Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCK1_LEIMA

TriTrypDb:

LmjF.21.0140 , LMJLV39_210006700 , LMJSD75_210006700

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.579
CLV_C14_Caspase3-7	620	624	PF00656	0.597
CLV_NRD_NRD_1	155	157	PF00675	0.451
CLV_NRD_NRD_1	413	415	PF00675	0.565
CLV_NRD_NRD_1	565	567	PF00675	0.505
CLV_NRD_NRD_1	570	572	PF00675	0.455
CLV_NRD_NRD_1	633	635	PF00675	0.693
CLV_PCSK_FUR_1	153	157	PF00082	0.511
CLV_PCSK_KEX2_1	155	157	PF00082	0.452
CLV_PCSK_KEX2_1	247	249	PF00082	0.577
CLV_PCSK_KEX2_1	565	567	PF00082	0.471
CLV_PCSK_KEX2_1	570	572	PF00082	0.441
CLV_PCSK_KEX2_1	633	635	PF00082	0.693
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.596
CLV_PCSK_PC7_1	566	572	PF00082	0.473
CLV_PCSK_SKI1_1	104	108	PF00082	0.416
CLV_PCSK_SKI1_1	15	19	PF00082	0.712
CLV_PCSK_SKI1_1	209	213	PF00082	0.417
CLV_PCSK_SKI1_1	219	223	PF00082	0.376
CLV_PCSK_SKI1_1	369	373	PF00082	0.470
CLV_PCSK_SKI1_1	459	463	PF00082	0.412
CLV_PCSK_SKI1_1	95	99	PF00082	0.475
DEG_APCC_DBOX_1	103	111	PF00400	0.404
DEG_Nend_UBRbox_3	1	3	PF02207	0.589
DEG_SCF_FBW7_1	361	368	PF00400	0.534
DEG_SPOP_SBC_1	327	331	PF00917	0.483
DEG_SPOP_SBC_1	83	87	PF00917	0.544
DOC_CKS1_1	362	367	PF01111	0.538
DOC_CKS1_1	401	406	PF01111	0.517
DOC_CYCLIN_RxL_1	152	162	PF00134	0.421
DOC_CYCLIN_RxL_1	366	377	PF00134	0.565
DOC_MAPK_gen_1	247	253	PF00069	0.557
DOC_MAPK_gen_1	98	107	PF00069	0.566
DOC_PP1_RVXF_1	153	160	PF00149	0.407
DOC_PP1_RVXF_1	207	213	PF00149	0.438
DOC_PP1_RVXF_1	217	223	PF00149	0.400
DOC_PP1_RVXF_1	259	266	PF00149	0.527
DOC_PP1_RVXF_1	367	374	PF00149	0.457
DOC_PP1_RVXF_1	447	454	PF00149	0.483
DOC_PP4_FxxP_1	341	344	PF00568	0.538
DOC_USP7_MATH_1	139	143	PF00917	0.554
DOC_USP7_MATH_1	22	26	PF00917	0.734
DOC_USP7_MATH_1	28	32	PF00917	0.470
DOC_USP7_MATH_1	365	369	PF00917	0.487
DOC_USP7_MATH_1	582	586	PF00917	0.522
DOC_USP7_MATH_1	83	87	PF00917	0.534
DOC_WW_Pin1_4	184	189	PF00397	0.504
DOC_WW_Pin1_4	26	31	PF00397	0.743
DOC_WW_Pin1_4	340	345	PF00397	0.614
DOC_WW_Pin1_4	361	366	PF00397	0.521
DOC_WW_Pin1_4	400	405	PF00397	0.500
DOC_WW_Pin1_4	465	470	PF00397	0.412
DOC_WW_Pin1_4	519	524	PF00397	0.457
LIG_14-3-3_CanoR_1	109	118	PF00244	0.496
LIG_14-3-3_CanoR_1	15	23	PF00244	0.656
LIG_14-3-3_CanoR_1	174	182	PF00244	0.447
LIG_14-3-3_CanoR_1	238	242	PF00244	0.625
LIG_14-3-3_CanoR_1	290	296	PF00244	0.511
LIG_14-3-3_CanoR_1	393	398	PF00244	0.533
LIG_14-3-3_CanoR_1	614	619	PF00244	0.587
LIG_Actin_WH2_2	65	81	PF00022	0.631
LIG_BRCT_BRCA1_1	177	181	PF00533	0.427
LIG_CaM_IQ_9	87	103	PF13499	0.501
LIG_deltaCOP1_diTrp_1	146	154	PF00928	0.369
LIG_deltaCOP1_diTrp_1	434	440	PF00928	0.441
LIG_deltaCOP1_diTrp_1	452	458	PF00928	0.448
