Metallo-peptidase, Clan ME, Family M16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial processing peptidase alpha subunit, putative

Species:

Leishmania major

UniProt:

Q4QCI1_LEIMA

TriTrypDb:

LmjF.21.0340 , LMJLV39_210008700 , LMJSD75_210008800

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QCI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	22
GO:0043167	ion binding	2	22
GO:0043169	cation binding	3	22
GO:0046872	metal ion binding	4	22
GO:0003824	catalytic activity	1	6
GO:0004175	endopeptidase activity	4	6
GO:0004222	metalloendopeptidase activity	5	6
GO:0008233	peptidase activity	3	6
GO:0008237	metallopeptidase activity	4	6
GO:0016787	hydrolase activity	2	6
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.273
CLV_C14_Caspase3-7	92	96	PF00656	0.301
CLV_NRD_NRD_1	129	131	PF00675	0.324
CLV_PCSK_KEX2_1	119	121	PF00082	0.285
CLV_PCSK_KEX2_1	129	131	PF00082	0.319
CLV_PCSK_KEX2_1	388	390	PF00082	0.498
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.281
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.498
CLV_PCSK_SKI1_1	208	212	PF00082	0.351
CLV_PCSK_SKI1_1	21	25	PF00082	0.566
CLV_PCSK_SKI1_1	222	226	PF00082	0.264
CLV_PCSK_SKI1_1	446	450	PF00082	0.405
CLV_PCSK_SKI1_1	86	90	PF00082	0.359
DEG_APCC_DBOX_1	221	229	PF00400	0.272
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DEG_SCF_FBW7_1	75	82	PF00400	0.253
DOC_CKS1_1	76	81	PF01111	0.253
DOC_MAPK_FxFP_2	456	459	PF00069	0.439
DOC_PP1_RVXF_1	118	125	PF00149	0.301
DOC_PP2B_LxvP_1	191	194	PF13499	0.387
DOC_PP4_FxxP_1	15	18	PF00568	0.471
DOC_PP4_FxxP_1	346	349	PF00568	0.346
DOC_PP4_FxxP_1	456	459	PF00568	0.429
DOC_USP7_MATH_1	327	331	PF00917	0.539
DOC_USP7_MATH_1	349	353	PF00917	0.266
DOC_USP7_MATH_1	39	43	PF00917	0.490
DOC_USP7_MATH_1	59	63	PF00917	0.292
DOC_USP7_UBL2_3	241	245	PF12436	0.575
DOC_WW_Pin1_4	26	31	PF00397	0.554
DOC_WW_Pin1_4	33	38	PF00397	0.524
DOC_WW_Pin1_4	413	418	PF00397	0.360
DOC_WW_Pin1_4	75	80	PF00397	0.253
LIG_14-3-3_CanoR_1	103	112	PF00244	0.299
LIG_14-3-3_CanoR_1	120	125	PF00244	0.290
LIG_14-3-3_CanoR_1	204	211	PF00244	0.464
LIG_14-3-3_CanoR_1	3	11	PF00244	0.475
LIG_14-3-3_CanoR_1	348	358	PF00244	0.309
LIG_14-3-3_CanoR_1	50	59	PF00244	0.390
LIG_APCC_ABBA_1	63	68	PF00400	0.301
LIG_BIR_III_2	68	72	PF00653	0.406
LIG_BRCT_BRCA1_1	374	378	PF00533	0.484
LIG_BRCT_BRCA1_1	454	458	PF00533	0.357
LIG_BRCT_BRCA1_1	95	99	PF00533	0.301
LIG_Clathr_ClatBox_1	98	102	PF01394	0.273
LIG_deltaCOP1_diTrp_1	131	137	PF00928	0.266
LIG_deltaCOP1_diTrp_1	212	218	PF00928	0.354
LIG_eIF4E_1	350	356	PF01652	0.310
LIG_FHA_1	140	146	PF00498	0.281
LIG_FHA_1	3	9	PF00498	0.596
LIG_FHA_1	314	320	PF00498	0.340
LIG_FHA_1	44	50	PF00498	0.466
LIG_FHA_1	76	82	PF00498	0.468
LIG_FHA_2	286	292	PF00498	0.422
LIG_LIR_Apic_2	12	18	PF02991	0.577
LIG_LIR_Apic_2	131	136	PF02991	0.266
LIG_LIR_Apic_2	167	173	PF02991	0.273
LIG_LIR_Apic_2	454	459	PF02991	0.419
LIG_LIR_Gen_1	134	145	PF02991	0.325
LIG_LIR_Gen_1	406	417	PF02991	0.319
LIG_LIR_Nem_3	134	140	PF02991	0.313
LIG_LIR_Nem_3	406	412	PF02991	0.364
LIG_LIR_Nem_3	455	461	PF02991	0.373
LIG_Pex14_1	133	137	PF04695	0.266
LIG_Pex14_1	214	218	PF04695	0.343
LIG_SH2_CRK	73	77	PF00017	0.280
LIG_SH2_NCK_1	350	354	PF00017	0.354
LIG_SH2_NCK_1	66	70	PF00017	0.327
LIG_SH2_NCK_1	73	77	PF00017	0.300
LIG_SH2_SRC	324	327	PF00017	0.491
LIG_SH2_SRC	66	69	PF00017	0.275
LIG_SH2_SRC	73	76	PF00017	0.272
LIG_SH2_STAP1	11	15	PF00017	0.665
LIG_SH2_STAP1	279	283	PF00017	0.402
LIG_SH2_STAP1	314	318	PF00017	0.293
LIG_SH2_STAP1	324	328	PF00017	0.316
LIG_SH2_STAT3	11	14	PF00017	0.636
LIG_SH2_STAT3	341	344	PF00017	0.449
LIG_SH2_STAT5	121	124	PF00017	0.315
LIG_SH2_STAT5	358	361	PF00017	0.384
LIG_SH2_STAT5	409	412	PF00017	0.350
LIG_SH2_STAT5	83	86	PF00017	0.328
LIG_SH3_3	141	147	PF00018	0.301
LIG_SH3_3	225	231	PF00018	0.375
LIG_SH3_3	297	303	PF00018	0.482
LIG_TRAF2_1	419	422	PF00917	0.507
LIG_WRPW_2	347	350	PF00400	0.313
MOD_CDK_SPxxK_3	26	33	PF00069	0.559
MOD_CK1_1	416	422	PF00069	0.459
MOD_CK1_1	428	434	PF00069	0.534
MOD_CK2_1	149	155	PF00069	0.300
MOD_CK2_1	416	422	PF00069	0.448
MOD_Cter_Amidation	127	130	PF01082	0.274
MOD_GlcNHglycan	246	249	PF01048	0.460
MOD_GlcNHglycan	329	332	PF01048	0.556
MOD_GlcNHglycan	351	354	PF01048	0.295
MOD_GlcNHglycan	375	378	PF01048	0.423
MOD_GlcNHglycan	427	430	PF01048	0.411
MOD_GSK3_1	101	108	PF00069	0.254
MOD_GSK3_1	22	29	PF00069	0.504
MOD_GSK3_1	309	316	PF00069	0.468
MOD_GSK3_1	327	334	PF00069	0.439
MOD_GSK3_1	39	46	PF00069	0.406
MOD_GSK3_1	412	419	PF00069	0.389
MOD_GSK3_1	75	82	PF00069	0.358
MOD_GSK3_1	89	96	PF00069	0.204
MOD_NEK2_1	105	110	PF00069	0.215
MOD_NEK2_1	139	144	PF00069	0.330
MOD_NEK2_1	2	7	PF00069	0.493
MOD_NEK2_1	412	417	PF00069	0.305
MOD_NEK2_1	460	465	PF00069	0.593
MOD_NEK2_1	89	94	PF00069	0.282
MOD_PIKK_1	309	315	PF00454	0.463
MOD_PKA_2	105	111	PF00069	0.243
MOD_PKA_2	157	163	PF00069	0.284
MOD_PKA_2	2	8	PF00069	0.492
MOD_PKA_2	203	209	PF00069	0.477
MOD_Plk_1	101	107	PF00069	0.281
MOD_Plk_1	94	100	PF00069	0.281
MOD_Plk_4	79	85	PF00069	0.306
MOD_Plk_4	94	100	PF00069	0.262
MOD_ProDKin_1	26	32	PF00069	0.553
MOD_ProDKin_1	33	39	PF00069	0.520
MOD_ProDKin_1	413	419	PF00069	0.362
MOD_ProDKin_1	75	81	PF00069	0.253
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.337
TRG_ENDOCYTIC_2	239	242	PF00928	0.394
TRG_ENDOCYTIC_2	409	412	PF00928	0.300
TRG_ENDOCYTIC_2	73	76	PF00928	0.223
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM61	Leptomonas seymouri	78%	100%
A0A0N1PFG1	Leptomonas seymouri	41%	89%
A0A0S4IY11	Bodo saltans	50%	96%
A0A0S4JST8	Bodo saltans	42%	99%
A0A1X0NPP7	Trypanosomatidae	40%	89%
A0A1X0NXN6	Trypanosomatidae	59%	100%
A0A3Q8IBQ6	Leishmania donovani	40%	88%
A0A3R7JXS6	Trypanosoma rangeli	61%	100%
A0A3R7MEV0	Trypanosoma rangeli	41%	89%
A0A3S7WWC3	Leishmania donovani	97%	100%
A4H775	Leishmania braziliensis	40%	89%
A4HBN2	Leishmania braziliensis	91%	100%
A4HVL5	Leishmania infantum	40%	88%
A4HZ33	Leishmania infantum	97%	100%
D0A6P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	90%
E9APB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	88%
E9AV01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O60044	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
O75439	Homo sapiens	22%	96%
P10507	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P11913	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	98%
P11914	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	97%
P20069	Rattus norvegicus	21%	89%
P22695	Homo sapiens	21%	100%
P23004	Bos taurus	22%	100%
P29677	Solanum tuberosum	21%	93%
P32551	Rattus norvegicus	23%	100%
P43265	Euglena gracilis	24%	99%
Q03346	Rattus norvegicus	24%	96%
Q0P5M8	Bos taurus	21%	89%
Q10713	Homo sapiens	21%	89%
Q23295	Caenorhabditis elegans	24%	100%
Q3SZ71	Bos taurus	23%	95%
Q4QG67	Leishmania major	40%	88%
Q54F93	Dictyostelium discoideum	23%	100%
Q5R513	Pongo abelii	21%	89%
Q5REK3	Pongo abelii	22%	96%
Q9CXT8	Mus musculus	23%	96%
Q9DB77	Mus musculus	23%	100%
Q9DC61	Mus musculus	22%	89%
V5BB16	Trypanosoma cruzi	39%	84%
V5BQ54	Trypanosoma cruzi	60%	100%