LeishMANIAdb
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Major vault protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Major vault protein-like protein
Gene product:
major vault protein-like protein
Species:
Leishmania major
UniProt:
Q4QCJ5_LEIMA
TriTrypDb:
LmjF.21.0200 , LMJLV39_210007300 , LMJSD75_210007300
Length:
960

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 9
GO:0005737 cytoplasm 2 9
GO:0032991 protein-containing complex 1 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9
GO:1990904 ribonucleoprotein complex 2 9

Expansion

Sequence features

Q4QCJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCJ5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 282 286 PF00656 0.438
CLV_C14_Caspase3-7 369 373 PF00656 0.449
CLV_C14_Caspase3-7 510 514 PF00656 0.704
CLV_C14_Caspase3-7 712 716 PF00656 0.510
CLV_C14_Caspase3-7 74 78 PF00656 0.516
CLV_NRD_NRD_1 300 302 PF00675 0.480
CLV_NRD_NRD_1 402 404 PF00675 0.343
CLV_NRD_NRD_1 449 451 PF00675 0.276
CLV_NRD_NRD_1 853 855 PF00675 0.422
CLV_NRD_NRD_1 875 877 PF00675 0.431
CLV_PCSK_FUR_1 297 301 PF00082 0.425
CLV_PCSK_KEX2_1 299 301 PF00082 0.489
CLV_PCSK_KEX2_1 401 403 PF00082 0.305
CLV_PCSK_KEX2_1 449 451 PF00082 0.276
CLV_PCSK_KEX2_1 855 857 PF00082 0.411
CLV_PCSK_PC1ET2_1 855 857 PF00082 0.492
CLV_PCSK_PC7_1 397 403 PF00082 0.428
CLV_PCSK_SKI1_1 158 162 PF00082 0.163
CLV_PCSK_SKI1_1 347 351 PF00082 0.391
CLV_PCSK_SKI1_1 403 407 PF00082 0.313
CLV_PCSK_SKI1_1 424 428 PF00082 0.298
CLV_PCSK_SKI1_1 449 453 PF00082 0.260
CLV_PCSK_SKI1_1 57 61 PF00082 0.264
CLV_PCSK_SKI1_1 742 746 PF00082 0.379
CLV_PCSK_SKI1_1 776 780 PF00082 0.408
CLV_PCSK_SKI1_1 856 860 PF00082 0.318
CLV_Separin_Metazoa 796 800 PF03568 0.441
CLV_Separin_Metazoa 851 855 PF03568 0.490
DEG_APCC_DBOX_1 793 801 PF00400 0.379
DEG_APCC_DBOX_1 863 871 PF00400 0.314
DOC_CKS1_1 177 182 PF01111 0.449
DOC_CKS1_1 701 706 PF01111 0.449
DOC_CYCLIN_RxL_1 446 454 PF00134 0.449
DOC_CYCLIN_yCln2_LP_2 28 34 PF00134 0.436
DOC_MAPK_gen_1 297 305 PF00069 0.475
DOC_MAPK_gen_1 401 407 PF00069 0.310
DOC_MAPK_gen_1 650 660 PF00069 0.464
DOC_MAPK_gen_1 854 861 PF00069 0.385
DOC_MAPK_gen_1 909 918 PF00069 0.476
DOC_MAPK_HePTP_8 624 636 PF00069 0.477
DOC_MAPK_MEF2A_6 627 636 PF00069 0.477
DOC_MAPK_MEF2A_6 653 660 PF00069 0.394
DOC_MAPK_MEF2A_6 747 755 PF00069 0.374
DOC_MAPK_MEF2A_6 776 783 PF00069 0.384
DOC_MAPK_NFAT4_5 776 784 PF00069 0.387
DOC_PP4_FxxP_1 172 175 PF00568 0.449
DOC_PP4_FxxP_1 232 235 PF00568 0.298
DOC_PP4_FxxP_1 427 430 PF00568 0.485
DOC_PP4_FxxP_1 583 586 PF00568 0.444
