Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCJ4_LEIMA

TriTrypDb:

LmjF.21.0210 , LMJLV39_210007400 , LMJSD75_210007400

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.542
CLV_NRD_NRD_1	141	143	PF00675	0.471
CLV_NRD_NRD_1	222	224	PF00675	0.450
CLV_NRD_NRD_1	245	247	PF00675	0.498
CLV_NRD_NRD_1	304	306	PF00675	0.414
CLV_NRD_NRD_1	376	378	PF00675	0.397
CLV_NRD_NRD_1	389	391	PF00675	0.307
CLV_PCSK_KEX2_1	141	143	PF00082	0.471
CLV_PCSK_KEX2_1	221	223	PF00082	0.475
CLV_PCSK_KEX2_1	245	247	PF00082	0.498
CLV_PCSK_KEX2_1	304	306	PF00082	0.448
CLV_PCSK_KEX2_1	376	378	PF00082	0.397
CLV_PCSK_KEX2_1	389	391	PF00082	0.307
CLV_PCSK_SKI1_1	179	183	PF00082	0.384
CLV_PCSK_SKI1_1	314	318	PF00082	0.416
CLV_PCSK_SKI1_1	347	351	PF00082	0.436
CLV_PCSK_SKI1_1	384	388	PF00082	0.396
CLV_PCSK_SKI1_1	456	460	PF00082	0.611
DEG_APCC_DBOX_1	389	397	PF00400	0.565
DEG_Nend_Nbox_1	1	3	PF02207	0.630
DOC_CYCLIN_RxL_1	374	385	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.446
DOC_MAPK_DCC_7	221	229	PF00069	0.477
DOC_MAPK_gen_1	141	147	PF00069	0.370
DOC_MAPK_gen_1	221	229	PF00069	0.477
DOC_MAPK_gen_1	245	253	PF00069	0.433
DOC_MAPK_gen_1	304	312	PF00069	0.460
DOC_MAPK_gen_1	376	383	PF00069	0.436
DOC_MAPK_gen_1	522	531	PF00069	0.279
DOC_MAPK_MEF2A_6	179	186	PF00069	0.408
DOC_MAPK_MEF2A_6	222	231	PF00069	0.462
DOC_MAPK_MEF2A_6	246	255	PF00069	0.376
DOC_MAPK_MEF2A_6	376	383	PF00069	0.436
DOC_MAPK_MEF2A_6	525	533	PF00069	0.282
DOC_MAPK_MEF2A_6	70	77	PF00069	0.338
DOC_MAPK_NFAT4_5	376	384	PF00069	0.441
DOC_USP7_MATH_1	439	443	PF00917	0.680
DOC_USP7_MATH_1	60	64	PF00917	0.431
DOC_WW_Pin1_4	21	26	PF00397	0.568
DOC_WW_Pin1_4	278	283	PF00397	0.632
DOC_WW_Pin1_4	437	442	PF00397	0.741
LIG_14-3-3_CanoR_1	376	380	PF00244	0.460
LIG_BIR_III_2	249	253	PF00653	0.426
LIG_BRCT_BRCA1_1	421	425	PF00533	0.458
LIG_Clathr_ClatBox_1	407	411	PF01394	0.455
LIG_CtBP_PxDLS_1	217	223	PF00389	0.417
LIG_deltaCOP1_diTrp_1	266	271	PF00928	0.554
LIG_deltaCOP1_diTrp_1	482	488	PF00928	0.496
LIG_EVH1_1	431	435	PF00568	0.611
LIG_FHA_1	138	144	PF00498	0.571
LIG_FHA_1	191	197	PF00498	0.401
LIG_FHA_1	199	205	PF00498	0.459
LIG_FHA_1	232	238	PF00498	0.510
LIG_FHA_1	453	459	PF00498	0.573
LIG_FHA_1	7	13	PF00498	0.677
LIG_FHA_2	134	140	PF00498	0.444
LIG_FHA_2	380	386	PF00498	0.521
LIG_FHA_2	89	95	PF00498	0.471
LIG_GBD_Chelix_1	379	387	PF00786	0.447
LIG_GBD_Chelix_1	400	408	PF00786	0.374
LIG_LIR_Apic_2	363	369	PF02991	0.378
LIG_LIR_Gen_1	483	494	PF02991	0.429
LIG_LIR_Nem_3	422	428	PF02991	0.596
LIG_LIR_Nem_3	483	489	PF02991	0.430
LIG_LYPXL_SIV_4	338	346	PF13949	0.383
LIG_NRBOX	382	388	PF00104	0.406
LIG_NRBOX	399	405	PF00104	0.283
LIG_NRBOX	73	79	PF00104	0.444
LIG_PCNA_yPIPBox_3	389	399	PF02747	0.459
LIG_RPA_C_Fungi	372	384	PF08784	0.332
LIG_SH2_STAP1	55	59	PF00017	0.445
LIG_SH2_STAT3	150	153	PF00017	0.383
LIG_SH2_STAT5	366	369	PF00017	0.434
LIG_SH2_STAT5	505	508	PF00017	0.520
LIG_SH3_3	123	129	PF00018	0.445
