Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCI7_LEIMA

TriTrypDb:

LmjF.21.0280 , LMJLV39_210008100 , LMJSD75_210008200

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.582
CLV_C14_Caspase3-7	324	328	PF00656	0.521
CLV_C14_Caspase3-7	438	442	PF00656	0.455
CLV_NRD_NRD_1	109	111	PF00675	0.589
CLV_NRD_NRD_1	113	115	PF00675	0.612
CLV_NRD_NRD_1	144	146	PF00675	0.541
CLV_NRD_NRD_1	313	315	PF00675	0.552
CLV_NRD_NRD_1	432	434	PF00675	0.738
CLV_NRD_NRD_1	461	463	PF00675	0.469
CLV_NRD_NRD_1	488	490	PF00675	0.574
CLV_PCSK_FUR_1	311	315	PF00082	0.605
CLV_PCSK_KEX2_1	109	111	PF00082	0.553
CLV_PCSK_KEX2_1	113	115	PF00082	0.596
CLV_PCSK_KEX2_1	144	146	PF00082	0.543
CLV_PCSK_KEX2_1	313	315	PF00082	0.552
CLV_PCSK_KEX2_1	432	434	PF00082	0.699
CLV_PCSK_KEX2_1	461	463	PF00082	0.510
CLV_PCSK_KEX2_1	488	490	PF00082	0.574
CLV_PCSK_PC7_1	109	115	PF00082	0.569
CLV_PCSK_SKI1_1	11	15	PF00082	0.635
CLV_PCSK_SKI1_1	133	137	PF00082	0.722
CLV_PCSK_SKI1_1	294	298	PF00082	0.491
CLV_PCSK_SKI1_1	321	325	PF00082	0.519
CLV_PCSK_SKI1_1	462	466	PF00082	0.503
CLV_PCSK_SKI1_1	497	501	PF00082	0.432
CLV_PCSK_SKI1_1	81	85	PF00082	0.572
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DEG_SPOP_SBC_1	216	220	PF00917	0.578
DEG_SPOP_SBC_1	241	245	PF00917	0.641
DOC_CKS1_1	253	258	PF01111	0.623
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.547
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.486
DOC_MAPK_gen_1	14	22	PF00069	0.553
DOC_MAPK_gen_1	288	297	PF00069	0.499
DOC_MAPK_gen_1	443	453	PF00069	0.437
DOC_MAPK_gen_1	461	468	PF00069	0.299
DOC_MAPK_gen_1	488	494	PF00069	0.559
DOC_MAPK_MEF2A_6	3	10	PF00069	0.428
DOC_MAPK_MEF2A_6	446	453	PF00069	0.562
DOC_MAPK_MEF2A_6	461	470	PF00069	0.333
DOC_PP1_RVXF_1	292	298	PF00149	0.491
DOC_PP2B_LxvP_1	151	154	PF13499	0.555
DOC_PP2B_LxvP_1	409	412	PF13499	0.448
DOC_PP4_FxxP_1	279	282	PF00568	0.585
DOC_USP7_MATH_1	122	126	PF00917	0.674
DOC_USP7_MATH_1	131	135	PF00917	0.678
DOC_USP7_MATH_1	209	213	PF00917	0.693
DOC_USP7_MATH_1	216	220	PF00917	0.621
DOC_USP7_MATH_1	221	225	PF00917	0.576
DOC_USP7_MATH_1	227	231	PF00917	0.516
DOC_USP7_MATH_1	241	245	PF00917	0.541
DOC_USP7_MATH_1	339	343	PF00917	0.531
DOC_USP7_MATH_1	38	42	PF00917	0.681
DOC_USP7_MATH_1	396	400	PF00917	0.564
DOC_USP7_MATH_1	472	476	PF00917	0.427
DOC_USP7_MATH_1	526	530	PF00917	0.528
DOC_WW_Pin1_4	212	217	PF00397	0.774
DOC_WW_Pin1_4	252	257	PF00397	0.618
DOC_WW_Pin1_4	28	33	PF00397	0.599
