614
MOD_GSK3_1	1458	1465	PF00069	0.646
MOD_GSK3_1	1552	1559	PF00069	0.471
MOD_GSK3_1	1570	1577	PF00069	0.391
MOD_GSK3_1	160	167	PF00069	0.554
MOD_GSK3_1	1638	1645	PF00069	0.459
MOD_GSK3_1	1703	1710	PF00069	0.459
MOD_GSK3_1	193	200	PF00069	0.514
MOD_GSK3_1	250	257	PF00069	0.742
MOD_GSK3_1	263	270	PF00069	0.670
MOD_GSK3_1	271	278	PF00069	0.636
MOD_GSK3_1	280	287	PF00069	0.586
MOD_GSK3_1	343	350	PF00069	0.348
MOD_GSK3_1	356	363	PF00069	0.316
MOD_GSK3_1	422	429	PF00069	0.501
MOD_GSK3_1	460	467	PF00069	0.563
MOD_GSK3_1	475	482	PF00069	0.502
MOD_GSK3_1	511	518	PF00069	0.528
MOD_GSK3_1	525	532	PF00069	0.567
MOD_GSK3_1	546	553	PF00069	0.538
MOD_GSK3_1	558	565	PF00069	0.436
MOD_GSK3_1	61	68	PF00069	0.516
MOD_GSK3_1	639	646	PF00069	0.522
MOD_GSK3_1	711	718	PF00069	0.477
MOD_GSK3_1	796	803	PF00069	0.511
MOD_GSK3_1	818	825	PF00069	0.550
MOD_GSK3_1	891	898	PF00069	0.532
MOD_GSK3_1	95	102	PF00069	0.714
MOD_N-GLC_1	1413	1418	PF02516	0.383
MOD_N-GLC_1	1446	1451	PF02516	0.370
MOD_N-GLC_1	1457	1462	PF02516	0.310
MOD_N-GLC_1	1516	1521	PF02516	0.259
MOD_N-GLC_1	230	235	PF02516	0.357
MOD_N-GLC_1	512	517	PF02516	0.266
MOD_N-GLC_1	576	581	PF02516	0.397
MOD_N-GLC_2	193	195	PF02516	0.370
MOD_N-GLC_2	607	609	PF02516	0.326
MOD_NEK2_1	1080	1085	PF00069	0.565
MOD_NEK2_1	1151	1156	PF00069	0.604
MOD_NEK2_1	1188	1193	PF00069	0.658
MOD_NEK2_1	1260	1265	PF00069	0.677
MOD_NEK2_1	1287	1292	PF00069	0.597
MOD_NEK2_1	1375	1380	PF00069	0.554
MOD_NEK2_1	1402	1407	PF00069	0.591
MOD_NEK2_1	1434	1439	PF00069	0.513
MOD_NEK2_1	145	150	PF00069	0.534
MOD_NEK2_1	1463	1468	PF00069	0.543
MOD_NEK2_1	1542	1547	PF00069	0.459
MOD_NEK2_1	1592	1597	PF00069	0.481
MOD_NEK2_1	1603	1608	PF00069	0.446
MOD_NEK2_1	197	202	PF00069	0.538
MOD_NEK2_1	230	235	PF00069	0.635
MOD_NEK2_1	313	318	PF00069	0.450
MOD_NEK2_1	33	38	PF00069	0.718
MOD_NEK2_1	345	350	PF00069	0.382
MOD_NEK2_1	464	469	PF00069	0.497
MOD_NEK2_1	483	488	PF00069	0.562
MOD_NEK2_1	520	525	PF00069	0.576
MOD_NEK2_1	670	675	PF00069	0.317
MOD_NEK2_1	72	77	PF00069	0.533
MOD_NEK2_1	798	803	PF00069	0.502
MOD_NEK2_1	876	881	PF00069	0.587
MOD_NEK2_2	422	427	PF00069	0.558
MOD_NEK2_2	460	465	PF00069	0.475
MOD_NEK2_2	65	70	PF00069	0.507
MOD_OFUCOSY	1346	1352	PF10250	0.386
MOD_PIKK_1	1188	1194	PF00454	0.657
MOD_PIKK_1	271	277	PF00454	0.628
MOD_PIKK_1	389	395	PF00454	0.453
MOD_PK_1	916	922	PF00069	0.454
MOD_PKA_1	1614	1620	PF00069	0.496
MOD_PKA_1	1707	1713	PF00069	0.459
MOD_PKA_2	116	122	PF00069	0.650
MOD_PKA_2	1238	1244	PF00069	0.680
MOD_PKA_2	132	138	PF00069	0.540
MOD_PKA_2	1463	1469	PF00069	0.459
MOD_PKA_2	1707	1713	PF00069	0.459
MOD_PKA_2	213	219	PF00069	0.630
MOD_PKA_2	231	237	PF00069	0.521
MOD_PKA_2	313	319	PF00069	0.450
MOD_PKA_2	426	432	PF00069	0.477
MOD_PKA_2	701	707	PF00069	0.546
MOD_PKA_2	818	824	PF00069	0.590
MOD_Plk_1	1088	1094	PF00069	0.625
MOD_Plk_1	1103	1109	PF00069	0.463
MOD_Plk_1	1309	1315	PF00069	0.632
MOD_Plk_1	1446	1452	PF00069	0.569
MOD_Plk_1	1516	1522	PF00069	0.459
MOD_Plk_1	206	212	PF00069	0.608
MOD_Plk_1	42	48	PF00069	0.626
MOD_Plk_1	633	639	PF00069	0.471
