Nucleolar protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleolar protein 9

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCJ8_LEIMA

TriTrypDb:

LmjF.21.0170 , LMJLV39_210007000 , LMJSD75_210007000

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0030686	90S preribosome	4	2
GO:0030688	preribosome, small subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QCJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCJ8

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	2
GO:0000056	ribosomal small subunit export from nucleus	4	2
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	2
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000966	RNA 5'-end processing	7	2
GO:0000967	rRNA 5'-end processing	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0031503	protein-containing complex localization	2	2
GO:0033750	ribosome localization	3	2
GO:0034470	ncRNA processing	7	2
GO:0034471	ncRNA 5'-end processing	8	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036260	RNA capping	7	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046907	intracellular transport	3	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051656	establishment of organelle localization	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.763
CLV_C14_Caspase3-7	467	471	PF00656	0.555
CLV_C14_Caspase3-7	602	606	PF00656	0.568
CLV_C14_Caspase3-7	74	78	PF00656	0.401
CLV_NRD_NRD_1	35	37	PF00675	0.443
CLV_NRD_NRD_1	420	422	PF00675	0.475
CLV_NRD_NRD_1	491	493	PF00675	0.450
CLV_NRD_NRD_1	640	642	PF00675	0.328
CLV_NRD_NRD_1	729	731	PF00675	0.426
CLV_NRD_NRD_1	747	749	PF00675	0.352
CLV_NRD_NRD_1	767	769	PF00675	0.315
CLV_PCSK_KEX2_1	34	36	PF00082	0.436
CLV_PCSK_KEX2_1	420	422	PF00082	0.475
CLV_PCSK_KEX2_1	445	447	PF00082	0.410
CLV_PCSK_KEX2_1	632	634	PF00082	0.409
CLV_PCSK_KEX2_1	640	642	PF00082	0.293
CLV_PCSK_KEX2_1	729	731	PF00082	0.382
CLV_PCSK_KEX2_1	767	769	PF00082	0.451
CLV_PCSK_KEX2_1	9	11	PF00082	0.568
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.410
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.419
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.568
CLV_PCSK_SKI1_1	118	122	PF00082	0.314
CLV_PCSK_SKI1_1	309	313	PF00082	0.340
CLV_PCSK_SKI1_1	420	424	PF00082	0.339
CLV_PCSK_SKI1_1	426	430	PF00082	0.305
CLV_PCSK_SKI1_1	446	450	PF00082	0.185
CLV_PCSK_SKI1_1	523	527	PF00082	0.500
CLV_PCSK_SKI1_1	547	551	PF00082	0.365
CLV_PCSK_SKI1_1	671	675	PF00082	0.381
CLV_PCSK_SKI1_1	767	771	PF00082	0.436
CLV_PCSK_SKI1_1	85	89	PF00082	0.421
DEG_APCC_DBOX_1	568	576	PF00400	0.453
DOC_CDC14_PxL_1	223	231	PF14671	0.340
DOC_CDC14_PxL_1	430	438	PF14671	0.382
DOC_CYCLIN_RxL_1	764	773	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.368
DOC_MAPK_DCC_7	500	508	PF00069	0.460