DOC_WW_Pin1_4	81	86	PF00397	0.639
LIG_14-3-3_CanoR_1	133	143	PF00244	0.688
LIG_14-3-3_CanoR_1	186	194	PF00244	0.724
LIG_14-3-3_CanoR_1	217	223	PF00244	0.559
LIG_14-3-3_CanoR_1	288	298	PF00244	0.515
LIG_14-3-3_CanoR_1	321	326	PF00244	0.525
LIG_14-3-3_CanoR_1	70	76	PF00244	0.474
LIG_CSL_BTD_1	213	216	PF09270	0.626
LIG_FHA_1	100	106	PF00498	0.507
LIG_FHA_1	290	296	PF00498	0.501
LIG_FHA_1	341	347	PF00498	0.489
LIG_FHA_1	395	401	PF00498	0.614
LIG_FHA_1	404	410	PF00498	0.464
LIG_FHA_1	518	524	PF00498	0.453
LIG_FHA_1	88	94	PF00498	0.531
LIG_FHA_2	119	125	PF00498	0.644
LIG_FHA_2	223	229	PF00498	0.697
LIG_FHA_2	314	320	PF00498	0.646
LIG_FHA_2	322	328	PF00498	0.478
LIG_GBD_Chelix_1	449	457	PF00786	0.390
LIG_LIR_Apic_2	74	80	PF02991	0.523
LIG_LIR_Gen_1	375	384	PF02991	0.513
LIG_LIR_Gen_1	479	485	PF02991	0.539
LIG_LIR_Gen_1	533	541	PF02991	0.442
LIG_LIR_Nem_3	375	379	PF02991	0.512
LIG_LIR_Nem_3	513	519	PF02991	0.446
LIG_LIR_Nem_3	533	538	PF02991	0.428
LIG_SH2_CRK	77	81	PF00017	0.540
LIG_SH2_NCK_1	46	50	PF00017	0.532
LIG_SH2_PTP2	376	379	PF00017	0.520
LIG_SH2_STAP1	405	409	PF00017	0.441
LIG_SH2_STAP1	46	50	PF00017	0.532
LIG_SH2_STAT5	376	379	PF00017	0.520
LIG_SH2_STAT5	394	397	PF00017	0.627
LIG_SH2_STAT5	405	408	PF00017	0.391
LIG_SH2_STAT5	46	49	PF00017	0.460
LIG_SH3_2	253	258	PF14604	0.623
LIG_SH3_3	140	146	PF00018	0.671
LIG_SH3_3	164	170	PF00018	0.622
LIG_SH3_3	195	201	PF00018	0.570
LIG_SH3_3	250	256	PF00018	0.630
LIG_SH3_3	409	415	PF00018	0.486
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.501
LIG_SUMO_SIM_anti_2	536	542	PF11976	0.400
LIG_SUMO_SIM_par_1	536	542	PF11976	0.400
LIG_TRAF2_1	188	191	PF00917	0.572
LIG_TRAF2_1	316	319	PF00917	0.735
LIG_WRC_WIRS_1	467	472	PF05994	0.394
MOD_CDK_SPK_2	212	217	PF00069	0.693
MOD_CDK_SPxK_1	252	258	PF00069	0.622
MOD_CK1_1	125	131	PF00069	0.620
MOD_CK1_1	134	140	PF00069	0.688
MOD_CK1_1	174	180	PF00069	0.556
MOD_CK1_1	212	218	PF00069	0.693
MOD_CK1_1	245	251	PF00069	0.610
MOD_CK1_1	31	37	PF00069	0.598
MOD_CK1_1	428	434	PF00069	0.705
MOD_CK1_1	476	482	PF00069	0.465
MOD_CK1_1	533	539	PF00069	0.405
MOD_CK1_1	87	93	PF00069	0.511
MOD_CK2_1	185	191	PF00069	0.565
MOD_CK2_1	296	302	PF00069	0.514
MOD_CK2_1	313	319	PF00069	0.639
MOD_CK2_1	339	345	PF00069	0.472
MOD_CK2_1	420	426	PF00069	0.544
MOD_GlcNHglycan	126	130	PF01048	0.642
MOD_GlcNHglycan	173	176	PF01048	0.555
MOD_GlcNHglycan	211	214	PF01048	0.675
MOD_GlcNHglycan	219	222	PF01048	0.613
MOD_GlcNHglycan	231	234	PF01048	0.532
