RTR1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rtr1/RPAP2 family, putative

Species:

Leishmania major

UniProt:

Q4QCH8_LEIMA

TriTrypDb:

LmjF.21.0370 , LMJLV39_210009000 , LMJSD75_210009100

Length:

721

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.564
CLV_C14_Caspase3-7	162	166	PF00656	0.649
CLV_C14_Caspase3-7	178	182	PF00656	0.540
CLV_C14_Caspase3-7	348	352	PF00656	0.598
CLV_C14_Caspase3-7	56	60	PF00656	0.510
CLV_MEL_PAP_1	293	299	PF00089	0.404
CLV_NRD_NRD_1	173	175	PF00675	0.687
CLV_NRD_NRD_1	18	20	PF00675	0.581
CLV_NRD_NRD_1	227	229	PF00675	0.538
CLV_NRD_NRD_1	295	297	PF00675	0.430
CLV_NRD_NRD_1	385	387	PF00675	0.546
CLV_NRD_NRD_1	501	503	PF00675	0.512
CLV_NRD_NRD_1	585	587	PF00675	0.469
CLV_PCSK_FUR_1	16	20	PF00082	0.577
CLV_PCSK_KEX2_1	173	175	PF00082	0.688
CLV_PCSK_KEX2_1	18	20	PF00082	0.581
CLV_PCSK_KEX2_1	295	297	PF00082	0.430
CLV_PCSK_KEX2_1	339	341	PF00082	0.717
CLV_PCSK_KEX2_1	385	387	PF00082	0.628
CLV_PCSK_KEX2_1	390	392	PF00082	0.738
CLV_PCSK_KEX2_1	501	503	PF00082	0.512
CLV_PCSK_KEX2_1	547	549	PF00082	0.515
CLV_PCSK_KEX2_1	585	587	PF00082	0.469
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.717
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.636
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.477
CLV_PCSK_PC7_1	386	392	PF00082	0.521
CLV_PCSK_SKI1_1	107	111	PF00082	0.395
CLV_PCSK_SKI1_1	129	133	PF00082	0.488
CLV_PCSK_SKI1_1	220	224	PF00082	0.469
CLV_PCSK_SKI1_1	339	343	PF00082	0.784
CLV_PCSK_SKI1_1	418	422	PF00082	0.495
CLV_PCSK_SKI1_1	479	483	PF00082	0.582
CLV_PCSK_SKI1_1	501	505	PF00082	0.454
CLV_PCSK_SKI1_1	512	516	PF00082	0.436
CLV_PCSK_SKI1_1	517	521	PF00082	0.515
CLV_PCSK_SKI1_1	586	590	PF00082	0.405
CLV_PCSK_SKI1_1	604	608	PF00082	0.474
DEG_APCC_DBOX_1	219	227	PF00400	0.474
DEG_APCC_DBOX_1	417	425	PF00400	0.457
DEG_APCC_DBOX_1	482	490	PF00400	0.462
DEG_Nend_UBRbox_4	1	3	PF02207	0.522
DOC_CYCLIN_RxL_1	126	136	PF00134	0.456
DOC_CYCLIN_RxL_1	583	591	PF00134	0.475
DOC_CYCLIN_RxL_1	601	611	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	645	651	PF00134	0.417
DOC_MAPK_MEF2A_6	370	378	PF00069	0.730
DOC_MAPK_MEF2A_6	483	491	PF00069	0.456
DOC_PP1_RVXF_1	602	608	PF00149	0.424
DOC_PP1_RVXF_1	641	648	PF00149	0.381
DOC_PP1_RVXF_1	69	76	PF00149	0.414
DOC_PP2B_LxvP_1	628	631	PF13499	0.546
DOC_PP4_FxxP_1	280	283	PF00568	0.457
DOC_PP4_FxxP_1	649	652	PF00568	0.444