LIG_SH3_3	155	161	PF00018	0.457
LIG_SH3_3	22	28	PF00018	0.475
LIG_SH3_3	262	268	PF00018	0.394
LIG_SH3_3	429	435	PF00018	0.667
LIG_SH3_3	455	461	PF00018	0.629
LIG_SUMO_SIM_anti_2	394	400	PF11976	0.384
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.381
LIG_SUMO_SIM_anti_2	69	76	PF11976	0.411
LIG_SUMO_SIM_par_1	182	187	PF11976	0.462
LIG_SUMO_SIM_par_1	227	235	PF11976	0.461
LIG_SUMO_SIM_par_1	405	412	PF11976	0.442
LIG_SUMO_SIM_par_1	73	79	PF11976	0.408
LIG_TRAF2_1	480	483	PF00917	0.349
LIG_TRAF2_1	85	88	PF00917	0.324
LIG_TYR_ITIM	81	86	PF00017	0.323
MOD_CK1_1	190	196	PF00069	0.390
MOD_CK1_1	476	482	PF00069	0.538
MOD_CK2_1	133	139	PF00069	0.447
MOD_CK2_1	29	35	PF00069	0.492
MOD_CK2_1	379	385	PF00069	0.469
MOD_CK2_1	476	482	PF00069	0.429
MOD_GlcNHglycan	241	244	PF01048	0.430
MOD_GlcNHglycan	411	414	PF01048	0.529
MOD_GlcNHglycan	421	424	PF01048	0.661
MOD_GlcNHglycan	441	444	PF01048	0.574
MOD_GlcNHglycan	475	478	PF01048	0.606
MOD_GlcNHglycan	499	502	PF01048	0.461
MOD_GlcNHglycan	52	55	PF01048	0.573
MOD_GlcNHglycan	56	59	PF01048	0.560
MOD_GSK3_1	133	140	PF00069	0.551
MOD_GSK3_1	274	281	PF00069	0.518
MOD_GSK3_1	375	382	PF00069	0.383
MOD_GSK3_1	437	444	PF00069	0.701
MOD_GSK3_1	50	57	PF00069	0.612
MOD_N-GLC_2	309	311	PF02516	0.284
MOD_NEK2_1	231	236	PF00069	0.510
MOD_NEK2_1	379	384	PF00069	0.383
MOD_NEK2_1	402	407	PF00069	0.479
MOD_NEK2_2	216	221	PF00069	0.491
MOD_PIKK_1	111	117	PF00454	0.469
MOD_PKA_2	133	139	PF00069	0.469
MOD_PKA_2	375	381	PF00069	0.471
MOD_PKA_2	452	458	PF00069	0.576
MOD_PKA_2	459	465	PF00069	0.500
MOD_Plk_1	232	238	PF00069	0.414
MOD_Plk_1	482	488	PF00069	0.534
MOD_Plk_2-3	274	280	PF00069	0.520
MOD_Plk_2-3	515	521	PF00069	0.445
MOD_Plk_2-3	88	94	PF00069	0.473
MOD_Plk_4	153	159	PF00069	0.457
MOD_Plk_4	232	238	PF00069	0.511
MOD_Plk_4	29	35	PF00069	0.516
MOD_Plk_4	402	408	PF00069	0.414
MOD_Plk_4	459	465	PF00069	0.462
MOD_ProDKin_1	21	27	PF00069	0.561
MOD_ProDKin_1	278	284	PF00069	0.614
MOD_ProDKin_1	437	443	PF00069	0.741
MOD_SUMO_for_1	92	95	PF00179	0.428
TRG_DiLeu_BaEn_1	394	399	PF01217	0.383
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.476
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.399
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.345
TRG_ENDOCYTIC_2	83	86	PF00928	0.328
TRG_ER_diArg_1	131	134	PF00400	0.477
TRG_ER_diArg_1	141	143	PF00400	0.373
TRG_ER_diArg_1	220	223	PF00400	0.512
TRG_ER_diArg_1	244	246	PF00400	0.487
TRG_ER_diArg_1	303	305	PF00400	0.410
TRG_ER_diArg_1	388	390	PF00400	0.417
TRG_ER_diArg_1	40	43	PF00400	0.462
TRG_NES_CRM1_1	397	411	PF08389	0.383
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I200	Leptomonas seymouri	44%	90%
A0A0S4IXJ4	Bodo saltans	25%	100%
A0A3R7KNI1	Trypanosoma rangeli	31%	89%
A0A3S5H793	Leishmania donovani	94%	100%
A4HBM0	Leishmania braziliensis	78%	100%
A4HZA8	Leishmania infantum	94%	100%
E9AUY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DGY6	Trypanosoma cruzi	30%	100%