PDDEXK_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCH6_LEIMA

TriTrypDb:

LmjF.21.0390 , LMJLV39_210009200 , LMJSD75_210009300

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.568
CLV_NRD_NRD_1	99	101	PF00675	0.623
CLV_PCSK_FUR_1	175	179	PF00082	0.519
CLV_PCSK_KEX2_1	177	179	PF00082	0.546
CLV_PCSK_KEX2_1	47	49	PF00082	0.484
CLV_PCSK_KEX2_1	5	7	PF00082	0.542
CLV_PCSK_KEX2_1	99	101	PF00082	0.502
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.484
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.554
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.502
CLV_PCSK_SKI1_1	240	244	PF00082	0.455
CLV_PCSK_SKI1_1	327	331	PF00082	0.478
CLV_PCSK_SKI1_1	47	51	PF00082	0.480
CLV_PCSK_SKI1_1	70	74	PF00082	0.430
CLV_PCSK_SKI1_1	85	89	PF00082	0.416
DEG_Nend_UBRbox_3	1	3	PF02207	0.642
DEG_SPOP_SBC_1	117	121	PF00917	0.669
DOC_MAPK_gen_1	175	184	PF00069	0.439
DOC_MAPK_gen_1	217	227	PF00069	0.405
DOC_MAPK_MEF2A_6	220	227	PF00069	0.387
DOC_PP2B_LxvP_1	134	137	PF13499	0.499
DOC_PP2B_LxvP_1	255	258	PF13499	0.602
DOC_USP7_MATH_1	10	14	PF00917	0.464
DOC_USP7_MATH_1	256	260	PF00917	0.625
DOC_USP7_MATH_1	282	286	PF00917	0.613
DOC_USP7_MATH_1	30	34	PF00917	0.392
DOC_USP7_UBL2_3	85	89	PF12436	0.551
DOC_WW_Pin1_4	118	123	PF00397	0.612
DOC_WW_Pin1_4	260	265	PF00397	0.608
DOC_WW_Pin1_4	327	332	PF00397	0.567
LIG_14-3-3_CanoR_1	248	258	PF00244	0.589
LIG_14-3-3_CanoR_1	300	309	PF00244	0.460
LIG_APCC_ABBA_1	225	230	PF00400	0.413
LIG_APCC_ABBA_1	41	46	PF00400	0.486
LIG_APCC_Cbox_2	39	45	PF00515	0.513
LIG_BIR_III_4	111	115	PF00653	0.651
LIG_EVH1_2	90	94	PF00568	0.525
LIG_FHA_1	118	124	PF00498	0.536
LIG_FHA_1	147	153	PF00498	0.509
LIG_FHA_1	177	183	PF00498	0.497
LIG_FHA_1	188	194	PF00498	0.497
LIG_FHA_1	250	256	PF00498	0.518
LIG_FHA_1	91	97	PF00498	0.417
LIG_FHA_2	119	125	PF00498	0.627
LIG_G3BP_FGDF_1	197	202	PF02136	0.550
LIG_LIR_Gen_1	148	158	PF02991	0.415
LIG_LIR_Gen_1	341	352	PF02991	0.497
LIG_LIR_Gen_1	93	98	PF02991	0.412
LIG_LIR_Nem_3	132	138	PF02991	0.415
LIG_LIR_Nem_3	148	153	PF02991	0.421
LIG_LIR_Nem_3	18	24	PF02991	0.443
LIG_LIR_Nem_3	226	231	PF02991	0.368
LIG_LIR_Nem_3	308	312	PF02991	0.421
LIG_LIR_Nem_3	325	329	PF02991	0.481
LIG_LIR_Nem_3	341	347	PF02991	0.476
LIG_LIR_Nem_3	39	44	PF02991	0.509
LIG_LIR_Nem_3	93	97	PF02991	0.421
LIG_PDZ_Class_2	352	357	PF00595	0.534
LIG_Pex14_2	17	21	PF04695	0.447
LIG_Pex14_2	238	242	PF04695	0.511
LIG_SH2_CRK	150	154	PF00017	0.390
