Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCJ6_LEIMA

TriTrypDb:

LmjF.21.0190 , LMJLV39_210007200 , LMJSD75_210007200

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

Q4QCJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.610
CLV_C14_Caspase3-7	154	158	PF00656	0.714
CLV_C14_Caspase3-7	235	239	PF00656	0.656
CLV_C14_Caspase3-7	520	524	PF00656	0.678
CLV_NRD_NRD_1	207	209	PF00675	0.616
CLV_NRD_NRD_1	400	402	PF00675	0.499
CLV_NRD_NRD_1	456	458	PF00675	0.457
CLV_NRD_NRD_1	5	7	PF00675	0.532
CLV_NRD_NRD_1	596	598	PF00675	0.665
CLV_PCSK_KEX2_1	207	209	PF00082	0.616
CLV_PCSK_KEX2_1	400	402	PF00082	0.499
CLV_PCSK_KEX2_1	456	458	PF00082	0.516
CLV_PCSK_KEX2_1	5	7	PF00082	0.580
CLV_PCSK_KEX2_1	596	598	PF00082	0.665
CLV_PCSK_SKI1_1	164	168	PF00082	0.563
CLV_PCSK_SKI1_1	261	265	PF00082	0.387
CLV_PCSK_SKI1_1	271	275	PF00082	0.436
CLV_PCSK_SKI1_1	308	312	PF00082	0.434
CLV_PCSK_SKI1_1	355	359	PF00082	0.378
CLV_PCSK_SKI1_1	511	515	PF00082	0.678
CLV_PCSK_SKI1_1	533	537	PF00082	0.618
CLV_PCSK_SKI1_1	575	579	PF00082	0.394
CLV_PCSK_SKI1_1	95	99	PF00082	0.497
CLV_Separin_Metazoa	556	560	PF03568	0.368
DEG_ODPH_VHL_1	550	563	PF01847	0.426
DEG_SCF_FBW7_2	649	655	PF00400	0.506
DOC_CKS1_1	649	654	PF01111	0.499
DOC_CYCLIN_RxL_1	268	278	PF00134	0.526
DOC_CYCLIN_RxL_1	572	582	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	544	547	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	609	612	PF00134	0.502
DOC_MAPK_gen_1	400	410	PF00069	0.356
DOC_MAPK_gen_1	425	433	PF00069	0.495
DOC_MAPK_gen_1	5	11	PF00069	0.533
DOC_MAPK_gen_1	93	101	PF00069	0.570
DOC_MAPK_MEF2A_6	634	641	PF00069	0.441
DOC_MAPK_MEF2A_6	95	103	PF00069	0.487
DOC_PP1_RVXF_1	4	11	PF00149	0.495
DOC_PP2B_LxvP_1	274	277	PF13499	0.457
DOC_PP2B_LxvP_1	544	547	PF13499	0.519
DOC_PP2B_LxvP_1	609	612	PF13499	0.497
DOC_USP7_MATH_1	136	140	PF00917	0.678
DOC_USP7_MATH_1	141	145	PF00917	0.509
DOC_USP7_MATH_1	281	285	PF00917	0.494
DOC_USP7_MATH_1	338	342	PF00917	0.617
DOC_USP7_MATH_1	406	410	PF00917	0.461
DOC_USP7_MATH_1	446	450	PF00917	0.480
DOC_USP7_MATH_1	538	542	PF00917	0.614
DOC_USP7_MATH_1	601	605	PF00917	0.687
DOC_USP7_MATH_1	625	629	PF00917	0.547
DOC_USP7_MATH_1	76	80	PF00917	0.676
DOC_WW_Pin1_4	126	131	PF00397	0.712
DOC_WW_Pin1_4	156	161	PF00397	0.503
DOC_WW_Pin1_4	206	211	PF00397	0.742
DOC_WW_Pin1_4	521	526	PF00397	0.624
DOC_WW_Pin1_4	59	64	PF00397	0.534