DOC_MAPK_gen_1	209	218	PF00069	0.286
DOC_MAPK_gen_1	566	575	PF00069	0.467
DOC_MAPK_gen_1	632	638	PF00069	0.438
DOC_MAPK_HePTP_8	206	218	PF00069	0.328
DOC_MAPK_MEF2A_6	118	125	PF00069	0.299
DOC_MAPK_MEF2A_6	209	218	PF00069	0.297
DOC_MAPK_MEF2A_6	375	384	PF00069	0.453
DOC_MAPK_MEF2A_6	420	429	PF00069	0.333
DOC_MAPK_MEF2A_6	500	508	PF00069	0.402
DOC_PP2B_LxvP_1	329	332	PF13499	0.358
DOC_PP2B_LxvP_1	407	410	PF13499	0.330
DOC_PP2B_LxvP_1	594	597	PF13499	0.516
DOC_PP4_FxxP_1	431	434	PF00568	0.446
DOC_USP7_MATH_1	135	139	PF00917	0.343
DOC_USP7_MATH_1	210	214	PF00917	0.319
DOC_USP7_MATH_1	274	278	PF00917	0.333
DOC_USP7_MATH_1	396	400	PF00917	0.460
DOC_USP7_MATH_1	448	452	PF00917	0.526
DOC_USP7_MATH_1	456	460	PF00917	0.676
DOC_USP7_MATH_1	468	472	PF00917	0.494
DOC_USP7_MATH_1	554	558	PF00917	0.360
DOC_USP7_MATH_1	610	614	PF00917	0.680
DOC_USP7_MATH_1	702	706	PF00917	0.679
DOC_USP7_MATH_1	71	75	PF00917	0.450
DOC_USP7_MATH_1	89	93	PF00917	0.288
DOC_USP7_MATH_2	11	17	PF00917	0.537
DOC_USP7_UBL2_3	489	493	PF12436	0.352
DOC_WW_Pin1_4	131	136	PF00397	0.303
DOC_WW_Pin1_4	24	29	PF00397	0.530
DOC_WW_Pin1_4	434	439	PF00397	0.390
DOC_WW_Pin1_4	499	504	PF00397	0.499
DOC_WW_Pin1_4	690	695	PF00397	0.585
DOC_WW_Pin1_4	722	727	PF00397	0.559
LIG_14-3-3_CanoR_1	209	215	PF00244	0.459
LIG_14-3-3_CanoR_1	22	28	PF00244	0.473
LIG_14-3-3_CanoR_1	640	650	PF00244	0.395
LIG_14-3-3_CanoR_1	686	694	PF00244	0.502
LIG_14-3-3_CterR_2	768	773	PF00244	0.492
LIG_Actin_RPEL_3	96	115	PF02755	0.326
LIG_Actin_WH2_2	199	214	PF00022	0.447
LIG_Actin_WH2_2	655	673	PF00022	0.326
LIG_APCC_ABBA_1	679	684	PF00400	0.405
LIG_eIF4E_1	139	145	PF01652	0.415
LIG_eIF4E_1	306	312	PF01652	0.468
LIG_eIF4E_1	400	406	PF01652	0.333
LIG_FAT_LD_1	141	149	PF03623	0.355
LIG_FHA_1	274	280	PF00498	0.485
LIG_FHA_1	333	339	PF00498	0.496
LIG_FHA_1	377	383	PF00498	0.550
LIG_FHA_1	396	402	PF00498	0.452
LIG_FHA_1	435	441	PF00498	0.321
LIG_FHA_1	471	477	PF00498	0.568
LIG_FHA_1	691	697	PF00498	0.489
LIG_FHA_2	156	162	PF00498	0.513
LIG_FHA_2	239	245	PF00498	0.428
LIG_FHA_2	600	606	PF00498	0.630
LIG_FHA_2	696	702	PF00498	0.712
LIG_FHA_2	708	714	PF00498	0.597
LIG_FHA_2	718	724	PF00498	0.583
LIG_IRF3_LxIS_1	128	134	PF10401	0.427
LIG_LIR_Gen_1	119	128	PF02991	0.290
LIG_LIR_Gen_1	17	28	PF02991	0.562
LIG_LIR_Gen_1	327	336	PF02991	0.440
LIG_LIR_Gen_1	652	662	PF02991	0.426
LIG_LIR_Gen_1	77	87	PF02991	0.322
LIG_LIR_LC3C_4	276	280	PF02991	0.410
LIG_LIR_Nem_3	119	125	PF02991	0.284
LIG_LIR_Nem_3	17	23	PF02991	0.554
LIG_LIR_Nem_3	327	331	PF02991	0.366
LIG_LIR_Nem_3	648	654	PF02991	0.364
LIG_LIR_Nem_3	750	755	PF02991	0.356
LIG_LIR_Nem_3	77	83	PF02991	0.320
LIG_LIR_Nem_3	90	96	PF02991	0.348
LIG_MYND_1	434	438	PF01753	0.353
LIG_NRBOX	140	146	PF00104	0.410