DOC_PP4_FxxP_1 660 663 PF00568 0.402
DOC_USP7_MATH_1 106 110 PF00917 0.425
DOC_USP7_MATH_1 455 459 PF00917 0.460
DOC_USP7_MATH_1 470 474 PF00917 0.393
DOC_USP7_MATH_1 505 509 PF00917 0.672
DOC_USP7_MATH_1 672 676 PF00917 0.438
DOC_USP7_MATH_1 759 763 PF00917 0.429
DOC_USP7_MATH_1 810 814 PF00917 0.495
DOC_USP7_MATH_1 840 844 PF00917 0.495
DOC_USP7_MATH_2 704 710 PF00917 0.440
DOC_WW_Pin1_4 115 120 PF00397 0.474
DOC_WW_Pin1_4 129 134 PF00397 0.499
DOC_WW_Pin1_4 176 181 PF00397 0.449
DOC_WW_Pin1_4 193 198 PF00397 0.550
DOC_WW_Pin1_4 43 48 PF00397 0.515
DOC_WW_Pin1_4 588 593 PF00397 0.419
DOC_WW_Pin1_4 700 705 PF00397 0.449
DOC_WW_Pin1_4 832 837 PF00397 0.437
DOC_WW_Pin1_4 85 90 PF00397 0.505
DOC_WW_Pin1_4 925 930 PF00397 0.485
DOC_WW_Pin1_4 945 950 PF00397 0.413
LIG_14-3-3_CanoR_1 442 451 PF00244 0.433
LIG_14-3-3_CanoR_1 456 460 PF00244 0.424
LIG_14-3-3_CanoR_1 57 62 PF00244 0.271
LIG_14-3-3_CanoR_1 864 868 PF00244 0.434
LIG_Actin_WH2_2 444 462 PF00022 0.449
LIG_BIR_II_1 1 5 PF00653 0.518
LIG_BIR_III_2 833 837 PF00653 0.494
LIG_BRCT_BRCA1_1 715 719 PF00533 0.419
LIG_CtBP_PxDLS_1 592 596 PF00389 0.419
LIG_deltaCOP1_diTrp_1 475 485 PF00928 0.454
LIG_FHA_1 1 7 PF00498 0.628
LIG_FHA_1 177 183 PF00498 0.464
LIG_FHA_1 20 26 PF00498 0.343
LIG_FHA_1 31 37 PF00498 0.387
LIG_FHA_1 320 326 PF00498 0.553
LIG_FHA_1 344 350 PF00498 0.455
LIG_FHA_1 418 424 PF00498 0.419
LIG_FHA_1 552 558 PF00498 0.437
LIG_FHA_1 579 585 PF00498 0.417
LIG_FHA_1 726 732 PF00498 0.483
LIG_FHA_1 793 799 PF00498 0.488
LIG_FHA_2 125 131 PF00498 0.520
LIG_FHA_2 136 142 PF00498 0.354
LIG_FHA_2 33 39 PF00498 0.368
LIG_FHA_2 365 371 PF00498 0.437
LIG_FHA_2 372 378 PF00498 0.402
LIG_FHA_2 479 485 PF00498 0.602
LIG_FHA_2 659 665 PF00498 0.484
LIG_FHA_2 701 707 PF00498 0.440
LIG_FHA_2 725 731 PF00498 0.402
LIG_FHA_2 803 809 PF00498 0.385
LIG_FHA_2 846 852 PF00498 0.454
LIG_FHA_2 882 888 PF00498 0.423
LIG_LIR_Apic_2 101 106 PF02991 0.412
LIG_LIR_Apic_2 191 197 PF02991 0.382
LIG_LIR_Apic_2 425 430 PF02991 0.449
LIG_LIR_Apic_2 437 443 PF02991 0.365
LIG_LIR_Apic_2 581 586 PF02991 0.485
LIG_LIR_Apic_2 610 615 PF02991 0.481
LIG_LIR_Apic_2 657 663 PF02991 0.449
LIG_LIR_Gen_1 13 19 PF02991 0.317
LIG_LIR_Gen_1 204 215 PF02991 0.419
LIG_LIR_Gen_1 249 258 PF02991 0.449
LIG_LIR_Gen_1 308 317 PF02991 0.406
LIG_LIR_Gen_1 548 557 PF02991 0.290
LIG_LIR_Gen_1 884 893 PF02991 0.427
LIG_LIR_Nem_3 117 123 PF02991 0.457
LIG_LIR_Nem_3 13 17 PF02991 0.312
LIG_LIR_Nem_3 204 210 PF02991 0.406
LIG_LIR_Nem_3 249 253 PF02991 0.418
LIG_LIR_Nem_3 254 258 PF02991 0.343
LIG_LIR_Nem_3 308 313 PF02991 0.404
