Matrin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein C, putative

Species:

Leishmania major

UniProt:

Q4QCI3_LEIMA

TriTrypDb:

LmjF.21.0320 , LMJLV39_210008500 , LMJSD75_210008600

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	2
GO:0005689	U12-type spliceosomal complex	4	2
GO:0032991	protein-containing complex	1	4
GO:0110165	cellular anatomical entity	1	5
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	4
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

Q4QCI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.579
CLV_NRD_NRD_1	56	58	PF00675	0.591
CLV_NRD_NRD_1	64	66	PF00675	0.489
CLV_PCSK_FUR_1	43	47	PF00082	0.557
CLV_PCSK_KEX2_1	40	42	PF00082	0.537
CLV_PCSK_KEX2_1	45	47	PF00082	0.547
CLV_PCSK_KEX2_1	56	58	PF00082	0.514
CLV_PCSK_KEX2_1	64	66	PF00082	0.454
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.590
CLV_PCSK_PC7_1	41	47	PF00082	0.546
CLV_PCSK_SKI1_1	196	200	PF00082	0.676
DEG_Nend_UBRbox_2	1	3	PF02207	0.766
DOC_CKS1_1	186	191	PF01111	0.658
DOC_PP2B_LxvP_1	169	172	PF13499	0.782
DOC_PP2B_LxvP_1	227	230	PF13499	0.808
DOC_PP2B_PxIxI_1	155	161	PF00149	0.622
DOC_PP2B_PxIxI_1	188	194	PF00149	0.625
DOC_PP4_FxxP_1	175	178	PF00568	0.799
DOC_USP7_MATH_1	102	106	PF00917	0.607
DOC_USP7_MATH_1	179	183	PF00917	0.687
DOC_USP7_MATH_1	201	205	PF00917	0.735
DOC_USP7_MATH_1	215	219	PF00917	0.698
DOC_WW_Pin1_4	144	149	PF00397	0.648
DOC_WW_Pin1_4	185	190	PF00397	0.740
DOC_WW_Pin1_4	204	209	PF00397	0.528
DOC_WW_Pin1_4	49	54	PF00397	0.593
LIG_14-3-3_CanoR_1	217	227	PF00244	0.805
LIG_14-3-3_CanoR_1	86	91	PF00244	0.556
LIG_14-3-3_CanoR_1	98	106	PF00244	0.551
LIG_CaM_NSCaTE_8	90	97	PF13499	0.556
LIG_EVH1_1	169	173	PF00568	0.780
LIG_EVH1_1	175	179	PF00568	0.697
LIG_EVH1_2	171	175	PF00568	0.786
LIG_FHA_1	186	192	PF00498	0.731
LIG_FHA_1	193	199	PF00498	0.662
LIG_FHA_2	211	217	PF00498	0.625
LIG_FHA_2	218	224	PF00498	0.574
LIG_LIR_Gen_1	105	113	PF02991	0.631
LIG_LIR_Gen_1	77	83	PF02991	0.517
LIG_LIR_Nem_3	100	106	PF02991	0.522
LIG_LIR_Nem_3	77	81	PF02991	0.517
LIG_SH2_CRK	107	111	PF00017	0.600
LIG_SH2_NCK_1	107	111	PF00017	0.475
LIG_SH2_STAP1	107	111	PF00017	0.529
LIG_SH2_STAT5	75	78	PF00017	0.517
LIG_SH3_1	168	174	PF00018	0.712
LIG_SH3_3	167	173	PF00018	0.727
LIG_SH3_3	183	189	PF00018	0.602
LIG_SH3_3	202	208	PF00018	0.717
MOD_CDK_SPxxK_3	185	192	PF00069	0.766
MOD_CDK_SPxxK_3	49	56	PF00069	0.593
MOD_CK1_1	204	210	PF00069	0.790
MOD_CK1_1	218	224	PF00069	0.676
MOD_CK2_1	210	216	PF00069	0.792
MOD_CK2_1	218	224	PF00069	0.761
MOD_CK2_1	32	38	PF00069	0.607
MOD_GlcNHglycan	139	142	PF01048	0.614
MOD_GlcNHglycan	181	184	PF01048	0.716
MOD_GlcNHglycan	2	6	PF01048	0.692
MOD_GlcNHglycan	23	26	PF01048	0.711
MOD_GlcNHglycan	29	32	PF01048	0.721
MOD_GlcNHglycan	95	98	PF01048	0.410
MOD_GSK3_1	82	89	PF00069	0.376
MOD_GSK3_1	93	100	PF00069	0.376
MOD_N-GLC_1	21	26	PF02516	0.679
MOD_NEK2_1	81	86	PF00069	0.378
MOD_PKA_2	218	224	PF00069	0.816
MOD_PKA_2	97	103	PF00069	0.502
MOD_Plk_4	102	108	PF00069	0.429
MOD_Plk_4	112	118	PF00069	0.430
MOD_Plk_4	194	200	PF00069	0.699
MOD_ProDKin_1	144	150	PF00069	0.648
MOD_ProDKin_1	185	191	PF00069	0.737
MOD_ProDKin_1	204	210	PF00069	0.529
MOD_ProDKin_1	49	55	PF00069	0.593
MOD_SUMO_rev_2	35	42	PF00179	0.652
TRG_ENDOCYTIC_2	106	109	PF00928	0.486
TRG_ENDOCYTIC_2	78	81	PF00928	0.376
TRG_ER_diArg_1	42	45	PF00400	0.542
TRG_ER_diArg_1	46	48	PF00400	0.569
TRG_NES_CRM1_1	108	120	PF08389	0.531
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0S9	Leptomonas seymouri	67%	100%
A0A3Q8IA85	Leishmania donovani	91%	97%
A4HBN0	Leishmania braziliensis	79%	97%
A4HZ31	Leishmania infantum	91%	97%
D0A1N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AUZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%