Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania major

UniProt:

Q4QCJ2_LEIMA

TriTrypDb:

LmjF.21.0230 , LMJLV39_210007600 , LMJSD75_210007600

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	2
GO:0000812	Swr1 complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0070603	SWI/SNF superfamily-type complex	3	2
GO:0097346	INO80-type complex	4	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1904949	ATPase complex	3	2
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QCJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCJ2

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	9
GO:0006338	chromatin remodeling	5	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0071840	cellular component organization or biogenesis	2	9

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2
GO:0031491	nucleosome binding	3	2
GO:0044877	protein-containing complex binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.505
CLV_C14_Caspase3-7	474	478	PF00656	0.677
CLV_NRD_NRD_1	184	186	PF00675	0.318
CLV_NRD_NRD_1	285	287	PF00675	0.330
CLV_NRD_NRD_1	314	316	PF00675	0.340
CLV_NRD_NRD_1	94	96	PF00675	0.226
CLV_PCSK_KEX2_1	186	188	PF00082	0.318
CLV_PCSK_KEX2_1	285	287	PF00082	0.286
CLV_PCSK_KEX2_1	314	316	PF00082	0.284
CLV_PCSK_KEX2_1	479	481	PF00082	0.606
CLV_PCSK_KEX2_1	94	96	PF00082	0.226
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.318
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.606
CLV_PCSK_SKI1_1	246	250	PF00082	0.300
CLV_PCSK_SKI1_1	421	425	PF00082	0.258
CLV_PCSK_SKI1_1	432	436	PF00082	0.280
CLV_PCSK_SKI1_1	547	551	PF00082	0.417
CLV_Separin_Metazoa	548	552	PF03568	0.398
DEG_APCC_DBOX_1	346	354	PF00400	0.439
DEG_APCC_DBOX_1	420	428	PF00400	0.458
DEG_SPOP_SBC_1	160	164	PF00917	0.467
DEG_SPOP_SBC_1	37	41	PF00917	0.534
DOC_CDC14_PxL_1	350	358	PF14671	0.439
DOC_CKS1_1	397	402	PF01111	0.518
DOC_CYCLIN_RxL_1	418	428	PF00134	0.486
DOC_CYCLIN_yClb3_PxF_3	504	512	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.486
DOC_MAPK_DCC_7	390	398	PF00069	0.518
DOC_MAPK_gen_1	151	160	PF00069	0.457
DOC_MAPK_gen_1	251	258	PF00069	0.457
DOC_MAPK_MEF2A_6	390	398	PF00069	0.518
DOC_PP2B_LxvP_1	131	134	PF13499	0.457
DOC_PP2B_LxvP_1	18	21	PF13499	0.407
DOC_PP2B_LxvP_1	61	64	PF13499	0.560
DOC_PP4_FxxP_1	135	138	PF00568	0.428
DOC_PP4_FxxP_1	391	394	PF00568	0.425
DOC_SPAK_OSR1_1	390	394	PF12202	0.518
DOC_USP7_MATH_1	200	204	PF00917	0.567
DOC_USP7_MATH_1	24	28	PF00917	0.590
DOC_USP7_MATH_1	284	288	PF00917	0.443
DOC_USP7_MATH_1	325	329	PF00917	0.375
DOC_USP7_MATH_1	37	41	PF00917	0.654
DOC_USP7_MATH_1	371	375	PF00917	0.528
DOC_WW_Pin1_4	196	201	PF00397	0.537
DOC_WW_Pin1_4	338	343	PF00397	0.519
DOC_WW_Pin1_4	396	401	PF00397	0.481
DOC_WW_Pin1_4	463	468	PF00397	0.567
DOC_WW_Pin1_4	500	505	PF00397	0.393
LIG_14-3-3_CanoR_1	175	180	PF00244	0.571
LIG_14-3-3_CanoR_1	187	193	PF00244	0.449
LIG_14-3-3_CanoR_1	285	289	PF00244	0.486
LIG_14-3-3_CanoR_1	29	38	PF00244	0.587
LIG_14-3-3_CanoR_1	496	504	PF00244	0.478
LIG_14-3-3_CanoR_1	571	575	PF00244	0.458
LIG_APCC_ABBA_1	4	9	PF00400	0.392
LIG_APCC_ABBAyCdc20_2	3	9	PF00400	0.439
LIG_BRCT_BRCA1_1	151	155	PF00533	0.452