LIG_deltaCOP1_diTrp_1	506	514	PF00928	0.538
LIG_EVH1_2	291	295	PF00568	0.547
LIG_FHA_1	111	117	PF00498	0.467
LIG_FHA_1	16	22	PF00498	0.655
LIG_FHA_1	193	199	PF00498	0.423
LIG_FHA_1	216	222	PF00498	0.401
LIG_FHA_1	223	229	PF00498	0.260
LIG_FHA_1	27	33	PF00498	0.726
LIG_FHA_1	304	310	PF00498	0.471
LIG_FHA_1	329	335	PF00498	0.466
LIG_FHA_1	85	91	PF00498	0.566
LIG_FHA_2	452	458	PF00498	0.541
LIG_FHA_2	483	489	PF00498	0.501
LIG_FHA_2	539	545	PF00498	0.538
LIG_FHA_2	595	601	PF00498	0.556
LIG_LIR_Apic_2	557	562	PF02991	0.469
LIG_LIR_Gen_1	146	154	PF02991	0.386
LIG_LIR_Gen_1	168	177	PF02991	0.402
LIG_LIR_Gen_1	396	405	PF02991	0.615
LIG_LIR_Gen_1	452	461	PF02991	0.501
LIG_LIR_Gen_1	479	487	PF02991	0.420
LIG_LIR_Nem_3	146	151	PF02991	0.364
LIG_LIR_Nem_3	168	173	PF02991	0.394
LIG_LIR_Nem_3	396	401	PF02991	0.621
LIG_LIR_Nem_3	452	456	PF02991	0.461
LIG_LIR_Nem_3	457	461	PF02991	0.397
LIG_LIR_Nem_3	479	484	PF02991	0.434
LIG_LIR_Nem_3	506	511	PF02991	0.476
LIG_NRP_CendR_1	639	641	PF00754	0.693
LIG_PCNA_PIPBox_1	296	305	PF02747	0.424
LIG_PCNA_TLS_4	475	482	PF02747	0.451
LIG_PCNA_yPIPBox_3	393	401	PF02747	0.612
LIG_Pex14_2	241	245	PF04695	0.558
LIG_REV1ctd_RIR_1	179	187	PF16727	0.373
LIG_REV1ctd_RIR_1	370	380	PF16727	0.585
LIG_SH2_CRK	217	221	PF00017	0.422
LIG_SH2_NCK_1	579	583	PF00017	0.586
LIG_SH2_PTP2	559	562	PF00017	0.469
LIG_SH2_SRC	481	484	PF00017	0.460
LIG_SH2_STAP1	112	116	PF00017	0.507
LIG_SH2_STAP1	217	221	PF00017	0.398
LIG_SH2_STAP1	579	583	PF00017	0.550
LIG_SH2_STAT5	112	115	PF00017	0.506
LIG_SH2_STAT5	217	220	PF00017	0.402
LIG_SH2_STAT5	230	233	PF00017	0.581
LIG_SH2_STAT5	303	306	PF00017	0.405
LIG_SH2_STAT5	398	401	PF00017	0.560
LIG_SH2_STAT5	4	7	PF00017	0.666
LIG_SH2_STAT5	44	47	PF00017	0.659
LIG_SH2_STAT5	481	484	PF00017	0.458
LIG_SH2_STAT5	559	562	PF00017	0.482
LIG_SH3_3	285	291	PF00018	0.494
LIG_SH3_3	341	347	PF00018	0.468
LIG_SH3_3	352	358	PF00018	0.509
LIG_SH3_3	634	640	PF00018	0.661
LIG_SUMO_SIM_par_1	310	318	PF11976	0.459
LIG_SUMO_SIM_par_1	522	528	PF11976	0.433
LIG_TRAF2_1	525	528	PF00917	0.559
LIG_TRAF2_1	86	89	PF00917	0.599
LIG_TYR_ITIM	215	220	PF00017	0.432
LIG_UBA3_1	618	622	PF00899	0.572
MOD_CDK_SPK_2	465	470	PF00069	0.412
MOD_CK1_1	189	195	PF00069	0.503
MOD_CK1_1	37	43	PF00069	0.677
MOD_CK2_1	237	243	PF00069	0.652
MOD_CK2_1	322	328	PF00069	0.582
MOD_CK2_1	451	457	PF00069	0.548
MOD_CK2_1	538	544	PF00069	0.527
MOD_CK2_1	594	600	PF00069	0.622
MOD_CK2_1	82	88	PF00069	0.546
MOD_GlcNHglycan	24	27	PF01048	0.653
MOD_GlcNHglycan	376	379	PF01048	0.424
MOD_GlcNHglycan	434	438	PF01048	0.531
MOD_GlcNHglycan	48	51	PF01048	0.711
MOD_GlcNHglycan	584	587	PF01048	0.612
MOD_GlcNHglycan	623	626	PF01048	0.672
MOD_GlcNHglycan	95	98	PF01048	0.618