LIG_NRBOX	311	317	PF00104	0.308
LIG_NRBOX	82	88	PF00104	0.331
LIG_PCNA_yPIPBox_3	637	650	PF02747	0.419
LIG_PCNA_yPIPBox_3	758	770	PF02747	0.442
LIG_Rb_pABgroove_1	425	433	PF01858	0.442
LIG_SH2_CRK	501	505	PF00017	0.452
LIG_SH2_CRK	734	738	PF00017	0.254
LIG_SH2_NCK_1	501	505	PF00017	0.434
LIG_SH2_NCK_1	663	667	PF00017	0.436
LIG_SH2_PTP2	122	125	PF00017	0.312
LIG_SH2_PTP2	588	591	PF00017	0.427
LIG_SH2_STAP1	651	655	PF00017	0.355
LIG_SH2_STAT3	400	403	PF00017	0.341
LIG_SH2_STAT5	122	125	PF00017	0.316
LIG_SH2_STAT5	139	142	PF00017	0.302
LIG_SH2_STAT5	328	331	PF00017	0.297
LIG_SH2_STAT5	400	403	PF00017	0.427
LIG_SH2_STAT5	51	54	PF00017	0.347
LIG_SH2_STAT5	531	534	PF00017	0.368
LIG_SH2_STAT5	588	591	PF00017	0.334
LIG_SH2_STAT5	745	748	PF00017	0.408
LIG_SH2_STAT5	94	97	PF00017	0.443
LIG_SH3_3	230	236	PF00018	0.468
LIG_SH3_3	268	274	PF00018	0.432
LIG_SH3_3	328	334	PF00018	0.321
LIG_SH3_3	419	425	PF00018	0.411
LIG_SH3_CIN85_PxpxPR_1	232	237	PF14604	0.333
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.318
LIG_SUMO_SIM_anti_2	570	577	PF11976	0.360
LIG_SUMO_SIM_par_1	378	383	PF11976	0.436
LIG_TRAF2_1	249	252	PF00917	0.459
LIG_TRAF2_1	58	61	PF00917	0.380
LIG_TRFH_1	452	456	PF08558	0.459
LIG_TYR_ITIM	120	125	PF00017	0.301
LIG_TYR_ITIM	499	504	PF00017	0.367
LIG_TYR_ITIM	732	737	PF00017	0.243
LIG_UBA3_1	572	580	PF00899	0.417
LIG_UBA3_1	83	88	PF00899	0.358
LIG_WRC_WIRS_1	449	454	PF05994	0.395
MOD_CDK_SPxxK_3	24	31	PF00069	0.528
MOD_CDK_SPxxK_3	722	729	PF00069	0.424
MOD_CK1_1	16	22	PF00069	0.612
MOD_CK1_1	182	188	PF00069	0.324
MOD_CK1_1	24	30	PF00069	0.521
MOD_CK1_1	349	355	PF00069	0.632
MOD_CK1_1	359	365	PF00069	0.596
MOD_CK1_1	515	521	PF00069	0.358
MOD_CK1_1	599	605	PF00069	0.579
MOD_CK1_1	613	619	PF00069	0.567
MOD_CK1_1	645	651	PF00069	0.442
MOD_CK1_1	689	695	PF00069	0.575
MOD_CK1_1	705	711	PF00069	0.457
MOD_CK2_1	155	161	PF00069	0.532
MOD_CK2_1	186	192	PF00069	0.452
MOD_CK2_1	238	244	PF00069	0.425
MOD_CK2_1	695	701	PF00069	0.534
MOD_Cter_Amidation	7	10	PF01082	0.661
MOD_GlcNHglycan	152	155	PF01048	0.394
MOD_GlcNHglycan	177	180	PF01048	0.424
MOD_GlcNHglycan	182	185	PF01048	0.323
MOD_GlcNHglycan	3	6	PF01048	0.638
MOD_GlcNHglycan	348	351	PF01048	0.495
MOD_GlcNHglycan	459	462	PF01048	0.531
MOD_GlcNHglycan	470	473	PF01048	0.591
MOD_GlcNHglycan	591	594	PF01048	0.464
MOD_GlcNHglycan	612	615	PF01048	0.658
MOD_GlcNHglycan	63	66	PF01048	0.496
MOD_GlcNHglycan	689	692	PF01048	0.698
MOD_GlcNHglycan	698	701	PF01048	0.655
MOD_GlcNHglycan	707	710	PF01048	0.573
MOD_GSK3_1	131	138	PF00069	0.299
MOD_GSK3_1	140	147	PF00069	0.298
MOD_GSK3_1	175	182	PF00069	0.450
MOD_GSK3_1	284	291	PF00069	0.462
MOD_GSK3_1	352	359	PF00069	0.609
MOD_GSK3_1	367	374	PF00069	0.422
MOD_GSK3_1	470	477	PF00069	0.600