MOD_Plk_1	710	716	PF00069	0.461
MOD_Plk_1	876	882	PF00069	0.554
MOD_Plk_1	883	889	PF00069	0.502
MOD_Plk_1	908	914	PF00069	0.478
MOD_Plk_2-3	284	290	PF00069	0.621
MOD_Plk_2-3	527	533	PF00069	0.548
MOD_Plk_2-3	619	625	PF00069	0.507
MOD_Plk_2-3	767	773	PF00069	0.648
MOD_Plk_2-3	822	828	PF00069	0.581
MOD_Plk_4	1004	1010	PF00069	0.603
MOD_Plk_4	1422	1428	PF00069	0.564
MOD_Plk_4	1458	1464	PF00069	0.565
MOD_Plk_4	1530	1536	PF00069	0.496
MOD_Plk_4	160	166	PF00069	0.700
MOD_Plk_4	242	248	PF00069	0.586
MOD_Plk_4	313	319	PF00069	0.473
MOD_Plk_4	356	362	PF00069	0.356
MOD_Plk_4	470	476	PF00069	0.514
MOD_Plk_4	499	505	PF00069	0.603
MOD_Plk_4	515	521	PF00069	0.481
MOD_Plk_4	558	564	PF00069	0.473
MOD_Plk_4	65	71	PF00069	0.516
MOD_Plk_4	651	657	PF00069	0.486
MOD_Plk_4	782	788	PF00069	0.678
MOD_Plk_4	908	914	PF00069	0.498
MOD_ProDKin_1	1084	1090	PF00069	0.578
MOD_ProDKin_1	1096	1102	PF00069	0.641
MOD_ProDKin_1	120	126	PF00069	0.637
MOD_ProDKin_1	1233	1239	PF00069	0.684
MOD_ProDKin_1	1243	1249	PF00069	0.643
MOD_ProDKin_1	1251	1257	PF00069	0.595
MOD_ProDKin_1	1266	1272	PF00069	0.599
MOD_ProDKin_1	1292	1298	PF00069	0.551
MOD_ProDKin_1	1361	1367	PF00069	0.653
MOD_ProDKin_1	1389	1395	PF00069	0.544
MOD_ProDKin_1	16	22	PF00069	0.677
MOD_ProDKin_1	1621	1627	PF00069	0.459
MOD_ProDKin_1	1633	1639	PF00069	0.459
MOD_ProDKin_1	1658	1664	PF00069	0.478
MOD_ProDKin_1	178	184	PF00069	0.696
MOD_ProDKin_1	254	260	PF00069	0.652
MOD_ProDKin_1	267	273	PF00069	0.536
MOD_ProDKin_1	48	54	PF00069	0.663
MOD_ProDKin_1	534	540	PF00069	0.663
MOD_ProDKin_1	552	558	PF00069	0.447
MOD_ProDKin_1	571	577	PF00069	0.546
MOD_ProDKin_1	588	594	PF00069	0.550
MOD_ProDKin_1	691	697	PF00069	0.527
MOD_ProDKin_1	775	781	PF00069	0.647
MOD_ProDKin_1	827	833	PF00069	0.622
MOD_ProDKin_1	87	93	PF00069	0.623
MOD_ProDKin_1	99	105	PF00069	0.750
MOD_SUMO_for_1	1223	1226	PF00179	0.552
MOD_SUMO_rev_2	1347	1351	PF00179	0.588
MOD_SUMO_rev_2	376	384	PF00179	0.522
TRG_DiLeu_BaEn_1	1507	1512	PF01217	0.459
TRG_DiLeu_BaLyEn_6	1073	1078	PF01217	0.488
TRG_ENDOCYTIC_2	1174	1177	PF00928	0.510
TRG_ENDOCYTIC_2	1207	1210	PF00928	0.540
TRG_ENDOCYTIC_2	1478	1481	PF00928	0.459
TRG_ENDOCYTIC_2	320	323	PF00928	0.348
TRG_ENDOCYTIC_2	454	457	PF00928	0.499
TRG_ENDOCYTIC_2	474	477	PF00928	0.514
TRG_ENDOCYTIC_2	669	672	PF00928	0.290
TRG_ENDOCYTIC_2	681	684	PF00928	0.480
TRG_ENDOCYTIC_2	873	876	PF00928	0.646
TRG_ER_diArg_1	1	4	PF00400	0.572
TRG_ER_diArg_1	1143	1145	PF00400	0.509
TRG_ER_diArg_1	1231	1233	PF00400	0.610
TRG_ER_diArg_1	189	191	PF00400	0.578
TRG_ER_diArg_1	342	344	PF00400	0.277
TRG_ER_diArg_1	747	750	PF00400	0.489
TRG_ER_diArg_1	904	906	PF00400	0.490
TRG_ER_diArg_1	936	938	PF00400	0.501
TRG_ER_diArg_1	945	948	PF00400	0.481
TRG_NES_CRM1_1	1036	1050	PF08389	0.491
TRG_Pf-PMV_PEXEL_1	1090	1094	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	1203	1208	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I1	Leptomonas seymouri	51%	95%
A0A3S7WWE3	Leishmania donovani	90%	100%
A4HZA0	Leishmania infantum	89%	100%
E9AUY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%