Vacuolar protein sorting-associated protein 51 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps51/Vps67, putative

Species:

Leishmania major

UniProt:

Q4QCI2_LEIMA

TriTrypDb:

LmjF.21.0330 , LMJLV39_210008600 , LMJSD75_210008700

Length:

1066

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000938	GARP complex	3	5
GO:0005829	cytosol	2	5
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	5
GO:0099023	vesicle tethering complex	2	5
GO:0110165	cellular anatomical entity	1	5
GO:1990745	EARP complex	2	2

Expansion

Sequence features

Q4QCI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCI2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0006996	organelle organization	4	5
GO:0007030	Golgi organization	5	5
GO:0007034	vacuolar transport	4	2
GO:0007041	lysosomal transport	5	2
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0016192	vesicle-mediated transport	4	5
GO:0016197	endosomal transport	4	5
GO:0016482	cytosolic transport	4	5
GO:0032456	endocytic recycling	5	5
GO:0042147	retrograde transport, endosome to Golgi	5	5
GO:0046907	intracellular transport	3	5
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0051641	cellular localization	2	5
GO:0051649	establishment of localization in cell	3	5
GO:0051668	localization within membrane	3	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:0098876	vesicle-mediated transport to the plasma membrane	4	5
GO:0006869	lipid transport	5	3
GO:0008104	protein localization	4	3
GO:0015031	protein transport	4	3
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.484
CLV_NRD_NRD_1	1041	1043	PF00675	0.645
CLV_NRD_NRD_1	14	16	PF00675	0.509
CLV_NRD_NRD_1	179	181	PF00675	0.466
CLV_NRD_NRD_1	662	664	PF00675	0.605
CLV_NRD_NRD_1	817	819	PF00675	0.597
CLV_NRD_NRD_1	86	88	PF00675	0.382
CLV_NRD_NRD_1	89	91	PF00675	0.401
CLV_PCSK_FUR_1	87	91	PF00082	0.384
CLV_PCSK_KEX2_1	1041	1043	PF00082	0.645
CLV_PCSK_KEX2_1	14	16	PF00082	0.504
CLV_PCSK_KEX2_1	179	181	PF00082	0.426
CLV_PCSK_KEX2_1	230	232	PF00082	0.582
CLV_PCSK_KEX2_1	317	319	PF00082	0.550
CLV_PCSK_KEX2_1	34	36	PF00082	0.418
CLV_PCSK_KEX2_1	661	663	PF00082	0.611
CLV_PCSK_KEX2_1	70	72	PF00082	0.318
CLV_PCSK_KEX2_1	86	88	PF00082	0.318
CLV_PCSK_KEX2_1	89	91	PF00082	0.318
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.369
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.550
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.671
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.408
CLV_PCSK_PC7_1	226	232	PF00082	0.342
CLV_PCSK_SKI1_1	114	118	PF00082	0.408
CLV_PCSK_SKI1_1	163	167	PF00082	0.502
CLV_PCSK_SKI1_1	283	287	PF00082	0.452
CLV_PCSK_SKI1_1	298	302	PF00082	0.350
CLV_PCSK_SKI1_1	426	430	PF00082	0.371
CLV_PCSK_SKI1_1	770	774	PF00082	0.444
