Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania major

UniProt:

Q4QCH5_LEIMA

TriTrypDb:

LmjF.21.0400 , LMJLV39_210009300 , LMJSD75_210009400

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005829	cytosol	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

Q4QCH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCH5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	15
GO:0006511	ubiquitin-dependent protein catabolic process	7	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009056	catabolic process	2	15
GO:0009057	macromolecule catabolic process	4	15
GO:0009987	cellular process	1	15
GO:0016579	protein deubiquitination	6	15
GO:0019538	protein metabolic process	3	15
GO:0019941	modification-dependent protein catabolic process	6	15
GO:0036211	protein modification process	4	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0043632	modification-dependent macromolecule catabolic process	5	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044248	cellular catabolic process	3	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0044265	obsolete cellular macromolecule catabolic process	4	15
GO:0051603	proteolysis involved in protein catabolic process	5	15
GO:0070646	protein modification by small protein removal	5	15
GO:0070647	protein modification by small protein conjugation or removal	5	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901575	organic substance catabolic process	3	15

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004175	endopeptidase activity	4	3
GO:0004197	cysteine-type endopeptidase activity	5	3
GO:0004843	cysteine-type deubiquitinase activity	5	15
GO:0008233	peptidase activity	3	15
GO:0008234	cysteine-type peptidase activity	4	15
GO:0016787	hydrolase activity	2	15
GO:0019783	ubiquitin-like protein peptidase activity	4	15
GO:0101005	deubiquitinase activity	5	15
GO:0140096	catalytic activity, acting on a protein	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.617
CLV_C14_Caspase3-7	541	545	PF00656	0.358
CLV_NRD_NRD_1	580	582	PF00675	0.344
CLV_NRD_NRD_1	623	625	PF00675	0.374
CLV_NRD_NRD_1	93	95	PF00675	0.721
CLV_PCSK_KEX2_1	140	142	PF00082	0.559
CLV_PCSK_KEX2_1	490	492	PF00082	0.324
CLV_PCSK_KEX2_1	580	582	PF00082	0.317
CLV_PCSK_KEX2_1	623	625	PF00082	0.374
CLV_PCSK_KEX2_1	93	95	PF00082	0.726
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.541
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.295
CLV_PCSK_SKI1_1	283	287	PF00082	0.270
CLV_PCSK_SKI1_1	470	474	PF00082	0.387
CLV_PCSK_SKI1_1	498	502	PF00082	0.330
CLV_PCSK_SKI1_1	636	640	PF00082	0.452
DEG_APCC_DBOX_1	228	236	PF00400	0.282
DEG_APCC_DBOX_1	579	587	PF00400	0.374
DEG_APCC_KENBOX_2	362	366	PF00400	0.232
DEG_SCF_FBW7_1	38	45	PF00400	0.515
DEG_SPOP_SBC_1	545	549	PF00917	0.386
DEG_SPOP_SBC_1	651	655	PF00917	0.294
DOC_MAPK_gen_1	340	347	PF00069	0.324
DOC_MAPK_gen_1	503	510	PF00069	0.258
DOC_MAPK_HePTP_8	421	433	PF00069	0.374
DOC_MAPK_HePTP_8	500	512	PF00069	0.247
DOC_MAPK_MEF2A_6	424	433	PF00069	0.278
DOC_MAPK_MEF2A_6	503	512	PF00069	0.329
DOC_MAPK_MEF2A_6	57	65	PF00069	0.546
DOC_MAPK_RevD_3	475	491	PF00069	0.281
DOC_PP4_FxxP_1	448	451	PF00568	0.258
DOC_PP4_FxxP_1	642	645	PF00568	0.374
DOC_USP7_MATH_1	152	156	PF00917	0.662
DOC_USP7_MATH_1	375	379	PF00917	0.322
DOC_USP7_MATH_1	42	46	PF00917	0.659
DOC_USP7_MATH_1	545	549	PF00917	0.313
DOC_USP7_MATH_1	72	76	PF00917	0.580
DOC_USP7_MATH_1	9	13	PF00917	0.675
DOC_USP7_UBL2_3	279	283	PF12436	0.360
DOC_WW_Pin1_4	111	116	PF00397	0.583
DOC_WW_Pin1_4	122	127	PF00397	0.436
DOC_WW_Pin1_4	145	150	PF00397	0.589
DOC_WW_Pin1_4	38	43	PF00397	0.514
DOC_WW_Pin1_4	396	401	PF00397	0.327
DOC_WW_Pin1_4	4	9	PF00397	0.693
DOC_WW_Pin1_4	45	50	PF00397	0.462
DOC_WW_Pin1_4	565	570	PF00397	0.339
DOC_WW_Pin1_4	84	89	PF00397	0.636
LIG_14-3-3_CanoR_1	132	137	PF00244	0.547
LIG_14-3-3_CanoR_1	44	49	PF00244	0.537
LIG_14-3-3_CanoR_1	73	82	PF00244	0.768
LIG_14-3-3_CanoR_1	93	101	PF00244	0.664
LIG_APCC_ABBAyCdc20_2	424	430	PF00400	0.374
LIG_BIR_II_1	1	5	PF00653	0.462
LIG_BIR_III_4	647	651	PF00653	0.374
LIG_BRCT_BRCA1_1	175	179	PF00533	0.464
LIG_BRCT_BRCA1_1	343	347	PF00533	0.357
LIG_BRCT_BRCA1_1	76	80	PF00533	0.737
LIG_FHA_1	15	21	PF00498	0.464
LIG_FHA_1	192	198	PF00498	0.500
LIG_FHA_1	306	312	PF00498	0.322
LIG_FHA_1	411	417	PF00498	0.303
LIG_FHA_1	437	443	PF00498	0.232
LIG_FHA_1	472	478	PF00498	0.374
LIG_FHA_1	5	11	PF00498	0.792
LIG_FHA_1	594	600	PF00498	0.374
LIG_FHA_1	653	659	PF00498	0.270
LIG_FHA_1	96	102	PF00498	0.660
LIG_FHA_2	374	380	PF00498	0.357
LIG_FHA_2	420	426	PF00498	0.343
LIG_FHA_2	519	525	PF00498	0.374
LIG_FHA_2	630	636	PF00498	0.317
LIG_LIR_Apic_2	32	38	PF02991	0.627
LIG_LIR_Apic_2	446	451	PF02991	0.302
LIG_LIR_Gen_1	194	204	PF02991	0.409
LIG_LIR_Gen_1	306	315	PF02991	0.241
LIG_LIR_Gen_1	425	436	PF02991	0.275
LIG_LIR_Gen_1	654	665	PF02991	0.297
LIG_LIR_Nem_3	194	199	PF02991	0.448
LIG_LIR_Nem_3	234	239	PF02991	0.349
LIG_LIR_Nem_3	306	310	PF02991	0.285
LIG_LIR_Nem_3	425	431	PF02991	0.273
LIG_LIR_Nem_3	654	660	PF02991	0.297
LIG_PCNA_PIPBox_1	513	522	PF02747	0.374
LIG_PTB_Apo_2	208	215	PF02174	0.253
LIG_PTB_Phospho_1	208	214	PF10480	0.238
LIG_SH2_CRK	35	39	PF00017	0.642
LIG_SH2_CRK	483	487	PF00017	0.258
LIG_SH2_NCK_1	661	665	PF00017	0.307
LIG_SH2_PTP2	657	660	PF00017	0.258
LIG_SH2_SRC	27	30	PF00017	0.591
LIG_SH2_STAP1	335	339	PF00017	0.398
LIG_SH2_STAP1	483	487	PF00017	0.311
LIG_SH2_STAP1	661	665	PF00017	0.364
LIG_SH2_STAT3	617	620	PF00017	0.322
LIG_SH2_STAT5	214	217	PF00017	0.308
LIG_SH2_STAT5	239	242	PF00017	0.436
LIG_SH2_STAT5	27	30	PF00017	0.608
LIG_SH2_STAT5	35	38	PF00017	0.691
LIG_SH2_STAT5	453	456	PF00017	0.367
LIG_SH2_STAT5	519	522	PF00017	0.365
LIG_SH2_STAT5	611	614	PF00017	0.275
LIG_SH2_STAT5	641	644	PF00017	0.376
LIG_SH2_STAT5	657	660	PF00017	0.239
LIG_SH3_2	88	93	PF14604	0.636
LIG_SH3_3	146	152	PF00018	0.638
LIG_SH3_3	505	511	PF00018	0.309
LIG_SH3_3	79	85	PF00018	0.665
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.327
LIG_SUMO_SIM_par_1	112	120	PF11976	0.660
LIG_TRAF2_1	423	426	PF00917	0.425
LIG_TRAF2_1	575	578	PF00917	0.365
LIG_TYR_ITIM	659	664	PF00017	0.292
LIG_UBA3_1	260	266	PF00899	0.294
LIG_UBA3_1	485	490	PF00899	0.253
MOD_CDC14_SPxK_1	90	93	PF00782	0.571
MOD_CDK_SPxK_1	38	44	PF00069	0.515
MOD_CDK_SPxK_1	87	93	PF00069	0.569
MOD_CDK_SPxxK_3	122	129	PF00069	0.529
MOD_CDK_SPxxK_3	4	11	PF00069	0.534
MOD_CDK_SPxxK_3	87	94	PF00069	0.571
MOD_CK1_1	122	128	PF00069	0.560
MOD_CK1_1	14	20	PF00069	0.631
MOD_CK1_1	148	154	PF00069	0.579
MOD_CK1_1	174	180	PF00069	0.617
MOD_CK1_1	187	193	PF00069	0.492
MOD_CK1_1	358	364	PF00069	0.319
MOD_CK1_1	4	10	PF00069	0.540
MOD_CK1_1	432	438	PF00069	0.349
MOD_CK1_1	45	51	PF00069	0.635
MOD_CK1_1	547	553	PF00069	0.289
MOD_CK1_1	554	560	PF00069	0.290
MOD_CK1_1	568	574	PF00069	0.308
MOD_CK1_1	75	81	PF00069	0.622
MOD_CK1_1	87	93	PF00069	0.548
MOD_CK2_1	358	364	PF00069	0.364
MOD_CK2_1	419	425	PF00069	0.373
MOD_CK2_1	518	524	PF00069	0.371
MOD_CK2_1	629	635	PF00069	0.295
MOD_GlcNHglycan	11	14	PF01048	0.559
MOD_GlcNHglycan	180	183	PF01048	0.609
MOD_GlcNHglycan	3	6	PF01048	0.661
MOD_GlcNHglycan	394	397	PF01048	0.353
MOD_GlcNHglycan	50	53	PF01048	0.590
MOD_GlcNHglycan	540	543	PF01048	0.331
MOD_GlcNHglycan	549	552	PF01048	0.317
MOD_GlcNHglycan	554	557	PF01048	0.386
MOD_GlcNHglycan	607	610	PF01048	0.323
MOD_GSK3_1	106	113	PF00069	0.563
MOD_GSK3_1	132	139	PF00069	0.554
MOD_GSK3_1	148	155	PF00069	0.583
MOD_GSK3_1	16	23	PF00069	0.636
MOD_GSK3_1	160	167	PF00069	0.557
MOD_GSK3_1	171	178	PF00069	0.611
MOD_GSK3_1	187	194	PF00069	0.501
MOD_GSK3_1	264	271	PF00069	0.354
MOD_GSK3_1	29	36	PF00069	0.478
MOD_GSK3_1	341	348	PF00069	0.284
MOD_GSK3_1	375	382	PF00069	0.318
MOD_GSK3_1	38	45	PF00069	0.609
MOD_GSK3_1	392	399	PF00069	0.388
MOD_GSK3_1	432	439	PF00069	0.280
MOD_GSK3_1	534	541	PF00069	0.364
MOD_GSK3_1	547	554	PF00069	0.194
MOD_GSK3_1	564	571	PF00069	0.370
MOD_GSK3_1	83	90	PF00069	0.590
MOD_GSK3_1	95	102	PF00069	0.550
MOD_N-GLC_1	110	115	PF02516	0.766
MOD_N-GLC_1	268	273	PF02516	0.385
MOD_N-GLC_1	419	424	PF02516	0.317
MOD_N-GLC_1	552	557	PF02516	0.453
MOD_N-GLC_1	563	568	PF02516	0.290
MOD_N-GLC_1	99	104	PF02516	0.788
MOD_N-GLC_2	211	213	PF02516	0.253
