DUF3533 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCI5_LEIMA

TriTrypDb:

LmjF.21.0300 , LMJLV39_210008300 , LMJSD75_210008400

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QCI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.544
CLV_PCSK_KEX2_1	223	225	PF00082	0.544
CLV_PCSK_SKI1_1	110	114	PF00082	0.507
CLV_PCSK_SKI1_1	63	67	PF00082	0.458
CLV_Separin_Metazoa	133	137	PF03568	0.436
DEG_SPOP_SBC_1	209	213	PF00917	0.657
DOC_USP7_MATH_1	188	192	PF00917	0.727
DOC_USP7_MATH_1	216	220	PF00917	0.660
DOC_USP7_MATH_1	28	32	PF00917	0.755
DOC_USP7_MATH_1	51	55	PF00917	0.687
DOC_WW_Pin1_4	210	215	PF00397	0.692
DOC_WW_Pin1_4	234	239	PF00397	0.784
DOC_WW_Pin1_4	3	8	PF00397	0.757
DOC_WW_Pin1_4	42	47	PF00397	0.709
LIG_14-3-3_CanoR_1	223	228	PF00244	0.816
LIG_BIR_III_4	125	129	PF00653	0.341
LIG_BRCT_BRCA1_1	43	47	PF00533	0.796
LIG_DLG_GKlike_1	223	231	PF00625	0.760
LIG_FHA_1	130	136	PF00498	0.430
LIG_FHA_1	168	174	PF00498	0.363
LIG_FHA_1	80	86	PF00498	0.363
LIG_LIR_Gen_1	88	99	PF02991	0.418
LIG_LIR_Nem_3	170	175	PF02991	0.387
LIG_LIR_Nem_3	237	243	PF02991	0.718
LIG_LIR_Nem_3	61	67	PF02991	0.661
LIG_LIR_Nem_3	88	94	PF02991	0.383
LIG_LYPXL_yS_3	118	121	PF13949	0.471
LIG_Pex14_2	91	95	PF04695	0.436
LIG_PTB_Apo_2	72	79	PF02174	0.627
LIG_SH2_CRK	116	120	PF00017	0.487
LIG_SH2_CRK	179	183	PF00017	0.655
LIG_SH2_CRK	67	71	PF00017	0.645
LIG_SH2_NCK_1	227	231	PF00017	0.816
LIG_SH2_STAP1	100	104	PF00017	0.485
LIG_SH2_STAT5	131	134	PF00017	0.468
LIG_SH2_STAT5	67	70	PF00017	0.644
LIG_SH3_1	235	241	PF00018	0.741
LIG_SH3_3	235	241	PF00018	0.783
LIG_SH3_3	54	60	PF00018	0.710
LIG_SUMO_SIM_par_1	164	171	PF11976	0.436
LIG_UBA3_1	94	103	PF00899	0.549
LIG_WRC_WIRS_1	169	174	PF05994	0.436
MOD_CDK_SPxxK_3	3	10	PF00069	0.754
MOD_CK1_1	217	223	PF00069	0.736
MOD_CK1_1	22	28	PF00069	0.815
MOD_CMANNOS	8	11	PF00535	0.552
MOD_GlcNHglycan	157	160	PF01048	0.459
MOD_GlcNHglycan	190	193	PF01048	0.587
MOD_GlcNHglycan	196	199	PF01048	0.561
MOD_GlcNHglycan	26	29	PF01048	0.563
MOD_GlcNHglycan	3	6	PF01048	0.485
MOD_GlcNHglycan	38	41	PF01048	0.450
MOD_GlcNHglycan	60	63	PF01048	0.516
MOD_GSK3_1	145	152	PF00069	0.483
MOD_GSK3_1	19	26	PF00069	0.801
MOD_GSK3_1	210	217	PF00069	0.813
MOD_GSK3_1	219	226	PF00069	0.703
MOD_GSK3_1	38	45	PF00069	0.596
MOD_GSK3_1	79	86	PF00069	0.424
MOD_N-GLC_1	51	56	PF02516	0.552
MOD_NEK2_1	1	6	PF00069	0.709
MOD_NEK2_1	167	172	PF00069	0.400
MOD_NEK2_1	65	70	PF00069	0.663
MOD_PKA_1	223	229	PF00069	0.816
MOD_PKA_2	223	229	PF00069	0.816
MOD_Plk_1	51	57	PF00069	0.606
MOD_Plk_4	168	174	PF00069	0.500
MOD_Plk_4	94	100	PF00069	0.496
MOD_ProDKin_1	210	216	PF00069	0.694
MOD_ProDKin_1	234	240	PF00069	0.786
MOD_ProDKin_1	3	9	PF00069	0.754
MOD_ProDKin_1	42	48	PF00069	0.709
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.702
TRG_ENDOCYTIC_2	118	121	PF00928	0.471
TRG_ENDOCYTIC_2	179	182	PF00928	0.643
TRG_ENDOCYTIC_2	67	70	PF00928	0.690
TRG_ER_diArg_1	30	33	PF00400	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBS2	Leishmania donovani	93%	100%
A0A3R7KF63	Trypanosoma rangeli	34%	100%
A4HBM8	Leishmania braziliensis	71%	100%
A4HZB7	Leishmania infantum	93%	100%
E9AUZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%