DOC_USP7_MATH_1	133	137	PF00917	0.693
DOC_USP7_MATH_1	241	245	PF00917	0.597
DOC_USP7_MATH_1	261	265	PF00917	0.612
DOC_USP7_MATH_1	354	358	PF00917	0.678
DOC_USP7_MATH_1	49	53	PF00917	0.616
DOC_USP7_MATH_1	528	532	PF00917	0.534
DOC_USP7_MATH_1	711	715	PF00917	0.517
DOC_WW_Pin1_4	19	24	PF00397	0.572
DOC_WW_Pin1_4	279	284	PF00397	0.597
DOC_WW_Pin1_4	295	300	PF00397	0.334
DOC_WW_Pin1_4	30	35	PF00397	0.537
DOC_WW_Pin1_4	384	389	PF00397	0.548
DOC_WW_Pin1_4	45	50	PF00397	0.531
DOC_WW_Pin1_4	453	458	PF00397	0.614
DOC_WW_Pin1_4	521	526	PF00397	0.486
DOC_WW_Pin1_4	659	664	PF00397	0.445
LIG_14-3-3_CanoR_1	18	23	PF00244	0.569
LIG_14-3-3_CanoR_1	239	249	PF00244	0.523
LIG_14-3-3_CanoR_1	438	444	PF00244	0.556
LIG_14-3-3_CanoR_1	517	525	PF00244	0.531
LIG_14-3-3_CanoR_1	529	534	PF00244	0.450
LIG_Actin_WH2_2	305	322	PF00022	0.401
LIG_Actin_WH2_2	93	109	PF00022	0.408
LIG_BIR_III_4	153	157	PF00653	0.550
LIG_BIR_III_4	59	63	PF00653	0.453
LIG_BRCT_BRCA1_1	297	301	PF00533	0.478
LIG_BRCT_BRCA1_1	530	534	PF00533	0.481
LIG_BRCT_BRCA1_1	590	594	PF00533	0.458
LIG_BRCT_BRCA1_1	643	647	PF00533	0.403
LIG_Clathr_ClatBox_1	486	490	PF01394	0.483
LIG_Clathr_ClatBox_1	605	609	PF01394	0.411
LIG_DLG_GKlike_1	529	537	PF00625	0.479
LIG_FHA_1	257	263	PF00498	0.597
LIG_FHA_1	498	504	PF00498	0.461
LIG_FHA_1	597	603	PF00498	0.429
LIG_FHA_1	660	666	PF00498	0.484
LIG_FHA_1	707	713	PF00498	0.427
LIG_FHA_1	75	81	PF00498	0.433
LIG_FHA_2	158	164	PF00498	0.610
LIG_FHA_2	194	200	PF00498	0.530
LIG_FHA_2	564	570	PF00498	0.613
LIG_FHA_2	702	708	PF00498	0.504
LIG_FHA_2	81	87	PF00498	0.549
LIG_LIR_Gen_1	112	122	PF02991	0.371
LIG_LIR_Gen_1	609	616	PF02991	0.417
LIG_LIR_Gen_1	691	701	PF02991	0.495
LIG_LIR_Nem_3	112	118	PF02991	0.383
LIG_LIR_Nem_3	298	303	PF02991	0.432
LIG_LIR_Nem_3	304	308	PF02991	0.402
LIG_LIR_Nem_3	313	319	PF02991	0.404
LIG_LIR_Nem_3	531	537	PF02991	0.626
LIG_LIR_Nem_3	609	613	PF02991	0.403
LIG_LIR_Nem_3	615	621	PF02991	0.422
LIG_LIR_Nem_3	691	697	PF02991	0.491
LIG_LYPXL_yS_3	305	308	PF13949	0.462
LIG_MLH1_MIPbox_1	297	301	PF16413	0.478
LIG_MYND_1	26	30	PF01753	0.562
LIG_NRBOX	601	607	PF00104	0.405
LIG_PDZ_Class_3	716	721	PF00595	0.600
LIG_Pex14_2	276	280	PF04695	0.394
LIG_SH2_CRK	303	307	PF00017	0.486
LIG_SH2_CRK	610	614	PF00017	0.466
LIG_SH2_SRC	303	306	PF00017	0.490
LIG_SH2_STAP1	203	207	PF00017	0.557
LIG_SH2_STAP1	289	293	PF00017	0.454
LIG_SH2_STAP1	535	539	PF00017	0.418