MOD_GSK3_1	22	29	PF00069	0.685
MOD_GSK3_1	222	229	PF00069	0.426
MOD_GSK3_1	318	325	PF00069	0.596
MOD_GSK3_1	33	40	PF00069	0.658
MOD_GSK3_1	361	368	PF00069	0.510
MOD_GSK3_1	44	51	PF00069	0.650
MOD_N-GLC_1	393	398	PF02516	0.533
MOD_N-GLC_1	519	524	PF02516	0.601
MOD_NEK2_1	159	164	PF00069	0.429
MOD_NEK2_1	222	227	PF00069	0.398
MOD_NEK2_1	32	37	PF00069	0.685
MOD_NEK2_1	372	377	PF00069	0.460
MOD_NEK2_1	38	43	PF00069	0.658
MOD_NEK2_1	443	448	PF00069	0.521
MOD_NEK2_1	531	536	PF00069	0.418
MOD_NEK2_1	575	580	PF00069	0.518
MOD_NEK2_1	621	626	PF00069	0.578
MOD_NEK2_1	93	98	PF00069	0.573
MOD_NEK2_2	169	174	PF00069	0.487
MOD_NEK2_2	74	79	PF00069	0.558
MOD_PIKK_1	588	594	PF00454	0.712
MOD_PK_1	393	399	PF00069	0.538
MOD_PKA_2	237	243	PF00069	0.626
MOD_PKB_1	184	192	PF00069	0.592
MOD_Plk_1	365	371	PF00069	0.468
MOD_Plk_1	393	399	PF00069	0.538
MOD_Plk_1	451	457	PF00069	0.541
MOD_Plk_4	186	192	PF00069	0.519
MOD_Plk_4	222	228	PF00069	0.379
MOD_Plk_4	28	34	PF00069	0.661
MOD_Plk_4	393	399	PF00069	0.538
MOD_Plk_4	531	537	PF00069	0.434
MOD_Plk_4	555	561	PF00069	0.465
MOD_Plk_4	614	620	PF00069	0.584
MOD_ProDKin_1	184	190	PF00069	0.496
MOD_ProDKin_1	26	32	PF00069	0.743
MOD_ProDKin_1	340	346	PF00069	0.609
MOD_ProDKin_1	361	367	PF00069	0.516
MOD_ProDKin_1	400	406	PF00069	0.497
MOD_ProDKin_1	465	471	PF00069	0.406
MOD_ProDKin_1	519	525	PF00069	0.451
MOD_SUMO_rev_2	468	477	PF00179	0.437
MOD_SUMO_rev_2	585	591	PF00179	0.552
MOD_SUMO_rev_2	617	624	PF00179	0.595
TRG_DiLeu_BaEn_1	473	478	PF01217	0.409
TRG_DiLeu_BaEn_1	600	605	PF01217	0.516
TRG_DiLeu_BaEn_2	456	462	PF01217	0.418
TRG_DiLeu_BaEn_2	485	491	PF01217	0.495
TRG_DiLeu_BaEn_3	88	94	PF01217	0.585
TRG_DiLeu_BaEn_4	424	430	PF01217	0.631
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.538
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.398
TRG_ENDOCYTIC_2	217	220	PF00928	0.426
TRG_ENDOCYTIC_2	398	401	PF00928	0.629
TRG_ENDOCYTIC_2	481	484	PF00928	0.440
TRG_ER_diArg_1	154	156	PF00400	0.438
TRG_ER_diArg_1	565	567	PF00400	0.490
TRG_ER_diArg_1	570	572	PF00400	0.434
TRG_ER_diArg_1	638	641	PF00400	0.749
TRG_NES_CRM1_1	544	557	PF08389	0.524
TRG_NLS_MonoExtN_4	411	418	PF00514	0.652
TRG_NLS_MonoExtN_4	509	516	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	354	359	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X2	Leptomonas seymouri	72%	96%
A0A0S4IQX1	Bodo saltans	45%	100%
A0A1X0NXS1	Trypanosomatidae	64%	94%
A0A3S7WWA1	Leishmania donovani	98%	100%
A4HBL3	Leishmania braziliensis	91%	100%
A4HZJ6	Leishmania infantum	98%	95%
D0A1K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
E9AUY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DGX7	Trypanosoma cruzi	62%	95%