CLV_Separin_Metazoa	498	502	PF03568	0.493
CLV_Separin_Metazoa	83	87	PF03568	0.357
DEG_APCC_DBOX_1	327	335	PF00400	0.515
DEG_APCC_DBOX_1	70	78	PF00400	0.318
DEG_APCC_DBOX_1	769	777	PF00400	0.488
DEG_SPOP_SBC_1	356	360	PF00917	0.585
DEG_SPOP_SBC_1	608	612	PF00917	0.710
DEG_SPOP_SBC_1	945	949	PF00917	0.590
DEG_SPOP_SBC_1	999	1003	PF00917	0.649
DOC_ANK_TNKS_1	246	253	PF00023	0.316
DOC_CKS1_1	562	567	PF01111	0.423
DOC_CKS1_1	969	974	PF01111	0.564
DOC_CKS1_1	990	995	PF01111	0.599
DOC_CYCLIN_yClb5_NLxxxL_5	322	331	PF00134	0.535
DOC_MAPK_gen_1	298	306	PF00069	0.517
DOC_MAPK_HePTP_8	368	380	PF00069	0.506
DOC_MAPK_MEF2A_6	347	356	PF00069	0.571
DOC_MAPK_MEF2A_6	371	380	PF00069	0.602
DOC_MAPK_MEF2A_6	501	508	PF00069	0.514
DOC_PP1_RVXF_1	164	171	PF00149	0.442
DOC_PP2B_LxvP_1	304	307	PF13499	0.437
DOC_PP2B_LxvP_1	622	625	PF13499	0.510
DOC_PP2B_LxvP_1	805	808	PF13499	0.367
DOC_PP4_MxPP_1	1035	1038	PF00568	0.698
DOC_USP7_MATH_1	1020	1024	PF00917	0.701
DOC_USP7_MATH_1	1040	1044	PF00917	0.694
DOC_USP7_MATH_1	29	33	PF00917	0.543
DOC_USP7_MATH_1	342	346	PF00917	0.464
DOC_USP7_MATH_1	410	414	PF00917	0.508
DOC_USP7_MATH_1	451	455	PF00917	0.698
DOC_USP7_MATH_1	725	729	PF00917	0.649
DOC_USP7_MATH_1	809	813	PF00917	0.522
DOC_USP7_MATH_1	869	873	PF00917	0.689
DOC_USP7_MATH_1	945	949	PF00917	0.821
DOC_USP7_MATH_1	961	965	PF00917	0.529
DOC_USP7_MATH_1	979	983	PF00917	0.510
DOC_USP7_MATH_1	999	1003	PF00917	0.509
DOC_USP7_UBL2_3	486	490	PF12436	0.433
DOC_USP7_UBL2_3	843	847	PF12436	0.523
DOC_WW_Pin1_4	1033	1038	PF00397	0.649
DOC_WW_Pin1_4	360	365	PF00397	0.715
DOC_WW_Pin1_4	561	566	PF00397	0.436
DOC_WW_Pin1_4	902	907	PF00397	0.776
DOC_WW_Pin1_4	964	969	PF00397	0.668
DOC_WW_Pin1_4	989	994	PF00397	0.679
LIG_14-3-3_CanoR_1	1041	1046	PF00244	0.614
LIG_14-3-3_CanoR_1	105	113	PF00244	0.408
LIG_14-3-3_CanoR_1	231	236	PF00244	0.529
LIG_14-3-3_CanoR_1	257	262	PF00244	0.444
LIG_14-3-3_CanoR_1	63	69	PF00244	0.370
LIG_14-3-3_CanoR_1	731	741	PF00244	0.568
LIG_Actin_WH2_2	243	259	PF00022	0.464
LIG_Actin_WH2_2	286	303	PF00022	0.502
LIG_Actin_WH2_2	70	88	PF00022	0.399
LIG_BRCT_BRCA1_1	55	59	PF00533	0.293
LIG_BRCT_BRCA1_1	796	800	PF00533	0.393
LIG_Clathr_ClatBox_1	351	355	PF01394	0.499
LIG_FHA_1	1001	1007	PF00498	0.654
LIG_FHA_1	1016	1022	PF00498	0.524
LIG_FHA_1	1050	1056	PF00498	0.684
LIG_FHA_1	108	114	PF00498	0.293
LIG_FHA_1	419	425	PF00498	0.447
LIG_FHA_1	487	493	PF00498	0.507
LIG_FHA_1	531	537	PF00498	0.358
LIG_FHA_1	565	571	PF00498	0.470
LIG_FHA_1	63	69	PF00498	0.295
LIG_FHA_1	728	734	PF00498	0.645
LIG_FHA_1	752	758	PF00498	0.545
LIG_FHA_1	797	803	PF00498	0.368
LIG_FHA_1	80	86	PF00498	0.281
LIG_FHA_1	850	856	PF00498	0.483
LIG_FHA_1	891	897	PF00498	0.824
LIG_FHA_1	912	918	PF00498	0.685