DOC_WW_Pin1_4	620	625	PF00397	0.640
DOC_WW_Pin1_4	648	653	PF00397	0.498
DOC_WW_Pin1_4	72	77	PF00397	0.686
DOC_WW_Pin1_4	78	83	PF00397	0.674
LIG_14-3-3_CanoR_1	252	257	PF00244	0.482
LIG_14-3-3_CanoR_1	345	350	PF00244	0.426
LIG_14-3-3_CanoR_1	407	411	PF00244	0.504
LIG_14-3-3_CanoR_1	432	437	PF00244	0.402
LIG_14-3-3_CanoR_1	456	462	PF00244	0.497
LIG_14-3-3_CanoR_1	511	521	PF00244	0.634
LIG_14-3-3_CanoR_1	559	564	PF00244	0.454
LIG_14-3-3_CanoR_1	575	585	PF00244	0.312
LIG_14-3-3_CanoR_1	689	697	PF00244	0.539
LIG_Actin_WH2_2	419	434	PF00022	0.474
LIG_Actin_WH2_2	632	647	PF00022	0.405
LIG_Actin_WH2_2	676	691	PF00022	0.414
LIG_AP_GAE_1	361	367	PF02883	0.402
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BIR_III_2	157	161	PF00653	0.498
LIG_BIR_III_4	616	620	PF00653	0.564
LIG_BRCT_BRCA1_1	395	399	PF00533	0.395
LIG_BRCT_BRCA1_1	68	72	PF00533	0.547
LIG_Clathr_ClatBox_1	124	128	PF01394	0.677
LIG_deltaCOP1_diTrp_1	675	684	PF00928	0.443
LIG_FHA_1	129	135	PF00498	0.614
LIG_FHA_1	161	167	PF00498	0.475
LIG_FHA_1	195	201	PF00498	0.630
LIG_FHA_1	324	330	PF00498	0.528
LIG_FHA_1	346	352	PF00498	0.422
LIG_FHA_1	50	56	PF00498	0.600
LIG_FHA_1	558	564	PF00498	0.431
LIG_FHA_1	59	65	PF00498	0.533
LIG_FHA_1	621	627	PF00498	0.607
LIG_FHA_1	717	723	PF00498	0.592
LIG_FHA_1	75	81	PF00498	0.515
LIG_FHA_2	348	354	PF00498	0.519
LIG_FHA_2	412	418	PF00498	0.375
LIG_FHA_2	518	524	PF00498	0.704
LIG_GBD_Chelix_1	573	581	PF00786	0.446
LIG_HP1_1	525	529	PF01393	0.545
LIG_Integrin_RGD_1	236	238	PF01839	0.634
LIG_Integrin_RGD_1	290	292	PF01839	0.490
LIG_IRF3_LxIS_1	684	691	PF10401	0.406
LIG_LIR_Gen_1	170	179	PF02991	0.436
LIG_LIR_Gen_1	246	256	PF02991	0.428
LIG_LIR_Gen_1	471	480	PF02991	0.392
LIG_LIR_Gen_1	494	503	PF02991	0.536
LIG_LIR_Gen_1	540	550	PF02991	0.523
LIG_LIR_Gen_1	576	586	PF02991	0.426
LIG_LIR_Gen_1	635	644	PF02991	0.324
LIG_LIR_Gen_1	651	660	PF02991	0.449
LIG_LIR_Gen_1	675	685	PF02991	0.442
LIG_LIR_Nem_3	170	176	PF02991	0.426
LIG_LIR_Nem_3	246	251	PF02991	0.504
LIG_LIR_Nem_3	361	367	PF02991	0.449
LIG_LIR_Nem_3	471	477	PF02991	0.399
LIG_LIR_Nem_3	494	498	PF02991	0.494
LIG_LIR_Nem_3	540	545	PF02991	0.563
LIG_LIR_Nem_3	635	639	PF02991	0.325
LIG_LIR_Nem_3	651	656	PF02991	0.450
LIG_LIR_Nem_3	675	681	PF02991	0.440
LIG_LIR_Nem_3	703	708	PF02991	0.437
LIG_Pex14_2	342	346	PF04695	0.571
LIG_RPA_C_Fungi	389	401	PF08784	0.406
