Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCI9_LEIMA

TriTrypDb:

LmjF.21.0260 , LMJLV39_210007900 , LMJSD75_210008000

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.460
CLV_NRD_NRD_1	358	360	PF00675	0.480
CLV_NRD_NRD_1	398	400	PF00675	0.423
CLV_NRD_NRD_1	423	425	PF00675	0.431
CLV_NRD_NRD_1	47	49	PF00675	0.771
CLV_NRD_NRD_1	89	91	PF00675	0.673
CLV_PCSK_KEX2_1	108	110	PF00082	0.518
CLV_PCSK_KEX2_1	205	207	PF00082	0.470
CLV_PCSK_KEX2_1	398	400	PF00082	0.423
CLV_PCSK_KEX2_1	46	48	PF00082	0.769
CLV_PCSK_KEX2_1	89	91	PF00082	0.673
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.489
CLV_PCSK_SKI1_1	131	135	PF00082	0.466
CLV_PCSK_SKI1_1	14	18	PF00082	0.526
CLV_PCSK_SKI1_1	193	197	PF00082	0.426
CLV_PCSK_SKI1_1	205	209	PF00082	0.473
CLV_PCSK_SKI1_1	271	275	PF00082	0.448
CLV_PCSK_SKI1_1	28	32	PF00082	0.602
CLV_PCSK_SKI1_1	294	298	PF00082	0.428
CLV_PCSK_SKI1_1	401	405	PF00082	0.519
CLV_PCSK_SKI1_1	424	428	PF00082	0.468
CLV_PCSK_SKI1_1	467	471	PF00082	0.437
DEG_APCC_DBOX_1	423	431	PF00400	0.521
DEG_Nend_UBRbox_1	1	4	PF02207	0.481
DOC_CKS1_1	219	224	PF01111	0.603
DOC_CYCLIN_RxL_1	22	34	PF00134	0.470
DOC_CYCLIN_RxL_1	335	344	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.668
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.614
DOC_MAPK_gen_1	205	213	PF00069	0.565
DOC_MAPK_gen_1	398	407	PF00069	0.502
DOC_MAPK_gen_1	587	596	PF00069	0.592
DOC_MAPK_gen_1	9	19	PF00069	0.467
DOC_MAPK_MEF2A_6	12	21	PF00069	0.551
DOC_MAPK_MEF2A_6	318	327	PF00069	0.352
DOC_MAPK_MEF2A_6	511	520	PF00069	0.409
DOC_PP2B_LxvP_1	24	27	PF13499	0.641
DOC_PP2B_LxvP_1	67	70	PF13499	0.682
DOC_USP7_MATH_1	183	187	PF00917	0.444
DOC_USP7_MATH_1	238	242	PF00917	0.733
DOC_USP7_MATH_1	248	252	PF00917	0.636
DOC_USP7_MATH_1	562	566	PF00917	0.554
DOC_USP7_MATH_1	578	582	PF00917	0.370
DOC_WW_Pin1_4	162	167	PF00397	0.606
DOC_WW_Pin1_4	214	219	PF00397	0.642
DOC_WW_Pin1_4	246	251	PF00397	0.704
DOC_WW_Pin1_4	31	36	PF00397	0.706
DOC_WW_Pin1_4	56	61	PF00397	0.732
DOC_WW_Pin1_4	80	85	PF00397	0.659
LIG_14-3-3_CanoR_1	242	250	PF00244	0.656
LIG_14-3-3_CanoR_1	285	293	PF00244	0.516
LIG_14-3-3_CanoR_1	367	371	PF00244	0.525
LIG_14-3-3_CanoR_1	442	447	PF00244	0.359
LIG_14-3-3_CanoR_1	455	461	PF00244	0.328
LIG_14-3-3_CanoR_1	535	541	PF00244	0.487
LIG_Actin_WH2_2	164	179	PF00022	0.561
LIG_Actin_WH2_2	184	199	PF00022	0.443
LIG_Actin_WH2_2	257	273	PF00022	0.455
LIG_Actin_WH2_2	538	555	PF00022	0.529