LIG_LIR_Nem_3 33 37 PF02991 0.225
LIG_LIR_Nem_3 548 553 PF02991 0.410
LIG_LIR_Nem_3 588 593 PF02991 0.440
LIG_LIR_Nem_3 641 645 PF02991 0.485
LIG_LIR_Nem_3 884 889 PF02991 0.420
LIG_Pex14_1 103 107 PF04695 0.431
LIG_Pex14_2 427 431 PF04695 0.485
LIG_Rb_pABgroove_1 560 568 PF01858 0.402
LIG_SH2_CRK 310 314 PF00017 0.306
LIG_SH2_CRK 395 399 PF00017 0.432
LIG_SH2_CRK 550 554 PF00017 0.374
LIG_SH2_CRK 82 86 PF00017 0.394
LIG_SH2_NCK_1 368 372 PF00017 0.449
LIG_SH2_PTP2 194 197 PF00017 0.463
LIG_SH2_PTP2 390 393 PF00017 0.419
LIG_SH2_SRC 14 17 PF00017 0.307
LIG_SH2_SRC 276 279 PF00017 0.320
LIG_SH2_SRC 37 40 PF00017 0.489
LIG_SH2_SRC 390 393 PF00017 0.402
LIG_SH2_STAP1 262 266 PF00017 0.320
LIG_SH2_STAP1 395 399 PF00017 0.432
LIG_SH2_STAP1 886 890 PF00017 0.517
LIG_SH2_STAT5 14 17 PF00017 0.301
LIG_SH2_STAT5 178 181 PF00017 0.408
LIG_SH2_STAT5 194 197 PF00017 0.419
LIG_SH2_STAT5 202 205 PF00017 0.309
LIG_SH2_STAT5 245 248 PF00017 0.450
LIG_SH2_STAT5 276 279 PF00017 0.427
LIG_SH2_STAT5 288 291 PF00017 0.457
LIG_SH2_STAT5 310 313 PF00017 0.281
LIG_SH2_STAT5 34 37 PF00017 0.221
LIG_SH2_STAT5 344 347 PF00017 0.372
LIG_SH2_STAT5 368 371 PF00017 0.526
LIG_SH2_STAT5 390 393 PF00017 0.402
LIG_SH2_STAT5 414 417 PF00017 0.421
LIG_SH2_STAT5 447 450 PF00017 0.481
LIG_SH2_STAT5 612 615 PF00017 0.511
LIG_SH2_STAT5 725 728 PF00017 0.446
LIG_SH2_STAT5 82 85 PF00017 0.445
LIG_SH3_3 118 124 PF00018 0.343
LIG_SH3_3 125 131 PF00018 0.392
LIG_SH3_3 150 156 PF00018 0.546
LIG_SH3_3 192 198 PF00018 0.447
LIG_SH3_3 310 316 PF00018 0.403
LIG_SH3_3 381 387 PF00018 0.402
LIG_SH3_3 48 54 PF00018 0.411
LIG_SH3_3 573 579 PF00018 0.485
LIG_SH3_3 58 64 PF00018 0.324
LIG_SH3_3 597 603 PF00018 0.444
LIG_SH3_3 948 954 PF00018 0.700
LIG_SUMO_SIM_anti_2 24 30 PF11976 0.358
LIG_SUMO_SIM_anti_2 847 854 PF11976 0.494
LIG_SUMO_SIM_par_1 591 596 PF11976 0.413
LIG_SUMO_SIM_par_1 620 626 PF11976 0.419
LIG_SUMO_SIM_par_1 727 733 PF11976 0.458
LIG_TRAF2_1 473 476 PF00917 0.545
LIG_TRFH_1 120 124 PF08558 0.327
LIG_TRFH_1 337 341 PF08558 0.352
LIG_TYR_ITIM 80 85 PF00017 0.303
LIG_TYR_ITSM 306 313 PF00017 0.428
LIG_TYR_ITSM 882 889 PF00017 0.505
LIG_UBA3_1 932 938 PF00899 0.544
LIG_WRC_WIRS_1 247 252 PF05994 0.390
LIG_WW_1 392 395 PF00397 0.384
LIG_WW_3 539 543 PF00397 0.453
MOD_CDK_SPK_2 176 181 PF00069 0.303
MOD_CDK_SPxK_1 832 838 PF00069 0.437
MOD_CK1_1 188 194 PF00069 0.419
MOD_CK1_1 2 8 PF00069 0.476
MOD_CK1_1 504 510 PF00069 0.655
MOD_CK1_1 511 517 PF00069 0.636
MOD_CK1_1 644 650 PF00069 0.290
MOD_CK1_1 709 715 PF00069 0.305
MOD_CK1_1 762 768 PF00069 0.503