LIG_FHA_2	110	116	PF00498	0.293
LIG_FHA_2	435	441	PF00498	0.480
LIG_FHA_2	613	619	PF00498	0.626
LIG_FHA_2	627	633	PF00498	0.449
LIG_FHA_2	695	701	PF00498	0.704
LIG_FHA_2	78	84	PF00498	0.370
LIG_FHA_2	878	884	PF00498	0.663
LIG_GBD_Chelix_1	540	548	PF00786	0.497
LIG_GSK3_LRP6_1	968	974	PF00069	0.540
LIG_LIR_Gen_1	390	399	PF02991	0.437
LIG_LIR_Gen_1	628	639	PF02991	0.431
LIG_LIR_Gen_1	788	796	PF02991	0.483
LIG_LIR_Nem_3	223	228	PF02991	0.441
LIG_LIR_Nem_3	390	394	PF02991	0.502
LIG_LIR_Nem_3	55	61	PF02991	0.318
LIG_LIR_Nem_3	628	634	PF02991	0.414
LIG_LIR_Nem_3	788	794	PF02991	0.492
LIG_LIR_Nem_3	797	803	PF02991	0.468
LIG_LIR_Nem_3	838	844	PF02991	0.450
LIG_LIR_Nem_3	97	103	PF02991	0.293
LIG_MLH1_MIPbox_1	55	59	PF16413	0.318
LIG_MYND_1	986	990	PF01753	0.524
LIG_NRBOX	423	429	PF00104	0.475
LIG_PCNA_yPIPBox_3	580	594	PF02747	0.422
LIG_PDZ_Class_2	1061	1066	PF00595	0.735
LIG_Pex14_1	627	631	PF04695	0.504
LIG_PTAP_UEV_1	912	917	PF05743	0.557
LIG_SH2_CRK	537	541	PF00017	0.423
LIG_SH2_CRK	803	807	PF00017	0.441
LIG_SH2_GRB2like	1046	1049	PF00017	0.661
LIG_SH2_GRB2like	468	471	PF00017	0.384
LIG_SH2_GRB2like	58	61	PF00017	0.408
LIG_SH2_NCK_1	594	598	PF00017	0.558
LIG_SH2_NCK_1	786	790	PF00017	0.532
LIG_SH2_SRC	249	252	PF00017	0.311
LIG_SH2_STAP1	103	107	PF00017	0.293
LIG_SH2_STAP1	468	472	PF00017	0.390
LIG_SH2_STAP1	537	541	PF00017	0.362
LIG_SH2_STAP1	594	598	PF00017	0.558
LIG_SH2_STAP1	64	68	PF00017	0.353
LIG_SH2_STAP1	729	733	PF00017	0.645
LIG_SH2_STAP1	803	807	PF00017	0.474
LIG_SH2_STAP1	844	848	PF00017	0.557
LIG_SH2_STAT3	729	732	PF00017	0.641
LIG_SH2_STAT3	771	774	PF00017	0.484
LIG_SH2_STAT5	249	252	PF00017	0.497
LIG_SH2_STAT5	442	445	PF00017	0.443
LIG_SH2_STAT5	58	61	PF00017	0.315
LIG_SH2_STAT5	64	67	PF00017	0.271
LIG_SH2_STAT5	729	732	PF00017	0.641
LIG_SH2_STAT5	771	774	PF00017	0.369
LIG_SH2_STAT5	786	789	PF00017	0.443
LIG_SH3_2	906	911	PF14604	0.580
LIG_SH3_3	1008	1014	PF00018	0.694
LIG_SH3_3	361	367	PF00018	0.590
LIG_SH3_3	377	383	PF00018	0.300
LIG_SH3_3	43	49	PF00018	0.673
LIG_SH3_3	501	507	PF00018	0.567
LIG_SH3_3	754	760	PF00018	0.590
LIG_SH3_3	883	889	PF00018	0.756
LIG_SH3_3	903	909	PF00018	0.649
LIG_SH3_3	910	916	PF00018	0.831
LIG_SH3_3	966	972	PF00018	0.791
LIG_SH3_3	984	990	PF00018	0.533
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.452
LIG_SUMO_SIM_anti_2	618	624	PF11976	0.525
LIG_SUMO_SIM_par_1	339	346	PF11976	0.503
LIG_SUMO_SIM_par_1	350	355	PF11976	0.573
LIG_SUMO_SIM_par_1	374	379	PF11976	0.415
LIG_TRAF2_1	615	618	PF00917	0.511
LIG_TYR_ITIM	801	806	PF00017	0.395
LIG_UBA3_1	427	436	PF00899	0.432
LIG_UBA3_1	801	810	PF00899	0.525
MOD_CK1_1	1044	1050	PF00069	0.628
MOD_CK1_1	139	145	PF00069	0.516
MOD_CK1_1	173	179	PF00069	0.506
MOD_CK1_1	206	212	PF00069	0.469
MOD_CK1_1	30	36	PF00069	0.711
MOD_CK1_1	359	365	PF00069	0.524
MOD_CK1_1	38	44	PF00069	0.610
MOD_CK1_1	512	518	PF00069	0.567
MOD_CK1_1	599	605	PF00069	0.636
MOD_CK1_1	686	692	PF00069	0.800
MOD_CK1_1	694	700	PF00069	0.788
MOD_CK1_1	872	878	PF00069	0.721
MOD_CK1_1	940	946	PF00069	0.671
MOD_CK1_1	964	970	PF00069	0.665
MOD_CK1_1	977	983	PF00069	0.603
MOD_CK2_1	1047	1053	PF00069	0.709
MOD_CK2_1	105	111	PF00069	0.336
MOD_CK2_1	213	219	PF00069	0.443
MOD_CK2_1	257	263	PF00069	0.545
MOD_CK2_1	434	440	PF00069	0.469
MOD_CK2_1	612	618	PF00069	0.556
MOD_CK2_1	626	632	PF00069	0.448
MOD_CK2_1	77	83	PF00069	0.355
MOD_CK2_1	877	883	PF00069	0.808
MOD_CK2_1	945	951	PF00069	0.771
MOD_CK2_1	979	985	PF00069	0.559
MOD_GlcNHglycan	1008	1011	PF01048	0.739
MOD_GlcNHglycan	107	110	PF01048	0.293
MOD_GlcNHglycan	28	32	PF01048	0.601
MOD_GlcNHglycan	359	362	PF01048	0.642
MOD_GlcNHglycan	4	7	PF01048	0.644
MOD_GlcNHglycan	40	43	PF01048	0.563
MOD_GlcNHglycan	404	407	PF01048	0.449
MOD_GlcNHglycan	412	415	PF01048	0.453
MOD_GlcNHglycan	453	456	PF01048	0.728
MOD_GlcNHglycan	598	601	PF01048	0.582
MOD_GlcNHglycan	605	608	PF01048	0.633
MOD_GlcNHglycan	664	668	PF01048	0.677
MOD_GlcNHglycan	706	709	PF01048	0.689
MOD_GlcNHglycan	720	723	PF01048	0.553
MOD_GlcNHglycan	761	764	PF01048	0.455
MOD_GlcNHglycan	811	814	PF01048	0.581
MOD_GlcNHglycan	943	946	PF01048	0.816
MOD_GlcNHglycan	954	957	PF01048	0.599
MOD_GlcNHglycan	976	979	PF01048	0.665
MOD_GlcNHglycan	981	984	PF01048	0.610
MOD_GlcNHglycan	994	997	PF01048	0.501
MOD_GSK3_1	1040	1047	PF00069	0.688
MOD_GSK3_1	105	112	PF00069	0.316
MOD_GSK3_1	138	145	PF00069	0.422
MOD_GSK3_1	169	176	PF00069	0.513
MOD_GSK3_1	199	206	PF00069	0.490
MOD_GSK3_1	257	264	PF00069	0.529
MOD_GSK3_1	277	284	PF00069	0.464
MOD_GSK3_1	29	36	PF00069	0.603
MOD_GSK3_1	292	299	PF00069	0.362
MOD_GSK3_1	355	362	PF00069	0.642
MOD_GSK3_1	430	437	PF00069	0.449
MOD_GSK3_1	447	454	PF00069	0.492
MOD_GSK3_1	509	516	PF00069	0.647
MOD_GSK3_1	599	606	PF00069	0.704
MOD_GSK3_1	608	615	PF00069	0.728
MOD_GSK3_1	692	699	PF00069	0.675
MOD_GSK3_1	733	740	PF00069	0.621
MOD_GSK3_1	747	754	PF00069	0.543
MOD_GSK3_1	871	878	PF00069	0.672
MOD_GSK3_1	898	905	PF00069	0.635
MOD_GSK3_1	937	944	PF00069	0.765
MOD_GSK3_1	964	971	PF00069	0.618
MOD_GSK3_1	973	980	PF00069	0.639
MOD_GSK3_1	994	1001	PF00069	0.602
MOD_LATS_1	716	722	PF00433	0.689
MOD_N-GLC_1	1047	1052	PF02516	0.653
MOD_N-GLC_1	509	514	PF02516	0.529
MOD_N-GLC_1	875	880	PF02516	0.691
MOD_N-GLC_1	937	942	PF02516	0.564
MOD_N-GLC_2	336	338	PF02516	0.503
MOD_NEK2_1	170	175	PF00069	0.424
MOD_NEK2_1	256	261	PF00069	0.427
MOD_NEK2_1	281	286	PF00069	0.520
MOD_NEK2_1	509	514	PF00069	0.501
MOD_NEK2_1	530	535	PF00069	0.337