LIG_APCC_ABBA_1	375	380	PF00400	0.275
LIG_eIF4E_1	287	293	PF01652	0.527
LIG_FHA_1	171	177	PF00498	0.477
LIG_FHA_1	198	204	PF00498	0.579
LIG_FHA_1	287	293	PF00498	0.503
LIG_FHA_1	317	323	PF00498	0.418
LIG_FHA_1	382	388	PF00498	0.435
LIG_FHA_1	407	413	PF00498	0.433
LIG_FHA_1	478	484	PF00498	0.321
LIG_FHA_1	80	86	PF00498	0.721
LIG_FHA_2	384	390	PF00498	0.479
LIG_LIR_Gen_1	135	144	PF02991	0.395
LIG_LIR_Gen_1	151	162	PF02991	0.492
LIG_LIR_Gen_1	344	352	PF02991	0.511
LIG_LIR_Gen_1	371	382	PF02991	0.289
LIG_LIR_Gen_1	443	450	PF02991	0.328
LIG_LIR_LC3C_4	184	189	PF02991	0.537
LIG_LIR_Nem_3	135	139	PF02991	0.385
LIG_LIR_Nem_3	278	282	PF02991	0.461
LIG_LIR_Nem_3	344	348	PF02991	0.441
LIG_LIR_Nem_3	371	377	PF02991	0.386
LIG_LIR_Nem_3	443	449	PF02991	0.328
LIG_LIR_Nem_3	480	484	PF02991	0.330
LIG_LIR_Nem_3	97	102	PF02991	0.427
LIG_MAD2	177	185	PF02301	0.562
LIG_MYND_3	518	522	PF01753	0.440
LIG_PDZ_Class_2	591	596	PF00595	0.566
LIG_Pex14_2	99	103	PF04695	0.529
LIG_PTB_Apo_2	97	104	PF02174	0.454
LIG_SH2_CRK	136	140	PF00017	0.400
LIG_SH2_CRK	4	8	PF00017	0.561
LIG_SH2_CRK	446	450	PF00017	0.344
LIG_SH2_GRB2like	4	7	PF00017	0.554
LIG_SH2_STAT3	351	354	PF00017	0.575
LIG_SH2_STAT5	102	105	PF00017	0.384
LIG_SH2_STAT5	138	141	PF00017	0.426
LIG_SH2_STAT5	260	263	PF00017	0.396
LIG_SH2_STAT5	282	285	PF00017	0.567
LIG_SH2_STAT5	287	290	PF00017	0.508
LIG_SH2_STAT5	351	354	PF00017	0.473
LIG_SH2_STAT5	368	371	PF00017	0.306
LIG_SH2_STAT5	374	377	PF00017	0.391
LIG_SH2_STAT5	4	7	PF00017	0.543
LIG_SH2_STAT5	500	503	PF00017	0.460
LIG_SH3_3	216	222	PF00018	0.706
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.354
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.344
LIG_SUMO_SIM_anti_2	565	570	PF11976	0.476
LIG_SUMO_SIM_par_1	186	192	PF11976	0.448
LIG_SUMO_SIM_par_1	264	269	PF11976	0.479
LIG_SUMO_SIM_par_1	305	312	PF11976	0.531
LIG_SUMO_SIM_par_1	403	409	PF11976	0.425
LIG_TRAF2_1	113	116	PF00917	0.503
LIG_TYR_ITIM	134	139	PF00017	0.407
LIG_TYR_ITIM	36	41	PF00017	0.706
LIG_UBA3_1	342	349	PF00899	0.390
LIG_WRC_WIRS_1	171	176	PF05994	0.575
LIG_WRC_WIRS_1	478	483	PF05994	0.475
LIG_WW_1	257	260	PF00397	0.428
MOD_CDC14_SPxK_1	217	220	PF00782	0.704
MOD_CDK_SPxK_1	214	220	PF00069	0.661
MOD_CDK_SPxK_1	56	62	PF00069	0.677
MOD_CK1_1	228	234	PF00069	0.801
MOD_CK1_1	246	252	PF00069	0.644
MOD_CK1_1	537	543	PF00069	0.469
MOD_CK2_1	383	389	PF00069	0.311
MOD_CK2_1	428	434	PF00069	0.522