MOD_CK1_1 88 94 PF00069 0.603
MOD_CK1_1 892 898 PF00069 0.442
MOD_CK1_1 944 950 PF00069 0.560
MOD_CK2_1 124 130 PF00069 0.463
MOD_CK2_1 135 141 PF00069 0.248
MOD_CK2_1 352 358 PF00069 0.307
MOD_CK2_1 364 370 PF00069 0.201
MOD_CK2_1 371 377 PF00069 0.145
MOD_CK2_1 462 468 PF00069 0.458
MOD_CK2_1 469 475 PF00069 0.443
MOD_CK2_1 478 484 PF00069 0.474
MOD_CK2_1 504 510 PF00069 0.715
MOD_CK2_1 700 706 PF00069 0.448
MOD_CK2_1 802 808 PF00069 0.403
MOD_CK2_1 845 851 PF00069 0.450
MOD_CK2_1 876 882 PF00069 0.422
MOD_Cter_Amidation 297 300 PF01082 0.433
MOD_GlcNHglycan 203 206 PF01048 0.379
MOD_GlcNHglycan 305 308 PF01048 0.322
MOD_GlcNHglycan 424 427 PF01048 0.272
MOD_GlcNHglycan 444 447 PF01048 0.225
MOD_GlcNHglycan 463 467 PF01048 0.620
MOD_GlcNHglycan 503 506 PF01048 0.691
MOD_GlcNHglycan 507 510 PF01048 0.597
MOD_GlcNHglycan 595 598 PF01048 0.260
MOD_GlcNHglycan 678 681 PF01048 0.303
MOD_GlcNHglycan 820 823 PF01048 0.497
MOD_GlcNHglycan 943 946 PF01048 0.492
MOD_GSK3_1 137 144 PF00069 0.303
MOD_GSK3_1 276 283 PF00069 0.394
MOD_GSK3_1 343 350 PF00069 0.552
MOD_GSK3_1 455 462 PF00069 0.305
MOD_GSK3_1 501 508 PF00069 0.685
MOD_GSK3_1 53 60 PF00069 0.520
MOD_GSK3_1 541 548 PF00069 0.457
MOD_GSK3_1 566 573 PF00069 0.239
MOD_GSK3_1 672 679 PF00069 0.354
MOD_GSK3_1 709 716 PF00069 0.296
MOD_GSK3_1 80 87 PF00069 0.540
MOD_GSK3_1 921 928 PF00069 0.482
MOD_GSK3_1 941 948 PF00069 0.401
MOD_N-GLC_1 691 696 PF02516 0.237
MOD_N-GLC_2 21 23 PF02516 0.411
MOD_NEK2_1 1 6 PF00069 0.433
MOD_NEK2_1 305 310 PF00069 0.474
MOD_NEK2_1 487 492 PF00069 0.590
MOD_NEK2_1 565 570 PF00069 0.286
MOD_NEK2_1 593 598 PF00069 0.330
MOD_NEK2_1 658 663 PF00069 0.348
MOD_NEK2_1 717 722 PF00069 0.263
MOD_NEK2_1 724 729 PF00069 0.212
MOD_NEK2_1 745 750 PF00069 0.353
MOD_NEK2_1 80 85 PF00069 0.481
MOD_NEK2_1 818 823 PF00069 0.499
MOD_NEK2_2 292 297 PF00069 0.413
MOD_NEK2_2 371 376 PF00069 0.303
MOD_NEK2_2 455 460 PF00069 0.354
MOD_PIKK_1 305 311 PF00454 0.433
MOD_PKA_1 876 882 PF00069 0.427
MOD_PKA_2 455 461 PF00069 0.296
MOD_PKA_2 541 547 PF00069 0.471
MOD_PKA_2 863 869 PF00069 0.484
MOD_Plk_1 470 476 PF00069 0.539
MOD_Plk_1 691 697 PF00069 0.237
MOD_Plk_1 802 808 PF00069 0.425
MOD_Plk_2-3 141 147 PF00069 0.303
MOD_Plk_2-3 730 736 PF00069 0.237
MOD_Plk_4 2 8 PF00069 0.476
MOD_Plk_4 24 30 PF00069 0.369
MOD_Plk_4 251 257 PF00069 0.351
MOD_Plk_4 284 290 PF00069 0.499
MOD_Plk_4 32 38 PF00069 0.432
MOD_Plk_4 333 339 PF00069 0.375
MOD_Plk_4 558 564 PF00069 0.354
MOD_Plk_4 578 584 PF00069 0.115
MOD_Plk_4 607 613 PF00069 0.294
MOD_Plk_4 692 698 PF00069 0.237
MOD_Plk_4 706 712 PF00069 0.237