MOD_GSK3_1	511	518	PF00069	0.360
MOD_GSK3_1	641	648	PF00069	0.457
MOD_GSK3_1	686	693	PF00069	0.523
MOD_N-GLC_1	717	722	PF02516	0.591
MOD_N-GLC_1	97	102	PF02516	0.336
MOD_NEK2_1	144	149	PF00069	0.336
MOD_NEK2_1	155	160	PF00069	0.388
MOD_NEK2_1	186	191	PF00069	0.445
MOD_NEK2_1	316	321	PF00069	0.353
MOD_NEK2_1	457	462	PF00069	0.418
MOD_NEK2_1	642	647	PF00069	0.425
MOD_NEK2_1	674	679	PF00069	0.392
MOD_NEK2_2	219	224	PF00069	0.340
MOD_NEK2_2	89	94	PF00069	0.391
MOD_PIKK_1	146	152	PF00454	0.478
MOD_PIKK_1	684	690	PF00454	0.474
MOD_PIKK_1	724	730	PF00454	0.396
MOD_PKA_2	21	27	PF00069	0.468
MOD_PKA_2	284	290	PF00069	0.386
MOD_PKA_2	346	352	PF00069	0.500
MOD_Plk_1	16	22	PF00069	0.404
MOD_Plk_1	359	365	PF00069	0.497
MOD_Plk_1	45	51	PF00069	0.370
MOD_Plk_1	89	95	PF00069	0.385
MOD_Plk_2-3	13	19	PF00069	0.524
MOD_Plk_4	116	122	PF00069	0.293
MOD_Plk_4	140	146	PF00069	0.288
MOD_Plk_4	16	22	PF00069	0.404
MOD_Plk_4	182	188	PF00069	0.381
MOD_Plk_4	274	280	PF00069	0.316
MOD_Plk_4	288	294	PF00069	0.344
MOD_Plk_4	324	330	PF00069	0.396
MOD_Plk_4	396	402	PF00069	0.531
MOD_Plk_4	478	484	PF00069	0.464
MOD_Plk_4	555	561	PF00069	0.355
MOD_Plk_4	579	585	PF00069	0.327
MOD_Plk_4	645	651	PF00069	0.381
MOD_Plk_4	674	680	PF00069	0.401
MOD_Plk_4	71	77	PF00069	0.364
MOD_Plk_4	89	95	PF00069	0.420
MOD_ProDKin_1	131	137	PF00069	0.299
MOD_ProDKin_1	24	30	PF00069	0.531
MOD_ProDKin_1	434	440	PF00069	0.385
MOD_ProDKin_1	499	505	PF00069	0.496
MOD_ProDKin_1	690	696	PF00069	0.588
MOD_ProDKin_1	722	728	PF00069	0.551
TRG_DiLeu_BaEn_1	383	388	PF01217	0.469
TRG_DiLeu_BaEn_1	82	87	PF01217	0.322
TRG_DiLeu_BaEn_2	543	549	PF01217	0.336
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.311
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.385
TRG_DiLeu_BaLyEn_6	761	766	PF01217	0.424
TRG_ENDOCYTIC_2	122	125	PF00928	0.294
TRG_ENDOCYTIC_2	328	331	PF00928	0.297
TRG_ENDOCYTIC_2	501	504	PF00928	0.377
TRG_ENDOCYTIC_2	588	591	PF00928	0.427
TRG_ENDOCYTIC_2	654	657	PF00928	0.426
TRG_ENDOCYTIC_2	682	685	PF00928	0.379
TRG_ENDOCYTIC_2	734	737	PF00928	0.441
TRG_ER_diArg_1	297	300	PF00400	0.402
TRG_ER_diArg_1	34	36	PF00400	0.451
TRG_ER_diArg_1	419	421	PF00400	0.439
TRG_ER_diArg_1	639	641	PF00400	0.331
TRG_ER_diArg_1	729	731	PF00400	0.363
TRG_ER_diArg_1	766	768	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	768	773	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K4	Leptomonas seymouri	67%	98%
A0A0S4J166	Bodo saltans	34%	100%
A0A1X0NXL8	Trypanosomatidae	41%	97%
A0A3S7WW94	Leishmania donovani	93%	100%
A4HBL6	Leishmania braziliensis	82%	100%
A4HZA4	Leishmania infantum	93%	100%
D0A1L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AUY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B0J8	Trypanosoma cruzi	44%	100%