MOD_GlcNHglycan	244	247	PF01048	0.542
MOD_GlcNHglycan	249	252	PF01048	0.551
MOD_GlcNHglycan	327	331	PF01048	0.566
MOD_GlcNHglycan	40	43	PF01048	0.654
MOD_GlcNHglycan	422	425	PF01048	0.591
MOD_GlcNHglycan	426	430	PF01048	0.675
MOD_GlcNHglycan	437	440	PF01048	0.522
MOD_GlcNHglycan	528	531	PF01048	0.518
MOD_GlcNHglycan	86	89	PF01048	0.549
MOD_GSK3_1	114	121	PF00069	0.688
MOD_GSK3_1	212	219	PF00069	0.664
MOD_GSK3_1	23	30	PF00069	0.623
MOD_GSK3_1	236	243	PF00069	0.645
MOD_GSK3_1	297	304	PF00069	0.559
MOD_GSK3_1	368	375	PF00069	0.475
MOD_GSK3_1	40	47	PF00069	0.588
MOD_GSK3_1	466	473	PF00069	0.417
MOD_GSK3_1	526	533	PF00069	0.532
MOD_N-GLC_1	154	159	PF02516	0.508
MOD_N-GLC_1	241	246	PF02516	0.678
MOD_NEK2_1	118	123	PF00069	0.689
MOD_NEK2_1	156	161	PF00069	0.600
MOD_NEK2_1	326	331	PF00069	0.508
MOD_NEK2_1	466	471	PF00069	0.530
MOD_NEK2_1	71	76	PF00069	0.476
MOD_NEK2_2	456	461	PF00069	0.416
MOD_OFUCOSY	278	285	PF10250	0.515
MOD_PIKK_1	368	374	PF00454	0.483
MOD_PIKK_1	451	457	PF00454	0.403
MOD_PIKK_1	483	489	PF00454	0.464
MOD_PKA_1	109	115	PF00069	0.569
MOD_PKA_1	144	150	PF00069	0.541
MOD_PKA_1	313	319	PF00069	0.569
MOD_PKA_2	109	115	PF00069	0.612
MOD_PKA_2	144	150	PF00069	0.586
MOD_PKA_2	185	191	PF00069	0.718
MOD_PKA_2	216	222	PF00069	0.692
MOD_PKA_2	313	319	PF00069	0.569
MOD_PKB_1	311	319	PF00069	0.619
MOD_Plk_1	326	332	PF00069	0.511
MOD_Plk_2-3	21	27	PF00069	0.569
MOD_Plk_4	114	120	PF00069	0.759
MOD_Plk_4	267	273	PF00069	0.668
MOD_Plk_4	31	37	PF00069	0.579
MOD_Plk_4	321	327	PF00069	0.519
MOD_Plk_4	372	378	PF00069	0.532
MOD_Plk_4	466	472	PF00069	0.388
MOD_Plk_4	476	482	PF00069	0.442
MOD_ProDKin_1	212	218	PF00069	0.774
MOD_ProDKin_1	252	258	PF00069	0.622
MOD_ProDKin_1	28	34	PF00069	0.601
MOD_ProDKin_1	81	87	PF00069	0.636
MOD_SUMO_rev_2	491	499	PF00179	0.515
TRG_DiLeu_BaEn_1	103	108	PF01217	0.503
TRG_DiLeu_BaEn_4	318	324	PF01217	0.614
TRG_ENDOCYTIC_2	2	5	PF00928	0.501
TRG_ENDOCYTIC_2	376	379	PF00928	0.520
TRG_ENDOCYTIC_2	481	484	PF00928	0.479
TRG_ER_diArg_1	108	110	PF00400	0.530
TRG_ER_diArg_1	113	115	PF00400	0.557
TRG_ER_diArg_1	143	145	PF00400	0.546
TRG_ER_diArg_1	310	313	PF00400	0.603
TRG_ER_diArg_1	460	462	PF00400	0.446
TRG_NES_CRM1_1	97	111	PF08389	0.498
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K7	Leptomonas seymouri	53%	93%
A0A3S7WWB2	Leishmania donovani	92%	100%
A4HBM6	Leishmania braziliensis	77%	99%
E9AUZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%