Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCI4_LEIMA

TriTrypDb:

LmjF.21.0310 , LMJLV39_210008400 , LMJSD75_210008500

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QCI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.580
CLV_MEL_PAP_1	153	159	PF00089	0.638
CLV_NRD_NRD_1	174	176	PF00675	0.660
CLV_NRD_NRD_1	240	242	PF00675	0.711
CLV_PCSK_FUR_1	47	51	PF00082	0.575
CLV_PCSK_KEX2_1	240	242	PF00082	0.553
CLV_PCSK_KEX2_1	49	51	PF00082	0.594
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.592
CLV_PCSK_SKI1_1	125	129	PF00082	0.615
CLV_PCSK_SKI1_1	280	284	PF00082	0.480
CLV_PCSK_SKI1_1	306	310	PF00082	0.421
CLV_PCSK_SKI1_1	53	57	PF00082	0.673
CLV_Separin_Metazoa	86	90	PF03568	0.515
DEG_APCC_DBOX_1	240	248	PF00400	0.344
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.711
DOC_CYCLIN_yCln2_LP_2	112	115	PF00134	0.469
DOC_MAPK_gen_1	49	59	PF00069	0.461
DOC_MAPK_JIP1_4	89	95	PF00069	0.512
DOC_MAPK_MEF2A_6	261	268	PF00069	0.435
DOC_MAPK_RevD_3	34	50	PF00069	0.470
DOC_MIT_MIM_1	184	193	PF04212	0.467
DOC_PP1_RVXF_1	230	236	PF00149	0.411
DOC_PP2B_LxvP_1	112	115	PF13499	0.473
DOC_PP2B_LxvP_1	93	96	PF13499	0.545
DOC_SPAK_OSR1_1	120	124	PF12202	0.385
DOC_SPAK_OSR1_1	156	160	PF12202	0.394
DOC_USP7_MATH_1	130	134	PF00917	0.415
DOC_USP7_MATH_1	138	142	PF00917	0.419
DOC_USP7_MATH_1	81	85	PF00917	0.407
DOC_WW_Pin1_4	115	120	PF00397	0.451
DOC_WW_Pin1_4	18	23	PF00397	0.558
DOC_WW_Pin1_4	254	259	PF00397	0.425
DOC_WW_Pin1_4	26	31	PF00397	0.541
LIG_14-3-3_CanoR_1	156	160	PF00244	0.389
LIG_14-3-3_CanoR_1	232	236	PF00244	0.360
LIG_14-3-3_CanoR_1	280	285	PF00244	0.403
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	117	121	PF00533	0.445
LIG_CSL_BTD_1	168	171	PF09270	0.363
LIG_FHA_1	177	183	PF00498	0.446
LIG_FHA_1	41	47	PF00498	0.362
LIG_FHA_2	81	87	PF00498	0.518
LIG_Integrin_RGD_1	241	243	PF01839	0.550
LIG_LIR_Nem_3	166	172	PF02991	0.347
LIG_LIR_Nem_3	234	239	PF02991	0.331
LIG_Pex14_2	117	121	PF04695	0.321
LIG_REV1ctd_RIR_1	234	245	PF16727	0.419
LIG_SH2_STAP1	178	182	PF00017	0.490
LIG_SH2_STAT3	178	181	PF00017	0.436
LIG_SH2_STAT5	178	181	PF00017	0.491
LIG_SH2_STAT5	229	232	PF00017	0.325
LIG_SH2_STAT5	45	48	PF00017	0.441
LIG_SH3_2	275	280	PF14604	0.472
LIG_SH3_3	16	22	PF00018	0.685
LIG_SH3_3	272	278	PF00018	0.514
LIG_SH3_3	297	303	PF00018	0.426
LIG_SH3_3	84	90	PF00018	0.515
LIG_Sin3_3	287	294	PF02671	0.480
LIG_SUMO_SIM_anti_2	286	293	PF11976	0.356
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.433
LIG_WRC_WIRS_1	247	252	PF05994	0.384
MOD_CDK_SPK_2	115	120	PF00069	0.452
MOD_CDK_SPxxK_3	254	261	PF00069	0.421
MOD_CK1_1	180	186	PF00069	0.499
MOD_CK1_1	23	29	PF00069	0.525
MOD_CK1_1	231	237	PF00069	0.381
MOD_CK1_1	293	299	PF00069	0.397
MOD_CK1_1	304	310	PF00069	0.605
MOD_CK2_1	138	144	PF00069	0.425
MOD_CK2_1	80	86	PF00069	0.520
MOD_GlcNHglycan	22	25	PF01048	0.768
MOD_GlcNHglycan	285	288	PF01048	0.384
MOD_GSK3_1	144	151	PF00069	0.396
MOD_GSK3_1	176	183	PF00069	0.421
MOD_GSK3_1	246	253	PF00069	0.365
MOD_GSK3_1	94	101	PF00069	0.534
MOD_N-GLC_1	131	136	PF02516	0.603
MOD_NEK2_1	155	160	PF00069	0.393
MOD_NEK2_1	182	187	PF00069	0.498
MOD_NEK2_1	215	220	PF00069	0.551
MOD_NEK2_1	250	255	PF00069	0.329
MOD_NEK2_1	309	314	PF00069	0.707
MOD_NEK2_1	98	103	PF00069	0.538
MOD_NEK2_2	131	136	PF00069	0.437
MOD_NEK2_2	138	143	PF00069	0.447
MOD_PIKK_1	177	183	PF00454	0.414
MOD_PIKK_1	309	315	PF00454	0.666
MOD_PK_1	28	34	PF00069	0.519
MOD_PKA_1	176	182	PF00069	0.473
MOD_PKA_2	155	161	PF00069	0.428
MOD_PKA_2	231	237	PF00069	0.358
MOD_Plk_1	131	137	PF00069	0.438
MOD_Plk_1	144	150	PF00069	0.460
MOD_Plk_1	165	171	PF00069	0.435
MOD_Plk_4	165	171	PF00069	0.416
MOD_Plk_4	231	237	PF00069	0.372
MOD_Plk_4	290	296	PF00069	0.369
MOD_Plk_4	40	46	PF00069	0.414
MOD_ProDKin_1	115	121	PF00069	0.452
MOD_ProDKin_1	18	24	PF00069	0.559
MOD_ProDKin_1	254	260	PF00069	0.425
MOD_ProDKin_1	26	32	PF00069	0.539
MOD_SUMO_rev_2	141	148	PF00179	0.346
MOD_SUMO_rev_2	257	262	PF00179	0.412
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.467
TRG_ER_diArg_1	239	241	PF00400	0.339
TRG_NES_CRM1_1	243	255	PF08389	0.399
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H6	Leptomonas seymouri	51%	90%
A0A1X0NXE2	Trypanosomatidae	29%	100%
A0A3S5IR94	Trypanosoma rangeli	29%	100%
A0A3S7WWC8	Leishmania donovani	93%	100%
A4HBM9	Leishmania braziliensis	75%	100%
A4HZB8	Leishmania infantum	93%	100%
D0A1M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AUZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	92%
V5B0L2	Trypanosoma cruzi	29%	100%