MOD_Plk_4 80 86 PF00069 0.426
MOD_Plk_4 894 900 PF00069 0.540
MOD_ProDKin_1 115 121 PF00069 0.470
MOD_ProDKin_1 129 135 PF00069 0.495
MOD_ProDKin_1 176 182 PF00069 0.303
MOD_ProDKin_1 193 199 PF00069 0.548
MOD_ProDKin_1 43 49 PF00069 0.517
MOD_ProDKin_1 588 594 PF00069 0.261
MOD_ProDKin_1 700 706 PF00069 0.303
MOD_ProDKin_1 832 838 PF00069 0.437
MOD_ProDKin_1 85 91 PF00069 0.504
MOD_ProDKin_1 925 931 PF00069 0.487
MOD_ProDKin_1 945 951 PF00069 0.410
MOD_SUMO_for_1 788 791 PF00179 0.481
MOD_SUMO_rev_2 772 778 PF00179 0.404
TRG_DiLeu_BaEn_1 24 29 PF01217 0.379
TRG_DiLeu_BaEn_1 356 361 PF01217 0.354
TRG_DiLeu_BaEn_1 558 563 PF01217 0.354
TRG_DiLeu_BaEn_2 250 256 PF01217 0.342
TRG_DiLeu_BaLyEn_6 118 123 PF01217 0.450
TRG_DiLeu_BaLyEn_6 132 137 PF01217 0.481
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.261
TRG_ENDOCYTIC_2 14 17 PF00928 0.307
TRG_ENDOCYTIC_2 207 210 PF00928 0.490
TRG_ENDOCYTIC_2 258 261 PF00928 0.393
TRG_ENDOCYTIC_2 310 313 PF00928 0.281
TRG_ENDOCYTIC_2 395 398 PF00928 0.429
TRG_ENDOCYTIC_2 550 553 PF00928 0.399
TRG_ENDOCYTIC_2 82 85 PF00928 0.445
TRG_ENDOCYTIC_2 886 889 PF00928 0.514
TRG_ER_diArg_1 296 299 PF00400 0.494
TRG_ER_diArg_1 401 403 PF00400 0.357
TRG_ER_diArg_1 448 450 PF00400 0.379
TRG_ER_diArg_1 631 634 PF00400 0.354
TRG_ER_diArg_1 853 856 PF00400 0.495
TRG_NES_CRM1_1 184 199 PF08389 0.399
TRG_NES_CRM1_1 907 919 PF08389 0.567
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 449 454 PF00026 0.264
TRG_Pf-PMV_PEXEL_1 876 880 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 911 915 PF00026 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Z8 Leptomonas seymouri 31% 100%
A0A0N1PCB5 Leptomonas seymouri 63% 96%
A0A0S4ISQ0 Bodo saltans 30% 100%
A0A0S4JL46 Bodo saltans 30% 100%
A0A1X0NXD4 Trypanosomatidae 43% 100%
A0A1X0P8P2 Trypanosomatidae 28% 100%
A0A3Q8IKW2 Leishmania donovani 96% 100%
A0A3S7XAQ4 Leishmania donovani 31% 100%
A4HP51 Leishmania braziliensis 31% 100%
A4HZA7 Leishmania infantum 96% 100%
A4IDF8 Leishmania infantum 31% 100%
C9ZPY2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D0A1L3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ASV9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AUY7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4CUM2 Trypanosoma cruzi (strain CL Brener) 30% 100%
Q4Q1N7 Leishmania major 31% 90%
Q57Z03 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 29% 100%
Q5ZMI4 Gallus gallus 36% 100%
Q62667 Rattus norvegicus 35% 100%
V5AUX6 Trypanosoma cruzi 30% 100%
V5B0K2 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS