Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCH9_LEIMA

TriTrypDb:

LmjF.21.0360 , LMJLV39_210008900 , LMJSD75_210009000

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.517
CLV_NRD_NRD_1	10	12	PF00675	0.514
CLV_NRD_NRD_1	118	120	PF00675	0.567
CLV_NRD_NRD_1	144	146	PF00675	0.630
CLV_NRD_NRD_1	217	219	PF00675	0.767
CLV_NRD_NRD_1	235	237	PF00675	0.583
CLV_NRD_NRD_1	36	38	PF00675	0.451
CLV_PCSK_FUR_1	118	122	PF00082	0.546
CLV_PCSK_KEX2_1	10	12	PF00082	0.514
CLV_PCSK_KEX2_1	118	120	PF00082	0.561
CLV_PCSK_KEX2_1	144	146	PF00082	0.558
CLV_PCSK_KEX2_1	217	219	PF00082	0.767
CLV_PCSK_KEX2_1	36	38	PF00082	0.455
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.575
DOC_MAPK_gen_1	89	97	PF00069	0.564
DOC_PP2B_LxvP_1	112	115	PF13499	0.486
DOC_PP4_FxxP_1	262	265	PF00568	0.577
DOC_USP7_MATH_1	2	6	PF00917	0.556
DOC_USP7_MATH_1	216	220	PF00917	0.676
DOC_WW_Pin1_4	126	131	PF00397	0.539
DOC_WW_Pin1_4	176	181	PF00397	0.611
DOC_WW_Pin1_4	204	209	PF00397	0.740
DOC_WW_Pin1_4	212	217	PF00397	0.697
DOC_WW_Pin1_4	265	270	PF00397	0.489
LIG_14-3-3_CanoR_1	49	53	PF00244	0.429
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_eIF4E_1	8	14	PF01652	0.369
LIG_FHA_1	182	188	PF00498	0.591
LIG_FHA_1	80	86	PF00498	0.544
LIG_FHA_2	1	7	PF00498	0.410
LIG_FHA_2	14	20	PF00498	0.460
LIG_FHA_2	144	150	PF00498	0.626
LIG_LIR_Apic_2	260	265	PF02991	0.658
LIG_LIR_Gen_1	17	27	PF02991	0.425
LIG_LIR_Nem_3	17	23	PF02991	0.424
LIG_MYND_1	265	269	PF01753	0.551
LIG_SH2_NCK_1	190	194	PF00017	0.682
LIG_SH2_SRC	190	193	PF00017	0.681
LIG_SH2_STAP1	20	24	PF00017	0.431
LIG_SH2_STAT5	63	66	PF00017	0.431
LIG_SH3_2	213	218	PF14604	0.654
LIG_SH3_3	164	170	PF00018	0.602
LIG_SH3_3	177	183	PF00018	0.670
LIG_SH3_3	195	201	PF00018	0.568
LIG_SH3_3	210	216	PF00018	0.610
LIG_WRC_WIRS_1	100	105	PF05994	0.388
MOD_CDC14_SPxK_1	215	218	PF00782	0.588
MOD_CDK_SPK_2	212	217	PF00069	0.580
MOD_CDK_SPK_2	265	270	PF00069	0.489
MOD_CDK_SPxK_1	212	218	PF00069	0.583
MOD_CK1_1	176	182	PF00069	0.560
MOD_CK2_1	13	19	PF00069	0.460
MOD_CK2_1	143	149	PF00069	0.614
MOD_CK2_1	246	252	PF00069	0.634
MOD_GlcNHglycan	157	160	PF01048	0.654
MOD_GlcNHglycan	163	167	PF01048	0.571
MOD_GlcNHglycan	175	178	PF01048	0.472
MOD_GlcNHglycan	218	221	PF01048	0.762
MOD_GlcNHglycan	222	225	PF01048	0.678
MOD_GlcNHglycan	238	241	PF01048	0.641
MOD_GlcNHglycan	248	251	PF01048	0.628
MOD_GlcNHglycan	252	255	PF01048	0.620
MOD_GlcNHglycan	259	262	PF01048	0.706
MOD_GSK3_1	171	178	PF00069	0.735
MOD_GSK3_1	212	219	PF00069	0.679
MOD_GSK3_1	232	239	PF00069	0.606
MOD_GSK3_1	246	253	PF00069	0.763
MOD_NEK2_1	175	180	PF00069	0.646
MOD_NEK2_1	257	262	PF00069	0.666
MOD_PIKK_1	123	129	PF00454	0.640
MOD_PKA_1	236	242	PF00069	0.544
MOD_PKA_2	143	149	PF00069	0.565
MOD_PKA_2	216	222	PF00069	0.709
MOD_PKA_2	48	54	PF00069	0.519
MOD_PKB_1	121	129	PF00069	0.642
MOD_Plk_4	182	188	PF00069	0.525
MOD_Plk_4	99	105	PF00069	0.381
MOD_ProDKin_1	126	132	PF00069	0.531
MOD_ProDKin_1	176	182	PF00069	0.611
MOD_ProDKin_1	204	210	PF00069	0.741
MOD_ProDKin_1	212	218	PF00069	0.700
MOD_SUMO_rev_2	192	198	PF00179	0.537
TRG_ENDOCYTIC_2	20	23	PF00928	0.430
TRG_ER_diArg_1	118	121	PF00400	0.561
TRG_ER_diArg_1	135	138	PF00400	0.502
TRG_ER_diArg_1	216	218	PF00400	0.758
TRG_ER_diArg_1	9	11	PF00400	0.526
TRG_NLS_MonoExtC_3	118	123	PF00514	0.647
TRG_NLS_MonoExtN_4	118	124	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD3	Leptomonas seymouri	52%	100%
A0A3S7WWE9	Leishmania donovani	85%	98%
A4HBN4	Leishmania braziliensis	70%	98%
A4HZ35	Leishmania infantum	85%	97%
E9AV03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%