LIG_SH2_STAT5	208	211	PF00017	0.502
LIG_SH2_STAT5	300	303	PF00017	0.436
LIG_SH2_STAT5	38	41	PF00017	0.528
LIG_SH2_STAT5	610	613	PF00017	0.489
LIG_SH2_STAT5	79	82	PF00017	0.378
LIG_SH3_1	250	256	PF00018	0.621
LIG_SH3_3	20	26	PF00018	0.574
LIG_SH3_3	250	256	PF00018	0.665
LIG_SH3_3	31	37	PF00018	0.530
LIG_SH3_3	86	92	PF00018	0.496
LIG_SUMO_SIM_anti_2	485	490	PF11976	0.440
LIG_SUMO_SIM_par_1	485	490	PF11976	0.440
LIG_TRAF2_1	160	163	PF00917	0.574
LIG_TRAF2_1	558	561	PF00917	0.558
LIG_TYR_ITIM	608	613	PF00017	0.399
LIG_UBA3_1	222	230	PF00899	0.474
LIG_WW_1	35	38	PF00397	0.507
LIG_WW_2	26	29	PF00397	0.534
LIG_WW_3	476	480	PF00397	0.617
MOD_CDC14_SPxK_1	387	390	PF00782	0.510
MOD_CDK_SPK_2	521	526	PF00069	0.486
MOD_CDK_SPxK_1	384	390	PF00069	0.519
MOD_CDK_SPxxK_3	384	391	PF00069	0.522
MOD_CK1_1	145	151	PF00069	0.571
MOD_CK1_1	168	174	PF00069	0.622
MOD_CK1_1	377	383	PF00069	0.685
MOD_CK1_1	456	462	PF00069	0.585
MOD_CK1_1	497	503	PF00069	0.375
MOD_CK1_1	614	620	PF00069	0.436
MOD_CK1_1	624	630	PF00069	0.432
MOD_CK1_1	637	643	PF00069	0.392
MOD_CK1_1	74	80	PF00069	0.383
MOD_CK2_1	149	155	PF00069	0.654
MOD_CK2_1	157	163	PF00069	0.595
MOD_CK2_1	193	199	PF00069	0.532
MOD_CK2_1	521	527	PF00069	0.511
MOD_CK2_1	658	664	PF00069	0.453
MOD_CK2_1	80	86	PF00069	0.410
MOD_Cter_Amidation	388	391	PF01082	0.583
MOD_GlcNHglycan	135	138	PF01048	0.578
MOD_GlcNHglycan	149	152	PF01048	0.520
MOD_GlcNHglycan	333	336	PF01048	0.523
MOD_GlcNHglycan	356	359	PF01048	0.679
MOD_GlcNHglycan	360	363	PF01048	0.761
MOD_GlcNHglycan	412	415	PF01048	0.543
MOD_GlcNHglycan	458	461	PF01048	0.599
MOD_GlcNHglycan	468	471	PF01048	0.516
MOD_GlcNHglycan	496	499	PF01048	0.353
MOD_GlcNHglycan	537	540	PF01048	0.430
MOD_GlcNHglycan	55	58	PF01048	0.623
MOD_GlcNHglycan	618	621	PF01048	0.400
MOD_GlcNHglycan	623	626	PF01048	0.437
MOD_GSK3_1	133	140	PF00069	0.543
MOD_GSK3_1	143	150	PF00069	0.520
MOD_GSK3_1	256	263	PF00069	0.597
MOD_GSK3_1	285	292	PF00069	0.430
MOD_GSK3_1	354	361	PF00069	0.677
MOD_GSK3_1	45	52	PF00069	0.575
MOD_GSK3_1	455	462	PF00069	0.632
MOD_GSK3_1	493	500	PF00069	0.419
MOD_GSK3_1	517	524	PF00069	0.537
MOD_GSK3_1	529	536	PF00069	0.408
MOD_GSK3_1	588	595	PF00069	0.412
MOD_GSK3_1	596	603	PF00069	0.362
MOD_GSK3_1	608	615	PF00069	0.282
MOD_GSK3_1	633	640	PF00069	0.479
MOD_GSK3_1	655	662	PF00069	0.606
MOD_N-GLC_1	354	359	PF02516	0.783
MOD_N-GLC_1	493	498	PF02516	0.411