MOD_GlcNHglycan	181	184	PF01048	0.584
MOD_GlcNHglycan	226	230	PF01048	0.808
MOD_GlcNHglycan	251	254	PF01048	0.692
MOD_GlcNHglycan	430	433	PF01048	0.544
MOD_GlcNHglycan	471	474	PF01048	0.449
MOD_GSK3_1	179	186	PF00069	0.502
MOD_GSK3_1	214	221	PF00069	0.638
MOD_GSK3_1	224	231	PF00069	0.775
MOD_GSK3_1	244	251	PF00069	0.696
MOD_GSK3_1	296	303	PF00069	0.533
MOD_GSK3_1	362	369	PF00069	0.513
MOD_GSK3_1	451	458	PF00069	0.361
MOD_GSK3_1	465	472	PF00069	0.293
MOD_GSK3_1	50	57	PF00069	0.663
MOD_GSK3_1	547	554	PF00069	0.552
MOD_N-GLC_1	382	387	PF02516	0.304
MOD_N-GLC_1	51	56	PF02516	0.673
MOD_NEK2_1	243	248	PF00069	0.692
MOD_NEK2_1	469	474	PF00069	0.389
MOD_NEK2_2	403	408	PF00069	0.458
MOD_PIKK_1	230	236	PF00454	0.659
MOD_PIKK_1	277	283	PF00454	0.565
MOD_PIKK_1	328	334	PF00454	0.493
MOD_PIKK_1	534	540	PF00454	0.522
MOD_PKA_1	89	95	PF00069	0.579
MOD_PKA_2	366	372	PF00069	0.547
MOD_PKA_2	456	462	PF00069	0.413
MOD_PKA_2	534	540	PF00069	0.401
MOD_PKA_2	89	95	PF00069	0.618
MOD_Plk_1	28	34	PF00069	0.541
MOD_Plk_1	382	388	PF00069	0.299
MOD_Plk_1	547	553	PF00069	0.497
MOD_Plk_4	170	176	PF00069	0.447
MOD_Plk_4	183	189	PF00069	0.395
MOD_Plk_4	383	389	PF00069	0.445
MOD_Plk_4	456	462	PF00069	0.410
MOD_Plk_4	547	553	PF00069	0.444
MOD_Plk_4	89	95	PF00069	0.511
MOD_ProDKin_1	162	168	PF00069	0.604
MOD_ProDKin_1	214	220	PF00069	0.658
MOD_ProDKin_1	246	252	PF00069	0.698
MOD_ProDKin_1	31	37	PF00069	0.708
MOD_ProDKin_1	56	62	PF00069	0.729
MOD_ProDKin_1	80	86	PF00069	0.658
MOD_SUMO_rev_2	422	427	PF00179	0.543
TRG_DiLeu_BaEn_1	321	326	PF01217	0.463
TRG_DiLeu_BaEn_2	114	120	PF01217	0.549
TRG_DiLeu_BaEn_4	422	428	PF01217	0.549
TRG_ENDOCYTIC_2	136	139	PF00928	0.385
TRG_ENDOCYTIC_2	374	377	PF00928	0.410
TRG_ENDOCYTIC_2	38	41	PF00928	0.731
TRG_ENDOCYTIC_2	4	7	PF00928	0.531
TRG_ENDOCYTIC_2	446	449	PF00928	0.344
TRG_ENDOCYTIC_2	466	469	PF00928	0.145
TRG_ER_diArg_1	46	48	PF00400	0.769
TRG_ER_diArg_1	579	582	PF00400	0.505
TRG_ER_diArg_1	88	90	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C5	Leptomonas seymouri	69%	78%
A0A0S4J3H1	Bodo saltans	40%	100%
A0A1X0NYY0	Trypanosomatidae	52%	96%
A0A3S7WWD8	Leishmania donovani	96%	100%
A0A422NII4	Trypanosoma rangeli	51%	100%
A4HBM4	Leishmania braziliensis	89%	100%
A4HZB3	Leishmania infantum	96%	100%
D0A1L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
E9AUZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	81%
V5BG17	Trypanosoma cruzi	52%	100%