LIG_SH2_CRK	309	313	PF00017	0.422
LIG_SH2_SRC	135	138	PF00017	0.486
LIG_SH2_STAP1	221	225	PF00017	0.386
LIG_SH2_STAT3	221	224	PF00017	0.389
LIG_SH2_STAT5	135	138	PF00017	0.486
LIG_SH2_STAT5	237	240	PF00017	0.412
LIG_SH3_2	265	270	PF14604	0.720
LIG_SH3_3	259	265	PF00018	0.701
LIG_SH3_3	331	337	PF00018	0.562
LIG_SUMO_SIM_par_1	48	54	PF11976	0.578
LIG_TYR_ITSM	224	231	PF00017	0.282
LIG_WRC_WIRS_1	199	204	PF05994	0.528
LIG_WRC_WIRS_1	295	300	PF05994	0.598
MOD_CK1_1	192	198	PF00069	0.546
MOD_CK1_1	201	207	PF00069	0.507
MOD_CK1_1	54	60	PF00069	0.616
MOD_CK2_1	118	124	PF00069	0.538
MOD_CK2_1	286	292	PF00069	0.511
MOD_CK2_1	8	14	PF00069	0.534
MOD_GlcNHglycan	10	13	PF01048	0.455
MOD_GSK3_1	187	194	PF00069	0.488
MOD_GSK3_1	247	254	PF00069	0.497
MOD_GSK3_1	256	263	PF00069	0.548
MOD_GSK3_1	26	33	PF00069	0.519
MOD_GSK3_1	282	289	PF00069	0.624
MOD_GSK3_1	290	297	PF00069	0.576
MOD_N-GLC_1	300	305	PF02516	0.621
MOD_NEK2_1	223	228	PF00069	0.279
MOD_NEK2_1	247	252	PF00069	0.564
MOD_NEK2_1	26	31	PF00069	0.481
MOD_NEK2_1	294	299	PF00069	0.591
MOD_PKA_2	176	182	PF00069	0.585
MOD_PKA_2	247	253	PF00069	0.571
MOD_PKA_2	273	279	PF00069	0.683
MOD_PKB_1	272	280	PF00069	0.684
MOD_PKB_1	6	14	PF00069	0.591
MOD_Plk_1	340	346	PF00069	0.509
MOD_Plk_2-3	286	292	PF00069	0.602
MOD_Plk_4	223	229	PF00069	0.279
MOD_Plk_4	290	296	PF00069	0.542
MOD_Plk_4	330	336	PF00069	0.448
MOD_Plk_4	343	349	PF00069	0.438
MOD_ProDKin_1	118	124	PF00069	0.600
MOD_ProDKin_1	260	266	PF00069	0.608
MOD_ProDKin_1	327	333	PF00069	0.563
MOD_SUMO_for_1	315	318	PF00179	0.507
MOD_SUMO_rev_2	319	329	PF00179	0.508
MOD_SUMO_rev_2	39	49	PF00179	0.472
MOD_SUMO_rev_2	80	87	PF00179	0.560
TRG_DiLeu_BaEn_4	131	137	PF01217	0.503
TRG_ENDOCYTIC_2	135	138	PF00928	0.405
TRG_ENDOCYTIC_2	150	153	PF00928	0.390
TRG_ENDOCYTIC_2	228	231	PF00928	0.381
TRG_ENDOCYTIC_2	309	312	PF00928	0.419
TRG_ER_diArg_1	175	178	PF00400	0.540
TRG_ER_diArg_1	272	275	PF00400	0.694
TRG_NES_CRM1_1	132	144	PF08389	0.548
TRG_NES_CRM1_1	246	261	PF08389	0.545
TRG_NLS_Bipartite_1	88	103	PF00514	0.569
TRG_NLS_MonoExtN_4	3	9	PF00514	0.499
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D3	Leptomonas seymouri	66%	92%
A0A1X0NXF1	Trypanosomatidae	43%	100%
A0A3Q8IDU8	Leishmania donovani	97%	100%
A4HBN7	Leishmania braziliensis	88%	100%
A4HZ38	Leishmania infantum	97%	100%
D0A1N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AV06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%