LIG_BRCT_BRCA1_1	161	165	PF00533	0.396
LIG_deltaCOP1_diTrp_1	128	135	PF00928	0.518
LIG_FHA_1	221	227	PF00498	0.440
LIG_FHA_1	247	253	PF00498	0.481
LIG_FHA_1	265	271	PF00498	0.550
LIG_FHA_1	371	377	PF00498	0.487
LIG_FHA_1	413	419	PF00498	0.518
LIG_FHA_1	426	432	PF00498	0.518
LIG_FHA_1	495	501	PF00498	0.434
LIG_FHA_2	297	303	PF00498	0.393
LIG_FHA_2	338	344	PF00498	0.567
LIG_FHA_2	397	403	PF00498	0.518
LIG_FHA_2	41	47	PF00498	0.636
LIG_LIR_Apic_2	389	394	PF02991	0.425
LIG_LIR_Gen_1	128	138	PF02991	0.518
LIG_LIR_Gen_1	162	173	PF02991	0.425
LIG_LIR_Gen_1	254	263	PF02991	0.447
LIG_LIR_LC3C_4	128	133	PF02991	0.412
LIG_LIR_Nem_3	128	133	PF02991	0.510
LIG_LIR_Nem_3	152	158	PF02991	0.455
LIG_LIR_Nem_3	162	168	PF02991	0.405
LIG_LIR_Nem_3	254	258	PF02991	0.467
LIG_MYND_1	354	358	PF01753	0.439
LIG_NRBOX	143	149	PF00104	0.518
LIG_NRBOX	380	386	PF00104	0.481
LIG_NRBOX	426	432	PF00104	0.486
LIG_PCNA_PIPBox_1	420	429	PF02747	0.486
LIG_PCNA_yPIPBox_3	571	585	PF02747	0.518
LIG_PTB_Apo_2	7	14	PF02174	0.300
LIG_PTB_Phospho_1	7	13	PF10480	0.300
LIG_SH2_CRK	235	239	PF00017	0.395
LIG_SH2_CRK	88	92	PF00017	0.481
LIG_SH2_GRB2like	228	231	PF00017	0.518
LIG_SH2_PTP2	231	234	PF00017	0.449
LIG_SH2_SRC	19	22	PF00017	0.483
LIG_SH2_SRC	231	234	PF00017	0.449
LIG_SH2_STAP1	13	17	PF00017	0.322
LIG_SH2_STAP1	235	239	PF00017	0.366
LIG_SH2_STAP1	291	295	PF00017	0.523
LIG_SH2_STAT5	19	22	PF00017	0.393
LIG_SH2_STAT5	228	231	PF00017	0.432
LIG_SH2_STAT5	255	258	PF00017	0.533
LIG_SH2_STAT5	349	352	PF00017	0.456
LIG_SH3_1	348	354	PF00018	0.425
LIG_SH3_2	342	347	PF14604	0.486
LIG_SH3_3	328	334	PF00018	0.544
LIG_SH3_3	339	345	PF00018	0.361
LIG_SH3_3	348	354	PF00018	0.397
LIG_SH3_3	461	467	PF00018	0.525
LIG_SH3_3	501	507	PF00018	0.504
LIG_SH3_3	90	96	PF00018	0.481
LIG_SUMO_SIM_anti_2	157	164	PF11976	0.455
LIG_TRAF2_1	123	126	PF00917	0.486
LIG_TYR_ITIM	229	234	PF00017	0.486
LIG_UBA3_1	423	429	PF00899	0.449
LIG_WRC_WIRS_1	255	260	PF05994	0.457
LIG_WRC_WIRS_1	574	579	PF05994	0.464
MOD_CK1_1	120	126	PF00069	0.449
MOD_CK1_1	164	170	PF00069	0.481
MOD_CK1_1	178	184	PF00069	0.481
MOD_CK1_1	203	209	PF00069	0.553
MOD_CK1_1	221	227	PF00069	0.358
MOD_CK1_1	23	29	PF00069	0.592
MOD_CK1_1	30	36	PF00069	0.561
MOD_CK1_1	40	46	PF00069	0.448
MOD_CK1_1	478	484	PF00069	0.724
MOD_CK2_1	120	126	PF00069	0.463
MOD_CK2_1	296	302	PF00069	0.412
MOD_CK2_1	40	46	PF00069	0.635
MOD_CK2_1	542	548	PF00069	0.567
MOD_CK2_1	557	563	PF00069	0.487
MOD_GlcNHglycan	177	180	PF01048	0.349
MOD_GlcNHglycan	181	184	PF01048	0.262
MOD_GlcNHglycan	202	205	PF01048	0.310
MOD_GlcNHglycan	22	25	PF01048	0.522
MOD_GlcNHglycan	220	223	PF01048	0.163
MOD_GlcNHglycan	29	32	PF01048	0.597
MOD_GlcNHglycan	319	322	PF01048	0.254
MOD_GlcNHglycan	35	38	PF01048	0.610
MOD_GlcNHglycan	373	376	PF01048	0.318
MOD_GlcNHglycan	500	503	PF01048	0.394
MOD_GlcNHglycan	532	535	PF01048	0.431
MOD_GlcNHglycan	537	540	PF01048	0.570
MOD_GlcNHglycan	558	562	PF01048	0.473
MOD_GSK3_1	156	163	PF00069	0.457
MOD_GSK3_1	175	182	PF00069	0.535
MOD_GSK3_1	187	194	PF00069	0.502
MOD_GSK3_1	196	203	PF00069	0.505
MOD_GSK3_1	20	27	PF00069	0.527
MOD_GSK3_1	33	40	PF00069	0.648