LIG_SH2_CRK	248	252	PF00017	0.427
LIG_SH2_CRK	474	478	PF00017	0.490
LIG_SH2_CRK	622	626	PF00017	0.643
LIG_SH2_GRB2like	314	317	PF00017	0.536
LIG_SH2_NCK_1	140	144	PF00017	0.586
LIG_SH2_SRC	381	384	PF00017	0.406
LIG_SH2_SRC	65	68	PF00017	0.491
LIG_SH2_STAP1	314	318	PF00017	0.463
LIG_SH2_STAP1	632	636	PF00017	0.404
LIG_SH2_STAT5	173	176	PF00017	0.540
LIG_SH2_STAT5	373	376	PF00017	0.421
LIG_SH2_STAT5	404	407	PF00017	0.464
LIG_SH2_STAT5	442	445	PF00017	0.470
LIG_SH2_STAT5	476	479	PF00017	0.572
LIG_SH2_STAT5	622	625	PF00017	0.513
LIG_SH3_3	163	169	PF00018	0.566
LIG_SH3_3	180	186	PF00018	0.509
LIG_Sin3_3	365	372	PF02671	0.386
LIG_SUMO_SIM_anti_2	348	353	PF11976	0.404
LIG_SUMO_SIM_anti_2	505	510	PF11976	0.669
LIG_SUMO_SIM_par_1	252	258	PF11976	0.488
LIG_SUMO_SIM_par_1	347	353	PF11976	0.408
LIG_SUMO_SIM_par_1	365	370	PF11976	0.397
LIG_TRAF2_1	110	113	PF00917	0.770
LIG_TRFH_1	542	546	PF08558	0.521
LIG_TYR_ITIM	171	176	PF00017	0.427
MOD_CDK_SPxK_1	78	84	PF00069	0.642
MOD_CK1_1	139	145	PF00069	0.580
MOD_CK1_1	220	226	PF00069	0.806
MOD_CK1_1	411	417	PF00069	0.369
MOD_CK1_1	576	582	PF00069	0.457
MOD_CK1_1	701	707	PF00069	0.345
MOD_CK1_1	75	81	PF00069	0.747
MOD_CK2_1	252	258	PF00069	0.450
MOD_CK2_1	411	417	PF00069	0.398
MOD_CK2_1	446	452	PF00069	0.509
MOD_CK2_1	576	582	PF00069	0.412
MOD_Cter_Amidation	3	6	PF01082	0.587
MOD_GlcNHglycan	141	144	PF01048	0.579
MOD_GlcNHglycan	153	156	PF01048	0.623
MOD_GlcNHglycan	2	5	PF01048	0.532
MOD_GlcNHglycan	223	226	PF01048	0.671
MOD_GlcNHglycan	240	243	PF01048	0.412
MOD_GlcNHglycan	395	398	PF01048	0.384
MOD_GlcNHglycan	470	473	PF01048	0.470
MOD_GlcNHglycan	498	501	PF01048	0.460
MOD_GlcNHglycan	68	71	PF01048	0.582
MOD_GlcNHglycan	700	703	PF01048	0.392
MOD_GSK3_1	10	17	PF00069	0.474
MOD_GSK3_1	156	163	PF00069	0.486
MOD_GSK3_1	188	195	PF00069	0.455
MOD_GSK3_1	217	224	PF00069	0.690
MOD_GSK3_1	281	288	PF00069	0.543
MOD_GSK3_1	319	326	PF00069	0.474
MOD_GSK3_1	475	482	PF00069	0.441
MOD_GSK3_1	513	520	PF00069	0.693
MOD_GSK3_1	559	566	PF00069	0.562
MOD_GSK3_1	576	583	PF00069	0.288
MOD_GSK3_1	601	608	PF00069	0.569
MOD_GSK3_1	684	691	PF00069	0.429
MOD_GSK3_1	712	719	PF00069	0.443
MOD_GSK3_1	72	79	PF00069	0.769
MOD_N-GLC_1	218	223	PF02516	0.610
MOD_N-GLC_1	457	462	PF02516	0.508
MOD_N-GLC_1	511	516	PF02516	0.622
MOD_NEK2_1	10	15	PF00069	0.464
MOD_NEK2_1	151	156	PF00069	0.490
MOD_NEK2_1	285	290	PF00069	0.592