MOD_NEK2_1	121	126	PF00069	0.589
MOD_NEK2_1	136	141	PF00069	0.681
MOD_NEK2_1	161	166	PF00069	0.548
MOD_NEK2_1	173	178	PF00069	0.639
MOD_NEK2_1	197	202	PF00069	0.446
MOD_NEK2_1	264	269	PF00069	0.349
MOD_NEK2_1	33	38	PF00069	0.688
MOD_NEK2_1	345	350	PF00069	0.407
MOD_NEK2_1	367	372	PF00069	0.342
MOD_NEK2_1	593	598	PF00069	0.258
MOD_NEK2_1	65	70	PF00069	0.626
MOD_NEK2_2	152	157	PF00069	0.512
MOD_NEK2_2	209	214	PF00069	0.258
MOD_NEK2_2	335	340	PF00069	0.239
MOD_NEK2_2	471	476	PF00069	0.357
MOD_PIKK_1	534	540	PF00454	0.319
MOD_PIKK_1	55	61	PF00454	0.697
MOD_PIKK_1	65	71	PF00454	0.671
MOD_PKA_1	341	347	PF00069	0.357
MOD_PKA_2	72	78	PF00069	0.705
MOD_Plk_1	249	255	PF00069	0.278
MOD_Plk_1	305	311	PF00069	0.370
MOD_Plk_1	335	341	PF00069	0.477
MOD_Plk_1	367	373	PF00069	0.296
MOD_Plk_1	42	48	PF00069	0.530
MOD_Plk_1	429	435	PF00069	0.255
MOD_Plk_1	526	532	PF00069	0.450
MOD_Plk_1	626	632	PF00069	0.301
MOD_Plk_2-3	518	524	PF00069	0.374
MOD_Plk_4	214	220	PF00069	0.393
MOD_Plk_4	249	255	PF00069	0.258
MOD_Plk_4	256	262	PF00069	0.265
MOD_Plk_4	29	35	PF00069	0.614
MOD_Plk_4	437	443	PF00069	0.282
MOD_ProDKin_1	111	117	PF00069	0.581
MOD_ProDKin_1	122	128	PF00069	0.436
MOD_ProDKin_1	145	151	PF00069	0.588
MOD_ProDKin_1	38	44	PF00069	0.515
MOD_ProDKin_1	396	402	PF00069	0.327
MOD_ProDKin_1	4	10	PF00069	0.695
MOD_ProDKin_1	45	51	PF00069	0.464
MOD_ProDKin_1	565	571	PF00069	0.339
MOD_ProDKin_1	84	90	PF00069	0.636
MOD_SUMO_for_1	291	294	PF00179	0.232
MOD_SUMO_for_1	333	336	PF00179	0.232
MOD_SUMO_rev_2	23	33	PF00179	0.490
MOD_SUMO_rev_2	463	468	PF00179	0.425
TRG_DiLeu_BaEn_2	305	311	PF01217	0.258
TRG_DiLeu_BaEn_2	593	599	PF01217	0.374
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.282
TRG_ENDOCYTIC_2	483	486	PF00928	0.306
TRG_ENDOCYTIC_2	641	644	PF00928	0.374
TRG_ENDOCYTIC_2	657	660	PF00928	0.307
TRG_ENDOCYTIC_2	661	664	PF00928	0.353
TRG_ER_diArg_1	228	231	PF00400	0.266
TRG_ER_diArg_1	579	581	PF00400	0.276
TRG_ER_diArg_1	622	624	PF00400	0.374
TRG_NLS_MonoExtC_3	241	246	PF00514	0.271
TRG_NLS_MonoExtN_4	580	585	PF00514	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z2	Leptomonas seymouri	23%	83%
A0A0N0P852	Leptomonas seymouri	68%	88%
A0A0S4IVV7	Bodo saltans	22%	100%
A0A3Q8IB18	Leishmania donovani	95%	92%
A0A422MZT5	Trypanosoma rangeli	42%	100%
A4HBN8	Leishmania braziliensis	79%	90%
A4HZ39	Leishmania infantum	95%	92%
A4IBF1	Leishmania infantum	24%	100%
D0A1P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AV07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AWQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	82%
P39944	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	83%
Q4QAS1	Leishmania major	22%	82%
V5DGZ8	Trypanosoma cruzi	40%	100%