MOD_NEK2_1	122	127	PF00069	0.404
MOD_NEK2_1	147	152	PF00069	0.643
MOD_NEK2_1	272	277	PF00069	0.450
MOD_NEK2_1	439	444	PF00069	0.613
MOD_NEK2_1	482	487	PF00069	0.459
MOD_NEK2_1	493	498	PF00069	0.411
MOD_NEK2_1	533	538	PF00069	0.474
MOD_NEK2_1	588	593	PF00069	0.462
MOD_NEK2_1	616	621	PF00069	0.488
MOD_NEK2_1	641	646	PF00069	0.398
MOD_NEK2_1	80	85	PF00069	0.398
MOD_NEK2_2	50	55	PF00069	0.537
MOD_PIKK_1	341	347	PF00454	0.644
MOD_PIKK_1	403	409	PF00454	0.518
MOD_PIKK_1	91	97	PF00454	0.483
MOD_PKA_1	18	24	PF00069	0.572
MOD_PKA_2	18	24	PF00069	0.572
MOD_PKA_2	43	49	PF00069	0.590
MOD_PKA_2	437	443	PF00069	0.572
MOD_PKA_2	482	488	PF00069	0.452
MOD_PKA_2	528	534	PF00069	0.482
MOD_PKB_1	16	24	PF00069	0.572
MOD_PKB_1	174	182	PF00069	0.623
MOD_Plk_1	143	149	PF00069	0.583
MOD_Plk_1	285	291	PF00069	0.458
MOD_Plk_1	50	56	PF00069	0.535
MOD_Plk_1	596	602	PF00069	0.325
MOD_Plk_1	608	614	PF00069	0.349
MOD_Plk_2-3	102	108	PF00069	0.450
MOD_Plk_2-3	157	163	PF00069	0.613
MOD_Plk_2-3	546	552	PF00069	0.455
MOD_Plk_4	289	295	PF00069	0.499
MOD_Plk_4	304	310	PF00069	0.461
MOD_Plk_4	482	488	PF00069	0.452
MOD_Plk_4	529	535	PF00069	0.530
MOD_Plk_4	608	614	PF00069	0.336
MOD_Plk_4	637	643	PF00069	0.485
MOD_Plk_4	71	77	PF00069	0.403
MOD_Plk_4	711	717	PF00069	0.542
MOD_ProDKin_1	19	25	PF00069	0.576
MOD_ProDKin_1	279	285	PF00069	0.594
MOD_ProDKin_1	295	301	PF00069	0.331
MOD_ProDKin_1	30	36	PF00069	0.532
MOD_ProDKin_1	384	390	PF00069	0.548
MOD_ProDKin_1	45	51	PF00069	0.532
MOD_ProDKin_1	453	459	PF00069	0.607
MOD_ProDKin_1	521	527	PF00069	0.489
MOD_ProDKin_1	659	665	PF00069	0.435
TRG_DiLeu_BaEn_1	379	384	PF01217	0.604
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.561
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.399
TRG_ENDOCYTIC_2	115	118	PF00928	0.398
TRG_ENDOCYTIC_2	305	308	PF00928	0.406
TRG_ENDOCYTIC_2	610	613	PF00928	0.397
TRG_ER_diArg_1	15	18	PF00400	0.568
TRG_ER_diArg_1	173	176	PF00400	0.646
TRG_ER_diArg_1	294	296	PF00400	0.441
TRG_ER_diArg_1	384	386	PF00400	0.552
TRG_ER_diArg_1	501	503	PF00400	0.507
TRG_ER_diArg_1	510	513	PF00400	0.480
TRG_NES_CRM1_1	706	720	PF08389	0.581
TRG_NLS_MonoExtN_4	225	232	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT3	Leptomonas seymouri	49%	100%
A0A3Q8IF20	Leishmania donovani	92%	99%
A4HBN5	Leishmania braziliensis	73%	100%
A4HZ36	Leishmania infantum	91%	99%
E9AV04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	95%