MOD_GSK3_1	475	482	PF00069	0.748
MOD_GSK3_1	494	501	PF00069	0.397
MOD_GSK3_1	514	521	PF00069	0.530
MOD_N-GLC_1	27	32	PF02516	0.512
MOD_N-GLC_2	438	440	PF02516	0.286
MOD_NEK2_1	147	152	PF00069	0.510
MOD_NEK2_1	220	225	PF00069	0.450
MOD_NEK2_1	38	43	PF00069	0.697
MOD_NEK2_1	475	480	PF00069	0.735
MOD_NEK2_2	11	16	PF00069	0.351
MOD_NEK2_2	149	154	PF00069	0.518
MOD_NEK2_2	309	314	PF00069	0.375
MOD_OFUCOSY	493	499	PF10250	0.493
MOD_PIKK_1	256	262	PF00454	0.463
MOD_PIKK_1	325	331	PF00454	0.467
MOD_PIKK_1	444	450	PF00454	0.486
MOD_PIKK_1	542	548	PF00454	0.451
MOD_PK_1	154	160	PF00069	0.465
MOD_PKA_1	479	485	PF00069	0.604
MOD_PKA_2	188	194	PF00069	0.449
MOD_PKA_2	284	290	PF00069	0.486
MOD_PKA_2	479	485	PF00069	0.711
MOD_PKA_2	495	501	PF00069	0.294
MOD_PKA_2	570	576	PF00069	0.514
MOD_PKB_1	185	193	PF00069	0.449
MOD_Plk_1	264	270	PF00069	0.481
MOD_Plk_1	518	524	PF00069	0.492
MOD_Plk_4	156	162	PF00069	0.425
MOD_Plk_4	164	170	PF00069	0.425
MOD_Plk_4	221	227	PF00069	0.439
MOD_Plk_4	234	240	PF00069	0.439
MOD_Plk_4	264	270	PF00069	0.498
MOD_ProDKin_1	196	202	PF00069	0.537
MOD_ProDKin_1	338	344	PF00069	0.519
MOD_ProDKin_1	396	402	PF00069	0.481
MOD_ProDKin_1	463	469	PF00069	0.567
MOD_ProDKin_1	500	506	PF00069	0.389
MOD_SUMO_rev_2	468	478	PF00179	0.582
TRG_DiLeu_BaEn_1	265	270	PF01217	0.439
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.486
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.424
TRG_ENDOCYTIC_2	231	234	PF00928	0.433
TRG_ENDOCYTIC_2	235	238	PF00928	0.435
TRG_ENDOCYTIC_2	255	258	PF00928	0.513
TRG_ENDOCYTIC_2	291	294	PF00928	0.505
TRG_ENDOCYTIC_2	88	91	PF00928	0.481
TRG_ER_diArg_1	185	188	PF00400	0.486
TRG_ER_diArg_1	284	286	PF00400	0.486
TRG_ER_diArg_1	313	315	PF00400	0.551
TRG_ER_diArg_1	550	553	PF00400	0.428
TRG_ER_diArg_1	93	95	PF00400	0.426
TRG_NLS_MonoCore_2	185	190	PF00514	0.486
TRG_NLS_MonoExtC_3	184	189	PF00514	0.518
TRG_NLS_MonoExtN_4	185	190	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	553	558	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I4	Leptomonas seymouri	53%	93%
A0A0S4IXC8	Bodo saltans	35%	100%
A0A3R7KCE3	Trypanosoma rangeli	38%	100%
A0A3S7WWF5	Leishmania donovani	94%	99%
A4HBM2	Leishmania braziliensis	78%	98%
A4HZB0	Leishmania infantum	93%	99%
D0A1L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AUZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
O94241	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P0CM04	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CM05	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P45890	Drosophila melanogaster	26%	100%
Q09443	Caenorhabditis elegans	27%	100%
Q4W9M3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q5AXH1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q6BML9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	100%
Q6CJF4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
Q74ZV8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	100%
Q7S6X6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
Q8LGE3	Arabidopsis thaliana	26%	100%
Q9D864	Mus musculus	25%	100%
Q9DEE9	Gallus gallus	25%	100%
Q9GZN1	Homo sapiens	25%	100%
V5B0N4	Trypanosoma cruzi	43%	100%