MOD_NEK2_1	536	541	PF00069	0.326
MOD_NEK2_1	544	549	PF00069	0.361
MOD_NEK2_1	570	575	PF00069	0.514
MOD_NEK2_1	598	603	PF00069	0.604
MOD_NEK2_1	737	742	PF00069	0.624
MOD_NEK2_1	794	799	PF00069	0.438
MOD_NEK2_1	941	946	PF00069	0.808
MOD_NEK2_2	109	114	PF00069	0.293
MOD_PIKK_1	128	134	PF00454	0.408
MOD_PIKK_1	139	145	PF00454	0.535
MOD_PIKK_1	208	214	PF00454	0.534
MOD_PIKK_1	293	299	PF00454	0.484
MOD_PIKK_1	382	388	PF00454	0.488
MOD_PK_1	203	209	PF00069	0.565
MOD_PKA_1	1041	1047	PF00069	0.637
MOD_PKA_1	70	76	PF00069	0.318
MOD_PKA_2	1040	1046	PF00069	0.695
MOD_PKA_2	256	262	PF00069	0.410
MOD_PKA_2	62	68	PF00069	0.345
MOD_PKA_2	70	76	PF00069	0.287
MOD_PKB_1	661	669	PF00069	0.660
MOD_Plk_1	155	161	PF00069	0.536
MOD_Plk_1	185	191	PF00069	0.472
MOD_Plk_1	318	324	PF00069	0.503
MOD_Plk_1	509	515	PF00069	0.625
MOD_Plk_4	1041	1047	PF00069	0.583
MOD_Plk_4	257	263	PF00069	0.430
MOD_Plk_4	277	283	PF00069	0.391
MOD_Plk_4	509	515	PF00069	0.645
MOD_Plk_4	626	632	PF00069	0.406
MOD_Plk_4	654	660	PF00069	0.595
MOD_Plk_4	747	753	PF00069	0.661
MOD_Plk_4	796	802	PF00069	0.397
MOD_ProDKin_1	1033	1039	PF00069	0.651
MOD_ProDKin_1	360	366	PF00069	0.711
MOD_ProDKin_1	561	567	PF00069	0.432
MOD_ProDKin_1	902	908	PF00069	0.770
MOD_ProDKin_1	964	970	PF00069	0.665
MOD_ProDKin_1	989	995	PF00069	0.680
MOD_SUMO_for_1	316	319	PF00179	0.553
MOD_SUMO_for_1	69	72	PF00179	0.384
MOD_SUMO_rev_2	122	127	PF00179	0.333
MOD_SUMO_rev_2	842	849	PF00179	0.552
MOD_SUMO_rev_2	899	904	PF00179	0.730
TRG_DiLeu_BaEn_1	251	256	PF01217	0.411
TRG_DiLeu_BaEn_1	618	623	PF01217	0.531
TRG_DiLeu_BaEn_1	94	99	PF01217	0.293
TRG_DiLeu_BaEn_4	1059	1065	PF01217	0.665
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.412
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.471
TRG_DiLeu_BaLyEn_6	828	833	PF01217	0.481
TRG_DiLeu_LyEn_5	251	256	PF01217	0.501
TRG_ENDOCYTIC_2	103	106	PF00928	0.293
TRG_ENDOCYTIC_2	225	228	PF00928	0.405
TRG_ENDOCYTIC_2	537	540	PF00928	0.441
TRG_ENDOCYTIC_2	58	61	PF00928	0.408
TRG_ENDOCYTIC_2	631	634	PF00928	0.411
TRG_ENDOCYTIC_2	803	806	PF00928	0.404
TRG_ER_diArg_1	14	17	PF00400	0.498
TRG_ER_diArg_1	178	180	PF00400	0.428
TRG_ER_diArg_1	661	663	PF00400	0.726
TRG_ER_diArg_1	85	87	PF00400	0.382
TRG_ER_diArg_1	88	90	PF00400	0.401
TRG_NES_CRM1_1	382	397	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	831	835	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P847	Leptomonas seymouri	67%	100%
A0A3S7WWG5	Leishmania donovani	93%	100%
A0A422MZA8	Trypanosoma rangeli	36%	100%
A4HBN1	Leishmania braziliensis	75%	100%
A4HZ32	Leishmania infantum	93%	100%
D0A1N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AV00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BKM5	Trypanosoma cruzi	36%	100%