MOD_NEK2_1	367	372	PF00069	0.343
MOD_NEK2_1	41	46	PF00069	0.536
MOD_NEK2_1	431	436	PF00069	0.482
MOD_NEK2_1	513	518	PF00069	0.763
MOD_NEK2_1	573	578	PF00069	0.438
MOD_NEK2_1	58	63	PF00069	0.587
MOD_NEK2_1	684	689	PF00069	0.399
MOD_NEK2_2	141	146	PF00069	0.548
MOD_PIKK_1	285	291	PF00454	0.585
MOD_PIKK_1	323	329	PF00454	0.611
MOD_PIKK_1	514	520	PF00454	0.630
MOD_PK_1	457	463	PF00069	0.489
MOD_PK_1	559	565	PF00069	0.460
MOD_PKA_2	232	238	PF00069	0.548
MOD_PKA_2	393	399	PF00069	0.394
MOD_PKA_2	406	412	PF00069	0.539
MOD_PKA_2	431	437	PF00069	0.420
MOD_PKA_2	538	544	PF00069	0.607
MOD_PKA_2	688	694	PF00069	0.516
MOD_Plk_1	338	344	PF00069	0.656
MOD_Plk_1	457	463	PF00069	0.510
MOD_Plk_1	478	484	PF00069	0.479
MOD_Plk_1	605	611	PF00069	0.514
MOD_Plk_2-3	113	119	PF00069	0.693
MOD_Plk_4	14	20	PF00069	0.443
MOD_Plk_4	178	184	PF00069	0.519
MOD_Plk_4	243	249	PF00069	0.433
MOD_Plk_4	314	320	PF00069	0.510
MOD_Plk_4	347	353	PF00069	0.499
MOD_Plk_4	457	463	PF00069	0.460
MOD_Plk_4	580	586	PF00069	0.478
MOD_Plk_4	605	611	PF00069	0.491
MOD_Plk_4	627	633	PF00069	0.461
MOD_Plk_4	701	707	PF00069	0.471
MOD_Plk_4	718	724	PF00069	0.495
MOD_ProDKin_1	126	132	PF00069	0.709
MOD_ProDKin_1	156	162	PF00069	0.494
MOD_ProDKin_1	206	212	PF00069	0.739
MOD_ProDKin_1	521	527	PF00069	0.618
MOD_ProDKin_1	59	65	PF00069	0.532
MOD_ProDKin_1	620	626	PF00069	0.628
MOD_ProDKin_1	648	654	PF00069	0.499
MOD_ProDKin_1	72	78	PF00069	0.688
MOD_SUMO_for_1	50	53	PF00179	0.649
MOD_SUMO_rev_2	66	75	PF00179	0.592
TRG_DiLeu_BaEn_1	540	545	PF01217	0.583
TRG_DiLeu_BaEn_4	53	59	PF01217	0.518
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.339
TRG_ENDOCYTIC_2	173	176	PF00928	0.506
TRG_ENDOCYTIC_2	248	251	PF00928	0.465
TRG_ENDOCYTIC_2	295	298	PF00928	0.468
TRG_ENDOCYTIC_2	474	477	PF00928	0.441
TRG_ER_diArg_1	333	336	PF00400	0.649
TRG_ER_diArg_1	399	401	PF00400	0.448
TRG_ER_diArg_1	447	450	PF00400	0.436
TRG_ER_diArg_1	536	539	PF00400	0.552
TRG_NES_CRM1_1	661	676	PF08389	0.483
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM2	Leptomonas seymouri	58%	99%
A0A1X0NXC5	Trypanosomatidae	34%	97%
A0A3Q8IB10	Leishmania donovani	95%	100%
A4HBL8	Leishmania braziliensis	85%	100%
A4HZA6	Leishmania infantum	95%	100%
D0A1L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AUY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BG13	Trypanosoma cruzi	29%	100%