DUF667 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF667), putative

Species:

Leishmania major

UniProt:

Q4QCH7_LEIMA

TriTrypDb:

LmjF.21.0380 , LMJLV39_210009100 , LMJSD75_210009200

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	3
GO:0031514	motile cilium	5	3
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

Q4QCH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCH7

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	2
GO:0003356	regulation of cilium beat frequency	7	2
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0032886	regulation of microtubule-based process	4	2
GO:0040012	regulation of locomotion	3	2
GO:0040017	positive regulation of locomotion	4	2
GO:0044782	cilium organization	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060271	cilium assembly	6	2
GO:0060295	regulation of cilium movement involved in cell motility	6	2
GO:0060296	regulation of cilium beat frequency involved in ciliary motility	3	2
GO:0060632	regulation of microtubule-based movement	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2
GO:1902019	regulation of cilium-dependent cell motility	5	2
GO:2000145	regulation of cell motility	4	2
GO:2000147	positive regulation of cell motility	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.175
CLV_NRD_NRD_1	141	143	PF00675	0.175
CLV_NRD_NRD_1	163	165	PF00675	0.175
CLV_PCSK_FUR_1	161	165	PF00082	0.175
CLV_PCSK_KEX2_1	100	102	PF00082	0.221
CLV_PCSK_KEX2_1	141	143	PF00082	0.175
CLV_PCSK_KEX2_1	163	165	PF00082	0.175
CLV_PCSK_KEX2_1	35	37	PF00082	0.185
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.185
CLV_PCSK_SKI1_1	182	186	PF00082	0.189
CLV_PCSK_SKI1_1	35	39	PF00082	0.185
CLV_PCSK_SKI1_1	81	85	PF00082	0.175
DEG_Nend_Nbox_1	1	3	PF02207	0.377
DOC_CYCLIN_RxL_1	157	169	PF00134	0.375
DOC_MAPK_MEF2A_6	66	75	PF00069	0.375
DOC_PP1_RVXF_1	161	168	PF00149	0.375
DOC_PP2B_LxvP_1	183	186	PF13499	0.529
DOC_USP7_UBL2_3	81	85	PF12436	0.442
LIG_14-3-3_CanoR_1	164	172	PF00244	0.386
LIG_14-3-3_CanoR_1	36	42	PF00244	0.375
LIG_deltaCOP1_diTrp_1	126	134	PF00928	0.375
LIG_FHA_1	109	115	PF00498	0.390
LIG_FHA_1	144	150	PF00498	0.382
LIG_FHA_1	54	60	PF00498	0.384
LIG_FHA_1	66	72	PF00498	0.426
LIG_FHA_2	36	42	PF00498	0.375
LIG_FHA_2	90	96	PF00498	0.375
LIG_LIR_Gen_1	126	136	PF02991	0.375
LIG_LIR_Nem_3	126	132	PF02991	0.375
LIG_LIR_Nem_3	180	184	PF02991	0.375
LIG_PCNA_yPIPBox_3	153	166	PF02747	0.375
LIG_SH2_STAT5	148	151	PF00017	0.375
LIG_SH2_STAT5	166	169	PF00017	0.409
LIG_SH2_STAT5	58	61	PF00017	0.375
LIG_SH2_STAT5	86	89	PF00017	0.387
LIG_SH3_3	59	65	PF00018	0.382
LIG_SUMO_SIM_anti_2	44	52	PF11976	0.375
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.375
LIG_TRAF2_1	173	176	PF00917	0.375
LIG_TRAF2_2	21	26	PF00917	0.375
LIG_UBA3_1	13	20	PF00899	0.442
LIG_UBA3_1	79	85	PF00899	0.375
LIG_WRC_WIRS_1	86	91	PF05994	0.375
MOD_CK1_1	137	143	PF00069	0.462
MOD_CK1_1	16	22	PF00069	0.392
MOD_CK1_1	52	58	PF00069	0.399
MOD_CK2_1	42	48	PF00069	0.375
MOD_GlcNHglycan	211	214	PF01048	0.490
MOD_GSK3_1	103	110	PF00069	0.375
MOD_GSK3_1	49	56	PF00069	0.379
MOD_GSK3_1	85	92	PF00069	0.375
MOD_GSK3_1	9	16	PF00069	0.424
MOD_LATS_1	33	39	PF00433	0.375
MOD_N-GLC_1	134	139	PF02516	0.242
MOD_N-GLC_1	52	57	PF02516	0.175
MOD_NEK2_1	103	108	PF00069	0.375
MOD_NEK2_1	117	122	PF00069	0.375
MOD_NEK2_1	2	7	PF00069	0.396
MOD_NEK2_1	89	94	PF00069	0.375
MOD_NEK2_2	148	153	PF00069	0.375
MOD_PIKK_1	24	30	PF00454	0.442
MOD_PKA_1	35	41	PF00069	0.375
MOD_PKA_2	103	109	PF00069	0.381
MOD_PKA_2	35	41	PF00069	0.375
MOD_Plk_1	89	95	PF00069	0.375
MOD_Plk_4	42	48	PF00069	0.375
MOD_Plk_4	89	95	PF00069	0.375
MOD_Plk_4	9	15	PF00069	0.375
MOD_SUMO_rev_2	174	184	PF00179	0.375
MOD_SUMO_rev_2	90	99	PF00179	0.375
TRG_DiLeu_BaEn_2	179	185	PF01217	0.375
TRG_ENDOCYTIC_2	86	89	PF00928	0.387
TRG_ER_diArg_1	161	164	PF00400	0.375
TRG_ER_diArg_1	99	102	PF00400	0.375
TRG_NES_CRM1_1	175	190	PF08389	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I925	Leptomonas seymouri	98%	99%
A0A1X0NXF4	Trypanosomatidae	89%	88%
A0A3Q8IAS4	Leishmania donovani	99%	100%
A0CDD4	Paramecium tetraurelia	86%	100%
A4HBN6	Leishmania braziliensis	97%	100%
A4HZ37	Leishmania infantum	99%	100%
A8IU92	Chlamydomonas reinhardtii	84%	100%
D0A1N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	78%
E9AV05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q499T7	Rattus norvegicus	85%	100%
Q5ZHP3	Gallus gallus	82%	100%
Q61JK7	Caenorhabditis briggsae	74%	100%
Q6B857	Bos taurus	83%	100%
Q6GL74	Xenopus tropicalis	82%	100%
Q6GPY6	Xenopus laevis	82%	100%
Q6PBJ2	Danio rerio	82%	100%
Q86D25	Caenorhabditis elegans	74%	100%
Q8BTU1	Mus musculus	83%	100%
Q9VKV8	Drosophila melanogaster	83%	100%
Q9Y6A4	Homo sapiens	82%	100%